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Comparative Genomics Reveals the Core Gene Toolbox for the Fungus-Insect Symbiosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Evolutionary implications of a rRNA-based phylogeny of Harpellales
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Confirmation and identification of parasitic stages of obligate endobionts (Harpellales) in blackflies (Simuliidae) by means of rRNA sequence data
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Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory?
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Using a five-gene phylogeny to test morphology-based hypotheses of Smittium and allies, endosymbiotic gut fungi (Harpellales) associated with arthropods
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An undescribed species of Smittium (Trichomycetes) pathogenic to mosquito larvae in Australia
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Metarhizium spp., Cosmopolitan Insect-Pathogenic Fungi: Mycological Aspects
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Requirement for potassium and pH shift in host-mediated sporangiospore extrusion from trichospores of Smittium culisetae and other Smittium species
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Novel Fold Revealed by the Structure of a FAS1 Domain Pair from the Insect Cell Adhesion Molecule Fasciclin I
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The Aspergillus nidulans alcA promoter drives tightly regulated conditional gene expression in Aspergillus fumigatus permitting validation of essential genes in this human pathogen
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Molecular evidence for an ancient duplication of the entire yeast genome
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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
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Discovery of insect and human dengue virus host factors
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A scorpion neurotoxin increases the potency of a fungal insecticide
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Contrasting host–pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes
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Widespread adenine N6-methylation of active genes in fungi
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Association of SET domain and myotubularin-related proteins modulates growth control
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SignalP 4.0: discriminating signal peptides from transmembrane regions
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The Magnaporthe oryzae nitrooxidative stress response suppresses rice innate immunity during blast disease
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Genomic perspectives on the evolution of fungal entomopathogenicity in Beauveria bassiana
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Candida albicans Als1p: an adhesin that is a downstream effector of the EFG1 filamentation pathway
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Genome-wide functional analysis reveals that infection-associated fungal autophagy is necessary for rice blast disease
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Three-dimensional visualization and a deep-learning model reveal complex fungal parasite networks in behaviorally manipulated ants
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A Saccharomyces gene family involved in invasive growth, cell–cell adhesion, and mating
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Molecular Basis of the Interaction between Plasma Platelet-activating Factor Acetylhydrolase and Low Density Lipoprotein
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The Microdistribution of the Trichomycete Smittium culisetae in the Hindgut of the Black Fly Host Simulium vittatum
inferredcites →https://doi.org/10.1080/15572536.2006.11832705openalex-snapshot
Trichomycete insect symbionts in Great Smoky Mountains National Park and vicinity
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The Scientific Rediscovery of an Ancient Chinese Herbal Medicine: Cordyceps sinensis Part I
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Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research
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Fast and accurate short read alignment with Burrows–Wheeler transform
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trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses
inferredcites →https://doi.org/10.1093/bioinformatics/btp352openalex-snapshot
The Sequence Alignment/Map format and SAMtools
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Scaffolding pre-assembled contigs using SSPACE
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The Cdc42p effector Gic2p is targeted for ubiquitin‐dependent degradation by the SCFGrr1 complex
inferredcites →https://doi.org/10.1093/gbe/evv090openalex-snapshot
Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell Walls of Algal Ancestors of Land Plants
inferredcites →https://doi.org/10.1093/infdis/jiw028openalex-snapshot
Protein Acetylation Is Involved inSalmonella entericaSerovar Typhimurium Virulence
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IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies
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Genome-Wide Survey of Gut Fungi (Harpellales) Reveals the First Horizontally Transferred Ubiquitin Gene from a Mosquito Host
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UFBoot2: Improving the Ultrafast Bootstrap Approximation
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MUSCLE: multiple sequence alignment with high accuracy and high throughput
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UniProt: the universal protein knowledgebase
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FSR1 Is Essential for Virulence and Female Fertility in Fusarium verticillioides and F. graminearum
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Polyploidy in fungi: evolution after whole-genome duplication
inferredcites →https://doi.org/10.1101/gr.081612.108openalex-snapshot
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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
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inferredcites →https://doi.org/10.1111/j.0030-1299.2005.13417.xopenalex-snapshot
Context‐dependent symbiosis between black flies (Diptera: Simuliidae) and trichomycete fungi (Harpellales: Legeriomycetaceae)
inferredcites →https://doi.org/10.1111/mec.12940openalex-snapshot
Phylogeography and evolution of a fungal–insect association on the T ibetan P lateau
inferredcites →https://doi.org/10.1126/science.1078155openalex-snapshot
Ancient Tripartite Coevolution in the Attine Ant-Microbe Symbiosis
inferredcites →https://doi.org/10.1126/science.1108639openalex-snapshot
An Entomopathogenic Fungus for Control of Adult African Malaria Mosquitoes
inferredcites →https://doi.org/10.1126/science.1187113openalex-snapshot
Lateral Transfer of Genes from Fungi Underlies Carotenoid Production in Aphids
inferredcites →https://doi.org/10.1126/science.274.5287.546openalex-snapshot
Life with 6000 Genes
inferredcites →https://doi.org/10.1128/ec.00409-06openalex-snapshot
The MAD1 Adhesin of Metarhizium anisopliae Links Adhesion with Blastospore Production and Virulence to Insects, and the MAD2 Adhesin Enables Attachment to Plants
inferredcites →https://doi.org/10.1128/ec.3.3.705-714.2004openalex-snapshot
Genome-Wide Single-Nucleotide Polymorphism Map for Candida albicans
inferredcites →https://doi.org/10.1128/genomea.00397-17openalex-snapshot
Draft Genome Sequences of the Antarctic Endolithic Fungi Rachicladosporium antarcticum CCFEE 5527 and Rachicladosporium sp. CCFEE 5018
inferredcites →https://doi.org/10.1128/genomea.00761-16openalex-snapshot
Draft Genome Sequence of Capniomyces stellatus , the Obligate Gut Fungal Symbiont of Stonefly
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Fungal Genomes and Insights into the Evolution of the Kingdom
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SNP marker discovery, linkage map construction and identification of QTLs for enhanced salinity tolerance in field pea (Pisum sativumL.)
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Versatile and open software for comparing large genomes
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Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
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Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions
inferredcites →https://doi.org/10.1186/gb-2011-12-11-r116openalex-snapshot
Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine
inferredcites →https://doi.org/10.1186/s12864-015-1812-xopenalex-snapshot
Gene expression during zombie ant biting behavior reflects the complexity underlying fungal parasitic behavioral manipulation
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Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi
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FASconCAT-G: extensive functions for multiple sequence alignment preparations concerning phylogenetic studies
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Repbase Update, a database of repetitive elements in eukaryotic genomes
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Trichomycetes and Other Fungal Groups
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Beyond the Whole-Genome Duplication: Phylogenetic Evidence for an Ancient Interspecies Hybridization in the Baker's Yeast Lineage
inferredcites →https://doi.org/10.1371/journal.pbio.1002221openalex-snapshot
Origin of the Yeast Whole-Genome Duplication
inferredcites →https://doi.org/10.1371/journal.pgen.1000549openalex-snapshot
Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication
inferredcites →https://doi.org/10.1371/journal.pgen.1001264openalex-snapshot
Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum
inferredcites →https://doi.org/10.1371/journal.pone.0044373openalex-snapshot
MRN1 Implicates Chromatin Remodeling Complexes and Architectural Factors in mRNA Maturation
inferredcites →https://doi.org/10.1371/journal.pone.0081686openalex-snapshot
Metarhizium anisopliae Pathogenesis of Mosquito Larvae: A Verdict of Accidental Death
inferredcites →https://doi.org/10.1371/journal.pone.0092293openalex-snapshot
Genetic Diversity and Distribution Patterns of Host Insects of Caterpillar Fungus Ophiocordyceps sinensis in the Qinghai-Tibet Plateau
inferredcites →https://doi.org/10.1534/g3.117.040691openalex-snapshot
Insight into the Recent Genome Duplication of the Halophilic Yeast Hortaea werneckii: Combining an Improved Genome with Gene Expression and Chromatin Structure
inferredcites →https://doi.org/10.1534/g3.118.200656openalex-snapshot
Early Diverging Insect-Pathogenic Fungi of the Order Entomophthorales Possess Diverse and Unique Subtilisin-Like Serine Proteases
inferredcites →https://doi.org/10.1631/jzus.b0920017openalex-snapshot
MoFLP1, encoding a novel fungal fasciclin-like protein, is involved in conidiation and pathogenicity in Magnaporthe oryzae
inferredcites →https://doi.org/10.2217/fmb.10.11openalex-snapshot
Entomopathogenic Fungi as the Next-Generation Control Agents Against Malaria Mosquitoes
inferredcites →https://doi.org/10.2307/3759499openalex-snapshot
Studies on the Nutritional Relationship of Larval Aedes aegypti (Diptera: Culicidae) with Smittium culisetae (Trichomycetes)
inferredcites →https://doi.org/10.2307/3792808openalex-snapshot
Capniomyces stellatus and Simuliomyces spica: New Taxa of Harpellales (Trichomycetes) from Winter-Emerging Stoneflies
inferredcites →https://doi.org/10.3114/sim.2007.57.01openalex-snapshot
Phylogenetic classification of Cordyceps and the clavicipitaceous fungi
inferredcites →https://doi.org/10.3733/hilg.v26n02p107openalex-snapshot
Microbial control—the emergence of an idea. A brief history of insect pathology through the nineteenth century
inferredcites →https://doi.org/10.3852/07-202openalex-snapshot
A multilocus phylogeny of theMetarhizium anisopliaelineage
inferredcites →https://doi.org/10.3852/13-253openalex-snapshot
An eight-gene molecular phylogeny of the Kickxellomycotina, including the first phylogenetic placement of Asellariales
inferredcites →https://doi.org/10.3852/16-042openalex-snapshot
A phylum-level phylogenetic classification of zygomycete fungi based on genome-scale data
inferredcites →https://doi.org/10.3897/zookeys.127.802openalex-snapshot
Host insect species of Ophiocordyceps sinensis: a review
inferredcites →https://doi.org/10.4161/cib.16721openalex-snapshot
Ophiocordyceps unilateralis: A keystone species for unraveling ecosystem functioning and biodiversity of fungi in tropical forests?
inferredcites →https://doi.org/10.5860/choice.39-5812openalex-snapshot
Trichomycetes and other fungal groups

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Fungi Are What They Secrete: Evolution of Zygomycete Secretomes and the Origins of Terrestrial Fungal Ecologies
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Insect Gut Microbiota Diversity Reveals Differences in Pathogenicity Between Metarhizium rileyi and Beauveria bassiana
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Genetics and Infection Biology of the Entomopathogenic Fungi
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Pan-genomics of fungi and its applications
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Transcriptome-based identification of small RNA in plants: The need for robust prediction algorithms
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Laboulbeniomycetes, Enigmatic Fungi With a Turbulent Taxonomic History
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Characteristics of cross transmission of gut fungal pathogens between wintering Hooded Cranes and sympatric Domestic Geese
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Enhancing entomopathogenic fungal resources through genetic engineering- A natural and pre-emptive approach to insect pest management
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Evolution of zygomycete secretomes and the origins of terrestrial fungal ecologies
inferred← citeshttps://doi.org/10.1016/j.jinsphys.2025.104842openalex-snapshot
Insect gut-dwelling fungus Zancudomyces culisetae: A hidden player in mosquito development
inferred← citeshttps://doi.org/10.1016/j.ympev.2019.106550openalex-snapshot
Diversification of the gut fungi Smittium and allies (Harpellales) co-occurred with the origin of complete metamorphosis of their symbiotic insect hosts (lower Diptera)
inferred← citeshttps://doi.org/10.1038/s41564-018-0354-9openalex-snapshot
Utilization of selenocysteine in early-branching fungal phyla
inferred← citeshttps://doi.org/10.1038/s42003-021-02925-1openalex-snapshot
Co-option of an extracellular protease for transcriptional control of nutrient degradation in the fungus Aspergillus nidulans
inferred← citeshttps://doi.org/10.1093/femsec/fiaa116openalex-snapshot
Caterpillar gut and host plant phylloplane mycobiomes differ: a new perspective on fungal involvement in insect guts
inferred← citeshttps://doi.org/10.1093/g3journal/jkaf204openalex-snapshot
From fragmentation to resolution: high-fidelity genome assembly of Zancudomyces culisetae through comparative insights from PacBio, Nanopore, and Illumina sequencing
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Mycoparasites, Gut Dwellers, and Saprotrophs: Phylogenomic Reconstructions and Comparative Analyses of Kickxellomycotina Fungi
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Divergent Evolution of Early Terrestrial Fungi Reveals the Evolution of Mucormycosis Pathogenicity Factors
inferred← citeshttps://doi.org/10.1093/gbe/evae259openalex-snapshot
De Novo Long-Read Genome Assembly and Annotation of the Mosquito Gut-Dwelling Fungus, Smittium minutisporum
inferred← citeshttps://doi.org/10.1093/molbev/msad045openalex-snapshot
Speciation Underpinned by Unexpected Molecular Diversity in the Mycorrhizal Fungal GenusPisolithus
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Taxonomy of the anaerobic gut fungi (Neocallimastigomycota): a review of classification criteria and description of current taxa
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Altered stereostructures of the DNA-binding domains in the mutant mating proteins of Ophiocordyceps sinensis and the Cordyceps sinensis insect‒fungal complex
inferred← citeshttps://doi.org/10.1111/1462-2920.70380openalex-snapshot
Single‐Thallus Genomics of Ejectosporus trisporus , an Unculturable Stonefly Gut Fungal Symbiont
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Harnessing Nutritional Niches to Explore Fungus‐Animal Symbioses
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First record of trichomycete fungi from Rouge National Urban Park and Greater Toronto Area
inferred← citeshttps://doi.org/10.1155/2024/8814592openalex-snapshot
Revealing the Diversity of the Mycobiome in Different Phases of Ticks: ITS Gene‐Based Analysis
inferred← citeshttps://doi.org/10.1371/journal.pone.0304908openalex-snapshot
Gut microbiota diversity in a dung beetle (Catharsius molossus) across geographical variations and brood ball-mediated microbial transmission
inferred← citeshttps://doi.org/10.20944/preprints202403.1854.v1openalex-snapshot
Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes in Hirsutella sinensis and Natural Cordyceps sinensis
inferred← citeshttps://doi.org/10.2139/ssrn.5500354openalex-snapshot
Genome-wide analyses to delimit the Smittium culicis complex, a globally distributed group of insect gut fungi
inferred← citeshttps://doi.org/10.3389/fphar.2020.575704openalex-snapshot
Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin
inferred← citeshttps://doi.org/10.3390/biology13080632openalex-snapshot
Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes in Hirsutella sinensis and the Natural Cordyceps sinensis Insect-Fungi Complex
inferred← citeshttps://doi.org/10.3390/biology15020186openalex-snapshot
Altered Stereostructures of the DNA-Binding Domains of Variant Mating Proteins of Ophiocordyceps sinensis and the Wild Insect–Fungal Complex
inferred← citeshttps://doi.org/10.3390/ijms27167191openalex-snapshot
Structural Diversity and Differential Natural Pairings of MAT1-1-1 and MAT1-2-1 Proteins Essential for Sexual Reproduction in Ophiocordyceps sinensis Strains
inferred← citeshttps://doi.org/10.3390/jof11040244openalex-snapshot
Three-Dimensional Structural Heteromorphs of Mating-Type Proteins in Hirsutella sinensis and the Natural Cordyceps sinensis Insect–Fungal Complex
inferred← citeshttps://doi.org/10.3390/microorganisms11071830openalex-snapshot
Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?
inferred← citeshttps://doi.org/10.3390/microorganisms12061129openalex-snapshot
Gut Microbial Diversity Reveals Differences in Pathogenicity between Metarhizium rileyi and Beauveria bassiana during the Early Stage of Infection in Spodoptera litura Larvae
inferred← citeshttps://doi.org/10.48022/mbl.2601.01010openalex-snapshot
Community Structure and Ecological Inference of Root Endophytic Fungi in Acanthus ilicifolius from the Sediment-Stressed Segara Anakan Lagoon, Indonesia
inferred← citeshttps://doi.org/10.5099/aj220300115openalex-snapshot
Molecular Identification of Ophiocordyceps sinensis Genotypes and the Indiscriminate Use of the Latin Name for Multiple Genotypes and the Natural Insect-fungi Complex
inferred← citeshttps://doi.org/10.5943/mycosphere/14/1/4openalex-snapshot
Freshwater fungal biology
inferred← citeshttps://doi.org/10.64898/2026.02.16.706022openalex-snapshot
Heteromorphic tertiary structures of MAT1-1-1 and MAT1-2-1 protein variants simultaneously produced in pairs by Ophiocordyceps sinensis strains
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