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The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis

https://doi.org/10.1111/jcmm.14074
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.1840150408openalex-snapshot
Hydroxypyridinium Collagen Cross–Links in Human Liver Fibrosis: Study of Alveolar Echinococcosis
inferredcites →https://doi.org/10.1002/hep.20701openalex-snapshot
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
inferredcites →https://doi.org/10.1002/jbt.2570010109openalex-snapshot
Changes in collagen cross‐linking in bleomycin‐induced pulmonary fibrosis
inferredcites →https://doi.org/10.1002/jcb.10413openalex-snapshot
Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
inferredcites →https://doi.org/10.1006/abio.1997.2391openalex-snapshot
A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases
inferredcites →https://doi.org/10.1006/bbrc.1998.8955openalex-snapshot
Altered Posttranslational Modifications of Collagen in Keloid
inferredcites →https://doi.org/10.1007/bf01845593openalex-snapshot
Biochemical properties of collagen from ligaments and periarticular tendons of the human knee
inferredcites →https://doi.org/10.1007/s00198-009-1066-zopenalex-snapshot
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
inferredcites →https://doi.org/10.1016/0005-2795(75)90106-3openalex-snapshot
Characterization of the collagen of human hypertrophic and normal scars
inferredcites →https://doi.org/10.1016/0020-711x(89)90001-3openalex-snapshot
Collagen cross-linking
inferredcites →https://doi.org/10.1016/0020-711x(90)90031-wopenalex-snapshot
Biosynthesis of collagen crosslinks
inferredcites →https://doi.org/10.1016/0925-4439(96)00019-1openalex-snapshot
Lung collagen cross-links in rats with experimentally induced pulmonary fibrosis
inferredcites →https://doi.org/10.1016/j.bbadis.2005.02.007openalex-snapshot
The type of collagen cross-link determines the reversibility of experimental skin fibrosis
inferredcites →https://doi.org/10.1016/j.bmcl.2012.04.111openalex-snapshot
The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1)
inferredcites →https://doi.org/10.1016/j.matbio.2004.06.001openalex-snapshot
Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon
inferredcites →https://doi.org/10.1016/j.molcel.2013.10.015openalex-snapshot
Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition
inferredcites →https://doi.org/10.1016/j.ymeth.2008.01.002openalex-snapshot
Advances in collagen cross-link analysis
inferredcites →https://doi.org/10.1016/s0168-8278(96)80265-0openalex-snapshot
Pyridinoline collagen cross-links in patients with chronic viral hepatitis and cirrhosis
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00345openalex-snapshot
Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
inferredcites →https://doi.org/10.1038/ncomms13710openalex-snapshot
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
inferredcites →https://doi.org/10.1038/nm.2208openalex-snapshot
Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
inferredcites →https://doi.org/10.1038/nri3623openalex-snapshot
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
inferredcites →https://doi.org/10.1038/onc.2014.23openalex-snapshot
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization
inferredcites →https://doi.org/10.1038/s41598-017-00270-0openalex-snapshot
Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
inferredcites →https://doi.org/10.1038/sj.emboj.7600781openalex-snapshot
A molecular role for lysyl oxidase‐like 2 enzyme in Snail regulation and tumor progression
inferredcites →https://doi.org/10.1038/srep10568openalex-snapshot
Origin and evolution of lysyl oxidases
inferredcites →https://doi.org/10.1046/j.0022-202x.2001.01414.xopenalex-snapshot
Different Pattern of Collagen Cross-Links in Two Sclerotic Skin Diseases: Lipodermatosclerosis and Circumscribed Scleroderma
inferredcites →https://doi.org/10.1053/j.gastro.2011.01.040openalex-snapshot
Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice
inferredcites →https://doi.org/10.1073/pnas.75.6.2945openalex-snapshot
Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat.
inferredcites →https://doi.org/10.1074/jbc.c113.502310openalex-snapshot
MCF-7 Cells Expressing Nuclear Associated Lysyl Oxidase-like 2 (LOXL2) Exhibit an Epithelial-to-Mesenchymal Transition (EMT) Phenotype and Are Highly Invasive in Vitro
inferredcites →https://doi.org/10.1074/jbc.m115.641670openalex-snapshot
Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells
inferredcites →https://doi.org/10.1080/10409238.2016.1269716openalex-snapshot
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
inferredcites →https://doi.org/10.1093/cvr/cvv214openalex-snapshot
Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction
inferredcites →https://doi.org/10.1093/ndt/gfm393openalex-snapshot
Treatment targets in renal fibrosis
inferredcites →https://doi.org/10.1111/liv.12731openalex-snapshot
Mechanisms of fibrosis in acute liver failure
inferredcites →https://doi.org/10.1136/gutjnl-2016-312473openalex-snapshot
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
inferredcites →https://doi.org/10.1152/ajpgi.00032.2007openalex-snapshot
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
inferredcites →https://doi.org/10.1155/2017/5316845openalex-snapshot
Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases
inferredcites →https://doi.org/10.1158/0008-5472.can-16-3152openalex-snapshot
Lysyl Oxidase–like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-3096openalex-snapshot
LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
inferredcites →https://doi.org/10.1158/1541-7786.mcr-13-0033-topenalex-snapshot
Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling
inferredcites →https://doi.org/10.1172/jci72267openalex-snapshot
Cellular and molecular mechanisms in kidney fibrosis
inferredcites →https://doi.org/10.1183/09031936.00141013openalex-snapshot
Serum lysyl oxidase-like 2 levels and idiopathic pulmonary fibrosis disease progression
inferredcites →https://doi.org/10.1186/s12931-015-0200-zopenalex-snapshot
Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration
inferredcites →https://doi.org/10.1271/bbb.66.2077openalex-snapshot
Effects of L -Ascorbic Acid on Lysyl Oxidase in the Formation of Collagen Cross-links
inferredcites →https://doi.org/10.1359/jbmr.2002.17.9.1621openalex-snapshot
Mechanical Properties of Adult Vertebral Cancellous Bone: Correlation With Collagen Intermolecular Cross‐Links
inferredcites →https://doi.org/10.1371/journal.pone.0112391openalex-snapshot
Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy
inferredcites →https://doi.org/10.1371/journal.pone.0144630openalex-snapshot
Histochemical Detection of Collagen Fibers by Sirius Red/Fast Green Is More Sensitive than van Gieson or Sirius Red Alone in Normal and Inflamed Rat Colon
inferredcites →https://doi.org/10.1503/cmaj.1040752openalex-snapshot
Liver enzyme alteration: a guide for clinicians
inferredcites →https://doi.org/10.15252/embj.201489975openalex-snapshot
Lysyl oxidase‐like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression
inferredcites →https://doi.org/10.3892/mmr.2017.6918openalex-snapshot
Lysyl oxidase-like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4654347openalex-extracted
Inhibition of Lysyl Oxidase Family of Enzymes Has No Effect on Healthy Fibroblast – Extracellular Matrix Cross-Talk in vitro
inferred← citeshttps://doi.org/10.1002/0471266949.bmc274openalex-snapshot
Therapeutic Approaches for Nonalcoholic Steatohepatitis ( NASH )
inferred← citeshttps://doi.org/10.1002/cmdc.202300331openalex-snapshot
Lysyl Oxidases as Targets for Cancer Therapy and Diagnostic Imaging
inferred← citeshttps://doi.org/10.1002/ctm2.572openalex-snapshot
An activity‐based bioprobe differentiates a novel small molecule inhibitor from a LOXL2 antibody and provides renewed promise for anti‐fibrotic therapeutic strategies
inferred← citeshttps://doi.org/10.1002/hep.31236openalex-snapshot
Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis
inferred← citeshttps://doi.org/10.1002/hep.32629openalex-snapshot
Noncellular components in the liver cancer stem cell niche: Biology and potential clinical implications
inferred← citeshttps://doi.org/10.1002/jcp.30915openalex-snapshot
Intercellular communication among liver cells in the perisinusoidal space of the injured liver: Pathophysiology and therapeutic directions
inferred← citeshttps://doi.org/10.1002/mc.70030openalex-snapshot
Targeting Posttranslational Modifications in the Tumor Stromal Microenvironment for Antitumor Therapy
inferred← citeshttps://doi.org/10.1007/s10620-025-09437-6openalex-snapshot
Exploring Transcriptomic and MRI-Derived Parameters Correlations in NAFLD Fibrosis: Insights from a Rat Model
inferred← citeshttps://doi.org/10.1007/s12012-026-10167-yopenalex-snapshot
Dual-Metal Regulation of Cardiac Remodeling: Targeting the LOXL2-Ferroptosis Axis in Metal-Induced Cardiac Dysfunction
inferred← citeshttps://doi.org/10.1007/s12185-019-02751-6openalex-snapshot
Novel lysyl oxidase inhibitors attenuate hallmarks of primary myelofibrosis in mice
inferred← citeshttps://doi.org/10.1007/s13577-025-01316-6openalex-snapshot
The "dual personality" of LOXL3: a tumor accomplice and a new hope for immunotherapy
inferred← citeshttps://doi.org/10.1007/s40265-020-01458-xopenalex-snapshot
Strategies Targeting the Innate Immune Response for the Treatment of Hepatitis C Virus-Associated Liver Fibrosis
inferred← citeshttps://doi.org/10.1007/s44174-023-00106-8openalex-snapshot
Glycosylation of Collagen Provokes Diabetic Wound Ulcers
inferred← citeshttps://doi.org/10.1007/s44174-025-00275-8openalex-snapshot
Clinical Efficacy of Type I Collagen Skin Substitutes Versus Human Amnion/Chorion in Treating Diabetic Foot Ulcers Using 55 Patient Randomized Controlled Independent Two Trials, One in India and the Other in the USA
inferred← citeshttps://doi.org/10.1016/b978-0-443-15617-5.00011-1openalex-snapshot
Collagen remodeling in inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167205openalex-snapshot
Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes collagen cross-linking and ECM stiffening to induce liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188435openalex-snapshot
LOXL2 in cancer: regulation, downstream effectors and novel roles
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188443openalex-snapshot
Unmasking carcinoma-associated fibroblasts: Key transformation player within the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.189036openalex-snapshot
Scientific and clinical relevance of non-cellular tumor microenvironment components in ovarian cancer chemotherapy resistance
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115740openalex-snapshot
Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110791openalex-snapshot
Lysyl oxidases: Emerging biomarkers and therapeutic targets for various diseases
inferred← citeshttps://doi.org/10.1016/j.bmc.2026.118719openalex-snapshot
Design, synthesis, and evaluation of 4-(aminomethyl)-2-(phenylamino)pyridine derivatives as novel lysyl oxidase-like 2 inhibitors against metastatic melanoma
inferred← citeshttps://doi.org/10.1016/j.cmet.2026.05.008openalex-snapshot
The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging
inferred← citeshttps://doi.org/10.1016/j.ejcb.2025.151527openalex-snapshot
The role of the LOX family in cancer
inferred← citeshttps://doi.org/10.1016/j.jaccao.2022.04.002openalex-snapshot
Cardiovascular Disease in Myeloproliferative Neoplasms
inferred← citeshttps://doi.org/10.1016/j.jncc.2026.08.004openalex-snapshot
Breaking physical and immunological barriers: a neutrophil-mimicking nanotherapeutics for enhanced pancreatic cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.mam.2023.101194openalex-snapshot
Cardiac Fibrosis in heart failure: Focus on non-invasive diagnosis and emerging therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.matbio.2019.11.003openalex-snapshot
Scavenger Receptor Cysteine-Rich domains of Lysyl Oxidase-Like2 regulate endothelial ECM and angiogenesis through non-catalytic scaffolding mechanisms
inferred← citeshttps://doi.org/10.1016/j.matbio.2022.06.006openalex-snapshot
Tissue mechanics coevolves with fibrillar matrisomes in healthy and fibrotic tissues
inferred← citeshttps://doi.org/10.1016/j.molmed.2022.05.010openalex-snapshot
Can’t handle the stress? Mechanobiology and disease
inferred← citeshttps://doi.org/10.1016/j.neo.2025.101267openalex-snapshot
LOXL2⁺ cancer-associated fibroblasts shape WNT signaling to drive chemoresistance and poor outcomes in colorectal cancer: Insights from multi-omics and epidemiological analyses
inferred← citeshttps://doi.org/10.1016/j.neuron.2024.07.026openalex-snapshot
Single-cell dissection of the human blood-brain barrier and glioma blood-tumor barrier
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107633openalex-snapshot
Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01112openalex-snapshot
2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01283openalex-snapshot
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01701openalex-snapshot
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
inferred← citeshttps://doi.org/10.1038/s41388-025-03466-1openalex-snapshot
LOXL2 reduces susceptibility to PARP inhibitors by promoting super-enhancer-regulated DNA damage repair in high-grade serous ovarian cancer
inferred← citeshttps://doi.org/10.1038/s41392-026-02673-wopenalex-snapshot
Biologics for cardiovascular diseases: from bench to bedside
inferred← citeshttps://doi.org/10.1038/s41467-022-33148-5openalex-snapshot
Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis
inferred← citeshttps://doi.org/10.1038/s41569-020-00504-1openalex-snapshot
Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches
inferred← citeshttps://doi.org/10.1038/s41598-021-91772-5openalex-snapshot
Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse
inferred← citeshttps://doi.org/10.1038/s41598-022-15640-6openalex-snapshot
Simple gene signature to assess murine fibroblast polarization
inferred← citeshttps://doi.org/10.1038/s41598-025-06312-2openalex-snapshot
The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement
inferred← citeshttps://doi.org/10.1039/9781788015783-00145openalex-snapshot
Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology
inferred← citeshttps://doi.org/10.1042/bst20190098openalex-snapshot
Targeting the lysyl oxidases in tumour desmoplasia
inferred← citeshttps://doi.org/10.1042/ebc20180050openalex-snapshot
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links
inferred← citeshttps://doi.org/10.1042/ebc20180051openalex-snapshot
Collagen cross-linking mediated by lysyl hydroxylase 2: an enzymatic battlefield to combat fibrosis
inferred← citeshttps://doi.org/10.1051/fopen/2019005openalex-snapshot
Prelude and premise to the special issue: disruption of homeostasis-induced signaling and crosstalk in the carcinogenesis paradigm “Epistemology of the origin of cancer”
inferred← citeshttps://doi.org/10.1063/5.0267032openalex-snapshot
Decoding force-transmission linkages for therapeutic targeting and engineering
inferred← citeshttps://doi.org/10.1074/jbc.ra119.007674openalex-snapshot
A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth factor β1
inferred← citeshttps://doi.org/10.1080/14737159.2021.1962711openalex-snapshot
Enzymatic cross-linking of collagens in organ fibrosis – resolution and assessment
inferred← citeshttps://doi.org/10.1101/2023.07.06.548012openalex-snapshot
Accurate quantification of lysyl oxidase concentration in human tissue
inferred← citeshttps://doi.org/10.1101/2024.05.15.594430openalex-snapshot
Clostridium ablates tumors by degrading collagen mesh and inducing ferroptosis
inferred← citeshttps://doi.org/10.1111/cbdd.70320openalex-snapshot
From Virtual Screening to Cell Phenotype: 4‐Thiazolidone Scaffolds Targeting LOXL2 in Breast Cancer
inferred← citeshttps://doi.org/10.1111/liv.15270openalex-snapshot
An MMP ‐degraded and cross‐linked fragment of type III collagen as a non‐invasive biomarker of hepatic fibrosis resolution
inferred← citeshttps://doi.org/10.1146/annurev-physiol-043024-115512openalex-snapshot
Scarred by Fibrosis: The Heart–Kidney Disease Connection
inferred← citeshttps://doi.org/10.1152/ajpcell.00124.2023openalex-snapshot
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
inferred← citeshttps://doi.org/10.1152/ajpcell.00176.2023openalex-snapshot
Lysyl oxidase like-2 in fibrosis and cardiovascular disease
inferred← citeshttps://doi.org/10.1152/ajpcell.01043.2024openalex-snapshot
The theatrics of collagens in the myocardium: the supreme architect of the fibrotic heart
inferred← citeshttps://doi.org/10.11606/d.5.2019.tde-08112019-161925openalex-snapshot
Análise funcional da enzima LOXL3 em astrocitomas
inferred← citeshttps://doi.org/10.1165/rcmb.2023-0176psopenalex-snapshot
Extracellular Matrix as a Driver of Chronic Lung Diseases
inferred← citeshttps://doi.org/10.1167/iovs.65.13.33openalex-snapshot
Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
inferred← citeshttps://doi.org/10.1177/03936155251396145openalex-snapshot
Human lysine oxidase-like 3 high expression as a potential biomarker and association with poor prognosis in pleural mesothelioma
inferred← citeshttps://doi.org/10.1183/16000617.0202-2021openalex-snapshot
Chronic lung diseases: entangled in extracellular matrix
inferred← citeshttps://doi.org/10.1186/s12967-024-05199-3openalex-snapshot
Understanding the matrix: collagen modifications in tumors and their implications for immunotherapy
inferred← citeshttps://doi.org/10.1186/s12967-025-06306-8openalex-snapshot
Mechanical forces in the tumor microenvironment: roles, pathways, and therapeutic approaches
inferred← citeshttps://doi.org/10.1186/s13045-022-01252-0openalex-snapshot
Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy
inferred← citeshttps://doi.org/10.12677/hjmce.2025.133029openalex-snapshot
The Research Progress of Lysyl Oxidase Inhibitors
inferred← citeshttps://doi.org/10.21037/atm-20-2948openalex-snapshot
It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6966692/v1openalex-snapshot
Characterization of fungal and bacterial Dysbiosis in Crohn's Disease Patients with Intestinal Fibrosis
inferred← citeshttps://doi.org/10.2174/1570163817666200121143959openalex-snapshot
Alcoholic and Non-Alcoholic Liver Diseases: Promising Molecular Drug Targets and their Clinical Development
inferred← citeshttps://doi.org/10.3389/fcell.2024.1412337openalex-snapshot
Cancer-associated fibroblasts and prostate cancer stem cells: crosstalk mechanisms and implications for disease progression
inferred← citeshttps://doi.org/10.3389/fimmu.2020.02093openalex-snapshot
Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
inferred← citeshttps://doi.org/10.3389/fimmu.2021.812627openalex-snapshot
Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1639196openalex-snapshot
ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1773909openalex-snapshot
Extracellular matrix stiffness in hepatocellular carcinoma: mechanisms and targeted therapeutic strategies
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1849447openalex-snapshot
The role of extracellular matrix stiffness in regulating fibroblast behaviors and disease progression
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1132353openalex-snapshot
Extracellular matrix stiffness—The central cue for skin fibrosis
inferred← citeshttps://doi.org/10.3389/fphar.2021.671640openalex-snapshot
Cellular Mechanisms of Liver Fibrosis
inferred← citeshttps://doi.org/10.3389/fphar.2023.1070973openalex-snapshot
Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention
inferred← citeshttps://doi.org/10.3389/fphar.2025.1574385openalex-snapshot
Mechanism-guided drug development and treatment for liver fibrosis: a clinical perspective
inferred← citeshttps://doi.org/10.3389/fphar.2026.1845077openalex-snapshot
The mechano-immunological barrier in fibrosis-associated lung cancer: targeting matrix stiffness and the Piezo1 axis for microenvironment normalization
inferred← citeshttps://doi.org/10.3390/antiox10020312openalex-snapshot
LOXL2 Inhibitors and Breast Cancer Progression
inferred← citeshttps://doi.org/10.3390/bioengineering13030335openalex-snapshot
The Extracellular Matrix in Liver Regeneration: Biological and Therapeutic Insights
inferred← citeshttps://doi.org/10.3390/biology10020136openalex-snapshot
Modeling of Old Scars: Histopathological, Biochemical and Thermal Analysis of the Scar Tissue Maturation
inferred← citeshttps://doi.org/10.3390/biom11121846openalex-snapshot
Oligomeric States and Hydrodynamic Properties of Lysyl Oxidase-Like 2
inferred← citeshttps://doi.org/10.3390/biom16060884openalex-snapshot
The Matrix Reloaded: The Hepatic Matrisome as a Therapeutic Opportunity to Fight Liver Fibrosis
inferred← citeshttps://doi.org/10.3390/biomedicines10020274openalex-snapshot
Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates
inferred← citeshttps://doi.org/10.3390/cancers11050705openalex-snapshot
LOXL1 Is Regulated by Integrin α11 and Promotes Non-Small Cell Lung Cancer Tumorigenicity
inferred← citeshttps://doi.org/10.3390/cancers11050729openalex-snapshot
Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.3390/cancers13030491openalex-snapshot
Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours
inferred← citeshttps://doi.org/10.3390/cancers14040981openalex-snapshot
Fibrosis in Mesothelioma: Potential Role of Lysyl Oxidases
inferred← citeshttps://doi.org/10.3390/cancers16101847openalex-snapshot
Targets in the Tumour Matrisome to Promote Cancer Therapy Response
inferred← citeshttps://doi.org/10.3390/cells10071824openalex-snapshot
Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved
inferred← citeshttps://doi.org/10.3390/cells13050438openalex-snapshot
Exploring Extracellular Matrix Crosslinking as a Therapeutic Approach to Fibrosis
inferred← citeshttps://doi.org/10.3390/cells8091080openalex-snapshot
Activity and Trafficking of Copper-Transporting ATPases in Tumor Development and Defense against Platinum-Based Drugs
inferred← citeshttps://doi.org/10.3390/cells8121483openalex-snapshot
The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling
inferred← citeshttps://doi.org/10.3390/cells9051212openalex-snapshot
Matrix Metalloproteinases as Potential Biomarkers and Therapeutic Targets in Liver Diseases
inferred← citeshttps://doi.org/10.3390/ijms20143587openalex-snapshot
LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer
inferred← citeshttps://doi.org/10.3390/ijms21165913openalex-snapshot
Linking LOXL2 to Cardiac Interstitial Fibrosis
inferred← citeshttps://doi.org/10.3390/ijms21249751openalex-snapshot
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer
inferred← citeshttps://doi.org/10.3390/ijms22041906openalex-snapshot
Inflammatory Microenvironment and Specific T Cells in Myeloproliferative Neoplasms: Immunopathogenesis and Novel Immunotherapies
inferred← citeshttps://doi.org/10.3390/ijms23105533openalex-snapshot
Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis
inferred← citeshttps://doi.org/10.3390/ijms23115879openalex-snapshot
Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2
inferred← citeshttps://doi.org/10.3390/ijms23147841openalex-snapshot
Pathogenesis and Therapeutic Strategies Related to Non-Alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.3390/ijms23147872openalex-snapshot
A Novel Morphological Parameter Predicting Fibrotic Evolution in Myeloproliferative Neoplasms: New Evidence and Molecular Insights
inferred← citeshttps://doi.org/10.3390/ijms232012270openalex-snapshot
Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer
inferred← citeshttps://doi.org/10.3390/ijms241411745openalex-snapshot
Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
inferred← citeshttps://doi.org/10.3390/ijms241814405openalex-snapshot
LOXL2 in Cancer: A Two-Decade Perspective
inferred← citeshttps://doi.org/10.3390/life15050779openalex-snapshot
Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes
inferred← citeshttps://doi.org/10.4254/wjh.v12.i11.931openalex-snapshot
Inhibition of vascular adhesion protein-1 modifies hepatic steatosisin vitroandin vivo
inferred← citeshttps://doi.org/10.46439/stemcell.1.005openalex-snapshot
Lysyl oxidase inhibition in primary myelofibrosis: A renewed strategy
inferred← citeshttps://doi.org/10.59057/iberoleon.20075316.202440746openalex-snapshot
En búsqueda de nuevos tratamientos para la fibrosis pulmonar idiopática
inferred← citeshttps://doi.org/10.70675/03ed9427zb86bz4a59z98f6zc12195d192f7openalex-snapshot
Rôle de l'enzyme LOXL2 dans le comportement pro-invasif des cellules de mélanome et le remodelage matriciel du stroma tumoral
inferred← citeshttps://doi.org/10.70675/8883bb6ez119az4246z8905z93ba834adb03openalex-snapshot
Methodological developments in high resolution mass spectrometry-based proteomics for the analysis of museum and archaeological objects : trace analysis and structural characterisation
inferred← citeshttps://doi.org/10.7717/peerj.20274openalex-snapshot
The function and mechanisms of action of lysyl oxidase-like 3 (LOXL3) in cancers
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