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Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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VMD: Visual molecular dynamics
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Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies
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Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
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Automated molecular microscopy: The new Leginon system
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Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein
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Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
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Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
inferredcites →https://doi.org/10.1038/nature17200openalex-snapshot
Pre-fusion structure of a human coronavirus spike protein
inferredcites →https://doi.org/10.1038/ncomms15092openalex-snapshot
Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
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cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
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SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
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Structural basis for human coronavirus attachment to sialic acid receptors
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A thermostable, closed SARS-CoV-2 spike protein trimer
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Controlling the SARS-CoV-2 spike glycoprotein conformation
inferredcites →https://doi.org/10.1038/s41594-020-0483-8openalex-snapshot
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
inferredcites →https://doi.org/10.1038/s41598-018-34171-7openalex-snapshot
Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
inferredcites →https://doi.org/10.1101/2020.06.03.129817openalex-snapshot
Closing coronavirus spike glycoproteins by structure-guided design
inferredcites →https://doi.org/10.1101/2020.06.11.146522openalex-snapshot
Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein
inferredcites →https://doi.org/10.1107/s2059798318002425openalex-snapshot
ISOLDE : a physically realistic environment for model building into low-resolution electron-density maps
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Real-space refinement in PHENIX for cryo-EM and crystallography
inferredcites →https://doi.org/10.1126/science.abb2507openalex-snapshot
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
inferredcites →https://doi.org/10.1126/science.abb9983openalex-snapshot
Site-specific glycan analysis of the SARS-CoV-2 spike
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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
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Distinct conformational states of SARS-CoV-2 spike protein
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Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Production of high‐quality SARS‐CoV‐2 antigens: Impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance
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Glycosylation in extracellular vesicles: Isolation, characterization, composition, analysis and clinical applications
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S-SPAM; a search method for Spatio-temporal Patterns of Mutations. Study case: A variability analysis in the spike protein of SARS-CoV-2
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The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2
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35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope
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Principles and practical applications of structure-based vaccine design
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A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
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Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2
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Principles of SARS-CoV-2 glycosylation
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Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct
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Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection
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Mass Spectrometry-Based Structural Virology
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Dynamic Network Modeling of Allosteric Interactions and Communication Pathways in the SARS-CoV-2 Spike Trimer Mutants: Differential Modulation of Conformational Landscapes and Signal Transmission via Cascades of Regulatory Switches
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The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV‑2 Spike Protein
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Epi -Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses
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Molecular Insights into the Interaction between CD147 and the SARS-CoV-2 Spike Protein
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Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
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Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
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Cold sensitivity of the SARS-CoV-2 spike ectodomain
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Expression and characterization of SARS-CoV-2 spike proteins
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SARS-CoV-2 spike opening dynamics and energetics reveal the individual roles of glycans and their collective impact
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Disulfide bonds stabilize the SARS-CoV-2 RBD and preserve binding to ACE2 following thermal denaturation
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Targeting spike glycans to inhibit SARS-CoV2 viral entry
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D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes
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Quantitative profiling of N-glycosylation of SARS-CoV-2 spike protein variants
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Map of SARS-CoV-2 spike epitopes not shielded by glycans
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Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution
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A Recombinant Protein SARS-CoV-2 Candidate Vaccine Elicits High-titer Neutralizing Antibodies in Macaques.
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Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry
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An alpaca-derived nanobody recognizes a unique conserved epitope and retains potent activity against the SARS-CoV-2 omicron variant
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Evolving spike-protein N -glycosylation in SARS-CoV-2 variants
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Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms
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The SARS-CoV-2 Spike variant D614G favors an open conformational state
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
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Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
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A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection
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SARS-CoV-2 neutralizing antibody specificities differ dramatically between recently infected infants and immune-imprinted individuals
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A study protocol to prepare an RBD protein for vaccine against COVID-19
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A study protocol to prepare an RBD protein for vaccine against COVID-19
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A study protocol to prepare an RBD protein for vaccine against COVID-19
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Computational epitope map of SARS-CoV-2 spike protein
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Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins
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Genome sequencing of SARS-CoV-2 omicron variants in Delhi reveals alterations in immunogenic regions in spike glycoprotein
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The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein
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