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The causal effect of educational attainment on Alzheimer’s disease: A two-sample Mendelian randomization study

https://doi.org/10.1101/127993
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1002/gepi.21998openalex-snapshot
Bias due to participant overlap in two‐sample Mendelian randomization
inferredcites →https://doi.org/10.1007/s00234-012-1005-0openalex-snapshot
Education increases reserve against Alzheimer’s disease—evidence from structural MRI analysis
inferredcites →https://doi.org/10.1016/j.annepidem.2015.10.006openalex-snapshot
Instrumental variable approaches to identifying the causal effect of educational attainment on dementia risk
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2007.10.008openalex-snapshot
Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease
inferredcites →https://doi.org/10.1016/s1474-4422(05)70286-6openalex-snapshot
A life-course approach to the aetiology of late-onset dementias
inferredcites →https://doi.org/10.1016/s1474-4422(12)70191-6openalex-snapshot
Cognitive reserve in ageing and Alzheimer's disease
inferredcites →https://doi.org/10.1038/nature17671openalex-snapshot
Genome-wide association study identifies 74 loci associated with educational attainment
inferredcites →https://doi.org/10.1038/ng.2802openalex-snapshot
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
inferredcites →https://doi.org/10.1038/ng.3406openalex-snapshot
An atlas of genetic correlations across human diseases and traits
inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
inferredcites →https://doi.org/10.1093/ije/dyh132openalex-snapshot
Mendelian randomization: prospects, potentials, and limitations
inferredcites →https://doi.org/10.1093/ije/dyp334openalex-snapshot
Illustrating bias due to conditioning on a collider
inferredcites →https://doi.org/10.1093/ije/dyq072openalex-snapshot
Intelligence and education: causal perceptions drive analytic processes and therefore conclusions
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/ije/dyw220openalex-snapshot
Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic
inferredcites →https://doi.org/10.1097/ede.0b013e31816bbe14openalex-snapshot
Cigarette Smoking and Dementia
inferredcites →https://doi.org/10.1097/wad.0b013e318211c83copenalex-snapshot
Relationship Between Education and Dementia
inferredcites →https://doi.org/10.1101/078972openalex-snapshot
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
inferredcites →https://doi.org/10.1111/j.2517-6161.1974.tb00994.xopenalex-snapshot
Cross-Validatory Choice and Assessment of Statistical Predictions
inferredcites →https://doi.org/10.1126/science.1235488openalex-snapshot
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
inferredcites →https://doi.org/10.1136/bmj.327.7414.557openalex-snapshot
Measuring inconsistency in meta-analyses
inferredcites →https://doi.org/10.1212/01.wnl.0000069923.64550.9fopenalex-snapshot
Education modifies the relation of AD pathology to level of cognitive function in older persons
inferredcites →https://doi.org/10.1212/01.wnl.0000277456.29440.16openalex-snapshot
Education and dementia
inferredcites →https://doi.org/10.1212/wnl.53.1.189openalex-snapshot
Relation of education to brain size in normal aging
inferredcites →https://doi.org/10.1371/journal.pmed.0040352openalex-snapshot
Clustered Environments and Randomized Genes: A Fundamental Distinction between Conventional and Genetic Epidemiology
inferredcites →https://doi.org/10.1371/journal.pmed.1001841openalex-snapshot
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
inferredcites →https://doi.org/10.1371/journal.pone.0038268openalex-snapshot
Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses
inferredcites →https://doi.org/10.17863/cam.26250openalex-snapshot
Abstract
inferredcites →https://doi.org/10.3945/ajcn.115.118216openalex-snapshot
Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.bpsgos.2021.07.010openalex-snapshot
Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1038/s41467-022-32183-6openalex-snapshot
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
inferred← citeshttps://doi.org/10.1093/aje/kwaa255openalex-snapshot
Does Prolonged Education Causally Affect Dementia Risk When Adult Socioeconomic Status Is Not Altered? A Swedish Natural Experiment in 1.3 Million Individuals
inferred← citeshttps://doi.org/10.1093/brain/awac392openalex-snapshot
Educational attainment, structural brain reserve and Alzheimer’s disease: a Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1093/ije/dyz080openalex-snapshot
Polygenic risk scores for Alzheimer’s disease, and academic achievement, cognitive and behavioural measures in children from the general population
inferred← citeshttps://doi.org/10.1093/ije/dyz280openalex-snapshot
Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1101/173682openalex-snapshot
Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome
inferred← citeshttps://doi.org/10.1212/nxg.0000000000000310openalex-snapshot
Genomic variation in educational attainment modifies Alzheimer disease risk
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