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Tumor mutational landscape is a record of the pre-malignant state
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The Pancreatic Duct Cell
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Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells
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Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia
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Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models
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Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
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Mutational Processes Molding the Genomes of 21 Breast Cancers
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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
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Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin
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Organoid Cultures Derived from Patients with Advanced Prostate Cancer
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Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
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Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
inferredcites →https://doi.org/10.1016/j.cell.2016.12.002openalex-snapshot
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer
inferredcites →https://doi.org/10.1016/j.celrep.2013.04.021openalex-snapshot
An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma
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Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks
inferredcites →https://doi.org/10.1016/j.celrep.2017.01.003openalex-snapshot
Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
inferredcites →https://doi.org/10.1016/j.celrep.2017.03.078openalex-snapshot
Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression
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Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus
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Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: Revisiting old hypotheses
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Breast Tumor Heterogeneity: Source of Fitness, Hurdle for Therapy
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Histological types of breast cancer: How special are they?
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Deconstructing the molecular portraits of breast cancer
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BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2010.12.007openalex-snapshot
Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate
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Lateral Thinking: How Histone Modifications Regulate Gene Expression
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Molecular Events in the Natural History of Pancreatic Cancer
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Frequency of “incidental” serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study
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Molecular portraits of human breast tumours
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Cell of origin of glioma: biological and clinical implications
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An integrated encyclopedia of DNA elements in the human genome
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Chromatin organization is a major influence on regional mutation rates in human cancer cells
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Mutational heterogeneity in cancer and the search for new cancer-associated genes
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Discovery and saturation analysis of cancer genes across 21 tumour types
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Cell-of-origin chromatin organization shapes the mutational landscape of cancer
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Integrative analysis of 111 reference human epigenomes
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Association analysis identifies 65 new breast cancer risk loci
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HER kinase inhibition in patients with HER2- and HER3-mutant cancers
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Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
inferredcites →https://doi.org/10.1038/ncomms1982openalex-snapshot
DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes
inferredcites →https://doi.org/10.1038/ncomms2502openalex-snapshot
DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes
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A fast and unbiased procedure to randomize ecological binary matrices with fixed row and column totals
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Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements
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Stem and progenitor cell division kinetics during postnatal mouse mammary gland development
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Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma
inferredcites →https://doi.org/10.1038/ng.3404openalex-snapshot
Partitioning heritability by functional annotation using genome-wide association summary statistics
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
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Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
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Neural stem cells and neurospheres—re-evaluating the relationship
inferredcites →https://doi.org/10.1038/nprot.2016.006openalex-snapshot
Organoid culture systems for prostate epithelial and cancer tissue
inferredcites →https://doi.org/10.1038/nrc.2017.5openalex-snapshot
Tissue-specific tumorigenesis: context matters
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Hedgehog signalling in cancer formation and maintenance
inferredcites →https://doi.org/10.1038/nrc3896openalex-snapshot
Triple-negative breast cancer in African-American women: disparities versus biology
inferredcites →https://doi.org/10.1038/nrg3890openalex-snapshot
The effects of chromatin organization on variation in mutation rates in the genome
inferredcites →https://doi.org/10.1038/nrgastro.2014.181openalex-snapshot
Barrett oesophagus: lessons on its origins from the lesion itself
inferredcites →https://doi.org/10.1038/s41525-017-0010-yopenalex-snapshot
Chromatin marks shape mutation landscape at early stage of cancer progression
inferredcites →https://doi.org/10.1038/s41586-018-0409-3openalex-snapshot
Genetic and transcriptional evolution alters cancer cell line drug response
inferredcites →https://doi.org/10.1038/s41586-019-1689-yopenalex-snapshot
Pan-cancer whole-genome analyses of metastatic solid tumours
inferredcites →https://doi.org/10.1038/sigtrans.2016.38openalex-snapshot
Mammary stem cells: angels or demons in mammary gland?
inferredcites →https://doi.org/10.1038/srep13526openalex-snapshot
Ethnicity-Dependent and -Independent Heterogeneity in Healthy Normal Breast Hierarchy Impacts Tumor Characterization
inferredcites →https://doi.org/10.1038/srep43265openalex-snapshot
Molecular Classification of Lobular Carcinoma of the Breast
inferredcites →https://doi.org/10.1073/pnas.1221068110openalex-snapshot
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
inferredcites →https://doi.org/10.1093/humupd/dmq030openalex-snapshot
Tubal ligation and the risk of ovarian cancer: review and meta-analysis
inferredcites →https://doi.org/10.1093/jnen/59.3.229openalex-snapshot
Expression of the Neurotrophin Receptor p75NTRin Medulloblastomas Is Correlated with Distinct Histological and Clinical Features: Evidence for a Medulloblastoma Subtype Derived from the External Granule Cell Layer
inferredcites →https://doi.org/10.1093/nar/gkx1081openalex-snapshot
The Encyclopedia of DNA elements (ENCODE): data portal update
inferredcites →https://doi.org/10.1098/rsob.160232openalex-snapshot
Challenging perspectives on the cellular origins of lymphoma
inferredcites →https://doi.org/10.1101/161562openalex-snapshot
The evolutionary history of 2,658 cancers
inferredcites →https://doi.org/10.1101/190330openalex-snapshot
The whole-genome panorama of cancer drivers
inferredcites →https://doi.org/10.1101/237313openalex-snapshot
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
inferredcites →https://doi.org/10.1101/350280openalex-snapshot
Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs
inferredcites →https://doi.org/10.1101/415133openalex-snapshot
Pan-cancer whole genome analyses of metastatic solid tumors
inferredcites →https://doi.org/10.1101/cshperspect.a020610openalex-snapshot
Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic Development
inferredcites →https://doi.org/10.1101/gad.242511.114openalex-snapshot
Mammary stem cells and the differentiation hierarchy: current status and perspectives
inferredcites →https://doi.org/10.1101/gr.136184.111openalex-snapshot
ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia
inferredcites →https://doi.org/10.1126/science.1217277openalex-snapshot
Epigenomic Enhancer Profiling Defines a Signature of Colon Cancer
inferredcites →https://doi.org/10.1126/science.aaf9011openalex-snapshot
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
inferredcites →https://doi.org/10.1126/science.aao4426openalex-snapshot
Aging and neurodegeneration are associated with increased mutations in single human neurons
inferredcites →https://doi.org/10.1128/mcb.00358-16openalex-snapshot
Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A
inferredcites →https://doi.org/10.1136/gut.2010.235804openalex-snapshot
Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1413openalex-snapshot
Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-15-1927openalex-snapshot
The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1650openalex-snapshot
Genes Predisposed to DNA Hypermethylation during Acquired Resistance to Chemotherapy Are Identified in Ovarian Tumors by Bivalent Chromatin Domains at Initial Diagnosis
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-0975openalex-snapshot
Genetic Susceptibility Loci for Breast Cancer by Estrogen Receptor Status
inferredcites →https://doi.org/10.1182/blood-2004-09-3740openalex-snapshot
B-cell kinetics in humans: rapid turnover of peripheral blood memory cells
inferredcites →https://doi.org/10.1186/bcr3334openalex-snapshot
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland
inferredcites →https://doi.org/10.1369/0022155411420569openalex-snapshot
Claudin-18 Is an Early-Stage Marker of Pancreatic Carcinogenesis
inferredcites →https://doi.org/10.15252/emmm.201606857openalex-snapshot
Genetically engineered mouse models in oncology research and cancer medicine
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.cell.2023.03.013openalex-snapshot
Impact of risk factors on early cancer evolution
inferred← citeshttps://doi.org/10.1016/j.heliyon.2020.e03350openalex-snapshot
Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancer
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2021.11.010openalex-snapshot
On the Origin of Pancreatic Cancer: Molecular Tumor Subtypes in Perspective of Exocrine Cell Plasticity
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.12.027openalex-snapshot
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks
inferred← citeshttps://doi.org/10.1016/j.xgen.2024.100528openalex-snapshot
Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature
inferred← citeshttps://doi.org/10.1038/s41467-019-13825-8openalex-snapshot
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
inferred← citeshttps://doi.org/10.1038/s41467-020-16097-9openalex-snapshot
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues
inferred← citeshttps://doi.org/10.1038/s41467-020-16296-4openalex-snapshot
Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations
inferred← citeshttps://doi.org/10.1038/s41467-025-63957-3openalex-snapshot
Learning the cellular origins across cancers using single-cell chromatin landscapes
inferred← citeshttps://doi.org/10.1038/s41586-022-05072-7openalex-snapshot
Diverse mutational landscapes in human lymphocytes
inferred← citeshttps://doi.org/10.1038/s41588-024-01801-yopenalex-snapshot
Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation
inferred← citeshttps://doi.org/10.1038/s41588-025-02196-0openalex-snapshot
Genomic landscape of multiple myeloma and its precursor conditions
inferred← citeshttps://doi.org/10.1038/s43018-023-00707-8openalex-snapshot
Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers
inferred← citeshttps://doi.org/10.1101/2021.04.29.441939openalex-snapshot
Genome-wide mutational signatures of immunological diversification in normal lymphocytes
inferred← citeshttps://doi.org/10.1101/2023.10.02.560432openalex-snapshot
Colon cancer arises from differentiated cell lineages in the context of inflammation
inferred← citeshttps://doi.org/10.1101/2025.04.06.646131openalex-snapshot
Learning the cellular origins of cancer using single-cell chromatin landscapes
inferred← citeshttps://doi.org/10.1101/214494openalex-snapshot
A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations
inferred← citeshttps://doi.org/10.1101/614305openalex-snapshot
Age, Sex, and Genetics Influence the Abundance of Infiltrating Immune Cells in Human Tissues
inferred← citeshttps://doi.org/10.1186/s13059-021-02318-xopenalex-snapshot
Functional and genetic determinants of mutation rate variability in regulatory elements of cancer genomes
inferred← citeshttps://doi.org/10.1186/s13073-021-00988-7openalex-snapshot
A mixture model for signature discovery from sparse mutation data
inferred← citeshttps://doi.org/10.3390/life13010071openalex-snapshot
COOBoostR: An Extreme Gradient Boosting-Based Tool for Robust Tissue or Cell-of-Origin Prediction of Tumors
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Endometriosis lesions are oligoclonal structures derived from the normal endometrium
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