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A phenome-wide approach to identify causal risk factors for deep vein thrombosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Trends in the Incidence of Deep Vein Thrombosis and Pulmonary Embolism

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Cardiovascular Risk Factors Associated With Venous Thromboembolism

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Inhibins, activins, and follistatins: Expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia

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Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

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Safety of direct oral anticoagulants versus traditional anticoagulants in venous thromboembolism

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Role and Mechanism of mir-5189-3p in Deep Vein Thrombosis of Lower Extremities

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Platelet populations and priming in hematological diseases

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Increased risk of venous thromboembolism among patients with hyperthyroidism: a systematic review and meta-analysis of cohort studies

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COPD is not only one of the several VTE risk factors

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Body size measures, hemostatic and inflammatory markers and risk of venous thrombosis: The Longitudinal Investigation of Thromboembolism Etiology

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Cancer, other comorbidity, and risk of venous thromboembolism after stroke: a population-based cohort study

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Effect of comorbidity on risk of venous thromboembolism in patients with renal cell carcinoma

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Notch: A multi-functional integrating system of microenvironmental signals

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Varicose veins are a risk factor for deep venous thrombosis in general practice patients

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A global reference for human genetic variation

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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

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Efficient Bayesian mixed-model analysis increases association power in large cohorts

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Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

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Perineuronal nets stabilize the grid cell network

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Achievement at school and socioeconomic background—an educational perspective

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Genomic atlas of the human plasma proteome

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The UK Biobank resource with deep phenotyping and genomic data

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Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix

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Epidemiology and Risk Factors for Venous Thrombosis

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A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other

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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

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Body Height and Risk of Venous Thromboembolism: The Tromso Study

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Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

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Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

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metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis

inferredcites →https://doi.org/10.1093/hmg/ddu328openalex-snapshot

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

inferredcites →https://doi.org/10.1093/ije/dyaa149openalex-snapshot

Let’s call it the effect allele: a suggestion for GWAS naming conventions

inferredcites →https://doi.org/10.1093/ije/dyg070openalex-snapshot

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

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Mendelian randomization: prospects, potentials, and limitations

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Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

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Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

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Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

inferredcites →https://doi.org/10.1093/ije/dyw127openalex-snapshot

Commentary: Two-sample Mendelian randomization: opportunities and challenges

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MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

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Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

inferredcites →https://doi.org/10.1093/ije/dyx204openalex-snapshot

Software Application Profile: PHESANT: a tool for performing automated phenome scans in UK Biobank

inferredcites →https://doi.org/10.1093/ije/dyy101openalex-snapshot

Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression

inferredcites →https://doi.org/10.1097/aog.0b013e31826af61aopenalex-snapshot

False Alarms and Pseudo-Epidemics

inferredcites →https://doi.org/10.1101/078972openalex-snapshot

MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations

inferredcites →https://doi.org/10.1101/148627openalex-snapshot

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

inferredcites →https://doi.org/10.1101/173682openalex-snapshot

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

inferredcites →https://doi.org/10.1111/joim.12299openalex-snapshot

Obesity as a causal risk factor for deep venous thrombosis: a M endelian randomization study

inferredcites →https://doi.org/10.1111/jth.13195openalex-snapshot

Comorbid risks of deep vein thrombosis and pulmonary thromboembolism in patients with chronic pancreatitis: a nationwide cohort study

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Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta‐analysis

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Relationship between neighborhood socioeconomic status and venous thromboembolism: results from a population‐based study

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Gonadotropins as novel active partners in vascular diseases: Insight from angiogenic properties and thrombotic potential of endothelial colony‐forming cells

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Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study

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Body size measures and risk of venous thromboembolism: protocol for a systematic review and meta-analysis

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Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality

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Thyroid Hormone Regulation of Metabolism

inferredcites →https://doi.org/10.1158/1055-9965.epi-05-0196openalex-snapshot

Alcohol, ALDH2, and Esophageal Cancer: A Meta-analysis Which Illustrates the Potentials and Limitations of a Mendelian Randomization Approach

inferredcites →https://doi.org/10.1161/circinterventions.120.010207openalex-snapshot

Treatment of Varicose Veins Affects the Incidences of Venous Thromboembolism and Peripheral Artery Disease

inferredcites →https://doi.org/10.1172/jci60229openalex-snapshot

New insights into the mechanisms of venous thrombosis

inferredcites →https://doi.org/10.1182/blood-2009-11-253724openalex-snapshot

Increasing levels of free thyroxine as a risk factor for a first venous thrombosis: a case-control study

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Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis?

inferredcites →https://doi.org/10.1186/s12959-017-0135-3openalex-snapshot

Reduced cardiac function and risk of venous thromboembolism in Asian countries

inferredcites →https://doi.org/10.1186/s13018-018-0716-2openalex-snapshot

Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty

inferredcites →https://doi.org/10.1186/s13059-020-02238-2openalex-snapshot

scMC learns biological variation through the alignment of multiple single-cell genomics datasets

inferredcites →https://doi.org/10.1258/jrsm.2010.100155openalex-snapshot

Prolonged work- and computer-related seated immobility and risk of venous thromboembolism

inferredcites →https://doi.org/10.1371/journal.pgen.1004383openalex-snapshot

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

inferredcites →https://doi.org/10.1371/journal.pgen.1006706openalex-snapshot

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

inferredcites →https://doi.org/10.1371/journal.pmed.1001779openalex-snapshot

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

inferredcites →https://doi.org/10.1371/journal.pone.0039321openalex-snapshot

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

inferredcites →https://doi.org/10.1373/clinchem.2018.296806openalex-snapshot

Can Mendelian Randomization Shift into Reverse Gear?

inferredcites →https://doi.org/10.1530/eje-14-0801openalex-snapshot

Prothrombotic changes due to an increase in thyroid hormone levels

inferredcites →https://doi.org/10.1534/genetics.117.300360openalex-snapshot

Transformation of Summary Statistics from Linear Mixed Model Association on All-or-None Traits to Odds Ratio

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Abstract

inferredcites →https://doi.org/10.21037/cdt.2017.09.01openalex-snapshot

Deep vein thrombosis: pathogenesis, diagnosis, and medical management

inferredcites →https://doi.org/10.2147/imcrj.s62100openalex-snapshot

Warfarin-induced deep vein thrombosis

inferredcites →https://doi.org/10.3945/ajcn.115.118216openalex-snapshot

Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies

inferredcites →https://doi.org/10.4238/2015.october.29.3openalex-snapshot

TGF-β1 and Serpine 1 expression changes in traumatic deep vein thrombosis

inferredcites →https://doi.org/10.7554/elife.34408openalex-snapshot

The MR-Base platform supports systematic causal inference across the human phenome

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s12013-025-01761-yopenalex-snapshot

Molecular Mechanism of Notch Signaling and Macrophages in Deep Vein Thrombosis: A Comprehensive Review

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