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Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Structural principles controlling HIV envelope glycosylation
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DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
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A Community Letter Regarding Sharing Biomolecular Simulation Data for COVID-19
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Simulating POPC and POPC/POPG Bilayers: Conserved Packing and Altered Surface Reactivity
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CHARMM Additive All-Atom Force Field for Glycosidic Linkages between Hexopyranoses
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Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
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Antibody neutralization and escape by HIV-1
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DC-SIGN 'AIDS' HIV immune evasion and infection
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I-TASSER: a unified platform for automated protein structure and function prediction
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SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
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PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
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Vulnerabilities in coronavirus glycan shields despite extensive glycosylation
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Origin and evolution of pathogenic coronaviruses
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
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Potently neutralizing and protective human antibodies against SARS-CoV-2
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Novel correlates of protection against pandemic H1N1 influenza A virus infection
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If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future
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Structural basis for human coronavirus attachment to sialic acid receptors
inferredcites →https://doi.org/10.1038/s41594-020-0479-4openalex-snapshot
Controlling the SARS-CoV-2 spike glycoprotein conformation
inferredcites →https://doi.org/10.1038/srep41926openalex-snapshot
Limb proportions show developmental plasticity in response to embryo movement
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Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
inferredcites →https://doi.org/10.1073/pnas.1006498107openalex-snapshot
Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens
inferredcites →https://doi.org/10.1073/pnas.1707304114openalex-snapshot
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
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Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
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Molecular dynamics study of binary POPC bilayers: molecular condensing effects on membrane structure and dynamics
inferredcites →https://doi.org/10.1093/glycob/cwaa042openalex-snapshot
Deducing the N- and O-glycosylation profile of the spike protein of novel coronavirus SARS-CoV-2
inferredcites →https://doi.org/10.1093/glycob/cwy097openalex-snapshot
Sequence-to-structure dependence of isolated IgG Fc complex biantennary N -glycans: a molecular dynamics study
inferredcites →https://doi.org/10.1093/glycob/cwz003openalex-snapshot
CHARMM-GUIGlycan Modelerfor modeling and simulation of carbohydrates and glycoconjugates
inferredcites →https://doi.org/10.1101/2020.04.07.030445openalex-snapshot
Analysis of the SARS-CoV-2 spike protein glycan shield: implications for immune recognition
inferredcites →https://doi.org/10.1101/2020.05.15.096719openalex-snapshot
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity
inferredcites →https://doi.org/10.1101/2020.07.04.187989openalex-snapshot
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
inferredcites →https://doi.org/10.1101/2020.08.12.248690openalex-snapshot
Multiscale simulations examining glycan shield effects on drug binding to influenza neuraminidase
inferredcites →https://doi.org/10.1126/science.abb2507openalex-snapshot
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
inferredcites →https://doi.org/10.1126/science.abb2762openalex-snapshot
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
inferredcites →https://doi.org/10.1126/science.abb7269openalex-snapshot
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
inferredcites →https://doi.org/10.1126/science.abb9983openalex-snapshot
Site-specific glycan analysis of the SARS-CoV-2 spike
inferredcites →https://doi.org/10.1126/science.abc2241openalex-snapshot
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
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Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
inferredcites →https://doi.org/10.1126/science.abc6952openalex-snapshot
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
inferredcites →https://doi.org/10.1126/science.abd0826openalex-snapshot
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
inferredcites →https://doi.org/10.1128/cmr.00023-07openalex-snapshot
Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection
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Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140
inferredcites →https://doi.org/10.1128/jvi.01403-18openalex-snapshot
Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells
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Role of DC-SIGN in Lassa Virus Entry into Human Dendritic Cells
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Palmitoylations on Murine Coronavirus Spike Proteins Are Essential for Virion Assembly and Infectivity
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Human Influenza A Virus Hemagglutinin Glycan Evolution Follows a Temporal Pattern to a Glycan Limit
inferredcites →https://doi.org/10.1146/annurev-biophys-060414-034156openalex-snapshot
Structure and Immune Recognition of the HIV Glycan Shield
inferredcites →https://doi.org/10.1186/s13073-020-00763-0openalex-snapshot
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
inferredcites →https://doi.org/10.1371/journal.pone.0023521openalex-snapshot
The Glycan Shield of HIV Is Predominantly Oligomannose Independently of Production System or Viral Clade
inferredcites →https://doi.org/10.1371/journal.ppat.1007236openalex-snapshot
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
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Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS‐CoV‐2: A Combinedin silicoandin vitroStudy
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Challenges and limitations in the studies of glycoproteins: A computational chemist's perspective
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Cerium Oxide Nanoparticles for Biomedical Applications
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The opportunity cost of automated glycopeptide analysis: case study profiling the SARS-CoV-2 S glycoprotein
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Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A Review
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A potential interaction between the SARS-CoV-2 spike protein and nicotinic acetylcholine receptors
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Exploring dynamics and network analysis of spike glycoprotein of SARS-COV-2
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Modeling coronavirus spike protein dynamics: implications for immunogenicity and immune escape
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Molecular Architecture of the SARS-CoV-2 Virus
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Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor
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Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike
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Therapeutic potential for clomiphene, a selective estrogen receptor modulator, in the treatment of COVID‐19
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Antiviral nanoparticles for sanitizing surfaces: A roadmap to self-sterilizing against COVID-19
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A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles
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Review: A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles — R0/PR1
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Review: A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles — R0/PR2
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Decision: A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles — R0/PR3
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Decision: A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles — R1/PR4
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Decision: A 3.4-Å cryo-EM structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles — R2/PR5
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InterMap: Accelerated Detection of Interaction Fingerprints on Large-Scale Molecular Ensembles
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The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV‑2 Spike Protein
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Molecular Simulations and Network Modeling Reveal an Allosteric Signaling in the SARS-CoV‑2 Spike Proteins
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Metal-Mediated Nanoscale Cerium Oxide Inactivates Human Coronavirus and Rhinovirus by Surface Disruption
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Open questions in chemical glycobiology
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The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
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The Role of the SARS-CoV-2 S-Protein Glycosylation in the Interaction of SARS-CoV-2/ACE2 and Immunological Responses
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Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation
inferred← citeshttps://doi.org/10.1101/2020.07.03.186825openalex-snapshot
Map of SARS-CoV-2 spike epitopes not shielded by glycans
inferred← citeshttps://doi.org/10.1101/2020.08.12.248690openalex-snapshot
Multiscale simulations examining glycan shield effects on drug binding to influenza neuraminidase
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The SARS-CoV-2 Spike Harbours a Lipid Binding Pocket Which Modulates Stability of the Prefusion Trimer
inferred← citeshttps://doi.org/10.1101/2020.09.17.300335openalex-snapshot
Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells
inferred← citeshttps://doi.org/10.1101/2024.05.15.594261openalex-snapshot
Protein structure, a genetic constraint on glycosylation
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Cleaved vs. Uncleaved: How Furin Cleavage Reshapes the Conformational Landscape of SARS-CoV-2 Spike
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COVID-19 Vaccines: “Warp Speed” Needs Mind Melds, Not Warped Minds
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AI-driven multiscale simulations illuminate mechanisms of SARS-CoV-2 spike dynamics
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DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist
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VULNERABLE ELECTRICALLY CHARGED SARS-COV-2 POINTS, ELECTRIC MODEL OF THE VIRUS AND ROLE OF TRACE ELEMENTS IN ITS INACTIVATION
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Allosteric Regulation of SARS-CoV-2 Protease: Towards Informed Structure-Based Drug Discovery
inferred← citeshttps://doi.org/10.26434/chemrxiv.12967655.v1openalex-snapshot
Allosteric Regulation of SARS-CoV-2 Protease: Towards Informed Structure-Based Drug Discovery
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Allosteric Regulation of SARS-CoV-2 Protease: Towards Informed Structure-Based Drug Discovery
inferred← citeshttps://doi.org/10.3389/fbinf.2021.667012openalex-snapshot
N-Glycosylation Network Construction and Analysis to Modify Glycans on the Spike (S) Glycoprotein of SARS-CoV-2
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Framework-mediated binding of foreign and self-glycans by IGHV4–34 antibodies
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Structural and functional dissection of neutralisation differences among SARS-CoV-2 variants using antigenicity prediction and CR3022 binding analysis
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Variations in O-Glycosylation Patterns Influence Viral Pathogenicity, Infectivity, and Transmissibility in SARS-CoV-2 Variants
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The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies
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Designing a Candidate Multi-Epitope Vaccine against Transmissible Gastroenteritis Virus Based on Immunoinformatic and Molecular Dynamics
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Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields
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Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines
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USE OF OF ANTIHOMOTOXIC MEDICATIONS IN PROPHYLAXIS OF CARIDIO-VASCULAR SYSTEM DISORDERS
inferred← citeshttps://doi.org/10.34660/inf.2020.52.34.021openalex-snapshot
PATHWAYS OF LECTIN AND LECTIN-LIKE PROTECTIVE INTERACTIONS INVOLVING GLYCOCONJUGATES IN CASES OF COVID INFECTIONS IN ORGANISM
inferred← citeshttps://doi.org/10.34660/inf.2020.59.88.008openalex-snapshot
SMALL GENRES OF FOLKLORE IN THE MANUSCRIPT HERITAGE OF P.E. SHESHKINA: TRANSLATION FEATURE
inferred← citeshttps://doi.org/10.34660/inf.2020.63.13.025openalex-snapshot
CONTROL OF THE PARTICLE SIZE AND PHASE COMPOSITION OF NANOFORMS OF THE ANTIBACTERIAL DRUG DIOXIDINE IN THE PROCESS OF CRYOCHEMICAL SYNTHESIS
inferred← citeshttps://doi.org/10.34660/inf.2020.71.25.012openalex-snapshot
THERAPEUTIC INDICATIONS FOR USAGE OF BOTULINUM TOXIN A IN DENTISTRY AND ORAL SURGERY
inferred← citeshttps://doi.org/10.34660/inf.2020.72.27.027openalex-snapshot
CREATIVE HERITAGE OF V. A. RAMENSKY: FROM THE COLLECTIONS OF MUSEUMS IN THE ALTAI KRAI AND PRIVATE COLLECTIONS
inferred← citeshttps://doi.org/10.34660/inf.2020.83.77.016openalex-snapshot
DIAGNOSIS AND CLINICAL AND PATHOMORPHOLOGICAL FEATURES OF CONGENITAL LISTERIOSIS
inferred← citeshttps://doi.org/10.54536/ajcp.v2i2.1634openalex-snapshot
Unveiling the SARS-CoV-2 Spike Protein: A Comparative Analysis of Vaccine Development Approaches and Glycosylation Implications
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