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The whole-genome panorama of cancer drivers

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mc.2940070303openalex-snapshot
How many mutations are required for tumorigenesis? implications from human cancer data
inferredcites →https://doi.org/10.1016/j.ccell.2015.02.007openalex-snapshot
In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities
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KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas
inferredcites →https://doi.org/10.1016/j.ccr.2014.07.014openalex-snapshot
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
inferredcites →https://doi.org/10.1016/j.cell.2017.09.042openalex-snapshot
Universal Patterns of Selection in Cancer and Somatic Tissues
inferredcites →https://doi.org/10.1038/bjc.1953.8openalex-snapshot
A New Theory on the Cancer-inducing Mechanism
inferredcites →https://doi.org/10.1038/nature07943openalex-snapshot
The cancer genome
inferredcites →https://doi.org/10.1038/nature12213openalex-snapshot
Mutational heterogeneity in cancer and the search for new cancer-associated genes
inferredcites →https://doi.org/10.1038/nature12634openalex-snapshot
Mutational landscape and significance across 12 major cancer types
inferredcites →https://doi.org/10.1038/nature12912openalex-snapshot
Discovery and saturation analysis of cancer genes across 21 tumour types
inferredcites →https://doi.org/10.1038/nature12981openalex-snapshot
Realizing the promise of cancer predisposition genes
inferredcites →https://doi.org/10.1038/nature14666openalex-snapshot
Non-coding recurrent mutations in chronic lymphocytic leukaemia
inferredcites →https://doi.org/10.1038/nature17676openalex-snapshot
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
inferredcites →https://doi.org/10.1038/nature18910openalex-snapshot
Non-coding recurrent mutations in chronic lymphocytic leukaemia
inferredcites →https://doi.org/10.1038/nature19057openalex-snapshot
Analysis of protein-coding genetic variation in 60,706 humans
inferredcites →https://doi.org/10.1038/nature22973openalex-snapshot
The whole-genome landscape of medulloblastoma subtypes
inferredcites →https://doi.org/10.1038/ncomms11383openalex-snapshot
The topography of mutational processes in breast cancer genomes
inferredcites →https://doi.org/10.1038/ng.2682openalex-snapshot
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
inferredcites →https://doi.org/10.1038/ng.2760openalex-snapshot
Pan-cancer patterns of somatic copy number alteration
inferredcites →https://doi.org/10.1038/ng.2762openalex-snapshot
Emerging landscape of oncogenic signatures across human cancers
inferredcites →https://doi.org/10.1038/ng.2892openalex-snapshot
A general framework for estimating the relative pathogenicity of human genetic variants
inferredcites →https://doi.org/10.1038/ng.3664openalex-snapshot
The rules and impact of nonsense-mediated mRNA decay in human cancers
inferredcites →https://doi.org/10.1038/ng.3722openalex-snapshot
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
inferredcites →https://doi.org/10.1038/ng.3987openalex-snapshot
Bayesian inference of negative and positive selection in human cancers
inferredcites →https://doi.org/10.1038/nmeth.2562openalex-snapshot
Computational approaches to identify functional genetic variants in cancer genomes
inferredcites →https://doi.org/10.1038/nmeth.2642openalex-snapshot
IntOGen-mutations identifies cancer drivers across tumor types
inferredcites →https://doi.org/10.1038/nrc1299openalex-snapshot
A census of human cancer genes
inferredcites →https://doi.org/10.1038/nrc3891openalex-snapshot
Therapeutic opportunities within the DNA damage response
inferredcites →https://doi.org/10.1038/nrc3999openalex-snapshot
The mini-driver model of polygenic cancer evolution
inferredcites →https://doi.org/10.1038/srep09465openalex-snapshot
PI3Kβ Inhibitor TGX221 Selectively Inhibits Renal Cell Carcinoma Cells with Both VHL and SETD2 mutations and Links Multiple Pathways
inferredcites →https://doi.org/10.1073/pnas.68.4.820openalex-snapshot
Mutation and Cancer: Statistical Study of Retinoblastoma
inferredcites →https://doi.org/10.1093/nar/gks743openalex-snapshot
Functional impact bias reveals cancer drivers
inferredcites →https://doi.org/10.1093/nar/gkt1113openalex-snapshot
ClinVar: public archive of relationships among sequence variation and human phenotype
inferredcites →https://doi.org/10.1101/140475openalex-snapshot
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
inferredcites →https://doi.org/10.1101/157560openalex-snapshot
Genomic footprints of activated telomere maintenance mechanisms in cancer
inferredcites →https://doi.org/10.1101/161562openalex-snapshot
The evolutionary history of 2,658 cancers
inferredcites →https://doi.org/10.1101/162784openalex-snapshot
Pan-cancer analysis of whole genomes
inferredcites →https://doi.org/10.1101/183889openalex-snapshot
Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types
inferredcites →https://doi.org/10.1101/187609openalex-snapshot
Selective and mechanistic sources of recurrent rearrangements across the cancer genome
inferredcites →https://doi.org/10.1101/237313openalex-snapshot
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
inferredcites →https://doi.org/10.1126/science.1200609openalex-snapshot
DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
inferredcites →https://doi.org/10.1126/science.1229259openalex-snapshot
Highly Recurrent TERT Promoter Mutations in Human Melanoma
inferredcites →https://doi.org/10.1126/science.1230062openalex-snapshot
TERT Promoter Mutations in Familial and Sporadic Melanoma
inferredcites →https://doi.org/10.1126/science.1235122openalex-snapshot
Cancer Genome Landscapes
inferredcites →https://doi.org/10.1126/science.aaf8399openalex-snapshot
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
inferredcites →https://doi.org/10.1158/0008-5472.can-16-0170openalex-snapshot
Burden of Nonsynonymous Mutations among TCGA Cancers and Candidate Immune Checkpoint Inhibitor Responses
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1207openalex-snapshot
Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments
inferredcites →https://doi.org/10.1186/gb-2011-12-4-r41openalex-snapshot
GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
inferredcites →https://doi.org/10.1186/s13059-016-0974-4openalex-snapshot
The Ensembl Variant Effect Predictor
inferredcites →https://doi.org/10.1371/journal.pone.0019541openalex-snapshot
Gitools: Analysis and Visualisation of Genomic Data Using Interactive Heat-Maps
inferredcites →https://doi.org/10.1371/journal.pone.0112438openalex-snapshot
Eribulin Mesylate Targets Human Telomerase Reverse Transcriptase in Ovarian Cancer Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/1873-3468.13781openalex-snapshot
Understanding oncogenicity of cancer driver genes and mutations in the cancer genomics era
inferred← citeshttps://doi.org/10.1016/j.ccell.2022.04.002openalex-snapshot
The translational challenges of precision oncology
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109873openalex-snapshot
Pan-cancer analysis of the interplay between mutational signatures and cellular signaling
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101446openalex-snapshot
Germline structural variation globally impacts the cancer transcriptome including disease-relevant genes
inferred← citeshttps://doi.org/10.1038/s41397-019-0102-4openalex-snapshot
Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41467-019-13825-8openalex-snapshot
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
inferred← citeshttps://doi.org/10.1038/s41467-019-14052-xopenalex-snapshot
Divergent mutational processes distinguish hypoxic and normoxic tumours
inferred← citeshttps://doi.org/10.1038/s41467-020-14351-8openalex-snapshot
Inferring structural variant cancer cell fraction
inferred← citeshttps://doi.org/10.1038/s41467-020-14407-9openalex-snapshot
Estimating growth patterns and driver effects in tumor evolution from individual samples
inferred← citeshttps://doi.org/10.1038/s41467-020-18988-3openalex-snapshot
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
inferred← citeshttps://doi.org/10.1038/s41467-021-24858-3openalex-snapshot
The evolution of hematopoietic cells under cancer therapy
inferred← citeshttps://doi.org/10.1038/s41467-022-31878-0openalex-snapshot
Discovering the drivers of clonal hematopoiesis
inferred← citeshttps://doi.org/10.1038/s41525-020-0133-4openalex-snapshot
MutSpot: detection of non-coding mutation hotspots in cancer genomes
inferred← citeshttps://doi.org/10.1038/s41559-021-01615-9openalex-snapshot
Spatial structure governs the mode of tumour evolution
inferred← citeshttps://doi.org/10.1038/s41576-020-0272-6openalex-snapshot
The road ahead in genetics and genomics
inferred← citeshttps://doi.org/10.1038/s41586-019-1672-7openalex-snapshot
The landscape of somatic mutation in normal colorectal epithelial cells
inferred← citeshttps://doi.org/10.1038/s41586-019-1689-yopenalex-snapshot
Pan-cancer whole-genome analyses of metastatic solid tumours
inferred← citeshttps://doi.org/10.1038/s41586-021-03771-1openalex-snapshot
In silico saturation mutagenesis of cancer genes
inferred← citeshttps://doi.org/10.1038/s41586-025-09521-xopenalex-snapshot
Sex and smoking bias in the selection of somatic mutations in human bladder
inferred← citeshttps://doi.org/10.1038/s41586-026-10386-xopenalex-snapshot
Tumour promotion through the lens of evolution
inferred← citeshttps://doi.org/10.1038/s41588-020-00730-wopenalex-snapshot
Are carcinogens direct mutagens?
inferred← citeshttps://doi.org/10.1038/s41598-019-48765-2openalex-snapshot
Estimating the Frequency of Single Point Driver Mutations across Common Solid Tumours
inferred← citeshttps://doi.org/10.1038/s42003-022-03238-7openalex-snapshot
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
inferred← citeshttps://doi.org/10.1038/s43018-019-0001-2openalex-snapshot
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
inferred← citeshttps://doi.org/10.1038/s43018-020-0027-5openalex-snapshot
A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies
inferred← citeshttps://doi.org/10.1038/s43018-021-00184-xopenalex-snapshot
The metabolic landscape of RAS-driven cancers from biology to therapy
inferred← citeshttps://doi.org/10.1073/pnas.1901156116openalex-snapshot
Leveraging protein dynamics to identify cancer mutational hotspots using 3D structures
inferred← citeshttps://doi.org/10.1093/bib/bbaa250openalex-snapshot
Prediction of driver variants in the cancer genome via machine learning methodologies
inferred← citeshttps://doi.org/10.1093/bioinformatics/bty624openalex-snapshot
DMCM: a Data-adaptive Mutation Clustering Method to identify cancer-related mutation clusters
inferred← citeshttps://doi.org/10.1093/nar/gkaf776openalex-snapshot
Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection
inferred← citeshttps://doi.org/10.1101/161562openalex-snapshot
The evolutionary history of 2,658 cancers
inferred← citeshttps://doi.org/10.1101/163907openalex-snapshot
A user’s guide to the online resources for data exploration, visualization, and discovery for the Pan-Cancer Analysis of Whole Genomes project (PCAWG)
inferred← citeshttps://doi.org/10.1101/168153openalex-snapshot
Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis
inferred← citeshttps://doi.org/10.1101/179705openalex-snapshot
Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours
inferred← citeshttps://doi.org/10.1101/183889openalex-snapshot
Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types
inferred← citeshttps://doi.org/10.1101/2024.05.21.593407openalex-snapshot
Benchmarking of spatial transcriptomics platforms across six cancer types
inferred← citeshttps://doi.org/10.1101/280446openalex-snapshot
Passenger mutations in 2500 cancer genomes: Overall molecular functional impact and consequences
inferred← citeshttps://doi.org/10.1101/321612openalex-snapshot
Patient-specific detection of cancer genes reveals recurrently perturbed processes in esophageal adenocarcinoma
inferred← citeshttps://doi.org/10.1101/415133openalex-snapshot
Pan-cancer whole genome analyses of metastatic solid tumors
inferred← citeshttps://doi.org/10.1101/416800openalex-snapshot
The landscape of somatic mutation in normal colorectal epithelial cells
inferred← citeshttps://doi.org/10.1101/517565openalex-snapshot
Tumor mutational landscape is a record of the pre-malignant state
inferred← citeshttps://doi.org/10.1101/528968openalex-snapshot
Sex Differences in Oncogenic Mutational Processes
inferred← citeshttps://doi.org/10.1101/534693openalex-snapshot
Characterizing and comparing missense variants in monogenic disease and in cancer
inferred← citeshttps://doi.org/10.1186/s12911-018-0680-0openalex-snapshot
SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics
inferred← citeshttps://doi.org/10.1186/s13059-018-1582-2openalex-snapshot
Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesis
inferred← citeshttps://doi.org/10.1186/s13059-026-03937-yopenalex-snapshot
A technical comparison of spatial transcriptomics platforms across six cancer types
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1007332openalex-snapshot
Dark-matter matters: Discriminating subtle blood cancers using the darkest DNA
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1007496openalex-snapshot
Recurrent somatic mutations reveal new insights into consequences of mutagenic processes in cancer
inferred← citeshttps://doi.org/10.2217/bmm-2020-0025openalex-snapshot
Predictive and Patient-Monitoring Biomarkers: Precision in the Management of Colorectal Cancer
inferred← citeshttps://doi.org/10.2217/fon-2020-0915openalex-snapshot
Tumor Heterogeneity-Driven Individualized Therapy
inferred← citeshttps://doi.org/10.2217/pgs-2020-0011openalex-snapshot
Precision in Cancer Pharmacogenomics
inferred← citeshttps://doi.org/10.24855/biosfera.v14i2.674openalex-snapshot
Общие принципы взаимоотношений живых организмов с экосистемой и злокачественных клеток с живым организмом
inferred← citeshttps://doi.org/10.29245/2578-2967/2019/1.1163openalex-snapshot
Commentary On SwissMTB: Establishing Comprehensive Molecular Cancer Diagnostics In Swiss Clinics
inferred← citeshttps://doi.org/10.3389/fonc.2022.855463openalex-snapshot
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis
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