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NNMT promotes tubular senescence and fibrosis in chronic kidney disease

https://doi.org/10.1101/2025.01.06.631437

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Spatial Transcriptomics

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KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

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Structure–Activity Relationship for Small Molecule Inhibitors of Nicotinamide N -Methyltransferase

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

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Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

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Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

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Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

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Fiji: an open-source platform for biological-image analysis

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Generation of kidney organoids from human pluripotent stem cells

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Correction: Diabetic kidney disease

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Chronic kidney disease

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Chronic kidney disease and the global public health agenda: an international consensus

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Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

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limma powers differential expression analyses for RNA-sequencing and microarray studies

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Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse

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Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

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Web-based LinRegPCR: application for the visualization and analysis of (RT)-qPCR amplification and melting data

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Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data

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Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure

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Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

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Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

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Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

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Welcome to the Tidyverse

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A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

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Nicotinamide N-Methyl Transferase as a Predictive Marker of Tubular Fibrosis in CKD

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Transcriptome Analysis of Human Diabetic Kidney Disease

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Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis

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Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy

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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

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NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.kint.2025.06.018openalex-snapshot

Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression

inferred← citeshttps://doi.org/10.1093/ckj/sfaf190openalex-snapshot

Understanding and targeting senescence in kidney disease

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