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4‐Hydroxynonenal‐induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi‐mediated anti‐inflammatory effects and Gβγ‐mediated cell death

https://doi.org/10.1111/bph.14174
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Age-Related Macular Degeneration and Smoking
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4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells
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Effect of 4-Hydroxynonenal on Superoxide Anion Production from Primed Human Neutrophils
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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity
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Serotonin disturbs colon epithelial tolerance of commensal E. coli by increasing NOX2-derived superoxide
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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
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4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases
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4-Hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells
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Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-Terminal protein kinase pathway
inferredcites →https://doi.org/10.1016/s0098-2997(03)00020-7openalex-snapshot
Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity
inferredcites →https://doi.org/10.1016/s0161-6420(88)33073-3openalex-snapshot
Niacin Maculopathy
inferredcites →https://doi.org/10.1016/s0378-1119(00)00220-1openalex-snapshot
Regulation of the human fas promoter by YB-1, Purα and AP-1 transcription factors
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Michael Addition-Type 4-Hydroxy-2-nonenal Adducts in Modified Low-Density Lipoproteins: Markers for Atherosclerosis
inferredcites →https://doi.org/10.1021/bi060780+openalex-snapshot
Regulation of CD95 (Fas) Expression and Fas-Mediated Apoptotic Signaling in HLE B-3 Cells by 4-Hydroxynonenal
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4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas
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Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
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4-Hydroxynonenal Induces Apoptosis via Caspase-3 Activation and CytochromecRelease
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Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
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Downregulation of p22phox in Retinal Pigment Epithelial Cells Inhibits Choroidal Neovascularization in Mice
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The FTMap family of web servers for determining and characterizing ligand-binding hot spots of proteins
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Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization
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4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
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(d)-β-Hydroxybutyrate Inhibits Adipocyte Lipolysis via the Nicotinic Acid Receptor PUMA-G
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Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid
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4-Hydroxynonenal As a Biological Signal: Molecular Basis and Pathophysiological Implications
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Silencer and Enhancer Regions in the Human CD95 (Fas/APO-1) Gene with Sequence Similarity to the Granulocyte-Macrophage Colony-Stimulating Factor Promoter: Binding of Single Strand-Specific Silencer Factors and AP-1 and NF-AT-Like Enhancer Factors
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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
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Resveratrol Protects Against 4-Hydroxynonenal-Induced Apoptosis by Blocking JNK and c-JUN/AP-1 Signaling
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Experimental design and analysis and their reporting: new guidance for publication in BJP
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage‐gated ion channels
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4‐Hydroxynonenal‐induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi‐mediated anti‐inflammatory effects and Gβγ‐mediated cell death
inferredcites →https://doi.org/10.1111/j.1365-2036.2007.03562.xopenalex-snapshot
Review article: the role of butyrate on colonic function
inferredcites →https://doi.org/10.1111/j.1742-7843.2011.00834.xopenalex-snapshot
4‐Hydroxynonenal Induces Mitochondrial‐Mediated Apoptosis and Oxidative Stress in SH‐SY5Y Human Neuronal Cells
inferredcites →https://doi.org/10.1111/j.1749-6632.2009.04720.xopenalex-snapshot
Protective Effects of Red Wine Flavonols on 4‐Hydroxynonenal‐Induced Apoptosis in PC12 Cells
inferredcites →https://doi.org/10.1124/jpet.102.033522openalex-snapshot
4-Hydroxynonenal Decreases Interleukin-6 Expression and Protein Production in Primary Rat Kupffer Cells by Inhibiting Nuclear Factor-κB Activation
inferredcites →https://doi.org/10.1124/mol.105.015750openalex-snapshot
Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G)
inferredcites →https://doi.org/10.1152/ajpgi.00543.2011openalex-snapshot
Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells
inferredcites →https://doi.org/10.1158/0008-5472.can-08-4466openalex-snapshot
GPR109A Is a G-protein–Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon
inferredcites →https://doi.org/10.1158/1055-9965.epi-06-0085openalex-snapshot
New Marker of Colon Cancer Risk Associated with Heme Intake: 1,4-Dihydroxynonane Mercapturic Acid
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Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
inferredcites →https://doi.org/10.1161/atvbaha.111.241836openalex-snapshot
Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent Mechanisms
inferredcites →https://doi.org/10.1167/iovs.06-1058openalex-snapshot
Age-Related Macular Degeneration and Retinal Protein Modification by 4-Hydroxy-2-nonenal
inferredcites →https://doi.org/10.1167/iovs.09-3755openalex-snapshot
Apical-to-Basolateral Transcytosis of Photoreceptor Outer Segments Induced by Lipid Peroxidation Products in Human Retinal Pigment Epithelial Cells
inferredcites →https://doi.org/10.1167/iovs.11-8447openalex-snapshot
GPR109A as an Anti-Inflammatory Receptor in Retinal Pigment Epithelial Cells and Its Relevance to Diabetic Retinopathy
inferredcites →https://doi.org/10.1172/jci41651openalex-snapshot
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
inferredcites →https://doi.org/10.1177/0960327111432500openalex-snapshot
Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells
inferredcites →https://doi.org/10.1179/135100007x162329openalex-snapshot
Apoptosis signalling by 4-hydroxynonenal: a role for JNK–c-Jun/AP-1 pathway
inferredcites →https://doi.org/10.1186/s12943-015-0379-0openalex-snapshot
NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7
inferredcites →https://doi.org/10.1242/jcs.1993.supplement_17.27openalex-snapshot
The retinal pigment epithelium: a versatile partner in vision
inferredcites →https://doi.org/10.1371/journal.pone.0019052openalex-snapshot
Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4795887openalex-extracted
Cinnamic Acid Improves Skeletal Muscle Hypertrophy and Metabolism Through Activation of Gpr109a/Pka Pathway
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A Sustainable Retinal Drug Co‐Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.109963openalex-snapshot
Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis
inferred← citeshttps://doi.org/10.1016/j.dci.2022.104562openalex-snapshot
Hydroxycarboxylic acid receptor 2 (HCA2) agonists induce NET formation and MMP-9 release from bovine polymorphonuclear leukocytes
inferred← citeshttps://doi.org/10.1016/j.exer.2019.107792openalex-snapshot
4-HNE induces proinflammatory cytokines of human retinal pigment epithelial cells by promoting extracellular efflux of HSP70
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.03.017openalex-snapshot
4-Hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone induces apoptosis in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2022.06.008openalex-snapshot
Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.11.011openalex-snapshot
Strategic delivery of rapamycin and ranibizumab with intravitreal hydrogel depot disrupts multipathway-driven angiogenesis loop for boosted wAMD therapy
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2023.109456openalex-snapshot
Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1)
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156851openalex-snapshot
Cinnamic acid-GPR109A pathway improves skeletal muscle hypertrophy and metabolism
inferred← citeshttps://doi.org/10.1017/s0007114519002216openalex-snapshot
Niacin nutrition and rumen-protected niacin supplementation in dairy cows: an updated review
inferred← citeshttps://doi.org/10.1021/acs.jproteome.8b00799openalex-snapshot
A Large-Scale, Multi-Center Urine Biomarkers Identification of Coronary Heart Disease in TCM Syndrome Differentiation
inferred← citeshttps://doi.org/10.1038/nrd.2018.135openalex-snapshot
Targeting G protein-coupled receptor signalling by blocking G proteins
inferred← citeshttps://doi.org/10.1038/s42003-020-01564-2openalex-snapshot
GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice
inferred← citeshttps://doi.org/10.1039/c9fo00273aopenalex-snapshot
Cyanidin-3-glucoside attenuates 4-hydroxynonenal- and visible light-induced retinal damage in vitro and in vivo
inferred← citeshttps://doi.org/10.1093/advances/nmaa072openalex-snapshot
Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases
inferred← citeshttps://doi.org/10.1096/fj.201801951ropenalex-snapshot
Niacin fine‐tunes energy homeostasis through canonical GPR109A signaling
inferred← citeshttps://doi.org/10.1101/2021.01.07.425690openalex-snapshot
Hydroxynonenal causes Langerhans cell degeneration in the pancreas of Japanese macaque monkeys
inferred← citeshttps://doi.org/10.1371/journal.pone.0245702openalex-snapshot
Hydroxynonenal causes Langerhans cell degeneration in the pancreas of Japanese macaque monkeys
inferred← citeshttps://doi.org/10.3389/fimmu.2021.606384openalex-snapshot
Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis
inferred← citeshttps://doi.org/10.3390/cimb48010092openalex-snapshot
Interferon Regulatory Factors in Alcohol-Associated Liver Disease: Cell-Type Programs, Danger Signaling, and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.3390/foods12091894openalex-snapshot
Effect of Lard or Plus Soybean Oil on Markers of Liver Function in Healthy Subjects: A Randomized Controlled-Feeding Trial
inferred← citeshttps://doi.org/10.3390/ijms241713527openalex-snapshot
JNK Cascade-Induced Apoptosis—A Unique Role in GqPCR Signaling
inferred← citeshttps://doi.org/10.3390/nu16234171openalex-snapshot
4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases
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