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No evidence that natural selection has been less effective at removing deleterious mutations in Europeans than in West Africans

https://doi.org/10.1101/002865
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471142905.hg0720s76openalex-snapshot
Predicting Functional Effect of Human Missense Mutations Using PolyPhen‐2
inferredcites →https://doi.org/10.1016/j.ajhg.2012.08.025openalex-snapshot
Population Genetic Inference from Personal Genome Data: Impact of Ancestry and Admixture on Human Genomic Variation
inferredcites →https://doi.org/10.1038/nature06611openalex-snapshot
Proportionally more deleterious genetic variation in European than in African populations
inferredcites →https://doi.org/10.1038/nature07485openalex-snapshot
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
inferredcites →https://doi.org/10.1038/nature08795openalex-snapshot
Complete Khoisan and Bantu genomes from southern Africa
inferredcites →https://doi.org/10.1038/nature10231openalex-snapshot
Inference of human population history from individual whole-genome sequences
inferredcites →https://doi.org/10.1038/nature11632openalex-snapshot
An integrated map of genetic variation from 1,092 human genomes
inferredcites →https://doi.org/10.1038/nature11690openalex-snapshot
Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants
inferredcites →https://doi.org/10.1038/nature12886openalex-snapshot
The complete genome sequence of a Neanderthal from the Altai Mountains
inferredcites →https://doi.org/10.1038/nbt.1523openalex-snapshot
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing
inferredcites →https://doi.org/10.1038/ng.2368openalex-snapshot
Evidence of widespread selection on standing variation in Europe at height-associated SNPs
inferredcites →https://doi.org/10.1038/ng.2896openalex-snapshot
The deleterious mutation load is insensitive to recent population history
inferredcites →https://doi.org/10.1038/ng.937openalex-snapshot
Bayesian inference of ancient human demography from individual genome sequences
inferredcites →https://doi.org/10.1038/ng2116openalex-snapshot
Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
inferredcites →https://doi.org/10.1038/nrg2526openalex-snapshot
Effective population size and patterns of molecular evolution and variation
inferredcites →https://doi.org/10.1073/pnas.1019276108openalex-snapshot
Demographic history and rare allele sharing among human populations
inferredcites →https://doi.org/10.1093/nar/gkq603openalex-snapshot
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
inferredcites →https://doi.org/10.1093/protein/12.5.387openalex-snapshot
PSIC: profile extraction from sequence alignments with position-specific counts of independent observations
inferredcites →https://doi.org/10.1101/003491openalex-snapshot
Response to a population bottleneck can be used to infer recessive selection
inferredcites →https://doi.org/10.1101/gr.176601openalex-snapshot
Predicting Deleterious Amino Acid Substitutions
inferredcites →https://doi.org/10.1126/science.1219240openalex-snapshot
Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes
inferredcites →https://doi.org/10.1126/science.1224344openalex-snapshot
A High-Coverage Genome Sequence from an Archaic Denisovan Individual
inferredcites →https://doi.org/10.1146/annurev-genom-082908-150001openalex-snapshot
Biased Gene Conversion and the Evolution of Mammalian Genomic Landscapes
inferredcites →https://doi.org/10.1214/aos/1176347265openalex-snapshot
The Jackknife and the Bootstrap for General Stationary Observations
inferredcites →https://doi.org/10.1371/journal.pgen.1000083openalex-snapshot
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
inferredcites →https://doi.org/10.1371/journal.pgen.1003815openalex-snapshot
Whole-Exome Sequencing Reveals a Rapid Change in the Frequency of Rare Functional Variants in a Founding Population of Humans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.ajhg.2014.09.006openalex-snapshot
Characteristics of Neutral and Deleterious Protein-Coding Variation among Individuals and Populations
inferred← citeshttps://doi.org/10.1016/j.gde.2014.09.005openalex-snapshot
The distribution of deleterious genetic variation in human populations
inferred← citeshttps://doi.org/10.1016/j.jhevol.2017.03.004openalex-snapshot
An evolutionary medicine perspective on Neandertal extinction
inferred← citeshttps://doi.org/10.1038/ncomms12522openalex-snapshot
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome
inferred← citeshttps://doi.org/10.1073/pnas.2015096118openalex-snapshot
The inflated significance of neutral genetic diversity in conservation genetics
inferred← citeshttps://doi.org/10.1186/s12915-016-0283-0openalex-snapshot
Secondary structure impacts patterns of selection in human lncRNAs
inferred← citeshttps://doi.org/10.1371/journal.pgen.1006549openalex-snapshot
Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data
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