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Function and regulation of Alx4 in limb development: Complex genetic interactions with Gli3 and Shh
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0177(199801)211:1<88::aid-aja8>3.0.co;2-3openalex-snapshot
Expression profile of Gli family members and Shh in normal and mutant mouse limb development
inferredcites →https://doi.org/10.1002/(sici)1097-0177(199810)213:2<159::aid-aja1>3.0.co;2-fopenalex-snapshot
Alx-4, a transcriptional activator whose expression is restricted to sites of epithelial-mesenchymal interactions
inferredcites →https://doi.org/10.1002/gene.10091openalex-snapshot
Isolation of differentially expressed genes from wild‐type and Twist mutant mouse limb buds
inferredcites →https://doi.org/10.1002/jmor.1051130307openalex-snapshot
The embryological development of the effects of Strong's luxoid gene in the mouse
inferredcites →https://doi.org/10.1006/dbio.1994.1097openalex-snapshot
Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development
inferredcites →https://doi.org/10.1006/dbio.1995.0010openalex-snapshot
HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo
inferredcites →https://doi.org/10.1006/dbio.1996.0300openalex-snapshot
Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development
inferredcites →https://doi.org/10.1006/dbio.1996.8457openalex-snapshot
Multigenic Control of the Localization of the Zone of Polarizing Activity in Limb Morphogenesis in the Mouse
inferredcites →https://doi.org/10.1006/dbio.1998.8921openalex-snapshot
MouseAlx3:Anaristaless-like Homeobox Gene Expressed during Embryogenesis in Ectomesenchyme and Lateral Plate Mesoderm
inferredcites →https://doi.org/10.1006/dbio.2001.0346openalex-snapshot
Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function
inferredcites →https://doi.org/10.1006/dbio.2001.0365openalex-snapshot
Hoxb2 and Hoxb4 Act Together to Specify Ventral Body Wall Formation
inferredcites →https://doi.org/10.1016/0012-1606(90)90211-zopenalex-snapshot
Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis
inferredcites →https://doi.org/10.1016/0092-8674(94)90030-2openalex-snapshot
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
inferredcites →https://doi.org/10.1016/0168-9525(86)90275-1openalex-snapshot
Manipulating the mouse embryo: A laboratory manual
inferredcites →https://doi.org/10.1016/0925-4773(91)90067-gopenalex-snapshot
The Hox-4.8 gene is localized at the 5′ extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development
inferredcites →https://doi.org/10.1016/0925-4773(95)00389-iopenalex-snapshot
Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain
inferredcites →https://doi.org/10.1016/s0092-8674(00)80364-5openalex-snapshot
Molecular Models for Vertebrate Limb Development
inferredcites →https://doi.org/10.1016/s0092-8674(00)80678-9openalex-snapshot
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
inferredcites →https://doi.org/10.1016/s0925-4773(00)00492-5openalex-snapshot
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
inferredcites →https://doi.org/10.1016/s0925-4773(01)00450-6openalex-snapshot
Expression patterns of group-I aristaless-related genes during craniofacial and limb development
inferredcites →https://doi.org/10.1016/s0925-4773(97)00656-4openalex-snapshot
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
inferredcites →https://doi.org/10.1038/350585a0openalex-snapshot
Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
inferredcites →https://doi.org/10.1038/371609a0openalex-snapshot
A positive feedback loop coordinates growth and patterning in the vertebrate limb
inferredcites →https://doi.org/10.1038/383407a0openalex-snapshot
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
inferredcites →https://doi.org/10.1038/44157openalex-snapshot
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
inferredcites →https://doi.org/10.1038/nature00902openalex-snapshot
Functions of FGF signalling from the apical ectodermal ridge in limb development
inferredcites →https://doi.org/10.1038/nature01033openalex-snapshot
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
inferredcites →https://doi.org/10.1038/ng1178openalex-snapshot
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
inferredcites →https://doi.org/10.1038/nrg1001openalex-snapshot
Pattern formation: old models out on a limb
inferredcites →https://doi.org/10.1046/j.1469-7580.2003.00138.xopenalex-snapshot
Patterning the limb before and after SHH signalling
inferredcites →https://doi.org/10.1093/bioinformatics/16.11.1046openalex-snapshot
VISTA : visualizing global DNA sequence alignments of arbitrary length
inferredcites →https://doi.org/10.1101/gad.10.3.301openalex-snapshot
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
inferredcites →https://doi.org/10.1101/gad.12.11.1571openalex-snapshot
The roles of FGFs in the early development of vertebrate limbs
inferredcites →https://doi.org/10.1101/gad.219202openalex-snapshot
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling
inferredcites →https://doi.org/10.1101/gad.5.10.1767openalex-snapshot
HOX-4 genes and the morphogenesis of mammalian genitalia.
inferredcites →https://doi.org/10.1101/gad.9.13.1645openalex-snapshot
A duplicated zone of polarizing activity in polydactylous mouse mutants.
inferredcites →https://doi.org/10.1101/gad.938601openalex-snapshot
Hedgehog signaling in animal development: paradigms and principles
inferredcites →https://doi.org/10.1101/gr.1933104openalex-snapshot
Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner
inferredcites →https://doi.org/10.1126/science.1075620openalex-snapshot
Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3
inferredcites →https://doi.org/10.1126/science.1096049openalex-snapshot
A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry
inferredcites →https://doi.org/10.1128/mcb.20.2.429-440.2000openalex-snapshot
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms
inferredcites →https://doi.org/10.1146/annurev.cellbio.17.1.87openalex-snapshot
Patterning Mechanisms Controlling Vertebrate Limb Development
inferredcites →https://doi.org/10.1242/dev.01251openalex-snapshot
Gremlin -mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
inferredcites →https://doi.org/10.1242/dev.01735openalex-snapshot
Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes
inferredcites →https://doi.org/10.1242/dev.121.7.1971openalex-snapshot
Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity
inferredcites →https://doi.org/10.1242/dev.124.1.113openalex-snapshot
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development
inferredcites →https://doi.org/10.1242/dev.124.20.3999openalex-snapshot
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
inferredcites →https://doi.org/10.1242/dev.124.21.4393openalex-snapshot
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
inferredcites →https://doi.org/10.1242/dev.125.14.2711openalex-snapshot
Mutations in mouse Aristaless-like4 cause Strong’s luxoid polydactyly
inferredcites →https://doi.org/10.1242/dev.125.22.4417openalex-snapshot
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
inferredcites →https://doi.org/10.1242/dev.126.1.13openalex-snapshot
Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity
inferredcites →https://doi.org/10.1242/dev.126.2.359openalex-snapshot
Physical and genetic interactions between Alx4 and Cart1
inferredcites →https://doi.org/10.1242/dev.126.6.1211openalex-snapshot
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo
inferredcites →https://doi.org/10.1242/dev.127.11.2471openalex-snapshot
Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation
inferredcites →https://doi.org/10.1242/dev.128.20.3975openalex-snapshot
Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice
inferredcites →https://doi.org/10.1387/ijdb.051984lpopenalex-snapshot
Genetic interaction of Gli3 and Alx4 during limb development
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/dvdy.21859openalex-snapshot
Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down‐regulation in limb bud and polydactyly in the rat
inferred← citeshttps://doi.org/10.1002/dvdy.22572openalex-snapshot
Evolution of vertebrate appendicular structures: Insight from genetic and palaeontological data
inferred← citeshttps://doi.org/10.1002/dvdy.24493openalex-snapshot
Upstream regulation for initiation of restricted Shh expression in the chick limb bud
inferred← citeshttps://doi.org/10.1002/dvdy.328openalex-snapshot
A transgenic Alx4‐CreER mouse to analyze anterior limb and nephric duct development
inferred← citeshttps://doi.org/10.1002/vrc2.968openalex-snapshot
Polydactyl canine case: Exploring possible linkage between anomalies, secondary infertility and SHH/ALX4 mutations
inferred← citeshttps://doi.org/10.1007/s00335-015-9557-zopenalex-snapshot
A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2018.12.007openalex-snapshot
Genetics of scapula and pelvis development: An evolutionary perspective
inferred← citeshttps://doi.org/10.1016/j.cca.2011.02.007openalex-snapshot
A novel frame-shift mutation of GLI3 causes non-syndromic and complex digital anomalies in a Chinese family
inferred← citeshttps://doi.org/10.1016/j.cell.2023.12.032openalex-snapshot
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117669openalex-snapshot
Conserved anterior/posterior tissue asymmetry encodes proximal/distal positional information during axolotl limb regeneration
inferred← citeshttps://doi.org/10.1016/j.cels.2024.10.006openalex-snapshot
Systematic analysis identifies a connection between spatial and genomic variations of chromatin states
inferred← citeshttps://doi.org/10.1016/j.gde.2014.03.011openalex-snapshot
Long range regulation of the sonic hedgehog gene
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.04.038openalex-snapshot
Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb
inferred← citeshttps://doi.org/10.1016/j.ydbio.2011.11.020openalex-snapshot
Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton
inferred← citeshttps://doi.org/10.1016/j.ydbio.2024.07.015openalex-snapshot
Sall4 regulates downstream patterning genes during limb regeneration
inferred← citeshttps://doi.org/10.1016/j.ygeno.2006.05.007openalex-snapshot
Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle
inferred← citeshttps://doi.org/10.1038/ejhg.2013.160openalex-snapshot
Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation
inferred← citeshttps://doi.org/10.1038/s41467-021-23373-9openalex-snapshot
Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors
inferred← citeshttps://doi.org/10.1038/s41556-023-01108-wopenalex-snapshot
A single-cell transcriptome atlas profiles early organogenesis in human embryos
inferred← citeshttps://doi.org/10.1038/s41586-023-06806-xopenalex-snapshot
A human embryonic limb cell atlas resolved in space and time
inferred← citeshttps://doi.org/10.1038/s41598-019-44913-wopenalex-snapshot
Evolution of the avian digital pattern
inferred← citeshttps://doi.org/10.1093/hmg/dds423openalex-snapshot
Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia
inferred← citeshttps://doi.org/10.1096/fj.202000330ropenalex-snapshot
Transcriptomic analysis of bone and fibrous tissue morphogenesis during digit tip regeneration in the adult mouse
inferred← citeshttps://doi.org/10.1097/sap.0000000000001685openalex-snapshot
A Novel Frameshift Mutation of GLI3 Causes Isolated Postaxial Polydactyly
inferred← citeshttps://doi.org/10.1101/2020.06.17.158501openalex-snapshot
HES1 is a Critical Mediator of the SHH-GLI3 Axis in Regulating Digit Number
inferred← citeshttps://doi.org/10.1101/2023.12.11.570452openalex-snapshot
Broad H3K4me3 Domain Is Associated with Spatial Coherence during Mammalian Embryonic Development
inferred← citeshttps://doi.org/10.1101/2024.09.17.613303openalex-snapshot
Endothelial regulatory circuits control cranial neural crest migration and plasticity
inferred← citeshttps://doi.org/10.1101/gad.1693008openalex-snapshot
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
inferred← citeshttps://doi.org/10.1111/ede.12011openalex-snapshot
Development of the marsupial shoulder girdle complex: a case study in Monodelphis domestica
inferred← citeshttps://doi.org/10.1111/evo.12773openalex-snapshot
On the serial homology of the pectoral and pelvic girdles of tetrapods
inferred← citeshttps://doi.org/10.1111/j.1440-169x.2007.00943.xopenalex-snapshot
How to make a zone of polarizing activity: Insights into limb development via the abnormality preaxial polydactyly
inferred← citeshttps://doi.org/10.1111/j.1741-4520.2009.00244.xopenalex-snapshot
Syndactyly lethal: New mutation with multiple malformations occurring in Sprague Dawley rats
inferred← citeshttps://doi.org/10.1111/mec.15162openalex-snapshot
Selection at behavioural, developmental and metabolic genes is associated with the northward expansion of a successful tropical colonizer
inferred← citeshttps://doi.org/10.1126/sciadv.abc3510openalex-snapshot
Sarcopterygian fin ontogeny elucidates the origin of hands with digits
inferred← citeshttps://doi.org/10.1186/s12881-019-0889-5openalex-snapshot
A novel missense in GLI3 possibly affecting one of the zinc finger domains may lead to postaxial synpolydactyly: case report
inferred← citeshttps://doi.org/10.1186/s12915-025-02300-0openalex-snapshot
Evolution of cetacean-specific conserved non-coding elements suggests their role in the limb changes during secondary aquatic adaptation
inferred← citeshttps://doi.org/10.1186/s13046-017-0643-9openalex-snapshot
ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.1186/s40851-015-0019-yopenalex-snapshot
Evidence for an amphibian sixth digit
inferred← citeshttps://doi.org/10.1242/dev.149963openalex-snapshot
Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis
inferred← citeshttps://doi.org/10.1242/dev.200182openalex-snapshot
SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
inferred← citeshttps://doi.org/10.1360/n972017-00512openalex-snapshot
How do fins and limbs develop and evolve?
inferred← citeshttps://doi.org/10.1371/journal.pgen.1004072openalex-snapshot
GATA6 Is a Crucial Regulator of Shh in the Limb Bud
inferred← citeshttps://doi.org/10.1371/journal.pgen.1009982openalex-snapshot
HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly
inferred← citeshttps://doi.org/10.1371/journal.pgen.1011787openalex-snapshot
Genetic disruption of the baculum compromises the ability of male mice to copulate
inferred← citeshttps://doi.org/10.1371/journal.pone.0016260openalex-snapshot
Genetic Analysis of Hedgehog Signaling in Ventral Body Wall Development and the Onset of Omphalocele Formation
inferred← citeshttps://doi.org/10.1371/journal.pone.0103813openalex-snapshot
Selection Signatures in Worldwide Sheep Populations
inferred← citeshttps://doi.org/10.1371/journal.pone.0129208openalex-snapshot
A 20 bp Duplication in Exon 2 of the Aristaless-Like Homeobox 4 Gene (ALX4) Is the Candidate Causative Mutation for Tibial Hemimelia Syndrome in Galloway Cattle
inferred← citeshttps://doi.org/10.26599/bdma.2023.9020007openalex-snapshot
Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach
inferred← citeshttps://doi.org/10.3389/fgene.2020.569314openalex-snapshot
Transcription Factors of the Alx Family: Evolutionarily Conserved Regulators of Deuterostome Skeletogenesis
inferred← citeshttps://doi.org/10.3390/jdb8040031openalex-snapshot
Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage
inferred← citeshttps://doi.org/10.3928/01477447-20100826-34openalex-snapshot
Understanding the Molecular Basis of Polydactyly
inferred← citeshttps://doi.org/10.4238/2013.august.2.2openalex-snapshot
Multiple abnormalities due to a nonsense mutation in the Alx4 gene
inferred← citeshttps://doi.org/10.64898/2025.12.15.694399openalex-snapshot
Spatial gene expression maps in vertebrate limbs display conserved and regenerative species-specific features within connective tissue
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