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Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06874.xopenalex-snapshot

Mutation of conserved domain II alters the sequence specificity of DNA binding by the p53 protein.

inferredcites →https://doi.org/10.1007/s00018-003-3304-4openalex-snapshot

The common and distinct target genes of the p53 family transcription factors

inferredcites →https://doi.org/10.1016/j.jmb.2011.11.007openalex-snapshot

Structure and Kinetic Stability of the p63 Tetramerization Domain

inferredcites →https://doi.org/10.1016/j.molcel.2006.05.015openalex-snapshot

Structural Basis of DNA Recognition by p53 Tetramers

inferredcites →https://doi.org/10.1016/j.molcel.2006.11.026openalex-snapshot

Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction

inferredcites →https://doi.org/10.1016/j.molcel.2010.02.037openalex-snapshot

DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

inferredcites →https://doi.org/10.1016/j.str.2009.11.011openalex-snapshot

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer

inferredcites →https://doi.org/10.1016/s0014-5793(00)02437-6openalex-snapshot

Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family

inferredcites →https://doi.org/10.1016/s0076-6879(03)74014-2openalex-snapshot

Macromolecular TLS Refinement in REFMAC at Moderate Resolutions

inferredcites →https://doi.org/10.1016/s0076-6879(97)76066-xopenalex-snapshot

[20] Processing of X-ray diffraction data collected in oscillation mode

inferredcites →https://doi.org/10.1016/s0092-8674(00)80540-1openalex-snapshot

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

inferredcites →https://doi.org/10.1016/s1097-2765(00)80275-0openalex-snapshot

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

inferredcites →https://doi.org/10.1038/19531openalex-snapshot

p63 is a p53 homologue required for limb and epidermal morphogenesis

inferredcites →https://doi.org/10.1038/19539openalex-snapshot

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

inferredcites →https://doi.org/10.1038/278261a0openalex-snapshot

T antigen is bound to a host protein in SY40-transformed cells

inferredcites →https://doi.org/10.1038/35003607openalex-snapshot

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

inferredcites →https://doi.org/10.1038/356215a0openalex-snapshot

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

inferredcites →https://doi.org/10.1038/416560aopenalex-snapshot

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

inferredcites →https://doi.org/10.1038/cdd.2010.35openalex-snapshot

p53-family proteins and their regulators: hubs and spokes in tumor suppression

inferredcites →https://doi.org/10.1038/cdd.2011.148openalex-snapshot

Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

inferredcites →https://doi.org/10.1038/cdd.2012.89openalex-snapshot

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

inferredcites →https://doi.org/10.1038/emboj.2011.127openalex-snapshot

An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity

inferredcites →https://doi.org/10.1038/ng0492-45openalex-snapshot

Definition of a consensus binding site for p53

inferredcites →https://doi.org/10.1038/nprot.2007.406openalex-snapshot

Version 1.2 of the Crystallography and NMR system

inferredcites →https://doi.org/10.1038/nrc2730openalex-snapshot

The expanding universe of p53 targets

inferredcites →https://doi.org/10.1038/nrm2395openalex-snapshot

Transcriptional control of human p53-regulated genes

inferredcites →https://doi.org/10.1038/nsmb.1800openalex-snapshot

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

inferredcites →https://doi.org/10.1038/onc.2008.37openalex-snapshot

Mechanisms of regulatory diversity within the p53 transcriptional network

inferredcites →https://doi.org/10.1038/onc.2008.400openalex-snapshot

Crystal structure of a p53 core tetramer bound to DNA

inferredcites →https://doi.org/10.1038/onc.2009.270openalex-snapshot

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

inferredcites →https://doi.org/10.1038/sj.onc.1204116openalex-snapshot

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay

inferredcites →https://doi.org/10.1038/sj.onc.1205069openalex-snapshot

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

inferredcites →https://doi.org/10.1038/sj.onc.1206511openalex-snapshot

Characterization of the p53 mutants ability to inhibit p73β transactivation using a yeast-based functional assay

inferredcites →https://doi.org/10.1038/sj.onc.1210561openalex-snapshot

p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm

inferredcites →https://doi.org/10.1046/j.1432-1327.2001.02225.xopenalex-snapshot

Post‐translational modifications and activation of p53 by genotoxic stresses

inferredcites →https://doi.org/10.1073/pnas.0401162101openalex-snapshot

A global suppressor motif for p53 cancer mutants

inferredcites →https://doi.org/10.1073/pnas.0500215102openalex-snapshot

Comparison of the protein–protein interfaces in the p53–DNA crystal structures: Towards elucidation of the biological interface

inferredcites →https://doi.org/10.1073/pnas.0704694105openalex-snapshot

Functional evolution of the p53 regulatory network through its target response elements

inferredcites →https://doi.org/10.1073/pnas.1013657108openalex-snapshot

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements

inferredcites →https://doi.org/10.1073/pnas.1105028108openalex-snapshot

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

inferredcites →https://doi.org/10.1073/pnas.1115463109openalex-snapshot

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

inferredcites →https://doi.org/10.1073/pnas.1205971109openalex-snapshot

Low-level p53 expression changes transactivation rules and reveals superactivating sequences

inferredcites →https://doi.org/10.1073/pnas.1633803100openalex-snapshot

Functional mutants of the sequence-specific transcription factor p53 and implications for master genes of diversity

inferredcites →https://doi.org/10.1073/pnas.2036296100openalex-snapshot

Chromosomal site-specific double-strand breaks are efficiently targeted for repair by oligonucleotides in yeast

inferredcites →https://doi.org/10.1073/pnas.94.26.14338openalex-snapshot

Thermodynamic stability of wild-type and mutant p53 core domain

inferredcites →https://doi.org/10.1073/pnas.96.5.1875openalex-snapshot

p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

inferredcites →https://doi.org/10.1074/jbc.m108080200openalex-snapshot

The p53 Family Member Genes Are Involved in the Notch Signal Pathway

inferredcites →https://doi.org/10.1074/jbc.m111.315820openalex-snapshot

Pliable DNA Conformation of Response Elements Bound to Transcription Factor p63

inferredcites →https://doi.org/10.1074/jbc.m112.408039openalex-snapshot

Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements

inferredcites →https://doi.org/10.1074/jbc.m603387200openalex-snapshot

Mutational Analysis of the p53 Core Domain L1 Loop

inferredcites →https://doi.org/10.1074/jbc.m603634200openalex-snapshot

Structure of the p53 Core Domain Dimer Bound to DNA

inferredcites →https://doi.org/10.1093/carcin/18.10.2019openalex-snapshot

Simple identification of dominant p53 mutants by a yeast functional assay

inferredcites →https://doi.org/10.1093/emboj/18.16.4424openalex-snapshot

Increased apoptosis induction by 121F mutant p53

inferredcites →https://doi.org/10.1093/nar/22.22.4673openalex-snapshot

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

inferredcites →https://doi.org/10.1093/nar/gkg680openalex-snapshot

3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures

inferredcites →https://doi.org/10.1093/nar/gkl1047openalex-snapshot

p53 and p73 display common and distinct requirements for sequence specific binding to DNA

inferredcites →https://doi.org/10.1093/nar/gkn044openalex-snapshot

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

inferredcites →https://doi.org/10.1093/nar/gkn232openalex-snapshot

Characterization of genome-wide p53-binding sites upon stress response

inferredcites →https://doi.org/10.1093/nar/gkp1229openalex-snapshot

RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability

inferredcites →https://doi.org/10.1093/nar/gkq1044openalex-snapshot

Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets

inferredcites →https://doi.org/10.1101/cshperspect.a000893openalex-snapshot

p53 Research: The Past Thirty Years and the Next Thirty Years

inferredcites →https://doi.org/10.1101/gad.1881010openalex-snapshot

Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin binding

inferredcites →https://doi.org/10.1107/s0021889807021206openalex-snapshot

Phaser crystallographic software

inferredcites →https://doi.org/10.1107/s0021889892009944openalex-snapshot

PROCHECK: a program to check the stereochemical quality of protein structures

inferredcites →https://doi.org/10.1107/s0907444904019158openalex-snapshot

Coot : model-building tools for molecular graphics

inferredcites →https://doi.org/10.1107/s0907444910045749openalex-snapshot

Overview of the CCP 4 suite and current developments

inferredcites →https://doi.org/10.1126/science.1589764openalex-snapshot

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

inferredcites →https://doi.org/10.1126/science.8023157openalex-snapshot

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

inferredcites →https://doi.org/10.1128/mcb.22.24.8612-8625.2002openalex-snapshot

Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

inferredcites →https://doi.org/10.1128/mcb.22.8.2575-2585.2002openalex-snapshot

Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

inferredcites →https://doi.org/10.1128/mcb.25.14.6077-6089.2005openalex-snapshot

Differential Recognition of Response Elements Determines Target Gene Specificity forp53 and p63

inferredcites →https://doi.org/10.1128/mcb.26.6.2297-2308.2006openalex-snapshot

The Biological Impact of the Human Master Regulator p53 Can Be Altered by Mutations That Change the Spectrum and Expression of Its Target Genes

inferredcites →https://doi.org/10.1155/2012/687359openalex-snapshot

p53 Family: Role of Protein Isoforms in Human Cancer

inferredcites →https://doi.org/10.1158/1541-7786.371.2.7openalex-snapshot

p63 and p73: Roles in Development and Tumor Formation

inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0496openalex-snapshot

Dominant-Negative Features of Mutant TP53 in Germline Carriers Have Limited Impact on Cancer Outcomes

inferredcites →https://doi.org/10.1158/1541-7786.mcr-11-0351openalex-snapshot

Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element

inferredcites →https://doi.org/10.1177/1947601911408890openalex-snapshot

p73 in Cancer

inferredcites →https://doi.org/10.1177/1947601911413466openalex-snapshot

Li-Fraumeni Syndrome

inferredcites →https://doi.org/10.1186/1471-2164-10-628openalex-snapshot

Conservation of DNA-binding specificity and oligomerisation properties within the p53 family

inferredcites →https://doi.org/10.1371/journal.pgen.1000104openalex-snapshot

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

inferredcites →https://doi.org/10.1371/journal.pone.0010236openalex-snapshot

The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

inferredcites →https://doi.org/10.1371/journal.pone.0020643openalex-snapshot

p53 Transactivation and the Impact of Mutations, Cofactors and Small Molecules Using a Simplified Yeast-Based Screening System

inferredcites →https://doi.org/10.4161/cc.10.8.15297openalex-snapshot

p73: A complex gene for building a complex brain

inferredcites →https://doi.org/10.4161/cc.6.3.3796openalex-snapshot

p63-Associated Disorders

inferredcites →https://doi.org/10.4161/cc.9.20.13595openalex-snapshot

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes

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TP53 Mutants in the Tower of Babel of Cancer Progression

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Diepoxybutane induces the expression of a novel p53‐target gene XCL1 that mediates apoptosis in exposed human lymphoblasts

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Advanced Methods of Protein Crystallization

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Structural Studies on Mechanisms to Activate Mutant p53

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Modeling human disease in yeast: recreating the PI3K-PTEN-Akt signaling pathway in Saccharomyces cerevisiae

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Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure

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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

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Chemical principles additive model aligns low consensus DNA targets of p53 tumor suppressor protein

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p53 family interactions and yeast: together in anticancer therapy

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Structural Basis for p53 Lys120-Acetylation-Dependent DNA-Binding Mode

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Sequence similarity in 3D for comparison of protein families

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ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells

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282: p53-directed translational control can shape and expand the universe of p53 target genes

inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00152openalex-snapshot

Sequence Variation in the Response Element Determines Binding by the Transcription Factor p73

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Preclinical Lead Optimization of Small Molecule Inhibitors of TFCP2 (LSF) for the Treatment of Liver Cancer

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p53-directed translational control can shape and expand the universe of p53 target genes

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ETV7 regulates breast cancer stem-like cell features by repressing IFN-response genes

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Exploring p53 isoforms: unraveling heterogeneous p53 tumor suppressor functionality in uveal melanoma

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P63 modulates the expression of theWDFY2gene which is implicated in cancer regulation and limb development

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The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast Saccharomyces cerevisiae

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Human transcription factors in yeast: the fruitful examples of P53 and NF-кB

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Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

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Two p53 tetramers bind one consensus DNA response element

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The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast S. cerevisiae

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Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

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The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches

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Identification of new p53 target microRNAs by bioinformatics and functional analysis

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Evolution of p53 Transactivation Specificity through the Lens of a Yeast-Based Functional Assay

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Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay

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ΔN-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites

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Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation

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