On the public citation graph

Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice

https://doi.org/10.1101/460808
0 signed · 54 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00018-013-1468-0openalex-snapshot
Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline
inferredcites →https://doi.org/10.1016/j.cell.2005.11.044openalex-snapshot
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
inferredcites →https://doi.org/10.1016/j.cell.2008.06.032openalex-snapshot
Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
inferredcites →https://doi.org/10.1016/j.cell.2008.10.025openalex-snapshot
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
inferredcites →https://doi.org/10.1016/j.cell.2009.12.041openalex-snapshot
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
inferredcites →https://doi.org/10.1016/j.cell.2010.05.020openalex-snapshot
Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons
inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot
The Hallmarks of Aging
inferredcites →https://doi.org/10.1016/j.celrep.2015.03.041openalex-snapshot
Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells
inferredcites →https://doi.org/10.1016/j.dnarep.2008.02.010openalex-snapshot
TREX1 DNA exonuclease deficiency, accumulation of single stranded DNA and complex human genetic disorders
inferredcites →https://doi.org/10.1016/j.gde.2012.02.006openalex-snapshot
Active human retrotransposons: variation and disease
inferredcites →https://doi.org/10.1016/j.jmb.2006.01.089openalex-snapshot
The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks
inferredcites →https://doi.org/10.1016/j.joca.2015.03.024openalex-snapshot
Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes
inferredcites →https://doi.org/10.1016/j.mad.2010.03.008openalex-snapshot
A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?
inferredcites →https://doi.org/10.1016/j.stem.2017.07.009openalex-snapshot
Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation
inferredcites →https://doi.org/10.1016/s0092-8674(02)00828-0openalex-snapshot
Genomic Deletions Created upon LINE-1 Retrotransposition
inferredcites →https://doi.org/10.1016/s0531-5565(96)00155-6openalex-snapshot
The heterochromatin loss model of aging
inferredcites →https://doi.org/10.1038/35057062openalex-snapshot
Initial sequencing and analysis of the human genome
inferredcites →https://doi.org/10.1038/nature01262openalex-snapshot
Initial sequencing and comparative analysis of the mouse genome
inferredcites →https://doi.org/10.1038/nature10815openalex-snapshot
The sirtuin SIRT6 regulates lifespan in male mice
inferredcites →https://doi.org/10.1038/nature24050openalex-snapshot
Cytoplasmic chromatin triggers inflammation in senescence and cancer
inferredcites →https://doi.org/10.1038/ncb3586openalex-snapshot
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
inferredcites →https://doi.org/10.1038/ncomms6011openalex-snapshot
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
inferredcites →https://doi.org/10.1038/ng1223openalex-snapshot
LINE-mediated retrotransposition of marked Alu sequences
inferredcites →https://doi.org/10.1038/ni.2872openalex-snapshot
The enemy within: endogenous retroelements and autoimmune disease
inferredcites →https://doi.org/10.1038/nrg3030openalex-snapshot
Dynamic interactions between transposable elements and their hosts
inferredcites →https://doi.org/10.1038/nri3787openalex-snapshot
Type I interferons in infectious disease
inferredcites →https://doi.org/10.1038/s41467-018-03555-8openalex-snapshot
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
inferredcites →https://doi.org/10.1055/s-2003-39947openalex-snapshot
Hepatotoxicity of Nucleoside Reverse Transcriptase Inhibitors
inferredcites →https://doi.org/10.1073/pnas.1200583109openalex-snapshot
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
inferredcites →https://doi.org/10.1073/pnas.1705499114openalex-snapshot
cGAS is essential for cellular senescence
inferredcites →https://doi.org/10.1074/jbc.m110.168039openalex-snapshot
SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice
inferredcites →https://doi.org/10.1084/jem.20180139openalex-snapshot
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
inferredcites →https://doi.org/10.1093/hmg/ddr437openalex-snapshot
Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration
inferredcites →https://doi.org/10.1093/infdis/jit006openalex-snapshot
Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging
inferredcites →https://doi.org/10.1093/nar/28.6.1418openalex-snapshot
Determination of L1 retrotransposition kinetics in cultured cells
inferredcites →https://doi.org/10.1093/nar/gkq1076openalex-snapshot
Characterization of L1 retrotransposition with high-throughput dual-luciferase assays
inferredcites →https://doi.org/10.1093/nar/gku687openalex-snapshot
Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a026340openalex-snapshot
LINE-1 (L1) Lineages in the Mouse
inferredcites →https://doi.org/10.1111/acel.12047openalex-snapshot
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
inferredcites →https://doi.org/10.1126/science.1202723openalex-snapshot
SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
inferredcites →https://doi.org/10.1126/science.1222077openalex-snapshot
Landscape of Somatic Retrotransposition in Human Cancers
inferredcites →https://doi.org/10.1126/science.1261754openalex-snapshot
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
inferredcites →https://doi.org/10.1128/9781555819217.ch51openalex-snapshot
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes
inferredcites →https://doi.org/10.1128/jvi.02257-13openalex-snapshot
LINE-1 Retrotransposable Element DNA Accumulates in HIV-1-Infected Cells
inferredcites →https://doi.org/10.1186/1471-2091-12-18openalex-snapshot
Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
inferredcites →https://doi.org/10.1186/1759-8753-4-3openalex-snapshot
Revisiting the evolution of mouse LINE-1 in the genomic era
inferredcites →https://doi.org/10.1371/journal.pone.0001547openalex-snapshot
Nucleoside Analogue Reverse Transcriptase Inhibitors Differentially Inhibit Human LINE-1 Retrotransposition
inferredcites →https://doi.org/10.1371/journal.pone.0047505openalex-snapshot
In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs
inferredcites →https://doi.org/10.1371/journal.pone.0171596openalex-snapshot
Multicenter study of skin rashes and hepatotoxicity in antiretroviral-naïve HIV-positive patients receiving non-nucleoside reverse-transcriptase inhibitor plus nucleoside reverse-transcriptase inhibitors in Taiwan
inferredcites →https://doi.org/10.1523/jneurosci.3369-13.2013openalex-snapshot
The Role of Transposable Elements in Health and Diseases of the Central Nervous System
inferredcites →https://doi.org/10.18632/aging.100621openalex-snapshot
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues
inferredcites →https://doi.org/10.2174/1568026043388358openalex-snapshot
Biochemical and Mechanistic Basis for the Activity of Nucleoside Analogue Inhibitors of HIV Reverse Transcriptase
inferredcites →https://doi.org/10.4049/jimmunol.1400737openalex-snapshot
TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102496openalex-snapshot
On the interface of aging, cancer, and neurodegeneration with SIRT6 and L1 retrotransposon protein interaction network
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.