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Multi-omic analysis of CIC’s functional networks reveals novel interaction partners and a potential role in mitotic fidelity

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Noncanonical functions of micro RNA pathway enzymes – Drosha, DGCR 8, Dicer and Ago proteins
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C IC inactivating mutations identify aggressive subset of 1p19q codeleted gliomas
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Exploring Epigenomic Datasets by ChIPseeker
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ETV /Pea3 family transcription factor‐encoding genes are overexpressed in CIC ‐mutant oligodendrogliomas
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The Capicua/ETS Translocation Variant 5 Axis Regulates Liver‐Resident Memory CD8+ T‐Cell Development and the Pathogenesis of Liver Injury
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Epigenetic role of CCAAT box‐binding transcription factor NF‐Y on ID gene family in human embryonic carcinoma cells
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Concurrent CIC mutations, IDH mutations, and 1p/19q loss distinguish oligodendrogliomas from other cancers
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Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua ( CIC ) loss to activation of the MAPK signalling cascade
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Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC ‐knockout and IDH1 ‐mutant cells
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Intron retention and its impact on gene expression and protein diversity: A review and a practical guide
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Integrative Analysis of ChIP-Chip and ChIP-Seq Dataset
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Characterization of a cell line derived from a human oligodendroglioma
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Rethinking synchronization of mammalian cells for cell cycle analysis
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The SWI/SNF subunit BRG1 affects alternative splicing by changing RNA binding factor interactions with nascent RNA
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Mutations of HNRNPA0 and WIF1 predispose members of a large family to multiple cancers
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Role of Cyclin B1 Levels in DNA Damage and DNA Damage-Induced Senescence
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The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives
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Cancer: a CINful evolution
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The Kank family proteins in adhesion dynamics
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ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
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Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
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Quantitative Proteomics of the Cancer Cell Line Encyclopedia
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BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
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ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens
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Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding
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Mapping a diversity of genetic interactions in yeast
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Identification of Novel Argonaute-Associated Proteins
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Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint
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Capicua Regulates Cell Proliferation Downstream of the Receptor Tyrosine Kinase/Ras Signaling Pathway
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Stuck in Division or Passing through
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An essential role of Cdc42‐like GTPases in mitosis of HeLa cells
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Synthetic lethality: General principles, utility and detection using genetic screens in human cells
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Tetraploidy, aneuploidy and cancer
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Small Maf proteins (MafF, MafG, MafK): History, structure and function
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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses
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CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop
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Inactivation of Transcriptional Repressor Capicua Confers Sorafenib Resistance in Human Hepatocellular Carcinoma
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Integrating genetic and protein–protein interaction networks maps a functional wiring diagram of a cell
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DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
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A Strategy to Combine Sample Multiplexing with Targeted Proteomics Assays for High-Throughput Protein Signature Characterization
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Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop
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Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
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14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
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Cyclin B1 transcription is enhanced by the p300 coactivator and regulated during the cell cycle by a CHR‐dependent repression mechanism
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Cytokinetic activities in a human cell line: the midbody and intracellular bridge
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CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons
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Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics
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Improvements to the Percolator Algorithm for Peptide Identification from Shotgun Proteomics Data Sets
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The Beclin 1 network regulates autophagy and apoptosis
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Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe
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Beclin‐1 is required for chromosome congression and proper outer kinetochore assembly
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Biological and clinical consequences of NPM1 mutations in AML
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Loss of CIC and FUBP1 expressions are potential markers of shorter time to recurrence in oligodendroglial tumors
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Hematopathology
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Integrated genomic characterization of endometrial carcinoma
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BAF complexes facilitate decatenation of DNA by topoisomerase IIα
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Comprehensive molecular characterization of gastric adenocarcinoma
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Cyclin C is a haploinsufficient tumour suppressor
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Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5
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Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
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Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis
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Inactivation of Capicua drives cancer metastasis
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Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
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Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes
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A module of negative feedback regulators defines growth factor signaling
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Building ProteomeTools based on a complete synthetic human proteome
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Semi-supervised learning for peptide identification from shotgun proteomics datasets
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Direct observation of individual endogenous protein complexes in situ by proximity ligation
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Cell cycle, CDKs and cancer: a changing paradigm
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SWI/SNF nucleosome remodellers and cancer
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Chromothripsis and cancer: causes and consequences of chromosome shattering
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Biological implications of cell fusion
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Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
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The SWI/SNF complex and cancer
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Regulation and function of capicua in mammals
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Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer
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FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA
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A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells
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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors
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The Sox2 transcription factor binds RNA
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Alternative splicing modulation by G-quadruplexes
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A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation
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The SWI/SNF complex in cancer — biology, biomarkers and therapy
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The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
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Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
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Next-generation characterization of the Cancer Cell Line Encyclopedia
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A genome-wide atlas of co-essential modules assigns function to uncharacterized genes
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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
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Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research
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KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors
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ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa
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A changing paradigm
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ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
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Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
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Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma
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The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes
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Cdc42 Promotes G1 Progression through p70 S6 Kinase-mediated Induction of Cyclin E Expression
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Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes
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Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation
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Beclin-1 knockdown shows abscission failure but not autophagy defect during oocyte meiotic maturation
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The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer
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Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells
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Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation
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Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors
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Human ZCCHC12 activates AP-1 and CREB signaling as a transcriptional co-activator
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Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
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Gene co-expression analysis for functional classification and gene–disease predictions
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GRETTA: an R package for mapping in silico genetic interaction and essentiality networks
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Fast and accurate short read alignment with Burrows–Wheeler transform
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The Sequence Alignment/Map format and SAMtools
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ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
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Role of the high mobility group A proteins in human lipomas
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Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
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Regulation of alternative pre‐mRNA splicing by the ERK MAP‐kinase pathway
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Twelve years of SAMtools and BCFtools
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The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
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UniProt: the universal protein knowledgebase in 2021
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The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
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Specific inhibition of NF-Y subunits triggers different cell proliferation defects
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The PRIDE database and related tools and resources in 2019: improving support for quantification data
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COXPRESdb v7: a gene coexpression database for 11 animal species supported by 23 coexpression platforms for technical evaluation and evolutionary inference
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Sarcomas With CIC-rearrangements Are a Distinct Pathologic Entity With Aggressive Outcome
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Resource: Scalable whole genome sequencing of 40,000 single cells identifies stochastic aneuploidies, genome replication states and clonal repertoires
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Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines
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mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells
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A genetic interaction analysis identifies cancer drivers that modify EGFR dependency
inferredcites →https://doi.org/10.1101/gad.300244.117openalex-snapshot
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma
inferredcites →https://doi.org/10.1101/gr.226530.117openalex-snapshot
Local sequence features that influence AP-1 cis-regulatory activity
inferredcites →https://doi.org/10.1101/gr.247759.118openalex-snapshot
Characterizing and inferring quantitative cell cycle phase in single-cell RNA-seq data analysis
inferredcites →https://doi.org/10.1101/mcs.a005991openalex-snapshot
Deletion of ERF and CIC causes abnormal skull morphology and global developmental delay
inferredcites →https://doi.org/10.1126/science.1102574openalex-snapshot
Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2
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From Birth to Death: The Complex Lives of Eukaryotic mRNAs
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Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
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Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites
inferredcites →https://doi.org/10.1126/science.1210557openalex-snapshot
Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma
inferredcites →https://doi.org/10.1126/science.aaa0355openalex-snapshot
The human transcriptome across tissues and individuals
inferredcites →https://doi.org/10.1126/scisignal.2004088openalex-snapshot
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
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Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts
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The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
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Cell Cycle Arrest and Apoptosis Induced by Human Polo-Like Kinase 3 Is Mediated through Perturbation of Microtubule Integrity
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ERF Nuclear Shuttling, a Continuous Monitor of Erk Activity That Links It to Cell Cycle Progression
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Animal Cytokinesis: From Parts List to Mechanisms
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Role for Brm in Cell Growth Control
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Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation
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The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation
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Retraction: Overexpression of Proteins HMGA1 Induces Cell Cycle Deregulation and Apoptosis in Normal Rat Thyroid Cells
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Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer
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Regulation of mitosis via mitotic kinases: new opportunities for cancer management
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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
inferredcites →https://doi.org/10.1172/jci.insight.135826openalex-snapshot
CIC is a critical regulator of neuronal differentiation
inferredcites →https://doi.org/10.1177/03000605221075511openalex-snapshot
Effects of HMGA2 gene silencing on cell cycle and apoptosis in the metastatic renal carcinoma cell line ACHN
inferredcites →https://doi.org/10.1186/1471-2105-11-237openalex-snapshot
ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip data
inferredcites →https://doi.org/10.1186/1471-2202-12-69openalex-snapshot
The MEK-ERK pathway negatively regulates bim expression through the 3' UTR in sympathetic neurons
inferredcites →https://doi.org/10.1186/gb-2008-9-9-r137openalex-snapshot
Model-based Analysis of ChIP-Seq (MACS)
inferredcites →https://doi.org/10.1186/gb-2010-11-3-r29openalex-snapshot
Genome-wide functional analysis of human 5' untranslated region introns
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1186/s13059-016-0947-7openalex-snapshot
Pooling across cells to normalize single-cell RNA sequencing data with many zero counts
inferredcites →https://doi.org/10.1186/s13059-021-02581-yopenalex-snapshot
Universal prediction of cell-cycle position using transfer learning
inferredcites →https://doi.org/10.1186/s13072-020-00370-8openalex-snapshot
GBAF, a small BAF sub-complex with big implications: a systematic review
inferredcites →https://doi.org/10.1186/s40478-023-01507-yopenalex-snapshot
CIC reduces xCT/SLC7A11 expression and glutamate release in glioma
inferredcites →https://doi.org/10.1242/jcs.092965openalex-snapshot
The Capicua repressor – a general sensor of RTK signaling in development and disease
inferredcites →https://doi.org/10.1261/rna.1606309openalex-snapshot
The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins
inferredcites →https://doi.org/10.12659/ajcr.892551openalex-snapshot
High-Grade Undifferentiated Small Round Cell Sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 Fusion: Emerging Entities of Soft Tissue Tumors with Unique Histopathologic Features – A Case Report and Literature Review
inferredcites →https://doi.org/10.1371/journal.pcbi.1003118openalex-snapshot
Software for Computing and Annotating Genomic Ranges
inferredcites →https://doi.org/10.1371/journal.pgen.1003367openalex-snapshot
A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating p21/Cdkn1a/Cip1/Waf1 mRNA Stability
inferredcites →https://doi.org/10.1371/journal.pgen.1005634openalex-snapshot
EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes
inferredcites →https://doi.org/10.1371/journal.pone.0043362openalex-snapshot
Interaction of OKL38 and p53 in Regulating Mitochondrial Structure and Function
inferredcites →https://doi.org/10.15252/msb.20145625openalex-snapshot
Ultrasensitive proteome analysis using paramagnetic bead technology
inferredcites →https://doi.org/10.15252/msb.20209946openalex-snapshot
The transcriptome dynamics of single cells during the cell cycle
inferredcites →https://doi.org/10.18632/oncotarget.2401openalex-snapshot
Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity
inferredcites →https://doi.org/10.18632/oncotarget.4372openalex-snapshot
miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression
inferredcites →https://doi.org/10.3389/fcell.2021.794475openalex-snapshot
Multi-Omics Analysis of Cancer Cell Lines with High/Low Ferroptosis Scores and Development of a Ferroptosis-Related Model for Multiple Cancer Types
inferredcites →https://doi.org/10.3389/fonc.2021.628480openalex-snapshot
Proteomic Analysis Reveals That Placenta-Specific Protein 9 Inhibits Proliferation and Stimulates Motility of Human Bronchial Epithelial Cells
inferredcites →https://doi.org/10.3390/cells9061554openalex-snapshot
Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors
inferredcites →https://doi.org/10.3390/ijms21072346openalex-snapshot
Understanding MAPK Signaling Pathways in Apoptosis
inferredcites →https://doi.org/10.3390/ijms23031521openalex-snapshot
Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis
inferredcites →https://doi.org/10.3892/etm.2020.8454openalex-snapshot
ERK/MAPK signalling pathway and tumorigenesis (Review)
inferredcites →https://doi.org/10.3892/or.2020.7807openalex-snapshot
Role of RASA1 in cancer: A review and update (Review)
inferredcites →https://doi.org/10.4110/in.2020.20.e43openalex-snapshot
Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation
inferredcites →https://doi.org/10.7554/elife.62585openalex-snapshot
Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney
inferredcites →https://doi.org/10.7554/elife.71769openalex-snapshot
Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua
inferredcites →https://doi.org/10.7554/elife.77072openalex-snapshot
The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/humu.24346openalex-snapshot
Novel CIC variants identified in individuals with neurodevelopmental phenotypes
inferred← citeshttps://doi.org/10.1002/path.5400openalex-snapshot
Making heads or tails – the emergence of capicua (CIC) as an important multifunctional tumour suppressor
inferred← citeshttps://doi.org/10.1038/s41586-022-04789-9openalex-snapshot
A pan-cancer compendium of chromosomal instability
inferred← citeshttps://doi.org/10.1186/s12915-020-00895-0openalex-snapshot
TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161537openalex-snapshot
Additional file 11 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161558openalex-snapshot
Additional file 1 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161561openalex-snapshot
Additional file 2 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161564openalex-snapshot
Additional file 3 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161570openalex-snapshot
Additional file 5 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161573openalex-snapshot
Additional file 6 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
inferred← citeshttps://doi.org/10.6084/m9.figshare.13161576openalex-snapshot
Additional file 7 of TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L
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