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Correcting subtle stratification in summary association statistics

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.ajhg.2015.12.022openalex-snapshot

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia

inferredcites →https://doi.org/10.1016/j.ajhg.2016.09.014openalex-snapshot

Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure

inferredcites →https://doi.org/10.1038/mp.2013.187openalex-snapshot

A genome-wide association study of anorexia nervosa

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Biological, clinical and population relevance of 95 loci for blood lipids

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Hundreds of variants clustered in genomic loci and biological pathways affect human height

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A map of human genome variation from population-scale sequencing

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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An integrated map of genetic variation from 1,092 human genomes

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Biological insights from 108 schizophrenia-associated genetic loci

inferredcites →https://doi.org/10.1038/ng.2274openalex-snapshot

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

inferredcites →https://doi.org/10.1038/ng.2368openalex-snapshot

Evidence of widespread selection on standing variation in Europe at height-associated SNPs

inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot

Defining the role of common variation in the genomic and biological architecture of adult human height

inferredcites →https://doi.org/10.1038/ng.3190openalex-snapshot

Efficient Bayesian mixed-model analysis increases association power in large cohorts

inferredcites →https://doi.org/10.1038/ng.3211openalex-snapshot

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

inferredcites →https://doi.org/10.1038/ng.3401openalex-snapshot

Population genetic differentiation of height and body mass index across Europe

inferredcites →https://doi.org/10.1038/ng.3403openalex-snapshot

Height-reducing variants and selection for short stature in Sardinia

inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot

Partitioning heritability by functional annotation using genome-wide association summary statistics

inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot

An atlas of genetic correlations across human diseases and traits

inferredcites →https://doi.org/10.1038/ng.3506openalex-snapshot

Integrative approaches for large-scale transcriptome-wide association studies

inferredcites →https://doi.org/10.1038/ng.3571openalex-snapshot

Fast and accurate long-range phasing in a UK Biobank cohort

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Genome-wide meta-analyses identify multiple loci associated with smoking behavior

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

inferredcites →https://doi.org/10.1038/ng.784openalex-snapshot

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

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Assessing the impact of population stratification on genetic association studies

inferredcites →https://doi.org/10.1038/ng1337openalex-snapshot

The effects of human population structure on large genetic association studies

inferredcites →https://doi.org/10.1038/ng1607openalex-snapshot

Demonstrating stratification in a European American population

inferredcites →https://doi.org/10.1038/ng1847openalex-snapshot

Principal components analysis corrects for stratification in genome-wide association studies

inferredcites →https://doi.org/10.1086/421051openalex-snapshot

Genetic Signatures of Strong Recent Positive Selection at the Lactase Gene

inferredcites →https://doi.org/10.1086/521987openalex-snapshot

Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering

inferredcites →https://doi.org/10.1093/bioinformatics/btu704openalex-snapshot

minimac2: faster genotype imputation

inferredcites →https://doi.org/10.1101/010512openalex-snapshot

Ancestry Composition: A Novel, Efficient Pipeline for Ancestry Deconvolution

inferredcites →https://doi.org/10.1101/035170openalex-snapshot

A reference panel of 64,976 haplotypes for genotype imputation

inferredcites →https://doi.org/10.1101/048181openalex-snapshot

Subtle stratification confounds estimates of heritability from rare variants

inferredcites →https://doi.org/10.1109/icsec.2015.7401397openalex-snapshot

An efficient process for enhancing genotype imputation in Genome-wide association studies using high performance computing

inferredcites →https://doi.org/10.1111/j.0006-341x.1999.00997.xopenalex-snapshot

Genomic Control for Association Studies

inferredcites →https://doi.org/10.1126/science.1235488openalex-snapshot

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

inferredcites →https://doi.org/10.1371/journal.pgen.1000993openalex-snapshot

Web-Based, Participant-Driven Studies Yield Novel Genetic Associations for Common Traits

inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

inferredcites →https://doi.org/10.1371/journal.pone.0023473openalex-snapshot

Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data

inferredcites →https://doi.org/10.1371/journal.pone.0034267openalex-snapshot

Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples

inferredcites →https://doi.org/10.1371/journal.pone.0048294openalex-snapshot

Genome-Wide Association Studies of Quantitatively Measured Skin, Hair, and Eye Pigmentation in Four European Populations

inferredcites →https://doi.org/10.1513/pats.200907-058dpopenalex-snapshot

Genome-Wide Association Studies: What Do They Teach Us about Asthma and Chronic Obstructive Pulmonary Disease?

inferredcites →https://doi.org/10.1534/genetics.115.178616openalex-snapshot

Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/cphg.48openalex-snapshot

Population Stratification in Genetic Association Studies

inferred← citeshttps://doi.org/10.1038/s41588-018-0255-0openalex-snapshot

Distinguishing genetic correlation from causation across 52 diseases and complex traits

inferred← citeshttps://doi.org/10.1093/cercor/bhaa327openalex-snapshot

The Evolutionary History of Common Genetic Variants Influencing Human Cortical Surface Area

inferred← citeshttps://doi.org/10.1186/s13059-024-03427-zopenalex-snapshot

Considerations in the search for epistasis

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