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Pervasive off-target and double-stranded DNA nicking by CRISPR-Cas12a

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.201600186openalex-snapshot

Coupling immunity and programmed cell suicide in prokaryotes: Life‐or‐death choices

inferredcites →https://doi.org/10.1002/wrna.1481openalex-snapshot

Cas9 versus Cas12a/Cpf1: Structure–function comparisons and implications for genome editing

inferredcites →https://doi.org/10.1016/b978-0-12-801185-0.00001-5openalex-snapshot

In Vitro Enzymology of Cas9

inferredcites →https://doi.org/10.1016/j.cell.2015.09.038openalex-snapshot

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

inferredcites →https://doi.org/10.1016/j.cell.2017.11.032openalex-snapshot

The Biology of CRISPR-Cas: Backward and Forward

inferredcites →https://doi.org/10.1016/j.cell.2018.10.045openalex-snapshot

Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

inferredcites →https://doi.org/10.1016/j.dnarep.2016.12.005openalex-snapshot

Nick-initiated homologous recombination: Protecting the genome, one strand at a time

inferredcites →https://doi.org/10.1016/j.molcel.2017.03.016openalex-snapshot

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

inferredcites →https://doi.org/10.1016/j.molcel.2017.06.035openalex-snapshot

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1

inferredcites →https://doi.org/10.1016/j.molcel.2017.09.007openalex-snapshot

The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit

inferredcites →https://doi.org/10.1016/j.molcel.2018.06.043openalex-snapshot

Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a

inferredcites →https://doi.org/10.1016/j.molcel.2018.11.021openalex-snapshot

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.

inferredcites →https://doi.org/10.1021/acs.biochem.5b01108openalex-snapshot

Nucleosomes Inhibit Cas9 Endonuclease Activity in Vitro

inferredcites →https://doi.org/10.1021/acsestwater.0c00105openalex-snapshot

Full-Scale Manipulation of the Empty Bed Contact Time to Optimize Dissolved Organic Matter Removal by Drinking Water Biofilters

inferredcites →https://doi.org/10.1021/ja0582105openalex-snapshot

Ultrafast Dynamics in DNA: “Fraying” at the End of the Helix

inferredcites →https://doi.org/10.1038/celldisc.2017.18openalex-snapshot

Multiplex gene regulation by CRISPR-ddCpf1

inferredcites →https://doi.org/10.1038/nature13011openalex-snapshot

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

inferredcites →https://doi.org/10.1038/nature17945openalex-snapshot

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

inferredcites →https://doi.org/10.1038/nature22398openalex-snapshot

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

inferredcites →https://doi.org/10.1038/nbt.2647openalex-snapshot

DNA targeting specificity of RNA-guided Cas9 nucleases

inferredcites →https://doi.org/10.1038/nbt.2889openalex-snapshot

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

inferredcites →https://doi.org/10.1038/nbt.3117openalex-snapshot

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

inferredcites →https://doi.org/10.1038/nbt.3609openalex-snapshot

Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells

inferredcites →https://doi.org/10.1038/nbt.3620openalex-snapshot

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

inferredcites →https://doi.org/10.1038/nbt.3737openalex-snapshot

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

inferredcites →https://doi.org/10.1038/nmeth.4104openalex-snapshot

In vivo high-throughput profiling of CRISPR–Cpf1 activity

inferredcites →https://doi.org/10.1038/nmeth.4278openalex-snapshot

CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

inferredcites →https://doi.org/10.1038/s41422-018-0022-xopenalex-snapshot

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

inferredcites →https://doi.org/10.1038/s41467-018-05245-xopenalex-snapshot

Direct observation of DNA target searching and cleavage by CRISPR-Cas12a

inferredcites →https://doi.org/10.1038/s41467-018-06129-wopenalex-snapshot

Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3′-overhang

inferredcites →https://doi.org/10.1038/s41467-018-08224-4openalex-snapshot

Engineering of CRISPR-Cas12b for human genome editing

inferredcites →https://doi.org/10.1038/s41564-019-0382-0openalex-snapshot

Target-dependent nickase activities of the CRISPR–Cas nucleases Cpf1 and Cas9

inferredcites →https://doi.org/10.1038/s41586-019-1257-5openalex-snapshot

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

inferredcites →https://doi.org/10.1038/s41594-019-0188-zopenalex-snapshot

DNA stretching induces Cas9 off-target activity

inferredcites →https://doi.org/10.1038/srep19675openalex-snapshot

Sequence features associated with the cleavage efficiency of CRISPR/Cas9 system

inferredcites →https://doi.org/10.1073/pnas.131009198openalex-snapshot

Single-strand interruptions in replicating chromosomes cause double-strand breaks

inferredcites →https://doi.org/10.1073/pnas.1316493110openalex-snapshot

Watching DNA breath one molecule at a time

inferredcites →https://doi.org/10.1073/pnas.1718686115openalex-snapshot

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)

inferredcites →https://doi.org/10.1073/pnas.1810062115openalex-snapshot

Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo

inferredcites →https://doi.org/10.1093/nar/gkw179openalex-snapshot

Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks

inferredcites →https://doi.org/10.1101/600890openalex-snapshot

Cas12a trans-cleavage can be modulated in vitro and is active on ssDNA, dsDNA, and RNA

inferredcites →https://doi.org/10.1126/sciadv.aar4134openalex-snapshot

Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9

inferredcites →https://doi.org/10.1126/science.1138140openalex-snapshot

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

inferredcites →https://doi.org/10.1126/science.1157358openalex-snapshot

Virus Population Dynamics and Acquired Virus Resistance in Natural Microbial Communities

inferredcites →https://doi.org/10.1126/science.aad8282openalex-snapshot

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

inferredcites →https://doi.org/10.1126/science.aaq0179openalex-snapshot

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

inferredcites →https://doi.org/10.1126/science.aar6245openalex-snapshot

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

inferredcites →https://doi.org/10.1126/science.aat5011openalex-snapshot

CRISPR-Cas guides the future of genetic engineering

inferredcites →https://doi.org/10.1126/science.aav7271openalex-snapshot

Functionally diverse type V CRISPR-Cas systems

inferredcites →https://doi.org/10.1128/jb.01412-07openalex-snapshot

Phage Response to CRISPR-Encoded Resistance in Streptococcus thermophilus

inferredcites →https://doi.org/10.1186/s13059-018-1458-5openalex-snapshot

A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice

inferredcites →https://doi.org/10.21769/bioprotoc.2842openalex-snapshot

Heterologous Expression and Purification of the CRISPR-Cas12a/Cpf1 Protein

inferredcites →https://doi.org/10.3390/genes10020169openalex-snapshot

The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

inferredcites →https://doi.org/10.4061/2010/260512openalex-snapshot

DNA Mismatch Repair in Eukaryotes and Bacteria

inferredcites →https://doi.org/10.7554/elife.13450openalex-snapshot

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1007/s00018-019-03396-8openalex-snapshot

Cas12a mediates efficient and precise endogenous gene tagging via MITI: microhomology-dependent targeted integrations

inferred← citeshttps://doi.org/10.1016/j.bj.2019.10.005openalex-snapshot

CRISPR-Cas12a: Functional overview and applications

inferred← citeshttps://doi.org/10.1038/s41587-020-0646-5openalex-snapshot

Massively parallel kinetic profiling of natural and engineered CRISPR nucleases

inferred← citeshttps://doi.org/10.1042/bst20190564openalex-snapshot

Making the cut(s): how Cas12a cleaves target and non-target DNA

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