On the public citation graph

Exploring repositioning opportunities and side-effects of statins: a Mendelian randomization study of HMG-CoA reductase inhibition with 55 complex traits

https://doi.org/10.1101/170241
0 signed · 102 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneurol.2011.203openalex-snapshot
Cholesterol Level and Statin Use in Alzheimer Disease
inferredcites →https://doi.org/10.1001/archneurol.2011.242openalex-snapshot
Cholesterol Level and Statin Use in Alzheimer Disease
inferredcites →https://doi.org/10.1001/jama.2016.14568openalex-snapshot
Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes
inferredcites →https://doi.org/10.1001/jamaophthalmol.2013.4575openalex-snapshot
Association of Statin Use With Cataracts
inferredcites →https://doi.org/10.1002/14651858.cd003160.pub3openalex-snapshot
Statins for the prevention of dementia
inferredcites →https://doi.org/10.1002/14651858.cd007784.pub2openalex-snapshot
HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
inferredcites →https://doi.org/10.1002/gepi.21965openalex-snapshot
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
inferredcites →https://doi.org/10.1002/gepi.22077openalex-snapshot
Mendelian randomization with fine‐mapped genetic data: Choosing from large numbers of correlated instrumental variables
inferredcites →https://doi.org/10.1002/gps.666openalex-snapshot
Serum cholesterol and depressive symptoms in elderly Finnish men
inferredcites →https://doi.org/10.1002/sim.6835openalex-snapshot
Combining information on multiple instrumental variables in Mendelian randomization: comparison of allele score and summarized data methods
inferredcites →https://doi.org/10.1007/s00415-012-6606-3openalex-snapshot
Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies
inferredcites →https://doi.org/10.1007/s40263-017-0422-3openalex-snapshot
Do Statins Have Antidepressant Effects?
inferredcites →https://doi.org/10.1007/s40264-014-0163-xopenalex-snapshot
Association of Statin Use with Sleep Disturbances: Data Mining of a Spontaneous Reporting Database and a Prescription Database
inferredcites →https://doi.org/10.1007/s40264-014-0200-9openalex-snapshot
Erratum to: Association of Statin Use with Sleep Disturbances: Data Mining of a Spontaneous Reporting Database and a Prescription Database
inferredcites →https://doi.org/10.1007/s40265-014-0309-2openalex-snapshot
Statins: Do They Have a Potential Role in Cancer Prevention and Modifying Cancer-Related Outcomes?
inferredcites →https://doi.org/10.1016/0140-6736(92)90609-7openalex-snapshot
Low serum cholesterol and suicide
inferredcites →https://doi.org/10.1016/0140-6736(93)90171-copenalex-snapshot
Depressive symptoms and pravastatin
inferredcites →https://doi.org/10.1016/0140-6736(93)92556-9openalex-snapshot
Plasma cholesterol and depressive symptoms in older men
inferredcites →https://doi.org/10.1016/0140-6736(93)92591-gopenalex-snapshot
Depressive symptoms and cholesterol-lowering drugs
inferredcites →https://doi.org/10.1016/0301-0082(92)90025-aopenalex-snapshot
Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance
inferredcites →https://doi.org/10.1016/j.ajhg.2010.11.011openalex-snapshot
GCTA: A Tool for Genome-wide Complex Trait Analysis
inferredcites →https://doi.org/10.1016/j.amjmed.2004.07.041openalex-snapshot
Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
inferredcites →https://doi.org/10.1016/j.amjmed.2011.08.007openalex-snapshot
Statin Use and Musculoskeletal Pain Among Adults With and Without Arthritis
inferredcites →https://doi.org/10.1016/j.bbr.2016.04.046openalex-snapshot
Statin use and risk of Parkinson’s disease: A meta-analysis
inferredcites →https://doi.org/10.1016/j.brainres.2004.02.083openalex-snapshot
Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice
inferredcites →https://doi.org/10.1016/j.diabet.2008.08.004openalex-snapshot
Hypercholesterolaemia in anorexia nervosa: Frequency and changes during refeeding
inferredcites →https://doi.org/10.1016/j.jacc.2015.02.020openalex-snapshot
Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
inferredcites →https://doi.org/10.1016/j.jad.2016.04.047openalex-snapshot
Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials
inferredcites →https://doi.org/10.1016/j.jclinepi.2014.03.012openalex-snapshot
False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies
inferredcites →https://doi.org/10.1016/j.neuropharm.2012.02.007openalex-snapshot
Continuous de novo synthesis of neurosteroids is required for normal synaptic transmission and plasticity in the dentate gyrus of the rat hippocampus
inferredcites →https://doi.org/10.1016/j.ophtha.2017.03.042openalex-snapshot
Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol–Associated Mechanisms in Etiology of Age-Related Macular Degeneration
inferredcites →https://doi.org/10.1016/j.phrs.2014.03.001openalex-snapshot
Statins: From cholesterol-lowering drugs to novel immunomodulators for the treatment of Th17-mediated autoimmune diseases
inferredcites →https://doi.org/10.1016/j.phrs.2014.06.007openalex-snapshot
Statins in neurological disorders: An overview and update
inferredcites →https://doi.org/10.1016/j.psychres.2004.11.005openalex-snapshot
Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission
inferredcites →https://doi.org/10.1016/j.schres.2014.08.021openalex-snapshot
A randomized placebo-controlled pilot study of pravastatin as an adjunctive therapy in schizophrenia patients: Effect on inflammation, psychopathology, cognition and lipid metabolism
inferredcites →https://doi.org/10.1016/j.sleep.2014.02.006openalex-snapshot
Sleep duration and abnormal serum lipids: the China Health and Nutrition Survey
inferredcites →https://doi.org/10.1016/s0140-6736(08)60104-xopenalex-snapshot
Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis
inferredcites →https://doi.org/10.1016/s0140-6736(10)61350-5openalex-snapshot
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials
inferredcites →https://doi.org/10.1016/s0140-6736(12)60367-5openalex-snapshot
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials
inferredcites →https://doi.org/10.1016/s0140-6736(14)61183-1openalex-snapshot
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
inferredcites →https://doi.org/10.1016/s0140-6736(16)31357-5openalex-snapshot
Interpretation of the evidence for the efficacy and safety of statin therapy
inferredcites →https://doi.org/10.1016/s0140-6736(17)31075-9openalex-snapshot
Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase
inferredcites →https://doi.org/10.1016/s0165-1781(01)00301-8openalex-snapshot
Symptoms of atypical depression
inferredcites →https://doi.org/10.1016/s0306-4530(02)00014-8openalex-snapshot
Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial
inferredcites →https://doi.org/10.1016/s0924-9338(14)78635-3openalex-snapshot
EPA-1435 - Add-on clinical effects of simvastatin and ondansetron in patients with schizophrenia stabilized on antipsychotic treatment: Pilot study
inferredcites →https://doi.org/10.1016/s2213-8587(16)30396-5openalex-snapshot
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
inferredcites →https://doi.org/10.1021/bi100276bopenalex-snapshot
Chronic Cholesterol Depletion Using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors
inferredcites →https://doi.org/10.1038/mp.2012.21openalex-snapshot
A mega-analysis of genome-wide association studies for major depressive disorder
inferredcites →https://doi.org/10.1038/ng.2213openalex-snapshot
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
inferredcites →https://doi.org/10.1038/ng.2797openalex-snapshot
Discovery and refinement of loci associated with lipid levels
inferredcites →https://doi.org/10.1038/ng.3552openalex-snapshot
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
inferredcites →https://doi.org/10.1038/nrneurol.2015.35openalex-snapshot
Statins, cognition, and dementia—systematic review and methodological commentary
inferredcites →https://doi.org/10.1038/srep16645openalex-snapshot
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization
inferredcites →https://doi.org/10.1056/nejmoa1604304openalex-snapshot
Variation inPCSK9andHMGCRand Risk of Cardiovascular Disease and Diabetes
inferredcites →https://doi.org/10.1073/pnas.1605334113openalex-snapshot
Genetic variants linked to education predict longevity
inferredcites →https://doi.org/10.1079/bjn20041151openalex-snapshot
Lipoprotein metabolism in patients with anorexia nervosa: a case–control study investigating the mechanisms leading to hypercholesterolaemia
inferredcites →https://doi.org/10.1093/aje/kwx246openalex-snapshot
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
inferredcites →https://doi.org/10.1093/ije/dyv080openalex-snapshot
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
inferredcites →https://doi.org/10.1093/ije/dyw087openalex-snapshot
A phenome-wide association study of a lipoprotein-associated phospholipase A2loss-of-function variant in 90 000 Chinese adults
inferredcites →https://doi.org/10.1093/ije/dyx206openalex-snapshot
Collider scope: when selection bias can substantially influence observed associations
inferredcites →https://doi.org/10.1093/ije/dyx207openalex-snapshot
Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities
inferredcites →https://doi.org/10.1093/qjmed/hch035openalex-snapshot
Severe irritability associated with statin cholesterol-lowering drugs
inferredcites →https://doi.org/10.1093/sleep/31.5.645openalex-snapshot
Associations of Usual Sleep Duration with Serum Lipid and Lipoprotein Levels
inferredcites →https://doi.org/10.1097/md.0000000000003042openalex-snapshot
Effects of Statins on Bone Mineral Density and Fracture Risk
inferredcites →https://doi.org/10.1097/mjt.0b013e31828e5bfbopenalex-snapshot
Statins as a Potential Risk Factor for Autoimmune Diseases
inferredcites →https://doi.org/10.1101/078972openalex-snapshot
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
inferredcites →https://doi.org/10.1101/079707openalex-snapshot
Collider Scope: When selection bias can substantially influence observed associations
inferredcites →https://doi.org/10.1111/j.1365-2249.2005.02915.xopenalex-snapshot
The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
inferredcites →https://doi.org/10.1111/j.1532-5415.2005.00542.xopenalex-snapshot
Simvastatin Causes Changes in Affective Processes in Elderly Volunteers
inferredcites →https://doi.org/10.1111/j.1582-4934.2001.tb00172.xopenalex-snapshot
Statins: mechanism of action and effects
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.286.5446.1946openalex-snapshot
Stimulation of Bone Formation in Vitro and in Rodents by Statins
inferredcites →https://doi.org/10.1128/aac.00192-16openalex-snapshot
Is There Potential for Repurposing Statins as Novel Antimicrobials?
inferredcites →https://doi.org/10.1136/bmj.301.6747.309openalex-snapshot
Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials.
inferredcites →https://doi.org/10.1136/bmj.j1648openalex-snapshot
Low LDL cholesterol,PCSK9andHMGCRgenetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
inferredcites →https://doi.org/10.1136/heartjnl-2016-310605openalex-snapshot
Mendelian randomisation in cardiovascular research: an introduction for clinicians
inferredcites →https://doi.org/10.1161/01.cir.84.2.613openalex-snapshot
Blood platelet count and function are related to total and cardiovascular death in apparently healthy men.
inferredcites →https://doi.org/10.1177/0269881112467089openalex-snapshot
A review of anti-inflammatory agents for symptoms of schizophrenia
inferredcites →https://doi.org/10.1177/0962280206077743openalex-snapshot
Mendelian randomization as an instrumental variable approach to causal inference
inferredcites →https://doi.org/10.1177/2047487313480435openalex-snapshot
Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: a network meta-analysis of placebo-controlled and active-comparator trials
inferredcites →https://doi.org/10.1186/1741-7015-10-154openalex-snapshot
The impact of statins on psychological wellbeing: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1186/s12967-016-1031-5openalex-snapshot
Repurposing of approved cardiovascular drugs
inferredcites →https://doi.org/10.1211/jpp.58.1.0002openalex-snapshot
Statins and osteoporosis: new role for old drugs
inferredcites →https://doi.org/10.1214/aos/1013699998openalex-snapshot
The control of the false discovery rate in multiple testing under dependency
inferredcites →https://doi.org/10.1214/aos/1074290335openalex-snapshot
The positive false discovery rate: a Bayesian interpretation and the q-value
inferredcites →https://doi.org/10.1371/journal.pgen.1006944openalex-snapshot
Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges
inferredcites →https://doi.org/10.1371/journal.pmed.1001361openalex-snapshot
Personalized Prediction of Lifetime Benefits with Statin Therapy for Asymptomatic Individuals: A Modeling Study
inferredcites →https://doi.org/10.1371/journal.pone.0132970openalex-snapshot
Effects of Statins on Renal Outcome in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0152564openalex-snapshot
Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis
inferredcites →https://doi.org/10.1517/14656566.2013.803067openalex-snapshot
The relationship between statins and depression: a review of the literature
inferredcites →https://doi.org/10.1517/14740331003662620openalex-snapshot
Statin use and cancer risk: a comprehensive review
inferredcites →https://doi.org/10.1590/1516-3180.20151336t2openalex-snapshot
HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
inferredcites →https://doi.org/10.1592/phco.29.7.800openalex-snapshot
Statin‐Associated Adverse Cognitive Effects: Survey Results from 171 Patients
inferredcites →https://doi.org/10.17863/cam.26250openalex-snapshot
Abstract
inferredcites →https://doi.org/10.18632/aging.100930openalex-snapshot
Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants
inferredcites →https://doi.org/10.48550/arxiv.1512.04486openalex-snapshot
Integrating summarized data from multiple genetic variants in Mendelian randomization: bias and coverage properties of inverse-variance weighted methods
inferredcites →https://doi.org/10.5114/aoms.2013.36905openalex-snapshot
Effect of statins on platelet function in patients with hyperlipidemia
inferredcites →https://doi.org/10.5114/aoms.2015.54841openalex-snapshot
Sleep changes following statin therapy: a systematic review and meta-analysis of randomized placebo-controlled polysomnographic trials.
inferredcites →https://doi.org/10.5603/kp.2013.0259openalex-snapshot
Statins decrease mean platelet volume irrespective of cholesterol lowering effect
inferredcites →https://doi.org/10.7326/0003-4819-159-10-201311190-00007openalex-snapshot
Statins and Cognitive Function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.csbj.2020.06.015openalex-snapshot
Turning genome-wide association study findings into opportunities for drug repositioning
inferred← citeshttps://doi.org/10.3389/fnagi.2022.968039openalex-snapshot
Statins and cognition: Modifying factors and possible underlying mechanisms
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.