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Pan-cancer whole genome analyses of metastatic solid tumors

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471250953.bi1110s43openalex-snapshot
From FastQ Data to High‐Confidence Variant Calls: The Genome Analysis Toolkit Best Practices Pipeline
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Y chromosome loss in esophageal carcinoma: An in situ hybridization study
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Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer
inferredcites →https://doi.org/10.1016/0165-4608(95)00030-sopenalex-snapshot
Y chromosome loss detected by FISH in bladder cancer
inferredcites →https://doi.org/10.1016/j.ccell.2016.04.003openalex-snapshot
Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism
inferredcites →https://doi.org/10.1016/j.ccell.2017.07.005openalex-snapshot
Genomic Evolution of Breast Cancer Metastasis and Relapse
inferredcites →https://doi.org/10.1016/j.ccell.2018.03.007openalex-snapshot
Genomic and Functional Approaches to Understanding Cancer Aneuploidy
inferredcites →https://doi.org/10.1016/j.cell.2013.09.034openalex-snapshot
The Somatic Genomic Landscape of Glioblastoma
inferredcites →https://doi.org/10.1016/j.cell.2013.10.011openalex-snapshot
Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome
inferredcites →https://doi.org/10.1016/j.cell.2016.12.015openalex-snapshot
Implementing Genome-Driven Oncology
inferredcites →https://doi.org/10.1016/j.cell.2017.01.018openalex-snapshot
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
inferredcites →https://doi.org/10.1016/j.cell.2017.09.042openalex-snapshot
Universal Patterns of Selection in Cancer and Somatic Tissues
inferredcites →https://doi.org/10.1016/j.cell.2018.02.060openalex-snapshot
Comprehensive Characterization of Cancer Driver Genes and Mutations
inferredcites →https://doi.org/10.1016/j.cell.2018.03.039openalex-snapshot
Pathogenic Germline Variants in 10,389 Adult Cancers
inferredcites →https://doi.org/10.1016/j.cell.2018.05.036openalex-snapshot
Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing
inferredcites →https://doi.org/10.1016/j.coisb.2016.12.017openalex-snapshot
Non-coding genetic variation in cancer
inferredcites →https://doi.org/10.1016/j.gendis.2015.01.003openalex-snapshot
Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer
inferredcites →https://doi.org/10.1016/j.immuni.2015.10.007openalex-snapshot
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia
inferredcites →https://doi.org/10.1016/j.jmoldx.2016.06.010openalex-snapshot
Reliable Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Tissue Using Single Molecule Tags
inferredcites →https://doi.org/10.1016/j.jmoldx.2018.04.005openalex-snapshot
Determining Performance Metrics for Targeted Next-Generation Sequencing Panels Using Reference Materials
inferredcites →https://doi.org/10.1016/s1470-2045(18)30119-0openalex-snapshot
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study
inferredcites →https://doi.org/10.1038/gim.2016.190openalex-snapshot
Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics
inferredcites →https://doi.org/10.1038/nature08987openalex-snapshot
International network of cancer genome projects
inferredcites →https://doi.org/10.1038/nature11404openalex-snapshot
Comprehensive genomic characterization of squamous cell lung cancers
inferredcites →https://doi.org/10.1038/nature12477openalex-snapshot
Signatures of mutational processes in human cancer
inferredcites →https://doi.org/10.1038/nature12628openalex-snapshot
Selection and adaptation during metastatic cancer progression
inferredcites →https://doi.org/10.1038/nature14347openalex-snapshot
The evolutionary history of lethal metastatic prostate cancer
inferredcites →https://doi.org/10.1038/nature23306openalex-snapshot
Integrative clinical genomics of metastatic cancer
inferredcites →https://doi.org/10.1038/nature25480openalex-snapshot
The landscape of genomic alterations across childhood cancers
inferredcites →https://doi.org/10.1038/nature25795openalex-snapshot
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
inferredcites →https://doi.org/10.1038/nbt.2203openalex-snapshot
Absolute quantification of somatic DNA alterations in human cancer
inferredcites →https://doi.org/10.1038/ng.2699openalex-snapshot
Integrated molecular analysis of clear-cell renal cell carcinoma
inferredcites →https://doi.org/10.1038/ng.2760openalex-snapshot
Pan-cancer patterns of somatic copy number alteration
inferredcites →https://doi.org/10.1038/ng.2764openalex-snapshot
The Cancer Genome Atlas Pan-Cancer analysis project
inferredcites →https://doi.org/10.1038/ng.2974openalex-snapshot
Dystrophin is a tumor suppressor in human cancers with myogenic programs
inferredcites →https://doi.org/10.1038/ng.3774openalex-snapshot
CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer
inferredcites →https://doi.org/10.1038/nm.3984openalex-snapshot
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity
inferredcites →https://doi.org/10.1038/nm.4333openalex-snapshot
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
inferredcites →https://doi.org/10.1038/nrc.2017.52openalex-snapshot
Fragile sites in cancer: more than meets the eye
inferredcites →https://doi.org/10.1038/nrc1299openalex-snapshot
A census of human cancer genes
inferredcites →https://doi.org/10.1038/s41587-019-0055-9openalex-snapshot
The International Cancer Genome Consortium Data Portal
inferredcites →https://doi.org/10.1038/s41588-018-0086-zopenalex-snapshot
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets
inferredcites →https://doi.org/10.1038/s41588-018-0165-1openalex-snapshot
Genome doubling shapes the evolution and prognosis of advanced cancers
inferredcites →https://doi.org/10.1038/s41598-018-21160-zopenalex-snapshot
ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner
inferredcites →https://doi.org/10.1038/srep13321openalex-snapshot
MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic Mutations
inferredcites →https://doi.org/10.1038/srep24607openalex-snapshot
A somatic reference standard for cancer genome sequencing
inferredcites →https://doi.org/10.1038/srep28103openalex-snapshot
OncoScape: Exploring the cancer aberration landscape by genomic data fusion
inferredcites →https://doi.org/10.1056/nejm200001133420201openalex-snapshot
Tumor Microsatellite Instability and Clinical Outcome in Young Patients with Colorectal Cancer
inferredcites →https://doi.org/10.1056/nejmoa1613493openalex-snapshot
First-Line Nivolumab in Stage IV or Recurrent Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1056/nejmoa1801946openalex-snapshot
Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden
inferredcites →https://doi.org/10.1073/pnas.1009843107openalex-snapshot
Allele-specific copy number analysis of tumors
inferredcites →https://doi.org/10.1073/pnas.1206004109openalex-snapshot
CDX2 is an amplified lineage-survival oncogene in colorectal cancer
inferredcites →https://doi.org/10.1073/pnas.68.4.820openalex-snapshot
Mutation and Cancer: Statistical Study of Retinoblastoma
inferredcites →https://doi.org/10.1093/annonc/mdy263openalex-snapshot
A framework to rank genomic alterations as targets for cancer precision medicine: the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT)
inferredcites →https://doi.org/10.1093/bioinformatics/btp324openalex-snapshot
Fast and accurate short read alignment with Burrows–Wheeler transform
inferredcites →https://doi.org/10.1093/bioinformatics/bts271openalex-snapshot
Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs
inferredcites →https://doi.org/10.1093/bioinformatics/btv710openalex-snapshot
Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications
inferredcites →https://doi.org/10.1093/database/bar026openalex-snapshot
International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data
inferredcites →https://doi.org/10.1093/nar/gku1011openalex-snapshot
Disease Ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data
inferredcites →https://doi.org/10.1093/nar/gkv1222openalex-snapshot
ClinVar: public archive of interpretations of clinically relevant variants
inferredcites →https://doi.org/10.1093/nar/gkw1121openalex-snapshot
COSMIC: somatic cancer genetics at high-resolution
inferredcites →https://doi.org/10.1093/nar/gkx1098openalex-snapshot
Ensembl 2018
inferredcites →https://doi.org/10.1101/120295openalex-snapshot
STAR-Fusion: Fast and Accurate Fusion Transcript Detection from RNA-Seq
inferredcites →https://doi.org/10.1101/162784openalex-snapshot
Pan-cancer analysis of whole genomes
inferredcites →https://doi.org/10.1101/190330openalex-snapshot
The whole-genome panorama of cancer drivers
inferredcites →https://doi.org/10.1101/201178openalex-snapshot
Scaling accurate genetic variant discovery to tens of thousands of samples
inferredcites →https://doi.org/10.1101/gr.107524.110openalex-snapshot
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
inferredcites →https://doi.org/10.1126/science.aai8515openalex-snapshot
Origins of lymphatic and distant metastases in human colorectal cancer
inferredcites →https://doi.org/10.1126/science.aat7171openalex-snapshot
Minimal functional driver gene heterogeneity among untreated metastases
inferredcites →https://doi.org/10.1136/gut.48.4.515openalex-snapshot
Can APC mutation analysis contribute to therapeutic decisions in familial adenomatous polyposis? Experience from 680 FAP families
inferredcites →https://doi.org/10.1155/2014/260549openalex-snapshot
p16INK4Aand p14ARFGene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review
inferredcites →https://doi.org/10.1158/0008-5472.can-12-2706openalex-snapshot
SMAD2 , SMAD3 and SMAD4 Mutations in Colorectal Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-15-0701-topenalex-snapshot
Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
inferredcites →https://doi.org/10.1158/1535-7163.mct-16-0163openalex-snapshot
SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody–Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression
inferredcites →https://doi.org/10.1158/1535-7163.mct-17-0386openalex-snapshot
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers
inferredcites →https://doi.org/10.1158/1538-7445.am2018-437openalex-snapshot
Abstract 437: Leveraging new methods in single-cell copy number analysis and clonotype detection to uncover and characterize hidden subclones within standard cell lines
inferredcites →https://doi.org/10.1158/2159-8290.cd-17-0321openalex-snapshot
Accelerating Discovery of Functional Mutant Alleles in Cancer
inferredcites →https://doi.org/10.1186/1471-2164-13-591openalex-snapshot
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
inferredcites →https://doi.org/10.1186/gb-2011-12-4-r41openalex-snapshot
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
inferredcites →https://doi.org/10.1186/s13073-018-0531-8openalex-snapshot
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
inferredcites →https://doi.org/10.1186/s13073-018-0539-0openalex-snapshot
MutationalPatterns: comprehensive genome-wide analysis of mutational processes
inferredcites →https://doi.org/10.1200/po.17.00011openalex-snapshot
OncoKB: A Precision Oncology Knowledge Base
inferredcites →https://doi.org/10.1634/theoncologist.2016-0085openalex-snapshot
Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies
inferredcites →https://doi.org/10.18632/oncotarget.10598openalex-snapshot
NETs: organ-related epigenetic derangements and potential clinical applications
inferredcites →https://doi.org/10.18632/oncotarget.12130openalex-snapshot
RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.cell.2020.08.006openalex-snapshot
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs
inferred← citeshttps://doi.org/10.1016/j.jocn.2019.08.044openalex-snapshot
Whole genome and biomarker analysis of patients with recurrent glioblastoma on bevacizumab: A subset analysis of the CABARET trial
inferred← citeshttps://doi.org/10.1038/s41467-019-12594-8openalex-snapshot
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
inferred← citeshttps://doi.org/10.1038/s41467-019-13084-7openalex-snapshot
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
inferred← citeshttps://doi.org/10.1038/s41467-020-19406-4openalex-snapshot
Pan-cancer landscape of homologous recombination deficiency
inferred← citeshttps://doi.org/10.1038/s41467-022-33663-5openalex-snapshot
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue
inferred← citeshttps://doi.org/10.1038/s41568-019-0185-xopenalex-snapshot
An analysis of genetic heterogeneity in untreated cancers
inferred← citeshttps://doi.org/10.1038/s41586-019-1600-xopenalex-snapshot
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs
inferred← citeshttps://doi.org/10.1038/s41588-019-0507-7openalex-snapshot
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies
inferred← citeshttps://doi.org/10.1038/s41588-019-0525-5openalex-snapshot
The mutational footprints of cancer therapies
inferred← citeshttps://doi.org/10.1038/s41591-019-0422-6openalex-snapshot
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
inferred← citeshttps://doi.org/10.1038/s41598-023-33932-3openalex-snapshot
The genome-wide mutational consequences of DNA hypomethylation
inferred← citeshttps://doi.org/10.1091/mbc.e21-02-0089openalex-snapshot
CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells
inferred← citeshttps://doi.org/10.1101/214494openalex-snapshot
A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations
inferred← citeshttps://doi.org/10.1101/517565openalex-snapshot
Tumor mutational landscape is a record of the pre-malignant state
inferred← citeshttps://doi.org/10.1101/546051openalex-snapshot
The genomic landscape of metastatic castration-resistant prostate cancers using whole genome sequencing reveals multiple distinct genotypes with potential clinical impact
inferred← citeshttps://doi.org/10.1101/781013openalex-snapshot
GRIDSS, PURPLE, LINX: Unscrambling the tumor genome via integrated analysis of structural variation and copy number
inferred← citeshttps://doi.org/10.1101/mcs.a003251openalex-snapshot
A case study of a long-term glioblastoma survivor with unmethylated MGMT and hypermutated genotype
inferred← citeshttps://doi.org/10.1111/his.14252openalex-snapshot
Driver mutations occur frequently in metastases of well‐differentiated small intestine neuroendocrine tumours
inferred← citeshttps://doi.org/10.1126/scitranslmed.aay2574openalex-snapshot
Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-20-4068openalex-snapshot
Structural Variants at the BRCA1/2 Loci are a Common Source of Homologous Repair Deficiency in High-grade Serous Ovarian Carcinoma
inferred← citeshttps://doi.org/10.1186/s13073-021-00990-zopenalex-snapshot
Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer
inferred← citeshttps://doi.org/10.21037/tlcr-21-48openalex-snapshot
Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung
inferred← citeshttps://doi.org/10.3389/fgene.2021.760039openalex-snapshot
The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time
inferred← citeshttps://doi.org/10.3390/cancers11081185openalex-snapshot
Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer
inferred← citeshttps://doi.org/10.3390/cancers15174416openalex-snapshot
Genomic Alterations Associated with Estrogen Receptor Pathway Activity in Metastatic Breast Cancer Have a Differential Impact on Downstream ER Signaling
inferred← citeshttps://doi.org/10.4414/smw.2020.20158openalex-snapshot
Holistic cancer genome profiling for every patient
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