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Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

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1 of the 54 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/srep26105 (notice 2018-02-21).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2017.8981openalex-snapshot
Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction
inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1002/sim.7221openalex-snapshot
A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
inferredcites →https://doi.org/10.1007/978-3-030-05318-5_4openalex-snapshot
Auto-WEKA: Automatic Model Selection and Hyperparameter Optimization in WEKA
inferredcites →https://doi.org/10.1007/978-3-540-73263-1openalex-snapshot
Metalearning - Applications to Data Mining
inferredcites →https://doi.org/10.1007/s10462-013-9406-yopenalex-snapshot
Metalearning: a survey of trends and technologies
inferredcites →https://doi.org/10.1007/s10654-015-0011-zopenalex-snapshot
Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors
inferredcites →https://doi.org/10.1016/j.ajhg.2017.09.003openalex-snapshot
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
inferredcites →https://doi.org/10.1016/j.econlet.2008.09.004openalex-snapshot
Detecting invalid instruments using L1-GMM
inferredcites →https://doi.org/10.1016/j.jhealeco.2015.10.007openalex-snapshot
Genetic markers as instrumental variables
inferredcites →https://doi.org/10.1016/j.tig.2012.10.010openalex-snapshot
The many faces of pleiotropy
inferredcites →https://doi.org/10.1016/s2213-8587(15)00386-1openalex-snapshot
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
inferredcites →https://doi.org/10.1037/0033-2909.87.2.245openalex-snapshot
Tests for comparing elements of a correlation matrix.
inferredcites →https://doi.org/10.1038/nature17671openalex-snapshot
Genome-wide association study identifies 74 loci associated with educational attainment
inferredcites →https://doi.org/10.1038/ncomms11122openalex-snapshot
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot
Discovery and refinement of loci associated with lipid levels
inferredcites →https://doi.org/10.1038/ng.2982openalex-snapshot
An atlas of genetic influences on human blood metabolites
inferredcites →https://doi.org/10.1038/ng.3538openalex-snapshot
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
inferredcites →https://doi.org/10.1038/nrcardio.2017.78openalex-snapshot
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
inferredcites →https://doi.org/10.1038/nrg.2016.87openalex-snapshot
Network biology concepts in complex disease comorbidities
inferredcites →https://doi.org/10.1038/nrg2949openalex-snapshot
The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
inferredcites →https://doi.org/10.1038/nrg2949-c1openalex-snapshot
Assessing pleiotropy and its evolutionary consequences: pleiotropy is not necessarily limited, nor need it hinder the evolution of complexity
inferredcites →https://doi.org/10.1038/nrg3461openalex-snapshot
Pleiotropy in complex traits: challenges and strategies
inferredcites →https://doi.org/10.1038/s41467-017-02317-2openalex-snapshot
Causal associations between risk factors and common diseases inferred from GWAS summary data
inferredcites →https://doi.org/10.1038/s41586-018-0175-2openalex-snapshot
Genomic atlas of the human plasma proteome
inferredcites →https://doi.org/10.1038/s41588-018-0099-7openalex-snapshot
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
inferredcites →https://doi.org/10.1038/srep26105openalex-snapshot
A significant causal association between C-reactive protein levels and schizophrenia
inferredcites →https://doi.org/10.1038/srep42691openalex-snapshot
A Mendelian randomization study of the effect of calcium on coronary artery disease, myocardial infarction and their risk factors
inferredcites →https://doi.org/10.1080/01621459.2014.994705openalex-snapshot
Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization
inferredcites →https://doi.org/10.1093/aje/kwt084openalex-snapshot
Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators
inferredcites →https://doi.org/10.1093/bioinformatics/btw373openalex-snapshot
PhenoScanner: a database of human genotype–phenotype associations
inferredcites →https://doi.org/10.1093/biostatistics/kxq046openalex-snapshot
Treatment-effect estimates adjusted for small-study effects via a limit meta-analysis
inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
inferredcites →https://doi.org/10.1093/ije/dyu192openalex-snapshot
Understanding variation in disease risk: the elusive concept of frailty
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/ije/dyw314openalex-snapshot
Triangulation in aetiological epidemiology
inferredcites →https://doi.org/10.1093/ije/dyx028openalex-snapshot
Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
inferredcites →https://doi.org/10.1093/ije/dyx102openalex-snapshot
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1101/078972openalex-snapshot
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
inferredcites →https://doi.org/10.1101/126102openalex-snapshot
Robust inference in summary data Mendelian randomisation via the zero modal pleiotropy assumption
inferredcites →https://doi.org/10.1101/127993openalex-snapshot
The causal effect of educational attainment on Alzheimer’s disease: A two-sample Mendelian randomization study
inferredcites →https://doi.org/10.1136/bmj.j3542openalex-snapshot
Education and coronary heart disease: mendelian randomisation study
inferredcites →https://doi.org/10.1145/1456650.1456656openalex-snapshot
Cross-disciplinary perspectives on meta-learning for algorithm selection
inferredcites →https://doi.org/10.1162/neco.1994.6.2.181openalex-snapshot
Hierarchical Mixtures of Experts and the EM Algorithm
inferredcites →https://doi.org/10.1371/journal.pcbi.1005703openalex-snapshot
Efficient and accurate causal inference with hidden confounders from genome-transcriptome variation data
inferredcites →https://doi.org/10.1371/journal.pgen.1007081openalex-snapshot
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
inferredcites →https://doi.org/10.1371/journal.pmed.1001976openalex-snapshot
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
inferredcites →https://doi.org/10.1371/journal.pmed.1002314openalex-snapshot
Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
inferredcites →https://doi.org/10.1371/journal.pone.0071494openalex-snapshot
Novel Genetic Analysis for Case-Control Genome-Wide Association Studies: Quantification of Power and Genomic Prediction Accuracy
inferredcites →https://doi.org/10.1371/journal.pone.0108891openalex-snapshot
Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions
inferredcites →https://doi.org/10.17863/cam.26250openalex-snapshot
Abstract
inferredcites →https://doi.org/10.2337/db16-0418openalex-snapshot
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization
inferredcites →https://doi.org/10.48550/arxiv.1407.4443openalex-snapshot
On the Complexity of Best Arm Identification in Multi-Armed Bandit Models

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/alz.13427openalex-snapshot
Artificial intelligence for dementia genetics and omics
inferred← citeshttps://doi.org/10.1002/gepi.22385openalex-snapshot
Caution against examining the role of reverse causality in Mendelian Randomization
inferred← citeshttps://doi.org/10.1002/gepi.22443openalex-snapshot
Collider bias from selecting disease samples distorts causal inferences
inferred← citeshttps://doi.org/10.1002/mds.27873openalex-snapshot
The Parkinson's Disease Mendelian Randomization Research Portal
inferred← citeshttps://doi.org/10.1002/path.5421openalex-snapshot
The use of Mendelian randomisation to identify causal cancer risk factors: promise and limitations
inferred← citeshttps://doi.org/10.1007/s00125-025-06484-6openalex-snapshot
Raising the bar for publication of Mendelian randomisation studies in Diabetologia
inferred← citeshttps://doi.org/10.1007/s00439-019-02014-8openalex-snapshot
Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?
inferred← citeshttps://doi.org/10.1007/s10654-025-01317-7openalex-snapshot
The rapid growth in Mendelian randomization studies
inferred← citeshttps://doi.org/10.1007/s11096-024-01754-6openalex-snapshot
Causal impact of statins on susceptibility to osteoarthritis: insights from a two-sample Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1007/s11096-024-01762-6openalex-snapshot
Genetic influence of meningioma on cisplatin resistance: a Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1007/s40471-017-0128-6openalex-snapshot
Recent Developments in Mendelian Randomization Studies
inferred← citeshttps://doi.org/10.1016/j.ajhg.2018.08.004openalex-snapshot
Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure
inferred← citeshttps://doi.org/10.1016/j.ajhg.2020.01.015openalex-snapshot
Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways
inferred← citeshttps://doi.org/10.1016/j.ajhg.2021.10.006openalex-snapshot
Welch-weighted Egger regression reduces false positives due to correlated pleiotropy in Mendelian randomization
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112803openalex-snapshot
Comprehensive analysis of single-cell transcriptomics and genetic factors reveals the mechanisms and preventive strategies for the progression from pulmonary fibrosis to lung cancer
inferred← citeshttps://doi.org/10.1016/j.jbi.2025.104810openalex-snapshot
Integrating Mendelian randomization and literature-mined evidence for breast cancer risk factors
inferred← citeshttps://doi.org/10.1016/j.jhealeco.2020.102300openalex-snapshot
Mendelian Randomization analysis of the causal effect of adiposity on hospital costs
inferred← citeshttps://doi.org/10.1016/j.molmed.2019.10.004openalex-snapshot
Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci
inferred← citeshttps://doi.org/10.1016/j.patter.2021.100328openalex-snapshot
Machine learning applications for therapeutic tasks with genomics data
inferred← citeshttps://doi.org/10.1017/s2045796024000593openalex-snapshot
Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study
inferred← citeshttps://doi.org/10.1038/s41416-018-0108-8openalex-snapshot
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41467-018-08219-1openalex-snapshot
Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis
inferred← citeshttps://doi.org/10.1038/s41467-019-12424-xopenalex-snapshot
Genetic evidence for assortative mating on alcohol consumption in the UK Biobank
inferred← citeshttps://doi.org/10.1038/s41467-020-14452-4openalex-snapshot
Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework
inferred← citeshttps://doi.org/10.1038/s41467-023-44079-0openalex-snapshot
Genome-wide association study meta-analysis of blood pressure traits and hypertension in sub-Saharan African populations: an AWI-Gen study
inferred← citeshttps://doi.org/10.1038/s41531-023-00611-zopenalex-snapshot
Mendelian randomization reveals association between retinal thickness and non-motor symptoms of Parkinson’s disease
inferred← citeshttps://doi.org/10.1038/s41576-018-0020-3openalex-snapshot
Using genetic data to strengthen causal inference in observational research
inferred← citeshttps://doi.org/10.1038/s41588-018-0099-7openalex-snapshot
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
inferred← citeshttps://doi.org/10.1038/s41588-020-0631-4openalex-snapshot
Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
inferred← citeshttps://doi.org/10.1038/s41588-020-0682-6openalex-snapshot
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
inferred← citeshttps://doi.org/10.1038/s41588-022-01165-1openalex-snapshot
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
inferred← citeshttps://doi.org/10.1038/s41598-022-19214-4openalex-snapshot
Applying Mendelian randomization to appraise causality in relationships between smoking, depression and inflammation
inferred← citeshttps://doi.org/10.1038/s41598-023-50459-9openalex-snapshot
A Mendelian randomization study on the effects of plasma lipids on irritable bowel syndrome and functional dyspepsia
inferred← citeshttps://doi.org/10.1038/s41598-025-86222-5openalex-snapshot
Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1038/s43586-021-00092-5openalex-snapshot
Mendelian randomization
inferred← citeshttps://doi.org/10.1038/s43856-023-00407-5openalex-snapshot
Distilling causality between physical activity traits and obesity via Mendelian randomization
inferred← citeshttps://doi.org/10.1038/s44184-026-00204-7openalex-snapshot
Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1042/etls20170129openalex-snapshot
Big knowledge from big data in functional genomics
inferred← citeshttps://doi.org/10.1053/j.ajkd.2017.10.006openalex-snapshot
Challenges in Interpreting Multivariable Mendelian Randomization: Might “Good Cholesterol” Be Good After All?
inferred← citeshttps://doi.org/10.1093/bib/bbaf140openalex-snapshot
MRAgent: an LLM-based automated agent for causal knowledge discovery in disease via Mendelian randomization
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaa961openalex-snapshot
EpiGraphDB: a database and data mining platform for health data science
inferred← citeshttps://doi.org/10.1093/bioinformatics/btae519openalex-snapshot
Triangulating evidence in health sciences with Annotated Semantic Queries
inferred← citeshttps://doi.org/10.1093/hmg/ddac050openalex-snapshot
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
inferred← citeshttps://doi.org/10.1093/hmg/ddac215openalex-snapshot
Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk
inferred← citeshttps://doi.org/10.1093/sleep/zsac003openalex-snapshot
Associations of sleep and circadian phenotypes with COVID-19 susceptibility and hospitalization: an observational cohort study based on the UK Biobank and a two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1101/200378openalex-snapshot
Improving the visualisation, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression
inferred← citeshttps://doi.org/10.1101/2020.02.25.20017525openalex-snapshot
Estimating the causal effect of hearing loss on Alzheimer’s disease: a Mendelian randomisation study
inferred← citeshttps://doi.org/10.1101/2020.11.24.20237156openalex-snapshot
Associations between alcohol use and accelerated biological ageing
inferred← citeshttps://doi.org/10.1101/2023.11.17.23297145openalex-snapshot
The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis
inferred← citeshttps://doi.org/10.1101/2024.03.20.24304624openalex-snapshot
Trans-ancestral Genome Wide Association Study of Sporadic and Recurrent Miscarriage
inferred← citeshttps://doi.org/10.1101/2024.07.24.24310950openalex-snapshot
Evaluating genetically-predicted causal effects of lipoprotein(a) in human diseases: a phenome-wide Mendelian randomization study
inferred← citeshttps://doi.org/10.1101/2025.11.25.25340987openalex-snapshot
Childhood Maltreatment Causally Associated with Osteoarthritis: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1101/476085openalex-snapshot
MR-TRYX: A Mendelian randomization framework that exploits horizontal pleiotropy to infer novel causal pathways
inferred← citeshttps://doi.org/10.1101/476135openalex-snapshot
A phenome-wide approach to identify causal risk factors for deep vein thrombosis
inferred← citeshttps://doi.org/10.1101/589820openalex-snapshot
The causal effect of adiposity on hospital costs: Mendelian Randomization analysis of over 300,000 individuals from the UK Biobank
inferred← citeshttps://doi.org/10.1101/630293openalex-snapshot
A Phenome-wide Mendelian Randomisation study on genetically determined serum urate levels in UK Biobank cohort
inferred← citeshttps://doi.org/10.1101/cshperspect.a039248openalex-snapshot
Computational Tools for Causal Inference in Genetics
inferred← citeshttps://doi.org/10.1101/cshperspect.a040501openalex-snapshot
Mendelian Randomization: Concepts and Scope
inferred← citeshttps://doi.org/10.1111/adb.13100openalex-snapshot
Associations between alcohol use and accelerated biological ageing
inferred← citeshttps://doi.org/10.1111/cen.14593openalex-snapshot
Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study
inferred← citeshttps://doi.org/10.1111/jnc.15937openalex-snapshot
The causal role of circulating amino acids on neurodegenerative disorders: A two‐sample Mendelian randomization study
inferred← citeshttps://doi.org/10.1111/joim.13352openalex-snapshot
Hypertension genetics past, present and future applications
inferred← citeshttps://doi.org/10.1111/opo.12596openalex-snapshot
Mendelian randomisation and the goal of inferring causation from observational studies in the vision sciences
inferred← citeshttps://doi.org/10.1136/heartjnl-2017-311198openalex-snapshot
Machine learning in cardiovascular medicine: are we there yet?
inferred← citeshttps://doi.org/10.1146/annurev-biodatasci-122120-024910openalex-snapshot
Phenotypic Causal Inference Using Genome-Wide Association Study Data: Mendelian Randomization and Beyond
inferred← citeshttps://doi.org/10.1158/1055-9965.epi-17-1177openalex-snapshot
Causal Inference in Cancer Epidemiology: What Is the Role of Mendelian Randomization?
inferred← citeshttps://doi.org/10.1186/s12916-024-03607-5openalex-snapshot
Addressing the credibility crisis in Mendelian randomization
inferred← citeshttps://doi.org/10.1186/s13059-020-02248-0openalex-snapshot
The variant call format provides efficient and robust storage of GWAS summary statistics
inferred← citeshttps://doi.org/10.1371/journal.pmed.1002937openalex-snapshot
Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study
inferred← citeshttps://doi.org/10.1371/journal.pmed.1003555openalex-snapshot
Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study
inferred← citeshttps://doi.org/10.1371/journal.pone.0293510openalex-snapshot
Approaches to estimate bidirectional causal effects using Mendelian randomization with application to body mass index and fasting glucose
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2123486/v1openalex-snapshot
Mendelian randomization study updates the effect of hypertension on the risk of primary open-angle glaucoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2532794/v1openalex-snapshot
Genome-wide Association Study Meta-analysis of Blood Pressure Traits and Hypertension in Sub-Saharan African Populations: An AWI-Gen Study
inferred← citeshttps://doi.org/10.2337/db23-0982openalex-snapshot
Association Between Low Sex Hormone–Binding Globulin and Increased Risk of Type 2 Diabetes Is Mediated by Increased Visceral and Liver Fat: Results From Observational and Mendelian Randomization Analyses
inferred← citeshttps://doi.org/10.31219/osf.io/6yzs7openalex-snapshot
A Mendelian Randomization dictionary: Useful definitions and descriptions for undertaking, understanding and interpreting Mendelian Randomization studies
inferred← citeshttps://doi.org/10.3233/jpd-202487openalex-snapshot
Unhealthy Behaviours and Risk of Parkinson’s Disease: A Mendelian Randomisation Study
inferred← citeshttps://doi.org/10.3389/fcvm.2018.00051openalex-snapshot
Common Methods for Performing Mendelian Randomization
inferred← citeshttps://doi.org/10.3389/fgene.2020.00350openalex-snapshot
Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci
inferred← citeshttps://doi.org/10.3389/fnut.2023.1047640openalex-snapshot
No evidence of a genetic causal relationship between ankylosing spondylitis and iron homeostasis: A two-sample Mendelian randomization study
inferred← citeshttps://doi.org/10.3389/fpubh.2023.1164647openalex-snapshot
Causal relationship between particulate matter 2.5 and diabetes: two sample Mendelian randomization
inferred← citeshttps://doi.org/10.3390/nu14142883openalex-snapshot
The Effects of Fatty Acids on Inflammatory Bowel Disease: A Two-Sample Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3410/f.733091753.793549148openalex-snapshot
Faculty Opinions recommendation of Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases.
inferred← citeshttps://doi.org/10.7554/elife.34408openalex-snapshot
The MR-Base platform supports systematic causal inference across the human phenome
inferred← citeshttps://doi.org/10.7759/cureus.89185openalex-snapshot
Dissecting the Causal Effects of Helicobacter pylori Serotypes on Gastric Cancer Risk: A Two-Sample Mendelian Randomization Study
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