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4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/neu.20086openalex-snapshot

Expression of a dominant negative form of Daxxin vivo rescues motoneurons from Fas (CD95)-induced cell death

inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

inferredcites →https://doi.org/10.1007/978-3-540-47648-1_1536openalex-snapshot

Death-Inducing Signaling Complex

inferredcites →https://doi.org/10.1016/0022-1759(83)90303-4openalex-snapshot

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

inferredcites →https://doi.org/10.1016/0891-5849(91)90192-6openalex-snapshot

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

inferredcites →https://doi.org/10.1016/j.cellsig.2004.09.014openalex-snapshot

Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.05.023openalex-snapshot

4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.05.033openalex-snapshot

Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2005.10.056openalex-snapshot

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

inferredcites →https://doi.org/10.1016/s0076-6879(05)01024-4openalex-snapshot

Regulation of 4‐Hydroxynonenal Mediated Signaling By Glutathione S‐Transferases

inferredcites →https://doi.org/10.1016/s0092-8674(00)81588-3openalex-snapshot

Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1

inferredcites →https://doi.org/10.1016/s0092-8674(00)81874-7openalex-snapshot

Apoptosis by Death Factor

inferredcites →https://doi.org/10.1016/s0098-2997(03)00017-7openalex-snapshot

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

inferredcites →https://doi.org/10.1016/s0098-2997(03)00018-9openalex-snapshot

4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions

inferredcites →https://doi.org/10.1016/s0098-2997(03)00020-7openalex-snapshot

Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity

inferredcites →https://doi.org/10.1016/s0098-2997(03)00021-9openalex-snapshot

4-Hydroxynonenal from pathology to physiology

inferredcites →https://doi.org/10.1016/s0891-5849(02)00991-7openalex-snapshot

4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells

inferredcites →https://doi.org/10.1016/s0960-9822(07)00420-4openalex-snapshot

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

inferredcites →https://doi.org/10.1021/bi060780+openalex-snapshot

Regulation of CD95 (Fas) Expression and Fas-Mediated Apoptotic Signaling in HLE B-3 Cells by 4-Hydroxynonenal

inferredcites →https://doi.org/10.1021/ja057358lopenalex-snapshot

Inhibition of Thioredoxin and Thioredoxin Reductase by 4-Hydroxy-2-nonenal in Vitro and in Vivo

inferredcites →https://doi.org/10.1021/tx034248oopenalex-snapshot

Induction of Apoptosis in Colorectal Carcinoma Cells Treated with 4-Hydroxy-2-nonenal and Structurally Related Aldehydic Products of Lipid Peroxidation

inferredcites →https://doi.org/10.1021/tx049838gopenalex-snapshot

Inhibition of Hsp72-Mediated Protein Refolding by 4-Hydroxy-2-nonenal

inferredcites →https://doi.org/10.1038/35087019openalex-snapshot

TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

inferredcites →https://doi.org/10.1038/nrc864openalex-snapshot

Live or let die: the cell's response to p53

inferredcites →https://doi.org/10.1038/nrm2240openalex-snapshot

Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?

inferredcites →https://doi.org/10.1038/sj.bjp.0703981openalex-snapshot

Phenolic antioxidants trolox and caffeic acid modulate the oxidized LDL‐induced EGF‐receptor activation

inferredcites →https://doi.org/10.1038/sj.cdd.4401559openalex-snapshot

Daxx is required for stress-induced cell death and JNK activation

inferredcites →https://doi.org/10.1038/sj.onc.1203385openalex-snapshot

EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes

inferredcites →https://doi.org/10.1073/pnas.0304768101openalex-snapshot

DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity

inferredcites →https://doi.org/10.1073/pnas.89.12.5611openalex-snapshot

Selective cleavage of thioether linkage in proteins modified with 4-hydroxynonenal.

inferredcites →https://doi.org/10.1074/jbc.m106838200openalex-snapshot

Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress

inferredcites →https://doi.org/10.1074/jbc.m111763200openalex-snapshot

The Interaction of Pax5 (BSAP) with Daxx Can Result in Transcriptional Activation in B Cells

inferredcites →https://doi.org/10.1074/jbc.m305766200openalex-snapshot

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

inferredcites →https://doi.org/10.1074/jbc.m403499200openalex-snapshot

A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus

inferredcites →https://doi.org/10.1074/jbc.m409795200openalex-snapshot

Epidermal Peroxisome Proliferator-activated Receptor γ as a Target for Ultraviolet B Radiation

inferredcites →https://doi.org/10.1080/15216540252774711openalex-snapshot

AP‐1: Linking Hydrogen Peroxide and Oxidative Stress

inferredcites →https://doi.org/10.1093/emboj/17.9.2596openalex-snapshot

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

inferredcites →https://doi.org/10.1093/emboj/18.13.3702openalex-snapshot

The Pax3–FKHR oncoprotein is unresponsive to the Pax3‐associated repressor hDaxx

inferredcites →https://doi.org/10.1093/emboj/18.5.1321openalex-snapshot

Regulation of JNK signaling by GSTp

inferredcites →https://doi.org/10.1093/intimm/9.2.201openalex-snapshot

Anti-Fas IgG1 antibodies recognizing the same epitope of Fas/APO-1 mediate different biological effects in vitro

inferredcites →https://doi.org/10.1111/j.1432-1033.2004.04067.xopenalex-snapshot

Transfection with 4‐hydroxynonenal‐metabolizing glutathione S‐transferase isozymes leads to phenotypic transformation and immortalization of adherent cells

inferredcites →https://doi.org/10.1124/jpet.105.088088openalex-snapshot

Modification of Heat Shock Protein 90 by 4-Hydroxynonenal in a Rat Model of Chronic Alcoholic Liver Disease

inferredcites →https://doi.org/10.1126/science.1080405openalex-snapshot

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

inferredcites →https://doi.org/10.1126/science.270.5239.1189openalex-snapshot

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

inferredcites →https://doi.org/10.1128/mcb.13.9.5427openalex-snapshot

The DNA-Binding Activity of the Human Heat Shock Transcription Factor Is Regulated In Vivo by hsp70

inferredcites →https://doi.org/10.1128/mcb.23.20.7108-7121.2003openalex-snapshot

Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways

inferredcites →https://doi.org/10.1152/ajpcell.00043.2003openalex-snapshot

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

inferredcites →https://doi.org/10.1172/jci1413openalex-snapshot

HNE interacts directly with JNK isoforms in human hepatic stellate cells.

inferredcites →https://doi.org/10.1242/jcs.00234openalex-snapshot

RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX

inferredcites →https://doi.org/10.1242/jcs.112.14.2409openalex-snapshot

4-Hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition

inferredcites →https://doi.org/10.1523/jneurosci.17-13-05089.1997openalex-snapshot

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4794612openalex-extracted

Molecular Mechanism of 4-Hydroxynonenal Induced Cell Death

inferred← citeshttps://doi.org/10.1002/9781119374947.ch12openalex-snapshot

Adipose Carbonylation and Mitochondrial Dysfunction

inferred← citeshttps://doi.org/10.1007/978-1-4419-9940-5_6openalex-snapshot

Neurochemical Aspects of 4-Hydroxynonenal

inferred← citeshttps://doi.org/10.1007/978-81-322-1533-2_8openalex-snapshot

Mechanisms of Chemopreventive Activity of Sulforaphane

inferred← citeshttps://doi.org/10.1007/s00204-023-03476-6openalex-snapshot

ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis

inferred← citeshttps://doi.org/10.1007/s11010-008-9851-0openalex-snapshot

Transcriptional regulation of plasminogen activator inhibitor-1 in vascular endothelial cells induced by oxidized very low density lipoproteins

inferred← citeshttps://doi.org/10.1016/j.abb.2008.09.016openalex-snapshot

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

inferred← citeshttps://doi.org/10.1016/j.bbalip.2010.02.002openalex-snapshot

Lipid mediators in the nucleus: Their potential contribution to Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bbamem.2013.12.015openalex-snapshot

Plasma membranes as heat stress sensors: From lipid-controlled molecular switches to therapeutic applications

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.149167openalex-snapshot

Lipid peroxidation: Reactive carbonyl species, protein/DNA adducts, and signaling switches in oxidative stress and cancer

inferred← citeshttps://doi.org/10.1016/j.exer.2010.11.010openalex-snapshot

Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2008.04.007openalex-snapshot

Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.04.012openalex-snapshot

Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.04.021openalex-snapshot

Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.06.025openalex-snapshot

An overview of the chemistry and biology of reactive aldehydes

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.10.493openalex-snapshot

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.12.025openalex-snapshot

4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2014.07.016openalex-snapshot

Docosahexaenoic acid aggravates photooxidative damage in retinal pigment epithelial cells via lipid peroxidation

inferred← citeshttps://doi.org/10.1016/j.labinv.2024.102027openalex-snapshot

Mediation of Ferroptosis Suppressor Protein 1 Expression via 4-Hydroxy-2-Nonenal Accumulation Contributes to Acquisition of Resistance to Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma

inferred← citeshttps://doi.org/10.1016/j.redox.2019.101103openalex-snapshot

Lipoxidation and cancer immunity

inferred← citeshttps://doi.org/10.1016/j.redox.2025.103719openalex-snapshot

Immunomodulatory effects of 4-hydroxynonenal

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.04.433openalex-snapshot

S-metolachlor promotes oxidative stress in green microalga Parachlorella kessleri - A potential environmental and health risk for higher organisms

inferred← citeshttps://doi.org/10.1016/j.taap.2015.10.006openalex-snapshot

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

inferred← citeshttps://doi.org/10.1016/j.tem.2012.05.008openalex-snapshot

Protein carbonylation and metabolic control systems

inferred← citeshttps://doi.org/10.1021/bi100104eopenalex-snapshot

Role of Lipid Peroxidation in Cellular Responses to d , l -Sulforaphane, a Promising Cancer Chemopreventive Agent

inferred← citeshttps://doi.org/10.1021/bi100517xopenalex-snapshot

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

inferred← citeshttps://doi.org/10.1021/bi200029wopenalex-snapshot

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

inferred← citeshttps://doi.org/10.1038/cdd.2013.138openalex-snapshot

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

inferred← citeshttps://doi.org/10.1038/s41419-020-2718-3openalex-snapshot

Opposing biological functions of the cytoplasm and nucleus DAXX modified by SUMO-2/3 in gastric cancer

inferred← citeshttps://doi.org/10.1038/s41598-025-99004-wopenalex-snapshot

Doxorubicin loaded polylactide nanoparticles functionalized histamine promote apoptosis of human gastric cancer cells AGS

inferred← citeshttps://doi.org/10.1074/jbc.m112.400663openalex-snapshot

Protein Carbonylation and Adipocyte Mitochondrial Function

inferred← citeshttps://doi.org/10.1074/jbc.m114.563403openalex-snapshot

A Role for the p75 Neurotrophin Receptor in Axonal Degeneration and Apoptosis Induced by Oxidative Stress

inferred← citeshttps://doi.org/10.1074/jbc.m708703200openalex-snapshot

Hsf-1 and POB1 Induce Drug Sensitivity and Apoptosis by Inhibiting Ralbp1

inferred← citeshttps://doi.org/10.1080/02713683.2026.2715153openalex-snapshot

Ginkgo Biloba Standardized Extract EGb 761 Reduces Light and Toxin-Induced Photoreceptor Cell Damage via Regulating Oxidative Stress and Autophagy

inferred← citeshttps://doi.org/10.1080/10937400903358975openalex-snapshot

Physiological and Pharmacological Significance of Glutathione-Conjugate Transport

inferred← citeshttps://doi.org/10.1080/13102818.2019.1674690openalex-snapshot

4-Hydroxynonenal (HNE) and hepatic injury related to chronic oxidative stress

inferred← citeshttps://doi.org/10.1080/17425247.2024.2398604openalex-snapshot

Photodynamic therapy of cancer using graphene nanomaterials

inferred← citeshttps://doi.org/10.1089/ars.2012.4583openalex-snapshot

Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy

inferred← citeshttps://doi.org/10.1093/jleuko/qiad152openalex-snapshot

AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

inferred← citeshttps://doi.org/10.1096/fj.202601892ropenalex-snapshot

LCN2 ‐Driven Fibroblast Ferroptosis‐Associated Injury Promotes Keratinocyte Proliferation via Lipid Peroxidation Signaling in Psoriasis

inferred← citeshttps://doi.org/10.1111/bph.14174openalex-snapshot

4‐Hydroxynonenal‐induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi‐mediated anti‐inflammatory effects and Gβγ‐mediated cell death

inferred← citeshttps://doi.org/10.1111/j.1742-7843.2011.00834.xopenalex-snapshot

4‐Hydroxynonenal Induces Mitochondrial‐Mediated Apoptosis and Oxidative Stress in SH‐SY5Y Human Neuronal Cells

inferred← citeshttps://doi.org/10.1155/2014/360438openalex-snapshot

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

inferred← citeshttps://doi.org/10.1155/2015/402386openalex-snapshot

Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species

inferred← citeshttps://doi.org/10.1177/0960327111432500openalex-snapshot

Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells

inferred← citeshttps://doi.org/10.1177/1073858409337035openalex-snapshot

Lipid Mediators in the Neural Cell Nucleus: Their Metabolism, Signaling, and Association with Neurological Disorders

inferred← citeshttps://doi.org/10.1515/cmble-2015-0048openalex-snapshot

Death domain associated protein (Daxx), a multi-functional protein

inferred← citeshttps://doi.org/10.18388/abp.2010_2397openalex-snapshot

Cytotoxicity of β-carotene cleavage products and its prevention by antioxidants.

inferred← citeshttps://doi.org/10.18632/oncotarget.9821openalex-snapshot

Mitochondrial dysfunction and oxidative stress in aging and cancer

inferred← citeshttps://doi.org/10.31083/fbl37139openalex-snapshot

Short Overview on the Involvement of Lipid Peroxidation Product 4-Hydroxynonenal in Diverse Pathways of Cell Death

inferred← citeshttps://doi.org/10.31083/fbl47727openalex-snapshot

Non-Enzymatic Lipid Peroxidation in Cancer Biology: An Overview

inferred← citeshttps://doi.org/10.3109/10715760903338071openalex-snapshot

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats

inferred← citeshttps://doi.org/10.3109/10715762.2010.498477openalex-snapshot

Chemistry and biochemistry of lipid peroxidation products

inferred← citeshttps://doi.org/10.3109/10715762.2014.999056openalex-snapshot

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

inferred← citeshttps://doi.org/10.3233/jad-2011-111085openalex-snapshot

Lipid Mediators and Their Metabolism in the Nucleus: Implications for Alzheimer's Disease

inferred← citeshttps://doi.org/10.3389/fendo.2025.1722623openalex-snapshot

Scars of oxidative stress: protein carbonylation and beta cell dysfunction in diabetes

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Neutrophils: Many Ways to Die

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Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

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The versatile utility of cysteine as a target for cancer treatment

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Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products

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Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products

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Regulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma

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Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells

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Are Sensory TRP Channels Biological Alarms for Lipid Peroxidation?

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Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling

inferred← citeshttps://doi.org/10.3390/nu16234171openalex-snapshot

4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal Cell Death for Lifestyle-Related Diseases

inferred← citeshttps://doi.org/10.3390/ph17030365openalex-snapshot

A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide

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Protein Carbonylation: Emerging Roles in Plant Redox Biology and Future Prospects

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Oxidative status of cardinal ligament in pelvic organ prolapse

inferred← citeshttps://doi.org/10.4236/ojapo.2013.21001openalex-snapshot

Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity

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Comparison of 4-hydroxynonenal induced p53-mediated apoptosis in prostate cancer cells LNCaP and DU145

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4-Hydroxynonenal Promotes Growth and Angiogenesis of Breast Cancer Cells through HIF-1α Stabilization

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