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Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The production and use of F18-labelled organic compounds
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A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution
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The role of O2.− in the production of HO.: in vitro and in vivo
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The oxidative environment and protein damage
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Oxidative stress involved in the antibacterial action of different antibiotics
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
inferredcites →https://doi.org/10.1016/j.cell.2008.09.038openalex-snapshot
Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death
inferredcites →https://doi.org/10.1016/j.molcel.2009.11.024openalex-snapshot
Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli
inferredcites →https://doi.org/10.1016/s0021-9258(18)52319-xopenalex-snapshot
Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase
inferredcites →https://doi.org/10.1016/s0021-9258(18)61255-4openalex-snapshot
alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.
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Assay of metabolic superoxide production in Escherichia coli.
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Quantitation of intracellular free iron by electron paramagnetic resonance spectroscopy
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Mechanism of fluoroquinolone action
inferredcites →https://doi.org/10.1021/ja805735gopenalex-snapshot
Red-Excitation Resonance Raman Analysis of the νFe═O Mode of Ferryl-Oxo Hemoproteins
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Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli
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Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx - mutants of Escherichia coli
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Iron enzyme ribulose-5-phosphate 3-epimerase in Escherichia coli is rapidly damaged by hydrogen peroxide but can be protected by manganese
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One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
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Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals
inferredcites →https://doi.org/10.1073/pnas.93.24.13635openalex-snapshot
Superoxide accelerates DNA damage by elevating free-iron levels
inferredcites →https://doi.org/10.1073/pnas.96.11.6161openalex-snapshot
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol—disulfide status
inferredcites →https://doi.org/10.1074/jbc.m110.127456openalex-snapshot
Iron Homeostasis Affects Antibiotic-mediated Cell Death in Pseudomonas Species
inferredcites →https://doi.org/10.1074/jbc.m209264200openalex-snapshot
Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species
inferredcites →https://doi.org/10.1074/jbc.m408754200openalex-snapshot
Are Respiratory Enzymes the Primary Sources of Intracellular Hydrogen Peroxide?
inferredcites →https://doi.org/10.1074/jbc.m607646200openalex-snapshot
Micromolar Intracellular Hydrogen Peroxide Disrupts Metabolism by Damaging Iron-Sulfur Enzymes
inferredcites →https://doi.org/10.1093/jac/dkp486openalex-snapshot
Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death
inferredcites →https://doi.org/10.1111/j.1365-2958.2010.07418.xopenalex-snapshot
Hydrogen peroxide inactivates the Escherichia coli Isc iron‐sulphur assembly system, and OxyR induces the Suf system to compensate
inferredcites →https://doi.org/10.1111/mmi.12061openalex-snapshot
E scherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains
inferredcites →https://doi.org/10.1126/science.1219192openalex-snapshot
Oxidation of the Guanine Nucleotide Pool Underlies Cell Death by Bactericidal Antibiotics
inferredcites →https://doi.org/10.1128/aac.50.3.949-954.2006openalex-snapshot
Involvement of Reactive Oxygen Species in the Action of Ciprofloxacin againstEscherichia coli
inferredcites →https://doi.org/10.1128/cmr.16.3.430-450.2003openalex-snapshot
Versatility of Aminoglycosides and Prospects for Their Future
inferredcites →https://doi.org/10.1128/jb.183.15.4562-4570.2001openalex-snapshot
DNA Microarray-Mediated Transcriptional Profiling of the Escherichia coli Response to Hydrogen Peroxide
inferredcites →https://doi.org/10.1128/jb.183.21.6384-6393.2001openalex-snapshot
Conditional-Replication, Integration, Excision, and Retrieval Plasmid-Host Systems for Gene Structure-Function Studies of Bacteria
inferredcites →https://doi.org/10.1128/jb.187.20.6962-6971.2005openalex-snapshot
Effect of RyhB Small RNA on Global Iron Use in Escherichia coli
inferredcites →https://doi.org/10.1128/mr.51.4.439-457.1987openalex-snapshot
Bacterial uptake of aminoglycoside antibiotics
inferredcites →https://doi.org/10.1146/annurev.biochem.77.061606.161055openalex-snapshot
Cellular Defenses against Superoxide and Hydrogen Peroxide
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics
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Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics
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HKOH‐1: A Highly Sensitive and Selective Fluorescent Probe for Detecting Endogenous Hydroxyl Radicals in Living Cells
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Understanding effect of interaction of nanoparticles and antibiotics on bacteria survival under aquatic conditions: Knowns and unknowns
inferred← citeshttps://doi.org/10.1016/j.etap.2015.12.013openalex-snapshot
What are the differences between aerobic and anaerobic toxic effects of sulfonamides on Escherichia coli ?
inferred← citeshttps://doi.org/10.1016/j.foodchem.2016.08.098openalex-snapshot
Tea polyphenol epigallocatechin gallate inhibits Escherichia coli by increasing endogenous oxidative stress
inferred← citeshttps://doi.org/10.1016/j.foodres.2015.12.003openalex-snapshot
Free radical formation by Lactobacillus acidophilus NCFM is enhanced by antioxidants and decreased by catalase
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.11.029openalex-snapshot
Exploring the redox balance inside gram-negative bacteria with redox-sensitive GFP
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.02.018openalex-snapshot
Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.03.025openalex-snapshot
Improved measurements of scant hydrogen peroxide enable experiments that define its threshold of toxicity for Escherichia coli
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.08.003openalex-snapshot
Antibacterial activity of new structural class of semisynthetic molecule, triphenyl-phosphonium conjugated diarylheptanoid
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27852openalex-snapshot
Evaluation of the synergistic potential and mechanisms of action for de novo designed cationic antimicrobial peptides
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2013.10.015openalex-snapshot
Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2014.10.024openalex-snapshot
Mutation of the gene encoding monothiol glutaredoxin (GrxD) in Pseudomonas aeruginosa increases its susceptibility to polymyxins
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2017.04.025openalex-snapshot
Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2017.05.071openalex-snapshot
Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.147078openalex-snapshot
Dose-dependent neurotoxicity of starch-adorned silver nanoparticles: A chronic in vivo study
inferred← citeshttps://doi.org/10.1016/j.ijfoodmicro.2014.08.008openalex-snapshot
Oxygenated monoterpenes citral and carvacrol cause oxidative damage in Escherichia coli without the involvement of tricarboxylic acid cycle and Fenton reaction
inferred← citeshttps://doi.org/10.1016/j.ijmm.2014.05.008openalex-snapshot
Metabolic and transcriptional activities of Staphylococcus aureus challenged with high-doses of daptomycin
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101875openalex-snapshot
Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101825openalex-snapshot
Nitric oxide precipitates catastrophic chromosome fragmentation by bolstering both hydrogen peroxide and Fe(II) Fenton reactants in E. coli
inferred← citeshttps://doi.org/10.1016/j.jgar.2022.01.026openalex-snapshot
Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.jmb.2015.08.016openalex-snapshot
Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2013.09.006openalex-snapshot
Photo-activated porphyrin in combination with antibiotics: Therapies against Staphylococci
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2020.112081openalex-snapshot
Screening of antimicrobial synergism between phenolic acids derivatives and UV-A light radiation
inferred← citeshttps://doi.org/10.1016/j.jphotochem.2017.08.008openalex-snapshot
A new pyrene-based fluorescent probe with large Stokes shift for detecting hydrogen peroxide in aqueous solution and living cells
inferred← citeshttps://doi.org/10.1016/j.jprot.2016.04.032openalex-snapshot
How different is the proteome of the extended spectrum β-lactamase producing Escherichia coli strains from seagulls of the Berlengas natural reserve of Portugal?
inferred← citeshttps://doi.org/10.1016/j.jtemb.2024.127394openalex-snapshot
Difference in the cellular response following THP-1 derived phagocytic monocyte cells exposure to commercial aluminum-based adjuvants and aluminum-containing vaccines
inferred← citeshttps://doi.org/10.1016/j.mib.2014.06.008openalex-snapshot
Reactive oxygen species and the bacterial response to lethal stress
inferred← citeshttps://doi.org/10.1016/j.mib.2014.06.017openalex-snapshot
Bacterial gasotransmitters: an innate defense against antibiotics
inferred← citeshttps://doi.org/10.1016/j.mib.2015.01.004openalex-snapshot
Diagnosing oxidative stress in bacteria: not as easy as you might think
inferred← citeshttps://doi.org/10.1016/j.mib.2017.09.002openalex-snapshot
Antibiotic efficacy — context matters
inferred← citeshttps://doi.org/10.1016/j.micpath.2016.08.027openalex-snapshot
Redox and respiratory chain related alterations in the lophirones B and C-mediated bacterial lethality
inferred← citeshttps://doi.org/10.1016/j.micpath.2017.08.012openalex-snapshot
Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid
inferred← citeshttps://doi.org/10.1016/j.micpath.2019.01.034openalex-snapshot
Contributions of reactive oxygen species, oxidative DNA damage and glutathione depletion to the sensitivity of Acinetobacter baumannii to 2-(2-nitrovinyl) furan
inferred← citeshttps://doi.org/10.1016/j.micpath.2019.03.011openalex-snapshot
Lophirones B and C induce oxidative cellular death pathway in Acinetobacter baumannii by inhibiting DNA gyrase
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.02.037openalex-snapshot
Gamblers: An Antibiotic-Induced Evolvable Cell Subpopulation Differentiated by Reactive-Oxygen-Induced General Stress Response
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.04.001openalex-snapshot
Metabolomics-Driven Exploration of the Chemical Drug Space to Predict Combination Antimicrobial Therapies
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.07.009openalex-snapshot
Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2013.07.009openalex-snapshot
Potential roles for DNA replication and repair functions in cell killing by streptomycin
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2014.02.008openalex-snapshot
Bipyridine (2,2′-dipyridyl) potentiates Escherichia coli lethality induced by nitrogen mustard mechlorethamine
inferred← citeshttps://doi.org/10.1016/j.mrrev.2016.08.006openalex-snapshot
Potentiation of hydrogen peroxide toxicity: From catalase inhibition to stable DNA-iron complexes
inferred← citeshttps://doi.org/10.1016/j.msec.2020.111256openalex-snapshot
Phytofabricated silver nanoparticles: Discovery of antibacterial targets against diabetic foot ulcer derived resistant bacterial isolates
inferred← citeshttps://doi.org/10.1016/j.mtcomm.2024.109534openalex-snapshot
Exploring potential of cold spray technology for medical devices: Current and future scenario
inferred← citeshttps://doi.org/10.1016/j.resmic.2016.07.008openalex-snapshot
Ciprofloxacin provokes SOS-dependent changes in respiration and membrane potential and causes alterations in the redox status of Escherichia coli
inferred← citeshttps://doi.org/10.1016/j.resmic.2022.103954openalex-snapshot
Study of the early response of Escherichia coli lpcA and ompF mutants to ciprofloxacin
inferred← citeshttps://doi.org/10.1016/j.synbio.2016.10.001openalex-snapshot
Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters
inferred← citeshttps://doi.org/10.1016/j.tig.2019.03.007openalex-snapshot
General Mechanisms Leading to Persister Formation and Awakening
inferred← citeshttps://doi.org/10.1016/j.tim.2014.02.001openalex-snapshot
Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms
inferred← citeshttps://doi.org/10.1016/j.tim.2014.03.008openalex-snapshot
Bacterial persisters: formation, eradication, and experimental systems
inferred← citeshttps://doi.org/10.1016/j.tim.2016.12.008openalex-snapshot
The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria
inferred← citeshttps://doi.org/10.1016/j.tim.2020.10.013openalex-snapshot
Heterogeneous Host–Pathogen Encounters Coordinate Antibiotic Resilience in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.vetmic.2020.108730openalex-snapshot
The functional identification of Dps in oxidative stress resistance and virulence of Riemerella anatipestifer CH-1 using a new unmarked gene deletion strategy
inferred← citeshttps://doi.org/10.1016/j.vetmic.2026.110941openalex-snapshot
Functional characterization of NuoB and SdhC subunits of respiratory complexes in antibiotic resistance and pathogenicity of Riemerella anatipestifer
inferred← citeshttps://doi.org/10.1016/s1473-3099(20)30602-2openalex-snapshot
To give or not to give antibiotics is not the only question
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00703openalex-snapshot
Eukaryotic Ribosomal Expansion Segments as Antimicrobial Targets
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00197openalex-snapshot
Application of Mouse Embryonic Stem Cell Test to Detect Gender-Specific Effect of Chemicals: A Supplementary Tool for Embryotoxicity Prediction
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01383openalex-snapshot
Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01243openalex-snapshot
Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria
inferred← citeshttps://doi.org/10.1021/acs.jpcb.2c01440openalex-snapshot
Blue or Near-Infrared Light-Triggered Release of Halogens via Blebbistatin Photocage
inferred← citeshttps://doi.org/10.1021/acs.jpcb.5b01524openalex-snapshot
Electron Paramagnetic Resonance Imaging and Spectroscopy of Polydopamine Radicals
inferred← citeshttps://doi.org/10.1021/acs.jpcb.8b03279openalex-snapshot
Measuring Drug-Induced Changes in Metabolite Populations of Live Bacteria: Real Time Analysis by Raman Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.jpclett.3c01574openalex-snapshot
Controllable Photocleavage of Blebbistatin Derivatives as Photoremovable Protecting Groups
inferred← citeshttps://doi.org/10.1021/acsabm.0c00298openalex-snapshot
Magnetic Iron Oxide Nanoparticles Immobilized with Sugar-Containing Poly(ionic liquid) Brushes for Efficient Trapping and Killing of Bacteria
inferred← citeshttps://doi.org/10.1021/acsabm.6c00014openalex-snapshot
A Smart Polypeptide-Based Photoresponsive Nanotherapeutic against Methicillin-Resistant Staphylococcus aureus
inferred← citeshttps://doi.org/10.1021/acsami.0c19330openalex-snapshot
In Situ Synthesis of FeOCl in Hollow Dendritic Mesoporous Organosilicon for Ascorbic Acid-Enhanced and MR Imaging-Guided Chemodynamic Therapy in Neutral pH Conditions
inferred← citeshttps://doi.org/10.1021/acsami.6b05905openalex-snapshot
Multifunctions of Excited Gold Nanoparticles Decorated Artificial Kidney with Efficient Hemodialysis and Therapeutic Potential
inferred← citeshttps://doi.org/10.1021/acsami.6b10052openalex-snapshot
Extracellular Electron Transfer from Aerobic Bacteria to Au-Loaded TiO 2 Semiconductor without Light: A New Bacteria-Killing Mechanism Other than Localized Surface Plasmon Resonance or Microbial Fuel Cells
inferred← citeshttps://doi.org/10.1021/acsami.6b16856openalex-snapshot
Synthesis of {111} Facet-Exposed MgO with Surface Oxygen Vacancies for Reactive Oxygen Species Generation in the Dark
inferred← citeshttps://doi.org/10.1021/acschembio.5b00517openalex-snapshot
First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-ReplicatingM. tuberculosis
inferred← citeshttps://doi.org/10.1021/acschemneuro.7b00310openalex-snapshot
The Analgesic Acetaminophen and the Antipsychotic Clozapine Can Each Redox-Cycle with Melanin
inferred← citeshttps://doi.org/10.1021/acsinfecdis.1c00417openalex-snapshot
Doxofylline Protects Gram-Negative Pathogens against Antibiotic-Mediated Killing
inferred← citeshttps://doi.org/10.1021/acsinfecdis.1c00660openalex-snapshot
Nanomaterials: The New Antimicrobial Magic Bullet
inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00522openalex-snapshot
CCCP Facilitates Aminoglycoside to Kill Late Stationary-Phase Escherichia coli by Elevating Hydroxyl Radical
inferred← citeshttps://doi.org/10.1021/acsinfecdis.4c00249openalex-snapshot
Quantifying Membrane Alterations with Tailored Fluorescent Dyes: A Rapid Antibiotic Resistance Profiling Methodology
inferred← citeshttps://doi.org/10.1021/acsinfecdis.6b00004openalex-snapshot
Identifying and Tackling Emergent Vulnerability in Drug-Resistant Mycobacteria
inferred← citeshttps://doi.org/10.1021/acsinfecdis.8b00171openalex-snapshot
Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1021/acsmaterialslett.4c00840openalex-snapshot
Interrupting Antibiotic Resistance Transmission via Natural Product-Embedded Lipopeptide–Polymeric Nanoblockers
inferred← citeshttps://doi.org/10.1021/acsnano.2c05756openalex-snapshot
Treating Multi-Drug-Resistant Bacterial Infections by Functionalized Nano-Bismuth Sulfide through the Synergy of Immunotherapy and Bacteria-Sensitive Phototherapy
inferred← citeshttps://doi.org/10.1021/acsomega.2c03943openalex-snapshot
Synthesis of Trimetallic (Ni-Cu)@Ag Core@Shell Nanoparticles without Stabilizing Materials for Antibacterial Applications
inferred← citeshttps://doi.org/10.1021/acsomega.6b00212openalex-snapshot
Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death
inferred← citeshttps://doi.org/10.1021/bk-2015-1200.ch001openalex-snapshot
Oxidative Stress and Human Health
inferred← citeshttps://doi.org/10.1021/jacs.8b10235openalex-snapshot
Dynamics of Oxygen-Independent Photocleavage of Blebbistatin as a One-Photon Blue or Two-Photon Near-Infrared Light-Gated Hydroxyl Radical Photocage
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