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Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/exmp.2000.2346openalex-snapshot
Tubular Cell Senescence and Expression of TGF-β1 and p21WAF1/CIP1 in Tubulointerstitial Fibrosis of Aging Rats
inferredcites →https://doi.org/10.1007/s00125-011-2314-2openalex-snapshot
Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy
inferredcites →https://doi.org/10.1007/s11010-013-1866-5openalex-snapshot
Wnt/β-catenin signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients through the p53/p21 pathway
inferredcites →https://doi.org/10.1016/j.cell.2013.10.019openalex-snapshot
Programmed Cell Senescence during Mammalian Embryonic Development
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.02.009openalex-snapshot
NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney
inferredcites →https://doi.org/10.1016/j.kint.2017.03.035openalex-snapshot
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1
inferredcites →https://doi.org/10.1016/j.trsl.2011.11.008openalex-snapshot
Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy
inferredcites →https://doi.org/10.1038/cdd.2015.6openalex-snapshot
JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein
inferredcites →https://doi.org/10.1038/ki.2012.184openalex-snapshot
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis
inferredcites →https://doi.org/10.1038/labinvest.2014.90openalex-snapshot
Renal expression of advanced oxidative protein products predicts progression of renal fibrosis in patients with IgA nephropathy
inferredcites →https://doi.org/10.1038/labinvest.2015.153openalex-snapshot
Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword
inferredcites →https://doi.org/10.1038/nature16932openalex-snapshot
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
inferredcites →https://doi.org/10.1038/ncb2784openalex-snapshot
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
inferredcites →https://doi.org/10.1038/nm.3218openalex-snapshot
Origin and function of myofibroblasts in kidney fibrosis
inferredcites →https://doi.org/10.1038/nrc2440openalex-snapshot
Living on a break: cellular senescence as a DNA-damage response
inferredcites →https://doi.org/10.1038/nrm2233openalex-snapshot
Cellular senescence: when bad things happen to good cells
inferredcites →https://doi.org/10.1038/nrneph.2016.183openalex-snapshot
Cellular senescence in renal ageing and disease
inferredcites →https://doi.org/10.1038/sj.ki.5002039openalex-snapshot
Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease
inferredcites →https://doi.org/10.1053/j.ajkd.2012.11.051openalex-snapshot
Chronic Kidney Disease: A Clinical Model of Premature Aging
inferredcites →https://doi.org/10.1053/j.ajkd.2015.05.004openalex-snapshot
CKD in the Elderly: Kidney Senescence or Blood Pressure–Related Nephropathy?
inferredcites →https://doi.org/10.1073/pnas.1516131112openalex-snapshot
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
inferredcites →https://doi.org/10.1074/jbc.m109.091256openalex-snapshot
Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling
inferredcites →https://doi.org/10.1089/ars.2016.6758openalex-snapshot
C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury
inferredcites →https://doi.org/10.1093/cvr/cvs352openalex-snapshot
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence
inferredcites →https://doi.org/10.1097/01.asn.0000106015.29070.e7openalex-snapshot
Epithelial to Mesenchymal Transition in Renal Fibrogenesis
inferredcites →https://doi.org/10.1111/acel.12514openalex-snapshot
mTORC 1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts
inferredcites →https://doi.org/10.1111/j.1523-1755.2004.00438.xopenalex-snapshot
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
inferredcites →https://doi.org/10.1111/j.1600-6143.2009.02762.xopenalex-snapshot
Wnt Pathway Regulation in Chronic Renal Allograft Damage
inferredcites →https://doi.org/10.1126/science.1143578openalex-snapshot
Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging
inferredcites →https://doi.org/10.1152/ajpcell.00096.2010openalex-snapshot
Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes
inferredcites →https://doi.org/10.1152/ajprenal.00378.2010openalex-snapshot
INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction
inferredcites →https://doi.org/10.1152/ajprenal.90302.2008openalex-snapshot
Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy
inferredcites →https://doi.org/10.1159/000446336openalex-snapshot
Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury
inferredcites →https://doi.org/10.1172/jci26958openalex-snapshot
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
inferredcites →https://doi.org/10.1172/jci90828openalex-snapshot
The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes
inferredcites →https://doi.org/10.1371/journal.pone.0070464openalex-snapshot
Increased Cellular Senescence and Vascular Rarefaction Exacerbate the Progression of Kidney Fibrosis in Aged Mice Following Transient Ischemic Injury
inferredcites →https://doi.org/10.1681/asn.2008060566openalex-snapshot
Wnt/β-Catenin Signaling Promotes Renal Interstitial Fibrosis
inferredcites →https://doi.org/10.1681/asn.2011050490openalex-snapshot
Matrix Metalloproteinase-7 as a Surrogate Marker Predicts Renal Wnt/β-Catenin Activity in CKD
inferredcites →https://doi.org/10.1681/asn.2011100967openalex-snapshot
Cellular Senescence Limits Regenerative Capacity and Allograft Survival
inferredcites →https://doi.org/10.1681/asn.2012080865openalex-snapshot
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling
inferredcites →https://doi.org/10.1681/asn.2013101067openalex-snapshot
Mutual Antagonism of Wilms’ Tumor 1 and β-Catenin Dictates Podocyte Health and Disease
inferredcites →https://doi.org/10.1681/asn.2014010085openalex-snapshot
Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/β-Catenin Signaling
inferredcites →https://doi.org/10.1681/asn.2015040449openalex-snapshot
Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression
inferredcites →https://doi.org/10.1681/asn.2016030354openalex-snapshot
Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis
inferredcites →https://doi.org/10.2215/cjn.04980515openalex-snapshot
Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl-β-D-Glucosaminidase, and Urinary β2-Microglobulin in Patients with Type 2 Diabetes and Biopsy–Proven Diabetic Nephropathy
inferredcites →https://doi.org/10.3389/fphys.2015.00082openalex-snapshot
TGF-β/Smad signaling in renal fibrosis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/advs.202402066openalex-snapshot
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis
inferred← citeshttps://doi.org/10.1002/advs.202414830openalex-snapshot
Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts
inferred← citeshttps://doi.org/10.1002/cbin.11736openalex-snapshot
Overexpression of NDUFV1 alleviates renal damage by improving mitochondrial function in unilateral ureteral obstruction model mice
inferred← citeshttps://doi.org/10.1002/ccs3.70046openalex-snapshot
Tri‐domain proteins 27 alleviates ischemia‐reperfusion injury‐induced acute kidney injury by promoting Gli‐like transcription factor 1 expression via the inhibition of polycomb repressive complex 2 activity
inferred← citeshttps://doi.org/10.1002/ctm2.70605openalex-snapshot
TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling
inferred← citeshttps://doi.org/10.1002/imm3.70028openalex-snapshot
Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway
inferred← citeshttps://doi.org/10.1002/jgm.3617openalex-snapshot
Erxian Decoction‐induced serum exosomes slowed bone marrow mesenchymal stem cell senescence through mitophagy
inferred← citeshttps://doi.org/10.1007/978-3-030-91623-7_7openalex-snapshot
Phosphate and Cellular Senescence
inferred← citeshttps://doi.org/10.1007/978-981-13-8871-2_12openalex-snapshot
Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation
inferred← citeshttps://doi.org/10.1007/s00109-020-01978-9openalex-snapshot
Wnt signaling in kidney: the initiator or terminator?
inferred← citeshttps://doi.org/10.1007/s00240-025-01734-zopenalex-snapshot
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals
inferred← citeshttps://doi.org/10.1007/s00418-022-02178-xopenalex-snapshot
Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney
inferred← citeshttps://doi.org/10.1007/s00428-020-02917-2openalex-snapshot
Senescence and autophagy in usual interstitial pneumonia of different etiology
inferred← citeshttps://doi.org/10.1007/s00467-023-06264-7openalex-snapshot
Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms
inferred← citeshttps://doi.org/10.1007/s00535-023-02020-8openalex-snapshot
A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s10753-026-02569-5openalex-snapshot
IL-18 Promotes the Development of Lupus Nephritis by Activating the Wnt/β-Catenin Signaling Pathway in Renal Tubular Epithelial Cells
inferred← citeshttps://doi.org/10.1007/s10787-025-02072-7openalex-snapshot
Neuroprotective effects of SRS11-92 against oxidative stress–induced senescence via Nrf2/HO-1/NF-κB in Alzheimer’s disease models
inferred← citeshttps://doi.org/10.1007/s11033-020-05749-0openalex-snapshot
Mechanism of progression of diabetic kidney disease mediated by podocyte mitochondrial injury
inferred← citeshttps://doi.org/10.1007/s11255-026-05271-5openalex-snapshot
Cellular senescence in kidney diseases: a bibliometric analysis of global trends, knowledge bases, and emerging therapeutic frontiers
inferred← citeshttps://doi.org/10.1007/s11274-018-2565-xopenalex-snapshot
Expression, purification, and evaluation of in vivo anti-fibrotic activity for soluble truncated TGF-β receptor II as a cleavable His-SUMO fusion protein
inferred← citeshttps://doi.org/10.1007/s11684-024-1117-zopenalex-snapshot
Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions
inferred← citeshttps://doi.org/10.1007/s13577-021-00611-2openalex-snapshot
The protective effects of Agomelatine against Aβ1-42 oligomers-induced cellular senescence mediated by SIRT6 and Agomelatine’s potential in AD treatment
inferred← citeshttps://doi.org/10.1007/s13577-023-00859-wopenalex-snapshot
Silencing of adipocyte enhancer-binding protein 1 (AEBP1) alleviates renal fibrosis in vivo and in vitro via inhibition of the β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1007/s13659-020-00262-0openalex-snapshot
Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00001-9openalex-snapshot
Stress-induced senescence as a forme fruste of chronic kidney disease—A case for failed regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00005-6openalex-snapshot
Therapeutic cell reconditioning
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00032-9openalex-snapshot
Injury and regeneration in renal aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00035-4openalex-snapshot
Characteristics of senescent cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-823318-4.00037-8openalex-snapshot
Stress-induced senescence of tubular cells
inferred← citeshttps://doi.org/10.1016/b978-0-443-15500-0.00003-7openalex-snapshot
Age-related disease: Kidneys
inferred← citeshttps://doi.org/10.1016/b978-0-443-34069-7.00005-7openalex-snapshot
Molecular mechanisms of aging
inferred← citeshttps://doi.org/10.1016/b978-0-443-40423-8.00012-9openalex-snapshot
The role of microphysiological models constructed with organoids and organ-on-chip technologies in tissue regeneration
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101063openalex-snapshot
Wnt signaling pathway in aging-related tissue fibrosis and therapies
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101151openalex-snapshot
The ageing kidney: Molecular mechanisms and clinical implications
inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166807openalex-snapshot
Pentraxin 3 plays a key role in tubular cell senescence and renal fibrosis through inducing β-catenin signaling
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.168088openalex-snapshot
METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of tubular epithelial cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149402openalex-snapshot
Perioperative acute kidney injury: The renoprotective effect and mechanism of dexmedetomidine
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116615openalex-snapshot
Andrographolide prevents renal fibrosis via decelerating lipotoxicity-mediated premature senescence of tubular epithelial cells
inferred← citeshttps://doi.org/10.1016/j.biochi.2025.10.008openalex-snapshot
Premature aging in chronic kidney disease: Decoding senescence biomarkers and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.111191openalex-snapshot
Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.116039openalex-snapshot
Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems
inferred← citeshttps://doi.org/10.1016/j.cellsig.2024.111531openalex-snapshot
Activation of HIF-1α C-terminal transactivation domain promotes tubulointerstitial fibrosis through hexokinase 2-mediated metabolic reprogramming
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112129openalex-snapshot
GPR108 deficiency promotes urate-induced renal interstitial fibrosis
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112182openalex-snapshot
IL-11 exacerbates cisplatin-induced acute kidney injury by facilitating apoptosis in renal tubular epithelial cells via ERK1/2-Drp1/TFEB-mediated defective autophagy
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112185openalex-snapshot
Core signaling pathways in renal ischemia-reperfusion injury: network regulation and therapeutic prospects
inferred← citeshttps://doi.org/10.1016/j.cellsig.2026.112688openalex-snapshot
Nicotinamide N-methyltransferase as a stress-responsive metabolic-epigenetic regulator of tubular senescence in chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.cellsig.2026.112737openalex-snapshot
Ubiquitin-specific protease 11 promotes tubular cell senescence via inhibiting p53 ubiquitin degradation during renal fibrosis
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116823openalex-snapshot
NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.diff.2024.100820openalex-snapshot
WNT9A and WNT9B in Development and Disease
inferred← citeshttps://doi.org/10.1016/j.ebiom.2018.10.006openalex-snapshot
Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.114098openalex-snapshot
Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.178354openalex-snapshot
Sulodexide can ameliorates renal interstitial fibrosis in adenine-induced kidney injury rats
inferred← citeshttps://doi.org/10.1016/j.exer.2025.110628openalex-snapshot
Distinct transcriptional regulation of the Wnt and TGFβ signaling families associated with wound healing and fibrotic outcomes to lens injury
inferred← citeshttps://doi.org/10.1016/j.fct.2024.114888openalex-snapshot
Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence
inferred← citeshttps://doi.org/10.1016/j.fmre.2022.02.010openalex-snapshot
Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer's disease and aging mice
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.07.004openalex-snapshot
GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.09.037openalex-snapshot
GLIS1 alleviates cell senescence and renal fibrosis through PGC1-α mediated mitochondrial quality control in kidney aging
inferred← citeshttps://doi.org/10.1016/j.hnm.2022.200149openalex-snapshot
An update on healthspan and lifespan enhancing attributes of tea amidst the emerging understanding of aging biology
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109583openalex-snapshot
Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112882openalex-snapshot
Artesunate induces HO-1-mediated cell cycle arrest and senescence to protect against ocular fibrosis
inferred← citeshttps://doi.org/10.1016/j.isci.2023.107332openalex-snapshot
Comprehensive analysis of the relationship between xanthine oxidoreductase activity and chronic kidney disease
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108681openalex-snapshot
HDAC1/2 inhibitor therapy improves multiple organ systems in aged mice
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116129openalex-snapshot
Wnt5b/FZD1/LRP6 signaling drives renal fibrosis by triggering cytoplasmic stabilization and nuclear translocation of β-catenin under hypoxia
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107598openalex-snapshot
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA
inferred← citeshttps://doi.org/10.1016/j.jid.2024.02.007openalex-snapshot
Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star
inferred← citeshttps://doi.org/10.1016/j.kint.2020.01.026openalex-snapshot
Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling
inferred← citeshttps://doi.org/10.1016/j.kint.2020.03.026openalex-snapshot
Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy
inferred← citeshttps://doi.org/10.1016/j.kint.2020.09.025openalex-snapshot
Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating β-catenin signaling
inferred← citeshttps://doi.org/10.1016/j.kint.2021.08.031openalex-snapshot
Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118116openalex-snapshot
Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120914openalex-snapshot
Phosphorylation by GSK-3β increases the stability of SIRT6 to alleviate TGF-β-induced fibrotic response in renal tubular cells
inferred← citeshttps://doi.org/10.1016/j.mad.2021.111475openalex-snapshot
Role and mechanism of TXNIP in ageing-related renal fibrosis
inferred← citeshttps://doi.org/10.1016/j.mad.2024.111932openalex-snapshot
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4
inferred← citeshttps://doi.org/10.1016/j.mad.2025.112103openalex-snapshot
DKK3, regulated by FOXF1-EZH2 axis, takes action on tubular epithelial cells senescence to trigger glomerular endothelial cells ferroptosis involving in renal fibrosis
inferred← citeshttps://doi.org/10.1016/j.mad.2026.112184openalex-snapshot
Targeting DYRK1A with harmine abrogates the FOXO1-NF-κB axis to alleviate cellular senescence and renal fibrosis
inferred← citeshttps://doi.org/10.1016/j.metabol.2020.154435openalex-snapshot
Roles for fibroblast growth factor-23 and α-Klotho in acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.peptides.2026.171467openalex-snapshot
Thymosin beta 4: An emerging therapeutic candidate for kidney diseases
inferred← citeshttps://doi.org/10.1016/j.pharmr.2026.100148openalex-snapshot
Renal aging and associated diseases: Common mechanisms and therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156787openalex-snapshot
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158339openalex-snapshot
Asiaticoside alleviates mesothelial cell senescence and peritoneal fibrosis by targeting macrophage-mesothelial communication in single-cell peritoneal landscape
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102939openalex-snapshot
HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression
inferred← citeshttps://doi.org/10.1016/j.redox.2025.103762openalex-snapshot
RETRACTED: Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2020.01.004openalex-snapshot
Wnt/β-Catenin in Acute Kidney Injury and Progression to Chronic Kidney Disease
inferred← citeshttps://doi.org/10.1016/j.semnephrol.2026.151713openalex-snapshot
Targeting Cellular Senescence in Kidney Aging with Traditional Chinese Medicine: Potential Senolytic and Senomorphic Strategies
inferred← citeshttps://doi.org/10.1016/j.taap.2021.115530openalex-snapshot
Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation
inferred← citeshttps://doi.org/10.1016/j.tips.2018.09.002openalex-snapshot
Natural Products as a Source for Antifibrosis Therapy
inferred← citeshttps://doi.org/10.1016/j.trsl.2022.03.002openalex-snapshot
Targeted inhibition of ZAK ameliorates renal interstitial fibrosis
inferred← citeshttps://doi.org/10.1016/j.trsl.2023.09.005openalex-snapshot
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
inferred← citeshttps://doi.org/10.1016/j.vesic.2024.100045openalex-snapshot
Therapeutic potential of human stem cell-derived extracellular vesicles in idiopathic pulmonary fibrosis
inferred← citeshttps://doi.org/10.1016/j.xcrm.2023.100945openalex-snapshot
Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
inferred← citeshttps://doi.org/10.1016/s1875-5364(23)60398-xopenalex-snapshot
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b02490openalex-snapshot
Belamchinanes A–D from Belamcanda chinensis: Triterpenoids with an Unprecedented Carbon Skeleton and Their Activity against Age-Related Renal Fibrosis
inferred← citeshttps://doi.org/10.1038/s41392-022-01036-5openalex-snapshot
Signaling pathways of chronic kidney diseases, implications for therapeutics
inferred← citeshttps://doi.org/10.1038/s41392-023-01379-7openalex-snapshot
Kidney fibrosis: from mechanisms to therapeutic medicines
inferred← citeshttps://doi.org/10.1038/s41392-023-01688-xopenalex-snapshot
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41392-025-02532-0openalex-snapshot
Decoding organ fibrosis: mechanistic insights and emerging therapeutic strategies
inferred← citeshttps://doi.org/10.1038/s41401-020-0463-xopenalex-snapshot
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury
inferred← citeshttps://doi.org/10.1038/s41401-021-00617-4openalex-snapshot
FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling
inferred← citeshttps://doi.org/10.1038/s41401-022-00977-5openalex-snapshot
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II
inferred← citeshttps://doi.org/10.1038/s41401-023-01113-7openalex-snapshot
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling
inferred← citeshttps://doi.org/10.1038/s41401-023-01140-4openalex-snapshot
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy
inferred← citeshttps://doi.org/10.1038/s41401-024-01298-5openalex-snapshot
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence
inferred← citeshttps://doi.org/10.1038/s41401-024-01345-1openalex-snapshot
Chromodomain Y‐like (CDYL) inhibition ameliorates acute kidney injury in mice by regulating tubular pyroptosis
inferred← citeshttps://doi.org/10.1038/s41401-026-01793-xopenalex-snapshot
CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy
inferred← citeshttps://doi.org/10.1038/s41419-020-03322-yopenalex-snapshot
Snai1-induced partial epithelial–mesenchymal transition orchestrates p53–p21-mediated G2/M arrest in the progression of renal fibrosis via NF-κB-mediated inflammation
inferred← citeshttps://doi.org/10.1038/s41419-022-04972-wopenalex-snapshot
Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy
inferred← citeshttps://doi.org/10.1038/s41419-022-05395-3openalex-snapshot
Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41419-023-05854-5openalex-snapshot
Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy
inferred← citeshttps://doi.org/10.1038/s41419-024-06702-wopenalex-snapshot
Targeting tumor suppressor p53 for organ fibrosis therapy
inferred← citeshttps://doi.org/10.1038/s41419-025-08268-7openalex-snapshot
Inhibition of MCL-1 to eliminate senescent cells and mitigate renal fibrosis in aristolochic acid nephropathy
inferred← citeshttps://doi.org/10.1038/s41420-022-01205-zopenalex-snapshot
Cellular senescence in ischemia/reperfusion injury
inferred← citeshttps://doi.org/10.1038/s41420-023-01432-yopenalex-snapshot
Sirtuin 6 is a key contributor to gender differences in acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41420-024-01831-9openalex-snapshot
Cellular senescence of renal tubular epithelial cells in acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41467-023-37450-8openalex-snapshot
Neuraminidase 1 promotes renal fibrosis development in male mice
inferred← citeshttps://doi.org/10.1038/s41467-025-62201-2openalex-snapshot
Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure
inferred← citeshttps://doi.org/10.1038/s41467-025-63152-4openalex-snapshot
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41467-026-71553-2openalex-snapshot
RETRACTED ARTICLE: Increased WNT10B/FOXO6 signaling promotes cell fate transition in renal tubular cells to aggravate renal inflammation and fibrosis
inferred← citeshttps://doi.org/10.1038/s41522-026-00923-xopenalex-snapshot
Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins
inferred← citeshttps://doi.org/10.1038/s41580-024-00738-8openalex-snapshot
SenNet recommendations for detecting senescent cells in different tissues
inferred← citeshttps://doi.org/10.1038/s41580-025-00883-8openalex-snapshot
Biomarkers of ageing of humans and non-human primates
inferred← citeshttps://doi.org/10.1038/s41581-020-00343-wopenalex-snapshot
WNT–β-catenin signalling — a versatile player in kidney injury and repair
inferred← citeshttps://doi.org/10.1038/s41581-022-00601-zopenalex-snapshot
Cellular senescence: the good, the bad and the unknown
inferred← citeshttps://doi.org/10.1038/s41581-025-01025-1openalex-snapshot
Cell–cell crosstalk in kidney health and disease
inferred← citeshttps://doi.org/10.1038/s44318-025-00422-3openalex-snapshot
Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis
inferred← citeshttps://doi.org/10.1038/s44318-026-00885-yopenalex-snapshot
Loss of Erbin in tubular epithelial cells sensitizes mice to acute kidney injury and aggravates renal fibrosis
inferred← citeshttps://doi.org/10.1042/cs20190893openalex-snapshot
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
inferred← citeshttps://doi.org/10.1042/cs20201213openalex-snapshot
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities
inferred← citeshttps://doi.org/10.1042/cs20210447openalex-snapshot
Brahma-related gene-1 promotes tubular senescence and renal fibrosis through Wnt/β-catenin/autophagy axis
inferred← citeshttps://doi.org/10.1042/cs20210858openalex-snapshot
Early elimination of uremic toxin ameliorates AKI-to-CKD transition
inferred← citeshttps://doi.org/10.1042/cs20230140openalex-snapshot
Cellular senescence and kidney aging
inferred← citeshttps://doi.org/10.1042/cs20240717openalex-snapshot
To target cellular senescence in diabetic kidney disease: the known and the unknown
inferred← citeshttps://doi.org/10.1042/cs20243221openalex-snapshot
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis
inferred← citeshttps://doi.org/10.1080/07853890.2025.2561232openalex-snapshot
Progress in the study of the role of C5a-induced tubular cell senescence in the progression of diabetic kidney disease
inferred← citeshttps://doi.org/10.1080/0886022x.2024.2338933openalex-snapshot
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
inferred← citeshttps://doi.org/10.1080/0886022x.2025.2511275openalex-snapshot
Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease
inferred← citeshttps://doi.org/10.1080/0886022x.2025.2539936openalex-snapshot
Protecting kidney function: from mechanisms to therapeutic targets and traditional Chinese medicine
inferred← citeshttps://doi.org/10.1080/14737159.2024.2379355openalex-snapshot
An overview of circulating and urinary biomarkers capable of predicting the transition of acute kidney injury to chronic kidney disease
inferred← citeshttps://doi.org/10.1080/15384101.2023.2287929openalex-snapshot
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
inferred← citeshttps://doi.org/10.1093/ckj/sfae133openalex-snapshot
SGLT2 inhibition to target kidney aging
inferred← citeshttps://doi.org/10.1093/ckj/sfaf190openalex-snapshot
Understanding and targeting senescence in kidney disease
inferred← citeshttps://doi.org/10.1093/gerona/glaf042openalex-snapshot
Ferroptosis Activation Contributes to Kidney Aging in Mice by Promoting Tubular Cell Senescence
inferred← citeshttps://doi.org/10.1096/fj.202101332ropenalex-snapshot
Nur77 ameliorates age‐related renal tubulointerstitial fibrosis by suppressing the TGF‐β/Smads signaling pathway
inferred← citeshttps://doi.org/10.1096/fj.202403361ropenalex-snapshot
A Novel Role of Adipokine ‘Intelectin‐1’: Ameliorating Renal Fibrosis Through Inhibition of Renal Tubular Epithelial Cell Senescence
inferred← citeshttps://doi.org/10.1096/fj.202504960ropenalex-snapshot
Revealing the Heterogeneity of Renal Tubular Epithelial Cell Senescence and Its Impact on Renal Fibrosis via Single‐Cell Sequencing and Spatial Omics Technologies
inferred← citeshttps://doi.org/10.1097/cm9.0000000000003698openalex-snapshot
Cellular senescence in renal ischemia-reperfusion injury
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000504openalex-snapshot
Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000605openalex-snapshot
Acute kidney injury and maladaptive tubular repair leading to renal fibrosis
inferred← citeshttps://doi.org/10.1097/mnh.0000000000000782openalex-snapshot
Ageing, cellular senescence and chronic kidney disease: experimental evidence
inferred← citeshttps://doi.org/10.1097/mot.0000000000000839openalex-snapshot
Epigenetic modifications and the development of kidney graft fibrosis
inferred← citeshttps://doi.org/10.1101/2021.01.21.427684openalex-snapshot
IGFBP2 protects against pulmonary fibrosis through inhibiting P21-mediated senescence
inferred← citeshttps://doi.org/10.1101/2023.04.16.537071openalex-snapshot
Screening and identification of key biomarkers in diabetic kidney disease and its complications: Evidence from bioinformatics and next generation sequencing data analysis
inferred← citeshttps://doi.org/10.1101/2023.08.29.555280openalex-snapshot
Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems
inferred← citeshttps://doi.org/10.1101/2025.01.06.631437openalex-snapshot
NNMT promotes tubular senescence and fibrosis in chronic kidney disease
inferred← citeshttps://doi.org/10.1111/acel.13004openalex-snapshot
Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1111/acel.13407openalex-snapshot
Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury
inferred← citeshttps://doi.org/10.1111/acel.13574openalex-snapshot
Loss of legumain induces premature senescence and mediates aging‐related renal fibrosis
inferred← citeshttps://doi.org/10.1111/acel.14184openalex-snapshot
PAR2‐mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease
inferred← citeshttps://doi.org/10.1111/acel.14275openalex-snapshot
Macrophage iron dyshomeostasis promotes aging‐related renal fibrosis
inferred← citeshttps://doi.org/10.1111/acel.14468openalex-snapshot
Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV
inferred← citeshttps://doi.org/10.1111/acel.14501openalex-snapshot
CAV1 Exacerbates Renal Tubular Epithelial Cell Senescence by Suppressing CaMKK2/AMPK‐Mediated Autophagy
inferred← citeshttps://doi.org/10.1111/cpr.13299openalex-snapshot
TGF ‐β1 peptide‐based inhibitor P144 ameliorates renal fibrosis after ischemia–reperfusion injury by modulating alternatively activated macrophages
inferred← citeshttps://doi.org/10.1111/dme.15408openalex-snapshot
Targeting senescence to prevent diabetic kidney disease: Exploring molecular mechanisms and potential therapeutic targets for disease management
inferred← citeshttps://doi.org/10.1111/febs.17057openalex-snapshot
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling
inferred← citeshttps://doi.org/10.1111/jcmm.14952openalex-snapshot
The emerging role of cellular senescence in renal diseases
inferred← citeshttps://doi.org/10.1111/jcmm.14973openalex-snapshot
C‐X‐C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β‐catenin pathway
inferred← citeshttps://doi.org/10.1111/jcmm.16857openalex-snapshot
Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing
inferred← citeshttps://doi.org/10.1111/jcmm.17447openalex-snapshot
Inhibition of polycomb repressive complex 2 by targeting EED protects against cisplatin‐induced acute kidney injury
inferred← citeshttps://doi.org/10.1111/jcmm.18075openalex-snapshot
C‐X‐C chemokine receptor type 4 promotes tubular cell senescence and renal fibrosis through β‐catenin‐inhibited fatty acid oxidation
inferred← citeshttps://doi.org/10.1111/jcmm.70090openalex-snapshot
LONP1 alleviates ageing‐related renal fibrosis by maintaining mitochondrial homeostasis
inferred← citeshttps://doi.org/10.1111/nep.13472openalex-snapshot
New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis
inferred← citeshttps://doi.org/10.1126/sciadv.adz9069openalex-snapshot
Bacteriocin-transport–inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis
inferred← citeshttps://doi.org/10.1126/scitranslmed.abb0203openalex-snapshot
Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
inferred← citeshttps://doi.org/10.1152/ajpcell.00382.2021openalex-snapshot
LncRNA NEAT1 accelerates renal fibrosis progression via targeting miR-31 and modulating RhoA/ROCK signal pathway
inferred← citeshttps://doi.org/10.1152/ajprenal.00119.2021openalex-snapshot
HIF-1α is transcriptionally regulated by NF-κB in acute kidney injury
inferred← citeshttps://doi.org/10.1155/2019/7495629openalex-snapshot
The Signaling of Cellular Senescence in Diabetic Nephropathy
inferred← citeshttps://doi.org/10.1159/000526139openalex-snapshot
KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging
inferred← citeshttps://doi.org/10.1159/000530344openalex-snapshot
Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis
inferred← citeshttps://doi.org/10.1159/000545209openalex-snapshot
Intercellular Communication Network of CellChat Uncovers Mechanisms of Kidney Fibrosis Based on Single-Cell RNA Sequencing
inferred← citeshttps://doi.org/10.1167/iovs.66.6.7openalex-snapshot
Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG
inferred← citeshttps://doi.org/10.1172/jci.insight.135454openalex-snapshot
Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease
inferred← citeshttps://doi.org/10.1172/jci.insight.161487openalex-snapshot
CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling
inferred← citeshttps://doi.org/10.1172/jci.insight.162060openalex-snapshot
Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling
inferred← citeshttps://doi.org/10.1172/jci188358openalex-snapshot
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
inferred← citeshttps://doi.org/10.1177/0300985820943841openalex-snapshot
Cellular Senescence: Mechanisms, Morphology, and Mouse Models
inferred← citeshttps://doi.org/10.1177/0963689720908198openalex-snapshot
Establishment of Immortalized Laryngeal Epithelial Cells Transfected with Bmi1
inferred← citeshttps://doi.org/10.1177/15230864251410936openalex-snapshot
Mitochondrial Dysfunction in Renal Aging: A Vicious Cycle Driving Kidney Disease Progression
inferred← citeshttps://doi.org/10.1177/2040622320964125openalex-snapshot
Advancements in therapeutic drugs targeting of senescence
inferred← citeshttps://doi.org/10.1186/s12906-025-05102-7openalex-snapshot
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis
inferred← citeshttps://doi.org/10.1186/s12951-021-00900-wopenalex-snapshot
Tubule-specific protein nanocages potentiate targeted renal fibrosis therapy
inferred← citeshttps://doi.org/10.1186/s12951-021-01122-wopenalex-snapshot
Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis
inferred← citeshttps://doi.org/10.1186/s12964-020-00624-8openalex-snapshot
Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
inferred← citeshttps://doi.org/10.1186/s12964-023-01245-7openalex-snapshot
Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury
inferred← citeshttps://doi.org/10.1186/s12964-024-01968-1openalex-snapshot
Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factors
inferred← citeshttps://doi.org/10.1186/s12967-026-07796-wopenalex-snapshot
Emerging therapeutic pipelines on kidney fibrosis: challenges in translational research
inferred← citeshttps://doi.org/10.1186/s13293-023-00519-6openalex-snapshot
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
inferred← citeshttps://doi.org/10.1186/s40779-025-00669-1openalex-snapshot
β-catenin initiates peritoneal fibrosis by triggering mitochondrial fission-mediated mesothelial cell senescence fate transition
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