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NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways

https://doi.org/10.1093/mutage/geab011
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1 of the 71 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1186/s13395-016-0075-9 (notice 2021-03-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.32200openalex-snapshot
Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors
inferredcites →https://doi.org/10.1002/jcb.28943openalex-snapshot
NEK5 interacts with topoisomerase IIβ and is involved in the DNA damage response induced by etoposide
inferredcites →https://doi.org/10.1002/jcp.21811openalex-snapshot
DNA interstrand crosslink repair in mammalian cells
inferredcites →https://doi.org/10.1007/s10863-008-9142-1openalex-snapshot
VDAC activation by the 18 kDa translocator protein (TSPO), implications for apoptosis
inferredcites →https://doi.org/10.1016/0092-8674(93)90509-oopenalex-snapshot
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
inferredcites →https://doi.org/10.1016/j.bbamcr.2010.10.002openalex-snapshot
DNA repair in organelles: Pathways, organization, regulation, relevance in disease and aging
inferredcites →https://doi.org/10.1016/j.bbrc.2010.03.077openalex-snapshot
Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1
inferredcites →https://doi.org/10.1016/j.bbrc.2016.05.156openalex-snapshot
Frequent Nek1 overexpression in human gliomas
inferredcites →https://doi.org/10.1016/j.canlet.2019.03.041openalex-snapshot
The TLK1-Nek1 axis promotes prostate cancer progression
inferredcites →https://doi.org/10.1016/j.cellsig.2015.02.021openalex-snapshot
Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration
inferredcites →https://doi.org/10.1016/j.molcel.2013.08.006openalex-snapshot
NEK8 Links the ATR-Regulated Replication Stress Response and S Phase CDK Activity to Renal Ciliopathies
inferredcites →https://doi.org/10.1016/j.molcel.2017.01.015openalex-snapshot
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
inferredcites →https://doi.org/10.1016/j.mrfmmm.2003.06.002openalex-snapshot
The interacting pathways for prevention and repair of oxidative DNA damage
inferredcites →https://doi.org/10.1016/j.tibs.2018.02.010openalex-snapshot
The Cellular Response to Transcription-Blocking DNA Damage
inferredcites →https://doi.org/10.1016/s0092-8674(00)81005-3openalex-snapshot
A License to Kill
inferredcites →https://doi.org/10.1016/s0300-9084(02)01370-6openalex-snapshot
The voltage-dependent anion channel: an essential player in apoptosis
inferredcites →https://doi.org/10.1016/s1050-1738(02)00184-6openalex-snapshot
Desmin Cytoskeleton A Potential Regulator of Muscle Mitochondrial Behavior and Function
inferredcites →https://doi.org/10.1021/bi034575vopenalex-snapshot
Identification of Proteins That Interact with the Central Coiled-Coil Region of the Human Protein Kinase NEK1
inferredcites →https://doi.org/10.1021/np990549fopenalex-snapshot
Bleomycin: New Perspectives on the Mechanism of Action
inferredcites →https://doi.org/10.1038/35004029openalex-snapshot
The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
inferredcites →https://doi.org/10.1038/cdd.2013.139openalex-snapshot
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
inferredcites →https://doi.org/10.1038/nature10348openalex-snapshot
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
inferredcites →https://doi.org/10.1038/ng.3626openalex-snapshot
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1038/nm0302-216openalex-snapshot
Apoptosis and cancer: When BAX is TRAILing away
inferredcites →https://doi.org/10.1038/nrm.2016.14openalex-snapshot
Nuclear DNA damage signalling to mitochondria in ageing
inferredcites →https://doi.org/10.1038/s41598-017-05325-wopenalex-snapshot
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
inferredcites →https://doi.org/10.1038/sj.cdd.4400476openalex-snapshot
Emerging roles of caspase-3 in apoptosis
inferredcites →https://doi.org/10.1042/bj3260001openalex-snapshot
Caspases: the executioners of apoptosis
inferredcites →https://doi.org/10.1073/pnas.1217781110openalex-snapshot
Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling
inferredcites →https://doi.org/10.1073/pnas.97.1.217openalex-snapshot
Mutations in a NIMA-related kinase gene, Nek1 , cause pleiotropic effects including a progressive polycystic kidney disease in mice
inferredcites →https://doi.org/10.1074/jbc.271.43.27099openalex-snapshot
The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32
inferredcites →https://doi.org/10.1074/jbc.m204599200openalex-snapshot
Nek11, a New Member of the NIMA Family of Kinases, Involved in DNA Replication and Genotoxic Stress Responses
inferredcites →https://doi.org/10.1080/15384101.2019.1711317openalex-snapshot
The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1
inferredcites →https://doi.org/10.1089/ars.2007.1830openalex-snapshot
DNA Damage and Repair: From Molecular Mechanisms to Health Implications
inferredcites →https://doi.org/10.1093/brain/aww033openalex-snapshot
NEK1 mutations in familial amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1093/mutage/geq026openalex-snapshot
Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest
inferredcites →https://doi.org/10.1093/nar/27.1.29openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/30.3.667openalex-snapshot
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction
inferredcites →https://doi.org/10.1093/nar/gki681openalex-snapshot
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
inferredcites →https://doi.org/10.1093/nar/gkq193openalex-snapshot
Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population
inferredcites →https://doi.org/10.1093/nar/gkt076openalex-snapshot
Mammalian Base Excision Repair: the Forgotten Archangel
inferredcites →https://doi.org/10.1093/nar/gkx015openalex-snapshot
A novel role for transcription-coupled nucleotide excision repair for thein vivorepair of 3,N4-ethenocytosine
inferredcites →https://doi.org/10.1101/cshperspect.a012641openalex-snapshot
The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update
inferredcites →https://doi.org/10.1101/gad.13.15.1899openalex-snapshot
BCL-2 family members and the mitochondria in apoptosis
inferredcites →https://doi.org/10.1126/science.1076182openalex-snapshot
53BP1, a Mediator of the DNA Damage Checkpoint
inferredcites →https://doi.org/10.1126/science.aaa3650openalex-snapshot
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
inferredcites →https://doi.org/10.1128/mcb.00436-12openalex-snapshot
Nek4 Regulates Entry into Replicative Senescence and the Response to DNA Damage in Human Fibroblasts
inferredcites →https://doi.org/10.1128/mcb.00648-10openalex-snapshot
Nek10 Mediates G2/M Cell Cycle Arrest and MEK Autoactivation in Response to UV Irradiation
inferredcites →https://doi.org/10.1128/mcb.20.9.3147-3156.2000openalex-snapshot
Mouse RAD54 Affects DNA Double-Strand Break Repair and Sister Chromatid Exchange
inferredcites →https://doi.org/10.1128/mmbr.63.2.349-404.1999openalex-snapshot
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1134/s0006297911010032openalex-snapshot
Role of nucleotide excision repair proteins in oxidative DNA damage repair: an updating
inferredcites →https://doi.org/10.1155/2019/4654206openalex-snapshot
Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2243openalex-snapshot
NIMA-Related Protein Kinase 1 Is Involved Early in the Ionizing Radiation-Induced DNA Damage Response
inferredcites →https://doi.org/10.1159/000477308openalex-snapshot
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
inferredcites →https://doi.org/10.1186/s12885-019-6408-4openalex-snapshot
Expression of the NEK family in normal and cancer tissue: an immunohistochemical study
inferredcites →https://doi.org/10.1186/s12953-020-00160-wopenalex-snapshot
NEK10 interactome and depletion reveal new roles in mitochondria
inferredcites →https://doi.org/10.1186/s13395-016-0075-9openalex-snapshot
RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
inferredcites →https://doi.org/10.1242/jcs.111195openalex-snapshot
Cell cycle regulation by the NEK family of protein kinases
inferredcites →https://doi.org/10.1371/journal.pone.0136812openalex-snapshot
Array CGH Analysis of Paired Blood and Tumor Samples from Patients with Sporadic Wilms Tumor
inferredcites →https://doi.org/10.1667/rr3211openalex-snapshot
Inhibition of Centrosome Separation after DNA Damage: A Role for Nek2
inferredcites →https://doi.org/10.18632/oncotarget.2005openalex-snapshot
Increased Nek1 expression in Renal Cell Carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment
inferredcites →https://doi.org/10.2741/3992openalex-snapshot
DNA repair mechanisms protect our genome from carcinogenesis
inferredcites →https://doi.org/10.4061/2010/201367openalex-snapshot
Cellular Responses to Cisplatin‐Induced DNA Damage
inferredcites →https://doi.org/10.4161/cc.10.4.14814openalex-snapshot
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR
inferredcites →https://doi.org/10.4161/cc.7.17.6551openalex-snapshot
Nek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylation
inferredcites →https://doi.org/10.4161/cc.7.20.6815openalex-snapshot
Never-in-mitosis related Kinase 1 functions in DNA damage response and checkpoint control
inferredcites →https://doi.org/10.4161/cc.8.2.7551openalex-snapshot
Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1
inferredcites →https://doi.org/10.4172/2576-1471.1000133openalex-snapshot
Nek5 Association with Mitochondria Proteins and Functions: Is It a Nek Family characteristic?
inferredcites →https://doi.org/10.4331/wjbc.v5.i2.141openalex-snapshot
“Stop Ne(c)king around”: How interactomics contributes to functionally characterize Nek family kinases
inferredcites →https://doi.org/10.7554/elife.32536openalex-snapshot
Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4781335openalex-extracted
The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.mad.2023.111838openalex-snapshot
Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances
inferred← citeshttps://doi.org/10.1016/j.neo.2025.101159openalex-snapshot
MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation
inferred← citeshttps://doi.org/10.1016/j.neulet.2024.137913openalex-snapshot
Association between NEK1 gene polymorphisms and the potential risk of sporadic Parkinson’s disease in the Chinese Northern Han population: A case-control study
inferred← citeshttps://doi.org/10.1038/s42003-025-07568-0openalex-snapshot
Fluo-Cast-Bright: a deep learning pipeline for the non-invasive prediction of chromatin structure and developmental potential in live oocytes
inferred← citeshttps://doi.org/10.1093/hmg/ddae121openalex-snapshot
NEK1 haploinsufficiency worsens DNA damage, but not defective ciliogenesis, in C9ORF72 patient-derived iPSC-motoneurons
inferred← citeshttps://doi.org/10.1093/nar/gkaf1201openalex-snapshot
The chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage
inferred← citeshttps://doi.org/10.1097/md.0000000000038961openalex-snapshot
Prognostic value and immune infiltration of the NEK family in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1111/bpa.13287openalex-snapshot
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1111/febs.16343openalex-snapshot
Nek4 regulates mitochondrial respiration and morphology
inferred← citeshttps://doi.org/10.1186/s12953-024-00234-zopenalex-snapshot
NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status
inferred← citeshttps://doi.org/10.1186/s12964-022-01006-yopenalex-snapshot
Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.1186/s40478-024-01852-6openalex-snapshot
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons
inferred← citeshttps://doi.org/10.3390/biom15101406openalex-snapshot
NEK Family Kinases: Structure, Function, and Role in Disease
inferred← citeshttps://doi.org/10.3390/cancers15194821openalex-snapshot
Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus
inferred← citeshttps://doi.org/10.3390/cells13060473openalex-snapshot
The Mitochondrial Connection: The Nek Kinases’ New Functional Axis in Mitochondrial Homeostasis
inferred← citeshttps://doi.org/10.3390/genes16040407openalex-snapshot
The Molecular Intersection of NEK1, C21ORF2, Cyclin F, and VCP in ALS Pathogenesis
inferred← citeshttps://doi.org/10.3390/ijms23074041openalex-snapshot
In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals
inferred← citeshttps://doi.org/10.3390/medicina61071184openalex-snapshot
Clinical and Genetic Characteristics of Patients with Essential Tremor Who Develop Parkinson’s Disease
inferred← citeshttps://doi.org/10.54680/fr26210110712openalex-snapshot
Impact of vitrification cryopreservation on the transcriptomic profile of metaphase II mouse oocytes
inferred← citeshttps://doi.org/10.6084/m9.figshare.22616342openalex-snapshot
Additional file 2 of Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
inferred← citeshttps://doi.org/10.6084/m9.figshare.22616348openalex-snapshot
Additional file 3 of Identification of biological pathways and processes regulated by NEK5 in breast epithelial cells via an integrated proteomic approach
inferred← citeshttps://doi.org/10.64898/2026.06.17.733013openalex-snapshot
NEK1 autophosphorylation is disrupted by amyotrophic lateral sclerosis-associated missense variants: activity biomarkers and structural insights
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