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A liquid biopsy platform for detecting gene-gene fusions as glioma diagnostic biomarkers and drug targets

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Direct Detection of Circulating Tumor Cells in Whole Blood Using Time‐Resolved Luminescent Lanthanide Nanoprobes
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Extracellular nucleic acids
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Circulating human papillomavirus DNA as a marker for disease extent and recurrence among patients with oropharyngeal cancer
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Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
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Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer
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Liquid biopsies
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Microsatellite analysis of serum DNA in patients with head and neck cancer
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Cell-free DNA in healthy individuals, noncancerous disease and strong prognostic value in colorectal cancer
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Diagnostic and prognostic role of cell‐free DNA testing for colorectal cancer patients
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cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant
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Molecular pathogenesis of IDH mutations in gliomas
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Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping
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Molecular mechanisms involved in gliomagenesis
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IDH wild-type WHO grade II diffuse low-grade gliomas. A heterogeneous family with different outcomes. Systematic review and meta-analysis
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Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis
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IDH1 and IDH2 Mutations in Gliomas
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The “Liquid Biopsy”: the Role of Circulating DNA and RNA in Central Nervous System Tumors
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Biomarkers
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Genetics of adult glioma
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The Somatic Genomic Landscape of Glioblastoma
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Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
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Circulating biomarkers to monitor cancer progression and treatment
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Techniques of using circulating tumor DNA as a liquid biopsy component in cancer management
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Prognostic importance of cell-free DNA in chemotherapy resistant ovarian cancer treated with bevacizumab
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A digital PCR based assay to detect all ALK fusion species
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Oligodendroglioma Patients with 1p/19q Co-deletion Treated with Early or Delayed Radiation Therapy over the Last Two Decades: A Multi-institutional Report
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Detection and Quantification of BCR-ABL1 Fusion Transcripts by Droplet Digital PCR
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Droplet Digital PCR for Absolute Quantification of EML4-ALK Gene Rearrangement in Lung Adenocarcinoma
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Clinical impact of molecular biomarkers in gliomas
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Clinical impact of crizotinib on central nervous system progression in ALK-positive non-small lung cancer
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IDH mutations in glioma and acute myeloid leukemia
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Multi‐marker analysis of circulating cell‐free DNA toward personalized medicine for colorectal cancer
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Epidemiology of Brain Tumors
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IDH Mutations in Human Glioma
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Application of circulating plasma/serum EBV DNA in the clinical management of nasopharyngeal carcinoma
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Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial
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High Sensitivity Detection and Quantitation of DNA Copy Number and Single Nucleotide Variants with Single Color Droplet Digital PCR
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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
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Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
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Mutational heterogeneity in cancer and the search for new cancer-associated genes
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C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma
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Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
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The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
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The Many Faces of Sirtuins: Sirtuins and the Warburg effect
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Recurrent MET fusion genes represent a drug target in pediatric glioblastoma
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Fast gapped-read alignment with Bowtie 2
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Choline metabolism in malignant transformation
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Liquid biopsy: monitoring cancer-genetics in the blood
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Integrating liquid biopsies into the management of cancer
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Circulating tumour cells and cell-free DNA in gastrointestinal cancer
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Cancer-associated IDH mutations: biomarker and therapeutic opportunities
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Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications
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Liquid biopsy and minimal residual disease — latest advances and implications for cure
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Evaluation of droplet digital PCR and next generation sequencing for characterizing DNA reference material for KRAS mutation detection
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Identification of recurrent fusion genes across multiple cancer types
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Fast and efficient microfluidic cell filter for isolation of circulating tumor cells from unprocessed whole blood of colorectal cancer patients
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Liquid biopsy for pediatric central nervous system tumors
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Targeting cellular pathways in glioblastoma multiforme
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BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia
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Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease
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Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level
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Extracellular vesicles as cancer liquid biopsies: from discovery, validation, to clinical application
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Application of droplet digital PCR to detect the pathogens of infectious diseases
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IDH1 and IDH2 Mutations in Gliomas
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Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
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Glioma Groups Based on 1p/19q, IDH , and TERT Promoter Mutations in Tumors
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
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Expression and rearrangement of the ROS1 gene in human glioblastoma cells.
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Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood–brain barrier and specifically reduce gene expression
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Liquid biopsy for brain tumors
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Non-Invasive Analysis of Acquired Resistance to Cancer Therapy By Sequencing of Plasma Dna
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The Sequence Alignment/Map format and SAMtools
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BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data
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Presence of Circulating Tumor Cells in High-Risk Early Breast Cancer During Follow-Up and Prognosis
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Modeling Chromosomal Translocations Using Conditional Alleles to Recapitulate Initiating Events in Human Leukemias
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NCBI BLAST: a better web interface
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Primer3—new capabilities and interfaces
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ChiTaRS 2.1—an improved database of the chimeric transcripts and RNA-seq data with novel sense–antisense chimeric RNA transcripts
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ChiTaRS-3.1—the enhanced chimeric transcripts and RNA-seq database matched with protein–protein interactions
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COSMIC: the Catalogue Of Somatic Mutations In Cancer
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New approach for understanding genome variations in KEGG
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ChiTaRS 5.0: the comprehensive database of chimeric transcripts matched with druggable fusions and 3D chromatin maps
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WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs
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TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas
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Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis
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Isocitrate dehydrogenase mutations in gliomas
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Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma
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Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors
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Glioma “Liquid Biopsy”: A New Frontier in Neurosurgery
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Circulating Tumor Cells: Overview and Opportunities in Cytology
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Isocitrate dehydrogenase mutations in gliomas
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Genomic analysis of circulating cell-free DNA infers breast cancer dormancy
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Presenting symptoms of glioma in adults
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Liquid biopsy: ready to guide therapy in advanced prostate cancer?
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Circulating RNA as a Tumor Marker
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Large amplicon droplet digital PCR for DNA‐based monitoring of pediatric chronic myeloid leukaemia
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A case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low‐grade diffuse astrocytoma
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Current Challenges and Opportunities in Treating Glioblastoma
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Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
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Circulating Tumor Cells
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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
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Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
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Applications of liquid biopsies for cancer
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2016 Updates to the WHO Brain Tumor Classification System: What the Radiologist Needs to Know
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TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer
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The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses
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Identifying and Targeting ROS1 Gene Fusions in Non–Small Cell Lung Cancer
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Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer
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Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study
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Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1)
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Circulating tumour cells: their utility in cancer management and predicting outcomes
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Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology
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Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib
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Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy
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The Ensembl Variant Effect Predictor
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Human Telomere Reverse Transcriptase Expression Predicts Progression and Survival in Pediatric Intracranial Ependymoma
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CSF Concentration of the Anaplastic Lymphoma Kinase Inhibitor Crizotinib
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Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review
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Multi-parametric liquid biopsy analysis of circulating tumor cells (CTCs), cell-free DNA (cfDNA), and cell-free RNA (cfRNA) in metastatic castrate resistant prostate cancer (mCRPC).
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Infiltrating the Blood-Brain Barrier in ALK-Positive Lung Cancer
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Highly Precise Measurement of HIV DNA by Droplet Digital PCR
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Multiplex Detection of Rare Mutations by Picoliter Droplet Based Digital PCR: Sensitivity and Specificity Considerations
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Characterization of Amplifiable, Circulating RNA in Plasma and Its Potential as a Tool for Cancer Diagnostics
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Circulating Tumor DNA as a Liquid Biopsy for Cancer
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Cutadapt removes adapter sequences from high-throughput sequencing reads
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Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content
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BCR-ABL as a target for novel therapeutic interventions
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Glioblastoma Heterogeneity and Cancer Cell Plasticity
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Characterization of the release and biological significance of cell-free DNA from breast cancer cell lines
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Frequent ATRX , CIC , FUBP1 and IDH1 mutations refine the classification of malignant gliomas
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Pros: Can tissue biopsy be replaced by liquid biopsy?
inferredcites →https://doi.org/10.21037/tlcr.2016.10.07openalex-snapshot
Liquid biopsy based biomarkers in non-small cell lung cancer for diagnosis and treatment monitoring
inferredcites →https://doi.org/10.2147/ahmt.s53391openalex-snapshot
Epidemiology, diagnosis, and optimal management of glioma in adolescents and young adults
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Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods
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Spotlight on lorlatinib and its potential in the treatment of NSCLC: the evidence to date
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Targeting ErbB Receptors in High-Grade Glioma
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Gliomas: New Perspectives in Diagnosis, Treatment and Prognosis
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The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision
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Analysis of cell-free circulating tumor DNA in 419 patients with glioblastoma and other primary brain tumors
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Circulating cell-free DNA: A promising marker of regional lymphonode metastasis in breast cancer patients
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Cell-free nucleic acids as noninvasive biomarkers for colorectal cancer detection
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Extracellular Vesicles As Modulators of Tumor Microenvironment and Disease Progression in Glioma
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Diagnostic Value of Concentration of Circulating Cell-Free DNA in Breast Cancer: A Meta-Analysis
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Circulating Cell-Free DNA and RNA Analysis as Liquid Biopsy: Optimal Centrifugation Protocol
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Liquid Biopsy in Glioblastoma: Opportunities, Applications and Challenges
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Blood-Based Cancer Biomarkers in Liquid Biopsy: A Promising Non-Invasive Alternative to Tissue Biopsy
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Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review
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dPCR: A Technology Review
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Liquid biopsy in patients with pancreatic cancer: Circulating tumor cells and cell-free nucleic acids
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Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids
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Epidermal growth factor receptor in glioblastoma
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Extracellular Vesicles and the Promise of Continuous Liquid Biopsies
inferredcites →https://doi.org/10.5732/cjc.013.10178openalex-snapshot
Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment
inferredcites →https://doi.org/10.5732/cjc.013.10217openalex-snapshot
Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00412-021-00766-9openalex-snapshot
NucPosDB: a database of nucleosome positioning in vivo and nucleosomics of cell-free DNA
inferred← citeshttps://doi.org/10.1093/nar/gkae1126openalex-snapshot
ChiTaRS 8.0: the comprehensive database of chimeric transcripts and RNA-seq data with applications in liquid biopsy
inferred← citeshttps://doi.org/10.17816/kmj679633openalex-snapshot
Liquid biopsy of plasma and cerebrospinal fluid for the detection of extracellular tumor DNA as a tool for glioma diagnosis and genotyping: a cross-sectional observational pilot study
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