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Deep learning does not outperform classical machine learning for cell-type annotation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.cell.2016.01.047openalex-snapshot
Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos
inferredcites →https://doi.org/10.1016/j.cell.2016.11.038openalex-snapshot
Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
inferredcites →https://doi.org/10.1016/j.cell.2018.06.021openalex-snapshot
Molecular Architecture of the Mouse Nervous System
inferredcites →https://doi.org/10.1016/j.cell.2018.07.028openalex-snapshot
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain
inferredcites →https://doi.org/10.1016/j.cell.2019.05.031openalex-snapshot
Comprehensive Integration of Single-Cell Data
inferredcites →https://doi.org/10.1016/j.cels.2016.08.011openalex-snapshot
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure
inferredcites →https://doi.org/10.1016/j.cels.2016.09.002openalex-snapshot
A Single-Cell Transcriptome Atlas of the Human Pancreas
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.018openalex-snapshot
RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes
inferredcites →https://doi.org/10.1016/j.cmet.2016.08.020openalex-snapshot
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.isci.2020.100882openalex-snapshot
scCATCH: Automatic Annotation on Cell Types of Clusters from Single-Cell RNA Sequencing Data
inferredcites →https://doi.org/10.1016/j.jbi.2013.08.007openalex-snapshot
Learning classification models from multiple experts
inferredcites →https://doi.org/10.1038/nature12364openalex-snapshot
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
inferredcites →https://doi.org/10.1038/nbt.3192openalex-snapshot
Spatial reconstruction of single-cell gene expression data
inferredcites →https://doi.org/10.1038/nbt.4091openalex-snapshot
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
inferredcites →https://doi.org/10.1038/nbt.4096openalex-snapshot
Integrating single-cell transcriptomic data across different conditions, technologies, and species
inferredcites →https://doi.org/10.1038/nbt.4231openalex-snapshot
Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells
inferredcites →https://doi.org/10.1038/nmeth.4177openalex-snapshot
Pooled CRISPR screening with single-cell transcriptome readout
inferredcites →https://doi.org/10.1038/nmeth.4197openalex-snapshot
Salmon provides fast and bias-aware quantification of transcript expression
inferredcites →https://doi.org/10.1038/nmeth.4380openalex-snapshot
Simultaneous epitope and transcriptome measurement in single cells
inferredcites →https://doi.org/10.1038/nmeth.4644openalex-snapshot
scmap: projection of single-cell RNA-seq data across data sets
inferredcites →https://doi.org/10.1038/s41467-018-07234-6openalex-snapshot
Discovery of rare cells from voluminous single cell expression data
inferredcites →https://doi.org/10.1038/s41467-018-07931-2openalex-snapshot
Single-cell RNA-seq denoising using a deep count autoencoder
inferredcites →https://doi.org/10.1038/s41467-020-14391-0openalex-snapshot
Surface protein imputation from single cell transcriptomes by deep neural networks
inferredcites →https://doi.org/10.1038/s41467-020-15523-2openalex-snapshot
SciBet as a portable and fast single cell type identifier
inferredcites →https://doi.org/10.1038/s41576-019-0122-6openalex-snapshot
Deep learning: new computational modelling techniques for genomics
inferredcites →https://doi.org/10.1038/s41586-018-0590-4openalex-snapshot
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
inferredcites →https://doi.org/10.1038/s41586-019-1184-5openalex-snapshot
Molecular recording of mammalian embryogenesis
inferredcites →https://doi.org/10.1038/s41590-018-0276-yopenalex-snapshot
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
inferredcites →https://doi.org/10.1038/s41592-018-0229-2openalex-snapshot
Deep generative modeling for single-cell transcriptomics
inferredcites →https://doi.org/10.1038/s41592-019-0494-8openalex-snapshot
scGen predicts single-cell perturbation responses
inferredcites →https://doi.org/10.1038/s41592-019-0535-3openalex-snapshot
Supervised classification enables rapid annotation of cell atlases
inferredcites →https://doi.org/10.1038/s41592-021-01336-8openalex-snapshot
Benchmarking atlas-level data integration in single-cell genomics
inferredcites →https://doi.org/10.1093/bioinformatics/btz292openalex-snapshot
scMatch: a single-cell gene expression profile annotation tool using reference datasets
inferredcites →https://doi.org/10.1101/574723openalex-snapshot
Deep learning of representations for transcriptomics-based phenotype prediction
inferredcites →https://doi.org/10.1101/gr.177725.114openalex-snapshot
Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
inferredcites →https://doi.org/10.1126/science.1245316openalex-snapshot
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
inferredcites →https://doi.org/10.1126/science.aam8999openalex-snapshot
Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding
inferredcites →https://doi.org/10.1126/science.aar4362openalex-snapshot
Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo
inferredcites →https://doi.org/10.1145/3065386openalex-snapshot
ImageNet classification with deep convolutional neural networks
inferredcites →https://doi.org/10.1186/s13059-015-0706-1openalex-snapshot
Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos
inferredcites →https://doi.org/10.1186/s13059-017-1382-0openalex-snapshot
SCANPY: large-scale single-cell gene expression data analysis
inferredcites →https://doi.org/10.1186/s13059-019-1639-xopenalex-snapshot
CellFishing.jl: an ultrafast and scalable cell search method for single-cell RNA sequencing
inferredcites →https://doi.org/10.1186/s13059-019-1795-zopenalex-snapshot
A comparison of automatic cell identification methods for single-cell RNA sequencing data
inferredcites →https://doi.org/10.18653/v1/n18-1202openalex-snapshot
Deep Contextualized Word Representations
inferredcites →https://doi.org/10.48550/arxiv.1103.0398openalex-snapshot
Natural Language Processing (almost) from Scratch

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s41060-024-00681-zopenalex-snapshot
Attention versus contrastive learning of tabular data: a data-centric benchmarking
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2022.106409openalex-snapshot
scWECTA: A weighted ensemble classification framework for cell type assignment based on single cell transcriptome
inferred← citeshttps://doi.org/10.1016/j.crmeth.2023.100577openalex-snapshot
Single-cell assignment using multiple-adversarial domain adaptation network with large-scale references
inferred← citeshttps://doi.org/10.1016/j.csbj.2023.07.041openalex-snapshot
Exploring the optimization of autoencoder design for imputing single-cell RNA sequencing data
inferred← citeshttps://doi.org/10.1016/j.neucom.2025.129359openalex-snapshot
Deep clustering of tabular data by weighted Gaussian distribution learning
inferred← citeshttps://doi.org/10.1016/j.neunet.2022.09.020openalex-snapshot
Perturbation of deep autoencoder weights for model compression and classification of tabular data
inferred← citeshttps://doi.org/10.1016/j.stemcr.2022.11.007openalex-snapshot
Deep learning models will shape the future of stem cell research
inferred← citeshttps://doi.org/10.1016/j.xcrm.2024.101535openalex-snapshot
Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets
inferred← citeshttps://doi.org/10.1038/s41467-024-51059-5openalex-snapshot
scTab: Scaling cross-tissue single-cell annotation models
inferred← citeshttps://doi.org/10.1038/s41592-023-02035-2openalex-snapshot
Population-level integration of single-cell datasets enables multi-scale analysis across samples
inferred← citeshttps://doi.org/10.1038/s41592-024-02353-zopenalex-snapshot
Transformers in single-cell omics: a review and new perspectives
inferred← citeshttps://doi.org/10.1038/s41598-023-49048-7openalex-snapshot
Enhancing autism spectrum disorder classification in children through the integration of traditional statistics and classical machine learning techniques in EEG analysis
inferred← citeshttps://doi.org/10.1093/bib/bbaf239openalex-snapshot
Evaluation of out-of-distribution detection methods for data shifts in single-cell transcriptomics
inferred← citeshttps://doi.org/10.1093/nargab/lqab102openalex-snapshot
Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research
inferred← citeshttps://doi.org/10.1093/nargab/lqag095openalex-snapshot
A systematic assessment of single-cell language model configurations
inferred← citeshttps://doi.org/10.1101/2020.05.28.121541openalex-snapshot
Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease
inferred← citeshttps://doi.org/10.1101/2021.04.28.441762openalex-snapshot
Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humans
inferred← citeshttps://doi.org/10.1101/2023.05.15.540808openalex-snapshot
MASIv2 enables standardization and integration of multi-modal single-cell and spatial omics data with one general framework
inferred← citeshttps://doi.org/10.1101/2023.10.07.561331openalex-snapshot
Scaling cross-tissue single-cell annotation models
inferred← citeshttps://doi.org/10.1101/655365openalex-snapshot
Accurate denoising of single-cell RNA-Seq data using unbiased principal component analysis
inferred← citeshttps://doi.org/10.1109/icaci58115.2023.10146161openalex-snapshot
Effectiveness of Deep Image Embedding Clustering Methods on Tabular Data
inferred← citeshttps://doi.org/10.1109/icece64886.2024.11024938openalex-snapshot
Transfer Learning of Tabular Data by Finetuning Large Language Models
inferred← citeshttps://doi.org/10.1126/science.abl5197openalex-snapshot
Cross-tissue immune cell analysis reveals tissue-specific features in humans
inferred← citeshttps://doi.org/10.1186/s13059-019-1795-zopenalex-snapshot
A comparison of automatic cell identification methods for single-cell RNA sequencing data
inferred← citeshttps://doi.org/10.1186/s13059-020-02100-5openalex-snapshot
Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data
inferred← citeshttps://doi.org/10.1186/s13059-021-02452-6openalex-snapshot
Sfaira accelerates data and model reuse in single cell genomics
inferred← citeshttps://doi.org/10.12688/f1000research.22969.1openalex-snapshot
clustifyr: an R package for automated single-cell RNA sequencing cluster classification
inferred← citeshttps://doi.org/10.33612/diss.255266474openalex-snapshot
Context matters
inferred← citeshttps://doi.org/10.64898/2026.01.06.697922openalex-snapshot
HEDeST: An Integrative Approach to Enhance Spatial Transcriptomic Deconvolution with Histology
inferred← citeshttps://doi.org/10.7554/elife.52155openalex-snapshot
The single-cell eQTLGen consortium
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