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Cancer cells have distinct electrical properties that predict a susceptibility to lipophilic anions; a new cancer drug paradigm
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Molecular bioelectricity in developmental biology: New tools and recent discoveries
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Phase II study of tariquidar, a selective P‐glycoprotein inhibitor, in patients with chemotherapy‐resistant, advanced breast carcinoma
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Toxicity of the Mitochondrial Poison Dequalinium Chloride in a Murine Model System
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The National Center for Biotechnology Information
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapies
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The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression
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pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant
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Synthetic trimethyllysine receptors that bind histone 3, trimethyllysine 27 (H3K27me3) and disrupt its interaction with the epigenetic reader protein CBX7
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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
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A new model for mitochondrial membrane potential production and storage
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Mitochondrial emitted electromagnetic signals mediate retrograde signaling
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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
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Cancer metabolism: The Warburg effect today
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Metabolically Derived Potential on the Outer Membrane of Mitochondria: A Computational Model
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Model of the Outer Membrane Potential Generation by the Inner Membrane of Mitochondria
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Low Dielectric Permittivity of Water at the Membrane Interface: Effect on the Energy Coupling Mechanism in Biological Membranes
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Kinetic Analysis of Rhodamines Efflux Mediated by the Multidrug Resistance Protein (MRP1)
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VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial function
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Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system
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Mitochondrial and plasma membrane potentials cause unusual accumulation and retention of rhodamine 123 by human breast adenocarcinoma-derived MCF-7 cells.
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
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Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells
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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth
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Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
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Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
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Stochastic Voyages into Uncharted Chemical Space Produce a Representative Library of All Possible Drug-Like Compounds
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Antiproliferative and Uncoupling Effects of Delocalized, Lipophilic, Cationic Gallic Acid Derivatives on Cancer Cell Lines. Validation in Vivo in Singenic Mice
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Phase I trial of the selective mitochondrial toxin MKT 077 in chemo-resistant solid tumours
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World's largest cancer charity lays out field's grand challenges
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Zscan4 regulates telomere elongation and genomic stability in ES cells
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides
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Separating NADH and NADPH fluorescence in live cells and tissues using FLIM
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Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells
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Why do cancers have high aerobic glycolysis?
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The productivity crisis in pharmaceutical R&D
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Diagnosing the decline in pharmaceutical R&D efficiency
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New drugs cost US$2.6 billion to develop
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Sensors and regulators of intracellular pH
inferredcites →https://doi.org/10.1038/sj.onc.1206953openalex-snapshot
The MRP family of drug efflux pumps
inferredcites →https://doi.org/10.1038/stemcells.2008.62openalex-snapshot
Cancer and embryonic stem cells share genetic fingerprints
inferredcites →https://doi.org/10.1046/j.1523-1755.2000.00251.xopenalex-snapshot
Cellular and molecular aspects of drug transport in the kidney
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Restoration of an absent G 1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation
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Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
inferredcites →https://doi.org/10.1073/pnas.1103621108openalex-snapshot
Macromolecular organization of ATP synthase and complex I in whole mitochondria
inferredcites →https://doi.org/10.1073/pnas.79.17.5292openalex-snapshot
Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells.
inferredcites →https://doi.org/10.1073/pnas.84.1.265openalex-snapshot
Expression of a multidrug-resistance gene in human tumors and tissues.
inferredcites →https://doi.org/10.1073/pnas.84.15.5444openalex-snapshot
Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation.
inferredcites →https://doi.org/10.1073/pnas.95.12.6803openalex-snapshot
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins
inferredcites →https://doi.org/10.1074/jbc.m511064200openalex-snapshot
Induction of Oxidative Metabolism by Mitochondrial Frataxin Inhibits Cancer Growth
inferredcites →https://doi.org/10.1089/ars.2014.5952openalex-snapshot
Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications
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Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
inferredcites →https://doi.org/10.1093/hesc/9780198830108.001.0001openalex-snapshot
Physical Chemistry for the Life Sciences
inferredcites →https://doi.org/10.1093/nar/gkv951openalex-snapshot
PubChem Substance and Compound databases
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Why cancer cells have a more hyperpolarised mitochondrial membrane potential and emergent prospects for therapy
inferredcites →https://doi.org/10.1109/iembs.2009.5334106openalex-snapshot
A novel near-infrared voltage-sensitive dye reveals the action potential wavefront orientation at increased depths of cardiac tissue
inferredcites →https://doi.org/10.1126/science.1126863openalex-snapshot
p53 Regulates Mitochondrial Respiration
inferredcites →https://doi.org/10.1126/science.1160809openalex-snapshot
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1126/science.6623064openalex-snapshot
Anticarcinoma Activity in Vivo of Rhodamine 123, a Mitochondrial-Specific Dye
inferredcites →https://doi.org/10.1126/science.7146897openalex-snapshot
Rhodamine-123 Selectively Reduces Clonal Growth of Carcinoma Cells in Vitro
inferredcites →https://doi.org/10.1146/annurev.cb.04.110188.001103openalex-snapshot
Mitochondrial Membrane Potential in Living Cells
inferredcites →https://doi.org/10.1146/annurev.cellbio.4.1.155openalex-snapshot
Mitochondrial Membrane Potential In Living Cells
inferredcites →https://doi.org/10.1146/annurev.med.53.082901.104028openalex-snapshot
Positron Emission Tomography Scanning: Current and Future Applications
inferredcites →https://doi.org/10.1152/ajprenal.00045.2002openalex-snapshot
Inner medullary lactate production and urine-concentrating mechanism: a flat medullary model
inferredcites →https://doi.org/10.1152/japplphysiol.00308.2010openalex-snapshot
What does glycolysis make and why is it important?
inferredcites →https://doi.org/10.1152/japplphysiol.00658.2012openalex-snapshot
Heat shock protein 70 (Hsp70) inhibits oxidative phosphorylation and compensates ATP balance through enhanced glycolytic activity
inferredcites →https://doi.org/10.1155/2011/978583openalex-snapshot
Stable Differences in Intrinsic Mitochondrial Membrane Potential of Tumor Cell Subpopulations Reflect Phenotypic Heterogeneity
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The Intrinsic Mitochondrial Membrane Potential of Colonic Carcinoma Cells Is Linked to the Probability of Tumor Progression
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2717openalex-snapshot
Growth Properties of Colonic Tumor Cells Are a Function of the Intrinsic Mitochondrial Membrane Potential
inferredcites →https://doi.org/10.1158/0008-5472.can-06-1501openalex-snapshot
Cancer's Molecular Sweet Tooth and the Warburg Effect
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Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein
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Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.
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Rhodamine-123: Therapy for Hormone Refractory Prostate Cancer, A Phase I Clinical Trial
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Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster
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Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model
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Complex Parameter Landscape for a Complex Neuron Model
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Inhibition Effect of a Custom Peptide on Lung Tumors
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The Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate Cancer Xenograft Model
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Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization.
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Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges
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The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?
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R: A Language and Environment for Statistical Computing
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Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs
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Membrane potential and cancer progression
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pH sensing and regulation in cancer
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Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
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Doxorubicin-resistant variants of human prostate cancer cell lines DU 145, PC-3, PPC-1, and TSU-PR1: characterization of biochemical determinants of antineoplastic drug sensitivity.
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Want to Cure Cancer? Then Revisit the Past; “Warburg Was Correct”, Cancer Is a Metabolic Disease
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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