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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ana.24506openalex-snapshot
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
inferredcites →https://doi.org/10.1002/biof.5openalex-snapshot
Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction
inferredcites →https://doi.org/10.1002/jcsm.12033openalex-snapshot
Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients
inferredcites →https://doi.org/10.1007/s00424-005-1473-8openalex-snapshot
Contributions of the ubiquitin–proteasome pathway and apoptosis to human skeletal muscle wasting with age
inferredcites →https://doi.org/10.1007/s10522-010-9297-0openalex-snapshot
Frailty and muscle metabolism dysregulation in the elderly
inferredcites →https://doi.org/10.1016/0092-8674(95)90311-9openalex-snapshot
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
inferredcites →https://doi.org/10.1016/0531-5565(80)90010-8openalex-snapshot
Mitochondrial role in cell aging
inferredcites →https://doi.org/10.1016/b978-0-12-378638-8.00004-xopenalex-snapshot
Aging and Apoptosis in Muscle
inferredcites →https://doi.org/10.1016/j.bbrc.2003.07.014openalex-snapshot
Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids
inferredcites →https://doi.org/10.1016/j.biochi.2007.09.001openalex-snapshot
Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species
inferredcites →https://doi.org/10.1016/j.cell.2017.02.004openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferredcites →https://doi.org/10.1016/j.cell.2017.03.035openalex-snapshot
mTOR Signaling in Growth, Metabolism, and Disease
inferredcites →https://doi.org/10.1016/j.cmet.2008.10.002openalex-snapshot
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
inferredcites →https://doi.org/10.1016/j.cmet.2013.03.015openalex-snapshot
Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
inferredcites →https://doi.org/10.1016/j.cmet.2013.10.001openalex-snapshot
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
inferredcites →https://doi.org/10.1016/j.exger.2005.04.003openalex-snapshot
Apoptosis in muscle atrophy: Relevance to sarcopenia
inferredcites →https://doi.org/10.1016/j.exger.2015.02.015openalex-snapshot
Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women
inferredcites →https://doi.org/10.1016/j.febslet.2006.09.008openalex-snapshot
Muscle atrophy in transgenic mice expressing a human TSC1 transgene
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.07.039openalex-snapshot
FoxO proteins’ nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells
inferredcites →https://doi.org/10.1016/j.jid.2016.07.016openalex-snapshot
High GDF-15 Serum Levels Independently Correlate with Poorer Overall Survival of Patients with Tumor-Free Stage III and Unresectable Stage IV Melanoma
inferredcites →https://doi.org/10.1016/s0960-9822(99)00268-7openalex-snapshot
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
inferredcites →https://doi.org/10.1038/387083a0openalex-snapshot
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
inferredcites →https://doi.org/10.1038/ijo.2014.27openalex-snapshot
NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism
inferredcites →https://doi.org/10.1038/ijo.2015.242openalex-snapshot
Anorexia–cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15
inferredcites →https://doi.org/10.1038/nature06322openalex-snapshot
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
inferredcites →https://doi.org/10.1038/nature08221openalex-snapshot
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
inferredcites →https://doi.org/10.1038/nature24042openalex-snapshot
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
inferredcites →https://doi.org/10.1038/ncb1101-1014openalex-snapshot
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
inferredcites →https://doi.org/10.1038/ncb731openalex-snapshot
TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase
inferredcites →https://doi.org/10.1038/ng1494openalex-snapshot
Dysregulation of the TSC-mTOR pathway in human disease
inferredcites →https://doi.org/10.1038/nm.2354openalex-snapshot
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
inferredcites →https://doi.org/10.1038/nm.4392openalex-snapshot
GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
inferredcites →https://doi.org/10.1038/nm.4393openalex-snapshot
The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
inferredcites →https://doi.org/10.1038/nm.4394openalex-snapshot
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
inferredcites →https://doi.org/10.1038/nm1677openalex-snapshot
Tumor-induced anorexia and weight loss are mediated by the TGF-β superfamily cytokine MIC-1
inferredcites →https://doi.org/10.1038/srep00134openalex-snapshot
The metabolic footprint of aging in mice
inferredcites →https://doi.org/10.1073/pnas.0501559102openalex-snapshot
Decline in skeletal muscle mitochondrial function with aging in humans
inferredcites →https://doi.org/10.1073/pnas.1412047111openalex-snapshot
Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
inferredcites →https://doi.org/10.1073/pnas.1716173114openalex-snapshot
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
inferredcites →https://doi.org/10.1074/jbc.m211958200openalex-snapshot
Smad3 Potentiates Transforming Growth Factor β (TGFβ)-induced Apoptosis and Expression of the BH3-only Protein Bim in WEHI 231 B Lymphocytes
inferredcites →https://doi.org/10.1074/jbc.m603536200openalex-snapshot
The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity
inferredcites →https://doi.org/10.1093/bmb/ldq008openalex-snapshot
Sarcopenia: characteristics, mechanisms and functional significance
inferredcites →https://doi.org/10.1093/gerona/59.2.b108openalex-snapshot
Fiber Atrophy and Hypertrophy in Skeletal Muscles of Late Middle-Aged Fischer 344 x Brown Norway F1-Hybrid Rats
inferredcites →https://doi.org/10.1093/gerona/61.3.245openalex-snapshot
Molecular Regulation of Apoptosis in Fast Plantaris Muscles of Aged Rats
inferredcites →https://doi.org/10.1096/fj.09-146308openalex-snapshot
Increased superoxide in vivo accelerates age‐associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration
inferredcites →https://doi.org/10.1111/acel.12194openalex-snapshot
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
inferredcites →https://doi.org/10.1111/acel.12399openalex-snapshot
Apoptosis and necrosis mediate skeletal muscle fiber loss in age‐induced mitochondrial enzymatic abnormalities
inferredcites →https://doi.org/10.1111/acel.12425openalex-snapshot
Sex‐ and tissue‐specific changes in mTOR signaling with age in C57 BL /6J mice
inferredcites →https://doi.org/10.1111/acel.12943openalex-snapshot
mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00347.xopenalex-snapshot
Mitochondrial function and apoptotic susceptibility in aging skeletal muscle
inferredcites →https://doi.org/10.1111/j.1474-9726.2010.00629.xopenalex-snapshot
Macrophage inhibitory cytokine‐1 (MIC‐1/GDF15): a new marker of all‐cause mortality
inferredcites →https://doi.org/10.1111/j.1532-5415.1972.tb00787.xopenalex-snapshot
The Biologic Clock: The Mitochondria?
inferredcites →https://doi.org/10.1111/j.1748-1716.1978.tb06187.xopenalex-snapshot
Histochemical and biochemical changes in human skeletal muscle with age in sedentary males, age 22–65 years
inferredcites →https://doi.org/10.1111/j.1749-6632.1986.tb54394.xopenalex-snapshot
Studies on Giant Mitochondria
inferredcites →https://doi.org/10.1126/scisignal.2004809openalex-snapshot
mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
inferredcites →https://doi.org/10.1126/scisignal.aab3715openalex-snapshot
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
inferredcites →https://doi.org/10.1136/thoraxjnl-2014-206225openalex-snapshot
Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs
inferredcites →https://doi.org/10.1152/ajpcell.00502.2008openalex-snapshot
FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner
inferredcites →https://doi.org/10.1152/ajplung.00134.2010openalex-snapshot
TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
inferredcites →https://doi.org/10.1152/japplphysiol.01102.2001openalex-snapshot
Mitochondrial abnormalities are more frequent in muscles undergoing sarcopenia
inferredcites →https://doi.org/10.1152/physrev.1998.78.2.547openalex-snapshot
The Free Radical Theory of Aging Matures
inferredcites →https://doi.org/10.1161/01.res.0000202805.73038.48openalex-snapshot
The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury
inferredcites →https://doi.org/10.1186/1471-2164-15-91openalex-snapshot
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies
inferredcites →https://doi.org/10.1186/2044-5040-3-6openalex-snapshot
Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
inferredcites →https://doi.org/10.1210/jcem.85.12.7007openalex-snapshot
The Transforming Growth Factor-β Superfamily Cytokine Macrophage Inhibitory Cytokine-1 Is Present in High Concentrations in the Serum of Pregnant Women1
inferredcites →https://doi.org/10.1242/dev.02192openalex-snapshot
GDF3, a BMP inhibitor, regulates cell fate in stem cells and early embryos
inferredcites →https://doi.org/10.1242/dmm.012559openalex-snapshot
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models
inferredcites →https://doi.org/10.1242/jcs.125773openalex-snapshot
Regulation of mTORC1 and its impact on gene expression at a glance
inferredcites →https://doi.org/10.1371/journal.pone.0011468openalex-snapshot
Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
inferredcites →https://doi.org/10.1371/journal.pone.0023238openalex-snapshot
Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1
inferredcites →https://doi.org/10.1371/journal.pone.0055174openalex-snapshot
TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
inferredcites →https://doi.org/10.1371/journal.pone.0059006openalex-snapshot
Mitochondrial Biogenesis Drives a Vicious Cycle of Metabolic Insufficiency and Mitochondrial DNA Deletion Mutation Accumulation in Aged Rat Skeletal Muscle Fibers
inferredcites →https://doi.org/10.1371/journal.pone.0100370openalex-snapshot
The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
inferredcites →https://doi.org/10.1371/journal.pone.0148709openalex-snapshot
GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction
inferredcites →https://doi.org/10.1529/biophysj.108.130005openalex-snapshot
Aging Enhances Indirect Flight Muscle Fiber Performance yet Decreases Flight Ability in Drosophila
inferredcites →https://doi.org/10.1530/ey.15.15.8openalex-snapshot
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
inferredcites →https://doi.org/10.2106/00004623-200100001-00004openalex-snapshot
Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development
inferredcites →https://doi.org/10.2165/00007256-200535060-00002openalex-snapshot
The Role of Apoptosis in Age-Related Skeletal Muscle Atrophy
inferredcites →https://doi.org/10.3109/08977194.2011.607137openalex-snapshot
The TGF-β superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism
inferredcites →https://doi.org/10.3390/ijms18050986openalex-snapshot
Oral Treatment with the Ghrelin Receptor Agonist HM01 Attenuates Cachexia in Mice Bearing Colon-26 (C26) Tumors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Therapeutic Use of Selected Food Samples (Amla, Peanut, Tomato, Moringa, Guava, Pomegranate) in Reducing Experimental Chemical Stress as Well as Their Total Phenol and Antioxidant Properties
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Oleuropein Aglycone Modulates Oxidative Stress and Autophagy‐Related Pathways in Human Skeletal Muscle Cells
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Physiological Systems in Promoting Frailty
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Physiological Systems in Promoting Frailty
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Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA (D257A/D257A) mice
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Changes in systemic GDF15 across the adult lifespan and their impact on maximal muscle power: the Copenhagen Sarcopenia Study
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Self‐transducible LRS‐UNE‐L peptide enhances muscle regeneration
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Activation of eIF4E ‐binding‐protein‐1 rescues mTORC1 ‐induced sarcopenia by expanding lysosomal degradation capacity
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Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions
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Mitochondrial Dysfunction in Age‐Related Metabolic Disorders
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Satellite cell activation and retention of muscle regenerative potential after long-term denervation
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GDF15, an update of the physiological and pathological roles it plays: a review
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Site-specific myopathy differences between spine and limb muscles: a kyphotic TSC1mKO mice model study
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Mechanism of maternal gestational diabetes mellitus exacerbating myocardial injury in male offspring by upregulating growth differentiation factor 15 to promote mitochondrial dysfunction
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The transcription regulator ATF4 is a mediator of skeletal muscle aging
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Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
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Mitochondria–sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass
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The Current Landscape of Pharmacotherapies for Sarcopenia
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The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review
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Metabolic Regulation of Stem Cells in Aging
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Hyperactivation of Transforming Growth Factor-β–Activated Kinase 1 Causes Skeletal Muscle Pathology Reminiscent of Inflammatory Myopathies
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Implications of Sarcopenia in Patients With Structural Valve Pathology
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The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing
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Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis
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The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging
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GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
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Oxidative stress: Roles in skeletal muscle atrophy
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Synergistic effects of fucoidan from Undaria pinnatifida and grouper peptides on glucocorticoid-induced muscle atrophy via protein turnover modulation
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Nutrition for Older Adults: Perspectives on Dietary Guidance for Healthy Aging
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Association between GDF-15 and sarcopenia progression in older adults: results from a population-based study
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Tryptophan supplementation and high-intensity interval training prevent muscle atrophy and adipose tissue inflammation in high-fat-fed aged rats
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Streptococcus salivarius subsp. thermophilus CCFM1095 alleviates age-related muscle mass loss and function decline via gut-muscle axis
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Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1
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Nrf2 contributes to the benefits of exercise interventions on age-related skeletal muscle disorder via regulating Drp1 stability and mitochondrial fission
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Interplay between mTORC1 signaling and iron homeostasis in muscle atrophy
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Crosstalk between epigenetics and mTOR as a gateway to new insights in pathophysiology and treatment of Alzheimer's disease
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Reduced protein intake and aging affects the sustainment of hematopoiesis by impairing bone marrow mesenchymal stem cells
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Dimethyl fumarate attenuates lipopolysaccharide-induced mitochondrial injury by activating Nrf2 pathway in cardiomyocytes
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MicroRNAs associated with signaling pathways and exercise adaptation in sarcopenia
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Defective mitochondrial quality control in the aging of skeletal muscle
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Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study
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Muscle aging and sarcopenia: The pathology, etiology, and most promising therapeutic targets
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Sestrins regulate muscle stem cell metabolic homeostasis
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Emerging molecular mediators and targets for age-related skeletal muscle atrophy
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Regulation of muscle hypertrophy: Involvement of the Akt-independent pathway and satellite cells in muscle hypertrophy
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Downregulation of CASTOR1 Inhibits Heat-Stress-Induced Apoptosis and Promotes Casein and Lipid Synthesis in Mammary Epithelial Cells
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Mechanisms Underlying the Effects of the Green Tea Polyphenol EGCG in Sarcopenia Prevention and Management
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The immunology of sickness metabolism
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The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
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Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy
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Muscle 4EBP1 activation modifies the structure and function of the neuromuscular junction in mice
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mTORC1 in energy expenditure: consequences for obesity
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Myofibrillar protein synthesis rates are increased in chronically exercised skeletal muscle despite decreased anabolic signaling
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Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
inferred← citeshttps://doi.org/10.1038/s43587-026-01190-3openalex-snapshot
Contractile myografts confer systemic anti-aging benefits
inferred← citeshttps://doi.org/10.1073/pnas.2508893122openalex-snapshot
Exercise suppresses DEAF1 to normalize mTORC1 activity and reverse muscle aging
inferred← citeshttps://doi.org/10.1080/07853890.2023.2284890openalex-snapshot
Activation of the Nrf-2/HO-1 signalling axis can alleviate metabolic syndrome in cardiovascular disease
inferred← citeshttps://doi.org/10.1080/15548627.2021.2016255openalex-snapshot
Simultaneous loss of TSC1 and DEPDC5 in skeletal and cardiac muscles produces early-onset myopathy and cardiac dysfunction associated with oxidative damage and SQSTM1/p62 accumulation
inferred← citeshttps://doi.org/10.1080/87559129.2023.2274487openalex-snapshot
Phytonutrients as Potential Dietary Supplements to Ameliorate Sarcopenia via the Involvement of Autophagic Pathway
inferred← citeshttps://doi.org/10.1088/2043-6262/ac42c7openalex-snapshot
Potential of nanoparticles and nanopolymers in treatment of age-associated diseases
inferred← citeshttps://doi.org/10.1089/thy.2020.0034openalex-snapshot
Growth Differentiation Factor 15 is a Cancer Cell-Induced Mitokine That Primes Thyroid Cancer Cells for Invasiveness
inferred← citeshttps://doi.org/10.1093/gerona/glad257openalex-snapshot
Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults
inferred← citeshttps://doi.org/10.1093/gerona/glaf231openalex-snapshot
Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats
inferred← citeshttps://doi.org/10.1093/jn/nxab440openalex-snapshot
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
inferred← citeshttps://doi.org/10.1096/fj.202601212ropenalex-snapshot
TAK1 Regulates Skeletal Muscle Mass, Hypertrophic Signaling, and Metabolic Homeostasis in Male and Female Mice
inferred← citeshttps://doi.org/10.1097/pas.0000000000002608openalex-snapshot
Unique Thyroid Carcinoma With Somatic Inactivating TSC2 Mutations, Follicular and Melanocytic Differentiation and Distinct Morphologic Features
inferred← citeshttps://doi.org/10.1098/rsob.200048openalex-snapshot
Satellite cells in ageing: use it or lose it
inferred← citeshttps://doi.org/10.1101/2021.01.22.21250336openalex-snapshot
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence
inferred← citeshttps://doi.org/10.1101/2021.05.28.446097openalex-snapshot
Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
inferred← citeshttps://doi.org/10.1101/2024.04.01.587665openalex-snapshot
mTORC1-dependent SOCE activity regulates synaptic gene expression and muscle response to denervation
inferred← citeshttps://doi.org/10.1101/2025.08.29.673011openalex-snapshot
Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle
inferred← citeshttps://doi.org/10.1111/acel.12970openalex-snapshot
Longevity‐related molecular pathways are subject to midlife “switch” in humans
inferred← citeshttps://doi.org/10.1111/acel.13304openalex-snapshot
Mtor inhibition by INK128 extends functions of the ovary reconstituted from germline stem cells in aging and premature aging mice
inferred← citeshttps://doi.org/10.1111/acel.13528openalex-snapshot
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
inferred← citeshttps://doi.org/10.1111/acel.13752openalex-snapshot
Depletion of growth differentiation factor 15 ( GDF15 ) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts
inferred← citeshttps://doi.org/10.1111/acel.70589openalex-snapshot
Senescent Myoblasts Exhibit ROS‐Dependent Akt‐mTORC1 Dysregulation and Are Susceptible to Reductive Stress‐Induced Cell Death
inferred← citeshttps://doi.org/10.1111/ggi.14021openalex-snapshot
Serum growth differentiation factor 15 level is associated with muscle strength and lower extremity function in older patients with cardiometabolic disease
inferred← citeshttps://doi.org/10.1111/nyas.15389openalex-snapshot
Hibernation as a model for skeletal muscle preservation
inferred← citeshttps://doi.org/10.1113/jp285616openalex-snapshot
Current limitations and future opportunities of tracer studies of muscle ageing
inferred← citeshttps://doi.org/10.1123/japa.2025-0321openalex-snapshot
Rapid Strength in Adults Over 90 Years Declines More Than Maximal Strength and Skeletal Muscle Mass
inferred← citeshttps://doi.org/10.1152/ajpcell.00528.2025openalex-snapshot
Making sense of MYC in skeletal muscle: location, duration, and magnitude
inferred← citeshttps://doi.org/10.1152/function.039.2026openalex-snapshot
Constitutive mTORC1 activation in skeletal muscle increases inflammation but is not sufficient to impair glucose tolerance
inferred← citeshttps://doi.org/10.1152/japplphysiol.00203.2025openalex-snapshot
The role of adipose tissue in critical illness-induced skeletal muscle wasting—new considerations for treatment approaches
inferred← citeshttps://doi.org/10.1152/japplphysiol.00289.2026openalex-snapshot
Research into resistance training response heterogeneity: a summary of the 2025 conference at the University of Jyväskylä
inferred← citeshttps://doi.org/10.1152/japplphysiol.00730.2025openalex-snapshot
Hyperactive muscle mTORC1 attenuates functional adaptations to endurance training despite alterations in mitochondrial and lipid profiles
inferred← citeshttps://doi.org/10.1152/japplphysiol.00987.2024openalex-snapshot
Constitutively active mTORC1 signaling modifies the skeletal muscle metabolome and lipidome response to exercise
inferred← citeshttps://doi.org/10.1152/physrev.00039.2022openalex-snapshot
Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions
inferred← citeshttps://doi.org/10.1155/ijne/8817404openalex-snapshot
Circulating Muscle Markers for Sarcopenia in Peritoneal Dialysis
inferred← citeshttps://doi.org/10.1172/jci.insight.200396openalex-snapshot
Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexia
inferred← citeshttps://doi.org/10.1172/jci.insight.203167openalex-snapshot
Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathy
inferred← citeshttps://doi.org/10.1177/19458924231152683openalex-snapshot
MiR-214 Expression Is Elevated in Chronic Rhinosinusitis Mucosa and Regulates Lipopolysaccharide-Mediated Responses in Undifferentiated Human Nasal Epithelial Cell Culture
inferred← citeshttps://doi.org/10.1186/s12877-025-06564-7openalex-snapshot
Altered serum short-chain fatty acids in sarcopenia among Chinese elderly women: a case–control study
inferred← citeshttps://doi.org/10.1186/s12915-023-01779-9openalex-snapshot
Geroprotector drugs and exercise: friends or foes on healthy longevity?
inferred← citeshttps://doi.org/10.1186/s12986-024-00839-3openalex-snapshot
Associations of serum arginine acid with sarcopenia in Chinese eldely women
inferred← citeshttps://doi.org/10.1186/s13045-023-01454-0openalex-snapshot
Cancer cachexia: molecular mechanisms and treatment strategies
inferred← citeshttps://doi.org/10.1186/s13395-025-00397-zopenalex-snapshot
Signaling networks governing skeletal muscle growth, atrophy, and cachexia
inferred← citeshttps://doi.org/10.1210/endocr/bqad176openalex-snapshot
Mechanisms of Ovarian Cancer-Associated Cachexia
inferred← citeshttps://doi.org/10.1210/endrev/bnad004openalex-snapshot
Intracellular to Interorgan Mitochondrial Communication in Striated Muscle in Health and Disease
inferred← citeshttps://doi.org/10.1242/dmm.049916openalex-snapshot
Vemurafenib improves muscle histopathology in a mouse model of LAMA2-related congenital muscular dystrophy
inferred← citeshttps://doi.org/10.1249/jes.0000000000000372openalex-snapshot
UBR5: A New Player in Protein Quality Control for Skeletal Muscle Growth and Remodeling
inferred← citeshttps://doi.org/10.1254/fpj19151openalex-snapshot
Role of skeletal muscle homeostasis of functional food material
inferred← citeshttps://doi.org/10.12677/pi.2026.151004openalex-snapshot
Pathological Mechanism and Drug Prevention and Treatment of Skeletal Muscle Atrophy
inferred← citeshttps://doi.org/10.12688/f1000research.17196.1openalex-snapshot
mTOR as a central regulator of lifespan and aging
inferred← citeshttps://doi.org/10.12703/r/11-32openalex-snapshot
The role of mTORC1 in the regulation of skeletal muscle mass
inferred← citeshttps://doi.org/10.14336/ad.2023.0210openalex-snapshot
Mitochondria Transplantation from Stem Cells for Mitigating Sarcopenia
inferred← citeshttps://doi.org/10.18632/aging.102176openalex-snapshot
Rapamycin protects aging muscle
inferred← citeshttps://doi.org/10.18632/aging.102355openalex-snapshot
Rapamycin for longevity: opinion article
inferred← citeshttps://doi.org/10.18632/aging.103987openalex-snapshot
Caloric restriction: implications for sarcopenia and potential mechanisms
inferred← citeshttps://doi.org/10.18632/aging.204435openalex-snapshot
Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence
inferred← citeshttps://doi.org/10.18632/aging.206423openalex-snapshot
mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes
inferred← citeshttps://doi.org/10.20307/nps.2026.32.2.120openalex-snapshot
Assessment of Antioxidant and Neuroprotective Effects of Phyllanthus emblica Extract in a Reserpine-Induced Oxidative Stress Model
inferred← citeshttps://doi.org/10.21037/apm-23-332openalex-snapshot
Hepatocellular carcinoma and sarcopenia: a narrative review
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3835855/v1openalex-snapshot
Polystyrene microplastics exposure induces growth toxicity and disturbs skeletal muscle angiogenesis via THBS1
inferred← citeshttps://doi.org/10.22424/jdsb.2026.44.1.1openalex-snapshot
Dairy Foods as a Dietary Strategy for Muscle Health in Older Adults: An Integrative Clinical and Mechanistic Review
inferred← citeshttps://doi.org/10.31083/j.jin2002035openalex-snapshot
Combining reverse end-to-side neurorrhaphy with rapamycin treatment on chronically denervated muscle in rats
inferred← citeshttps://doi.org/10.3389/fendo.2022.966644openalex-snapshot
Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00915openalex-snapshot
GDF15 Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1597222openalex-snapshot
Resistance training alleviates muscle atrophy and muscle dysfunction by reducing inflammation and regulating compromised autophagy in aged skeletal muscle
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1808488openalex-snapshot
Immunometabolic mechanisms of osteosarcopenic obesity: chronic inflammation, trained immunity, and systemic immune dysregulation
inferred← citeshttps://doi.org/10.3389/fmed.2026.1920342openalex-snapshot
Association of Serum GDF-15 with Bone and Muscle Parameters in Community-Dwelling Individuals
inferred← citeshttps://doi.org/10.3389/fnmol.2020.00162openalex-snapshot
The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?
inferred← citeshttps://doi.org/10.3389/fphar.2021.695687openalex-snapshot
The Mitochondrial Na+/Ca2+ Exchanger Inhibitor CGP37157 Preserves Muscle Structure and Function to Increase Lifespan and Healthspan in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.3389/fphar.2026.1733798openalex-snapshot
Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets
inferred← citeshttps://doi.org/10.3389/fphar.2026.1877665openalex-snapshot
Atractylodes chinensis polysaccharides downregulate RHEB to confer splenoprotective effects against aging-associated disorders
inferred← citeshttps://doi.org/10.3389/fphys.2022.892749openalex-snapshot
Contribution of muscle satellite cells to sarcopenia
inferred← citeshttps://doi.org/10.3389/fphys.2023.1132830openalex-snapshot
The crosstalk between BAT thermogenesis and skeletal muscle dysfunction
inferred← citeshttps://doi.org/10.3389/fphys.2024.1338875openalex-snapshot
Unlocking the potential of exercise: harnessing myokines to delay musculoskeletal aging and improve cognitive health
inferred← citeshttps://doi.org/10.3389/fphys.2025.1620294openalex-snapshot
Acute effects of blood flow restriction training at various arterial occlusion pressures on muscle activation, blood lactate responses, and RPE in healthy adult males
inferred← citeshttps://doi.org/10.3389/fpubh.2025.1611571openalex-snapshot
Trends and frontiers in disuse muscle atrophy research
inferred← citeshttps://doi.org/10.3389/fragi.2021.738512openalex-snapshot
Evidence that C/EBP-β LAP Increases Fat Metabolism and Protects Against Diet-Induced Obesity in Response to mTOR Inhibition
inferred← citeshttps://doi.org/10.3389/fragi.2022.1005848openalex-snapshot
The non-modifiable factors age, gender, and genetics influence resistance exercise
inferred← citeshttps://doi.org/10.3389/fragi.2025.1696473openalex-snapshot
Dietary polyphenols and sarcopenia: epigenetic mechanisms and geroscience perspectives for muscle health in aging
inferred← citeshttps://doi.org/10.3390/ani15172615openalex-snapshot
Super-Enhancer Drives THBS3 Expression to Regulate the Proliferation and Differentiation of Bovine Muscle Stem Cells
inferred← citeshttps://doi.org/10.3390/antiox11091642openalex-snapshot
Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction
inferred← citeshttps://doi.org/10.3390/antiox13050557openalex-snapshot
Physical Activity and Oxidative Stress in Aging
inferred← citeshttps://doi.org/10.3390/antiox13111359openalex-snapshot
TORC1 Regulates Thermotolerance via Modulating Metabolic Rate and Antioxidant Capacity in Scallop Argopecten irradians irradians
inferred← citeshttps://doi.org/10.3390/cancers18010104openalex-snapshot
Systematic Exploration of Molecular Mechanisms and Natural Herbal Therapeutic Strategies for Cancer Cachexia
inferred← citeshttps://doi.org/10.3390/cells12020249openalex-snapshot
Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of Sarcopenia
inferred← citeshttps://doi.org/10.3390/cells14080619openalex-snapshot
Induced Pluripotent Stem Cells-Based Regenerative Therapies in Treating Human Aging-Related Functional Decline and Diseases
inferred← citeshttps://doi.org/10.3390/cells15090744openalex-snapshot
Cell Death in Skeletal Muscle Diseases: Diverse Roles and Pathological Processes
inferred← citeshttps://doi.org/10.3390/dietetics5040055openalex-snapshot
Mitochondria-Targeted Nutraceuticals as Metabolic Adjuncts to Physical Rehabilitation in Older Adults with Sarcopenia or Frailty: A Narrative Review
inferred← citeshttps://doi.org/10.3390/genes12050688openalex-snapshot
Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links
inferred← citeshttps://doi.org/10.3390/genes16080948openalex-snapshot
Muscle Aging Heterogeneity: Genetic and Structural Basis of Sarcopenia Resistance
inferred← citeshttps://doi.org/10.3390/ijms20236062openalex-snapshot
Analysis of the Molecular Signaling Signatures of Muscle Protein Wasting Between the Intercostal Muscles and the Gastrocnemius Muscles in db/db Mice
inferred← citeshttps://doi.org/10.3390/ijms21134759openalex-snapshot
Signaling Pathways That Control Muscle Mass
inferred← citeshttps://doi.org/10.3390/ijms22010091openalex-snapshot
The Interplay between Mitochondrial Morphology and Myomitokines in Aging Sarcopenia
inferred← citeshttps://doi.org/10.3390/ijms23158713openalex-snapshot
Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging
inferred← citeshttps://doi.org/10.3390/ijms23158747openalex-snapshot
mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
inferred← citeshttps://doi.org/10.3390/ijms232213823openalex-snapshot
Mammalian Target of Rapamycin (mTOR) Signaling at the Crossroad of Muscle Fiber Fate in Sarcopenia
inferred← citeshttps://doi.org/10.3390/ijms24010297openalex-snapshot
The Importance of mTORC1-Autophagy Axis for Skeletal Muscle Diseases
inferred← citeshttps://doi.org/10.3390/ijms242316951openalex-snapshot
Fibroblast Growth Factor 21: A Fascinating Perspective on the Regulation of Muscle Metabolism
inferred← citeshttps://doi.org/10.3390/ijms25042052openalex-snapshot
Mitochondrial Quantity and Quality in Age-Related Sarcopenia
inferred← citeshttps://doi.org/10.3390/ijms25137060openalex-snapshot
Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage
inferred← citeshttps://doi.org/10.3390/ijms26136079openalex-snapshot
Cortisol-Induced Chromatin Remodeling and Gene Expression in Skeletal Muscle of Rainbow Trout: Integrative ATAC-Seq and RNA-Seq Analysis
inferred← citeshttps://doi.org/10.3390/ijms26157115openalex-snapshot
Protective Effects of Regular Physical Activity: Differential Expression of FGF21, GDF15, and Their Receptors in Trained and Untrained Individuals
inferred← citeshttps://doi.org/10.3390/ijms26157573openalex-snapshot
Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise
inferred← citeshttps://doi.org/10.3390/jcm10184099openalex-snapshot
Comparison of SARC-F Score among Gastrointestinal Diseases
inferred← citeshttps://doi.org/10.3390/medicina62030609openalex-snapshot
The Impact of Inspiratory Muscle Training on Diaphragm Thickness in Healthy Adults: A Systematic Review and Meta-Regression
inferred← citeshttps://doi.org/10.3390/medsci14050538openalex-snapshot
A Six-Week Multimodal Functional Training Program Improves Physical Function and Modulates Redox Homeostasis in Older Women
inferred← citeshttps://doi.org/10.3390/molecules26020407openalex-snapshot
Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
inferred← citeshttps://doi.org/10.3390/muscles4030026openalex-snapshot
Mechanisms Underlying Muscle-Related Diseases and Aging: Insights into Pathophysiology and Therapeutic Strategies
inferred← citeshttps://doi.org/10.3390/nu11092094openalex-snapshot
Native Whey Induces Similar Adaptation to Strength Training as Milk, despite Higher Levels of Leucine, in Elderly Individuals
inferred← citeshttps://doi.org/10.3390/nu15081853openalex-snapshot
Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle–Brain Axis
inferred← citeshttps://doi.org/10.3390/nu18071161openalex-snapshot
Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review
inferred← citeshttps://doi.org/10.3390/ph19071091openalex-snapshot
Mechanisms of Impaired Skeletal Muscle Regeneration and Therapeutic Approaches in Aging and Chronic Disease
inferred← citeshttps://doi.org/10.34133/research.0901openalex-snapshot
Cancer-Associated Fibroblast-Derived GDF15 Induces Oxidative Stress and Neutrophil Infiltration in Head and Neck Squamous Cell Carcinoma through the PI3K/AKT/STAT3 Axis Cascade
inferred← citeshttps://doi.org/10.37506/ijfmt.v14i4.12076openalex-snapshot
Importance of FoxO3 Level in Progression of Nodal Osteoarthritis Disease
inferred← citeshttps://doi.org/10.3892/ijmm.2021.4989openalex-snapshot
Pathophysiology and mechanisms of primary sarcopenia (Review)
inferred← citeshttps://doi.org/10.5772/intechopen.94276openalex-snapshot
Mineral Deficiencies: A Root Cause for Reduced Longevity in Mammals
inferred← citeshttps://doi.org/10.64898/2026.05.04.722644openalex-snapshot
Nuclear Speckles Regulate Splicing During Muscle Stem Cell Activation and Aging
inferred← citeshttps://doi.org/10.64898/2026.07.02.736117openalex-snapshot
Rapamycin Mitigates a Sex-biased Convergent Aging Trajectory
inferred← citeshttps://doi.org/10.70675/19dc039az0402z4e9az85d2zb006131eb3e9openalex-snapshot
Analyse des réseaux transcriptomiques et des communications cellulaires au cours de l'hypertrophie du muscle strié squelettique
inferred← citeshttps://doi.org/10.70675/1a11a81bzf829z4ba2zba9az6f3f4841c773openalex-snapshot
Identification of new levers to fight muscle atrophy : benefit of the hibernating brown bear model
inferred← citeshttps://doi.org/10.7554/elife.108680openalex-snapshot
Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle
inferred← citeshttps://doi.org/10.7554/elife.108680.1openalex-snapshot
Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle
inferred← citeshttps://doi.org/10.7554/elife.108680.2openalex-snapshot
Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle
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