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Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

https://doi.org/10.1161/01.cir.98.4.346
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts
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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
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Expression of Nuclear Proto-oncogenes in Isoproterenol-induced Cardiac Hypertrophy
inferredcites →https://doi.org/10.1007/bf00229801openalex-snapshot
Adrenergic hormones and control of cardiac myocyte growth
inferredcites →https://doi.org/10.1016/0003-2697(87)90021-2openalex-snapshot
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
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Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways
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Cytokine signal transduction
inferredcites →https://doi.org/10.1016/0092-8674(95)90311-9openalex-snapshot
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
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Efficient selection for high-expression transfectants with a novel eukaryotic vector
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Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.
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Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase
inferredcites →https://doi.org/10.1016/s0021-9258(19)50309-xopenalex-snapshot
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes
inferredcites →https://doi.org/10.1073/pnas.85.2.339openalex-snapshot
Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.
inferredcites →https://doi.org/10.1073/pnas.92.11.4862openalex-snapshot
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
inferredcites →https://doi.org/10.1073/pnas.92.4.1142openalex-snapshot
Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.
inferredcites →https://doi.org/10.1073/pnas.93.9.3963openalex-snapshot
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line.
inferredcites →https://doi.org/10.1074/jbc.270.39.23173openalex-snapshot
Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice
inferredcites →https://doi.org/10.1074/jbc.271.14.8452openalex-snapshot
Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes
inferredcites →https://doi.org/10.1074/jbc.271.16.9535openalex-snapshot
Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy
inferredcites →https://doi.org/10.1074/jbc.272.9.5783openalex-snapshot
Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway
inferredcites →https://doi.org/10.1083/jcb.126.6.1565openalex-snapshot
Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.
inferredcites →https://doi.org/10.1093/nar/23.19.3816openalex-snapshot
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
inferredcites →https://doi.org/10.1096/fasebj.5.15.1835945openalex-snapshot
Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response
inferredcites →https://doi.org/10.1096/fasebj.9.9.7601337openalex-snapshot
The MAPK signaling cascade
inferredcites →https://doi.org/10.1126/science.6542248openalex-snapshot
Nucleotide Sequences of the Human and Mouse Atrial Natriuretic Factor Genes
inferredcites →https://doi.org/10.1126/science.7701321openalex-snapshot
Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes
inferredcites →https://doi.org/10.1152/ajpheart.1990.259.2.h610openalex-snapshot
Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells
inferredcites →https://doi.org/10.1152/ajpheart.1994.266.6.h2468openalex-snapshot
ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice
inferredcites →https://doi.org/10.1161/01.cir.94.10.2626openalex-snapshot
Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes
inferredcites →https://doi.org/10.1161/01.res.56.6.884openalex-snapshot
Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.
inferredcites →https://doi.org/10.1161/01.res.69.1.209openalex-snapshot
Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.
inferredcites →https://doi.org/10.1161/01.res.73.3.413openalex-snapshot
Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.
inferredcites →https://doi.org/10.1161/01.res.78.6.954openalex-snapshot
Depletion of Mitogen-Activated Protein Kinase Using an Antisense Oligodeoxynucleotide Approach Downregulates the Phenylephrine-Induced Hypertrophic Response in Rat Cardiac Myocytes
inferredcites →https://doi.org/10.1161/01.res.78.6.971openalex-snapshot
Novel Adenovirus Component System That Transfects Cultured Cardiac Cells With High Efficiency
inferredcites →https://doi.org/10.1172/jci113179openalex-snapshot
Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.
inferredcites →https://doi.org/10.1172/jci114924openalex-snapshot
Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.
inferredcites →https://doi.org/10.1172/jci116577openalex-snapshot
Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.
inferredcites →https://doi.org/10.1182/blood.v88.8.2906.bloodjournal8882906openalex-snapshot
Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor
inferredcites →https://doi.org/10.7883/yoken1952.47.157openalex-snapshot
A SIMPLE AND EFFICIENT METHOD FOR PURIFICATION OF INFECTIOUS RECOMBINANT ADENOVIRUS

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
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Sphingosine 1‐Phosphate (S1P) Signaling in Cardiovascular Physiology and Disease
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Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology
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Gallic Acid Suppresses Cardiac Hypertrophic Remodeling and Heart Failure
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Linkage between α1 Adrenergic Receptor and the Jak/STAT Signaling Pathway in Vascular Smooth Muscle Cells
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gp130-DEPENDENT SIGNALLING PATHWAY IS NOT ENHANCED IN gp130 TRANSGENIC HEART AFTER LIF STIMULATION
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CARDIOTROPHIN-1 AND UROCORTIN CAUSE PROTECTION BY THE SAME PATHWAY AND HYPERTROPHY VIA DISTINCT PATHWAYS IN CARDIAC MYOCYTES
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Angiotensin Blockade Inhibits SIF DNA Binding Activities via STAT3 after Myocardial Infarction
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Epidermal Growth Factor Induces Hypertrophic Responses and Stat5 Activation in Rat Ventricular Cardiomyocytes
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Requirement of Activation of the Extracellular Signal-regulated Kinase Cascade in Myocardial Cell Hypertrophy
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Myocardial Ischemia Activates the JAK–STAT Pathway Through Angiotensin II Signaling in in vivo Myocardium of Rats
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Heat Shock Protein-56 is Induced by Cardiotrophin-1 and Mediates its Hypertrophic Effect
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Interplay Between the Cardiac Renin Angiotensin System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion Dysfunction, and Heart Failure
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Autocrine and Intracrine Signaling for Cardiogenesis in Embryonic Stem Cells: A Clue for the Development of Novel Differentiating Agents
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Inhibition of cardiac myocyte apoptosis by gp130-dependent cytokines
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Reducing Oxidative Stress and Manipulating Molecular Signaling Events Using Resveratrol as a Therapy for Pathological Cardiac Hypertrophy
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Novel Aspects of Mechanical Signaling in Cardiac Tissue
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The Role of Interleukin-6 in the Failing Heart
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gp130-Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease
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Inhibition of the HER-2/neu Oncogene
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Cardiac Hypertrophy
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Cardiac Development: Toward a Molecular Basis for Congenital Heart Disease
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Ischemic Mitral Regurgitation
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The role of IL-6 in experimental and clinical heart failure
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Molecular Targets in the Treatment of Cardiac Hypertrophy
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Autocrine and Intracrine Signaling for Cardiogenesis in Embryonic Stem Cells: A Clue for the Development of Novel Differentiating Agents
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Apoptosis in the overloaded myocardium: potential stimuli and modifying signals
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Cardiovascular Effects of Sphingosine-1-Phosphate (S1P)
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Hypertrophy and Hypertension
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Adenovirus Vectors in Functional Genomics
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STATs in the Cardiovascular System
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The role of STATs in proliferation, differentiation, and apoptosis
inferred← citeshttps://doi.org/10.1007/s00059-007-3040-xopenalex-snapshot
JAK-STAT Signaling Circuits in Myocarditis and Dilated Cardiomyopathy*
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Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats
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Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
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Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis
inferred← citeshttps://doi.org/10.1007/s00395-016-0543-8openalex-snapshot
Understanding STAT3 signaling in cardiac ischemia
inferred← citeshttps://doi.org/10.1007/s00421-011-2270-zopenalex-snapshot
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats
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Norepinephrine-induced interleukin-6 increase in rat hearts: differential signal transduction in myocytes and non-myocytes
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Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure
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Proinflammatory cytokines in heart failure: double-edged swords
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STAT3 and cardiac remodeling
inferred← citeshttps://doi.org/10.1007/s11010-010-0578-3openalex-snapshot
BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells
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Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population
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Interleukin-6 Signaling, Soluble Glycoprotein 130, and Inflammation in Heart Failure
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Leukemia Inhibitory Factor Increases Survival of Pluripotent Stem Cell-Derived Cardiomyocytes
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Multiple Roles of STAT3 in Cardiovascular Inflammatory Responses
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Signal Transduction of Cardiac Myocyte Hypertrophy
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Ischemic Mitral Regurgitation
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Regulation of the JAK/STAT signaling pathway: The promising targets for cardiovascular disease
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Molecular regulation of cardiac hypertrophy
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Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning
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Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy
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Transcriptional activation of c-Fos by constitutively active Gα16QL through a STAT1-dependent pathway
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Scutellarin protects human cardiac microvascular endothelial cells with hypoxia-reoxygenation injury via JAK2/STAT3 signal pathway
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The lack of cardiotrophin-1 alters expression of interleukin-6 and leukemia inhibitory factor mRNA but does not impair cardiac injury response
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Identification of cardiac myocytes as the target of interleukin 11, a cardioprotective cytokine
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Anti-cytokine therapy in chronic heart failure: new approaches and unmet promises
inferred← citeshttps://doi.org/10.1016/j.febslet.2004.07.082openalex-snapshot
Signals through gp130 upregulate Wnt5a and contribute to cell adhesion in cardiac myocytes
inferred← citeshttps://doi.org/10.1016/j.jacbts.2019.07.008openalex-snapshot
Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
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Molecular Mechanisms in Heart Failure
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Mitral Regurgitation Augments Post-Myocardial Infarction Remodeling
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Bioactive peptides attenuate cardiac hypertrophy and fibrosis in spontaneously hypertensive rat hearts
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PKCζ interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy
inferred← citeshttps://doi.org/10.1016/j.molimm.2008.02.020openalex-snapshot
Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
inferred← citeshttps://doi.org/10.1016/j.molmed.2006.12.002openalex-snapshot
Role of the JAK–STAT pathway in myocardial injury
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Many good reasons to have STAT3 in the heart
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The myocardial JAK/STAT pathway: From protection to failure
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Peripartum cardiomyopathy: An update
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Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes
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Cross-talk between bone morphogenetic protein 2 and leukemia inhibitory factor through ERK 1/2 and Smad1 in protection against doxorubicin-induced injury of cardiomyocytes
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Differential hypertrophic effects of cardiotrophin-1 on adult cardiomyocytes from normotensive and spontaneously hypertensive rats
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Novel insights into the role of cardiotrophin-1 in cardiovascular diseases
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Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2011.01.020openalex-snapshot
Affixin (β-parvin) promotes cardioprotective signaling via STAT3 activation
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2011.04.013openalex-snapshot
STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2012.07.014openalex-snapshot
Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis
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Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure
inferred← citeshttps://doi.org/10.1016/s0002-9440(10)61187-xopenalex-snapshot
Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines
inferred← citeshttps://doi.org/10.1016/s0002-9440(10)63781-9openalex-snapshot
Signal Transducer and Activator of Transcription-3 Activation Contributes to High Tissue Inhibitor of Metalloproteinase-1 Expression in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma
inferred← citeshttps://doi.org/10.1016/s0008-6363(00)00138-3openalex-snapshot
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction
inferred← citeshttps://doi.org/10.1016/s0008-6363(01)00492-8openalex-snapshot
Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression
inferred← citeshttps://doi.org/10.1016/s0008-6363(02)00664-8openalex-snapshot
Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts
inferred← citeshttps://doi.org/10.1016/s0008-6363(03)00463-2openalex-snapshot
Glycoprotein 130 ligand oncostatin-M induces expression of vascular endothelial growth factor in human adult cardiac myocytes
inferred← citeshttps://doi.org/10.1016/s0008-6363(99)00386-7openalex-snapshot
Signalling via stress-activated mitogen-activated protein kinases in the cardiovascular system
inferred← citeshttps://doi.org/10.1016/s0014-5793(99)00936-9openalex-snapshot
Endothelin‐1 induces expression of fetal genes through the interleukin‐6 family of cytokines in cardiac myocytes
inferred← citeshttps://doi.org/10.1016/s0065-2423(10)52002-xopenalex-snapshot
Cardiotrophin-1 in Cardiovascular Regulation
inferred← citeshttps://doi.org/10.1016/s0889-1591(03)00053-9openalex-snapshot
Myocardial IL-6 regulation by neurohormones—an in vitro superfusion study
inferred← citeshttps://doi.org/10.1016/s1050-1738(01)00066-4openalex-snapshot
A Novel Role for STAT3 in Cardiac Remodeling
inferred← citeshttps://doi.org/10.1016/s1568-9972(03)00103-4openalex-snapshot
Inflammation and chronic heart failure–potential therapeutic role of intravenous immunoglobulin
inferred← citeshttps://doi.org/10.1016/s1937-6448(10)84003-1openalex-snapshot
What Causes a Broken Heart—Molecular Insights into Heart Failure
inferred← citeshttps://doi.org/10.1017/s1431927600035479openalex-snapshot
Decrease Tyrosine Phosphorylation of Stat3 in Human Myocardium with End-Stage Congestive Heart Failure
inferred← citeshttps://doi.org/10.1023/a:1009855720081openalex-snapshot
Changes in Gene Expression during the Transition from Compensated Hypertrophy to Heart Failure
inferred← citeshttps://doi.org/10.1023/a:1011401825680openalex-snapshot
The Role of Interleukin-6 in the Failing Heart
inferred← citeshttps://doi.org/10.1023/a:1020648425895openalex-snapshot
Cytokine G-protein signaling crosstalk in cardiomyocytes: Attentuation of Jak-STAT activation by endothelin-1
inferred← citeshttps://doi.org/10.1023/a:1021655023870openalex-snapshot
Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase
inferred← citeshttps://doi.org/10.1023/b:mcbi.0000044393.67980.99openalex-snapshot
Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction
inferred← citeshttps://doi.org/10.1038/bjp.2008.1openalex-snapshot
Role of gp130‐mediated signalling pathways in the heart and its impact on potential therapeutic aspects
inferred← citeshttps://doi.org/10.1038/labinvest.3700322openalex-snapshot
Interleukin-6/soluble interleukin-6 receptor complex reduces infarct size via inhibiting myocardial apoptosis
inferred← citeshttps://doi.org/10.1038/s41418-021-00789-wopenalex-snapshot
Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3
inferred← citeshttps://doi.org/10.1038/s44321-026-00411-xopenalex-snapshot
JAK1/2 inhibitor ruxolitinib reduces aggregates in cardiac proteinopathy
inferred← citeshttps://doi.org/10.1038/sj.bjc.6603597openalex-snapshot
Stat3 activation in human endometrial and cervical cancers
inferred← citeshttps://doi.org/10.1038/sj.bjp.0705562openalex-snapshot
Expression and effects of cardiotrophin‐1 (CT‐1) in human airway smooth muscle cells
inferred← citeshttps://doi.org/10.1038/sj.onc.1205440openalex-snapshot
N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth
inferred← citeshttps://doi.org/10.1038/sj.onc.1207466openalex-snapshot
Arsenic inhibition of the JAK-STAT pathway
inferred← citeshttps://doi.org/10.1038/sj.onc.1207703openalex-snapshot
Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma
inferred← citeshttps://doi.org/10.1046/j.1365-201x.2002.00989.xopenalex-snapshot
Gene expression of colony‐stimulating factors and stem cell factor after myocardial infarction in the mouse
inferred← citeshttps://doi.org/10.1046/j.1365-2362.2001.00795.xopenalex-snapshot
Myocardial gene expression of leukaemia inhibitory factor, interleukin‐6 and glycoprotein 130 in end‐stage human heart failure
inferred← citeshttps://doi.org/10.1046/j.1365-2613.2000.00139.xopenalex-snapshot
Cytokines and their receptors in cardiovascular diseases — role of gp130 signalling pathway in cardiac myocyte growth and maintenance
inferred← citeshttps://doi.org/10.1046/j.1432-0436.2001.068001031.xopenalex-snapshot
Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm
inferred← citeshttps://doi.org/10.1046/j.1432-1033.2002.03066.xopenalex-snapshot
N‐myc oncogene overexpression down‐regulates leukemia inhibitory factor in neuroblastoma
inferred← citeshttps://doi.org/10.1053/plac.1999.0493openalex-snapshot
Pregnancy-dependent Expression of Leukaemia Inhibitory Factor (LIF), LIF Receptor-β and Interleukin-6 (IL-6) Messenger Ribonucleic Acids in the Porcine Female Reproductive Tract
inferred← citeshttps://doi.org/10.1073/pnas.0508023102openalex-snapshot
Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease
inferred← citeshttps://doi.org/10.1073/pnas.0510460103openalex-snapshot
Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity
inferred← citeshttps://doi.org/10.1073/pnas.100127897openalex-snapshot
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy
inferred← citeshttps://doi.org/10.1073/pnas.2134694100openalex-snapshot
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
inferred← citeshttps://doi.org/10.1073/pnas.97.1.315openalex-snapshot
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy
inferred← citeshttps://doi.org/10.1074/jbc.275.12.8508openalex-snapshot
Urocortin Protects against Ischemic and Reperfusion Injury via a MAPK-dependent Pathway
inferred← citeshttps://doi.org/10.1074/jbc.275.14.10561openalex-snapshot
Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1074/jbc.m001748200openalex-snapshot
DNA Binding Specificity of Different STAT Proteins
inferred← citeshttps://doi.org/10.1074/jbc.m100699200openalex-snapshot
A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology
inferred← citeshttps://doi.org/10.1074/jbc.m100814200openalex-snapshot
gp130 Plays a Critical Role in Pressure Overload-induced Cardiac Hypertrophy
inferred← citeshttps://doi.org/10.1074/jbc.m103166200openalex-snapshot
Glycogen Synthase Kinase 3β Regulates GATA4 in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1074/jbc.m104626200openalex-snapshot
The Transcriptional Co-activators CBP and p300 Are Activated via Phenylephrine through the p42/p44 MAPK Cascade
inferred← citeshttps://doi.org/10.1074/jbc.m106718200openalex-snapshot
The Ribosomal S6 Kinases, cAMP-responsive Element-binding, and STAT3 Proteins Are Regulated by Different Leukemia Inhibitory Factor Signaling Pathways in Mouse Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1074/jbc.m108246200openalex-snapshot
Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart
inferred← citeshttps://doi.org/10.1074/jbc.m111.246173openalex-snapshot
Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart
inferred← citeshttps://doi.org/10.1074/jbc.m211762200openalex-snapshot
The Transcriptional Co-activators CREB-binding Protein (CBP) and p300 Play a Critical Role in Cardiac Hypertrophy That Is Dependent on Their Histone Acetyltransferase Activity
inferred← citeshttps://doi.org/10.1074/jbc.m212321200openalex-snapshot
JAK2/STAT3, Not ERK1/2, Mediates Interleukin-6-induced Activation of Inducible Nitric-oxide Synthase and Decrease in Contractility of Adult Ventricular Myocytes
inferred← citeshttps://doi.org/10.1074/jbc.m508969200openalex-snapshot
Leukemia Inhibitory Factor Induces Endothelial Differentiation in Cardiac Stem Cells
inferred← citeshttps://doi.org/10.1074/mcp.m400155-mcp200openalex-snapshot
Proteomic Analysis Reveals Different Protein Changes during Endothelin-1- or Leukemic Inhibitory Factor-induced Hypertrophy of Cardiomyocytes in Vitro
inferred← citeshttps://doi.org/10.1078/0171-2985-00110openalex-snapshot
Systemic Immunosuppression Fails to Suppress Cardiac Cytokine Induction in Pressure Overload Hypertrophy in Rats
inferred← citeshttps://doi.org/10.1080/07853890510007232openalex-snapshot
Inflammatory and anti‐inflammatory cytokines in chronic heart failure: Potential therapeutic implications
inferred← citeshttps://doi.org/10.1080/21623996.2016.1158379openalex-snapshot
IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor
inferred← citeshttps://doi.org/10.1084/jem.20051151openalex-snapshot
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis
inferred← citeshttps://doi.org/10.1089/104303403321618128openalex-snapshot
Inhibition of STAT3 Prevents Neointima Formation by Inhibiting Proliferation and Promoting Apoptosis of Neointimal Smooth Muscle Cells
inferred← citeshttps://doi.org/10.1089/humc.2019.087openalex-snapshot
MiR-625-5p Inhibits Cardiac Hypertrophy Through Targeting STAT3 and CaMKII
inferred← citeshttps://doi.org/10.1093/cvr/cvv170openalex-snapshot
SH2B1 is critical for the regulation of cardiac remodelling in response to pressure overload
inferred← citeshttps://doi.org/10.1093/cvr/cvx011openalex-snapshot
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1093/ecam/neq066openalex-snapshot
Ameliorate Effects of Li‐Fu Formula on IL‐6‐Mediated Cardiac Hypertrophy in Hamsters Fed with a Hyper‐Cholesterol Diet
inferred← citeshttps://doi.org/10.1096/fj.08-117721openalex-snapshot
Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4
inferred← citeshttps://doi.org/10.1097/00002480-200009000-00009openalex-snapshot
Dynamic Cardiomyoplasty Decreases Myocardial Workload as Assessed by Tissue Tagged MRI
inferred← citeshttps://doi.org/10.1097/01.shk.0000226341.32786.b9openalex-snapshot
JAK/STAT/SOCS SIGNALING CIRCUITS AND ASSOCIATED CYTOKINE-MEDIATED INFLAMMATION AND HYPERTROPHY IN THE HEART
inferred← citeshttps://doi.org/10.1101/2024.10.11.615348openalex-snapshot
Ruxolitinib clears CRYAB p.Arg120Gly aggregates through the ubiquitin-proteasome system
inferred← citeshttps://doi.org/10.1111/j.1356-9597.2004.00715.xopenalex-snapshot
Cytoplasmic c‐Fos induced by the YXXQ‐derived STAT3 signal requires the co‐operative MEK/ERK signal for its nuclear translocation
inferred← citeshttps://doi.org/10.1111/j.1540-8191.1998.tb01086.xopenalex-snapshot
Myocardial Oxygen Consumption Is Affected by Dynamic Cardiomyoplasty in Dogs with Adriamycin-Induced Cardiomyopathy
inferred← citeshttps://doi.org/10.1111/j.1540-8191.2001.tb01221.xopenalex-snapshot
Adynamic Cardiomyoplasty: Effect on Cardiac Efficiency and Contractile Reserve in Dogs with Adriamycin-Induced Cardiomyopathy
inferred← citeshttps://doi.org/10.1111/j.1742-4658.2008.06504.xopenalex-snapshot
The gp130/STAT3 signaling pathway mediates β‐adrenergic receptor‐induced atrial natriuretic factor expression in cardiomyocytes
inferred← citeshttps://doi.org/10.1113/expphysiol.2006.036590openalex-snapshot
Eccentric cardiac hypertrophy was induced by long‐term intermittent hypoxia in rats
inferred← citeshttps://doi.org/10.1124/mol.108.054320openalex-snapshot
α1-Adrenergic Receptor Stimulates Interleukin-6 Expression and Secretion through Both mRNA Stability and Transcriptional Regulation: Involvement of p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB
inferred← citeshttps://doi.org/10.1124/mol.109.062455openalex-snapshot
Priming of Signal Transducer and Activator of Transcription Proteins for Cytokine-Triggered Polyubiquitylation and Degradation by the A2A Adenosine Receptor
inferred← citeshttps://doi.org/10.1124/mol.112.084483openalex-snapshot
α1A-Adrenergic Receptors Regulate Cardiac Hypertrophy In Vivo Through Interleukin-6 Secretion
inferred← citeshttps://doi.org/10.1146/annurev.physiol.63.1.391openalex-snapshot
Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy
inferred← citeshttps://doi.org/10.1146/annurev.physiol.65.092101.142243openalex-snapshot
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
inferred← citeshttps://doi.org/10.1152/ajpendo.00039.2012openalex-snapshot
JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
inferred← citeshttps://doi.org/10.1152/ajpheart.01334.2005openalex-snapshot
STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium
inferred← citeshttps://doi.org/10.1152/ajpheart.2000.279.4.h1635openalex-snapshot
Significance of ERK cascade compared with JAK/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy
inferred← citeshttps://doi.org/10.1152/ajplung.00171.2004openalex-snapshot
Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants
inferred← citeshttps://doi.org/10.1152/ajprenal.00200.2006openalex-snapshot
Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors
inferred← citeshttps://doi.org/10.1152/japplphysiol.00392.2005openalex-snapshot
Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise
inferred← citeshttps://doi.org/10.1155/2016/1324347openalex-snapshot
Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy
inferred← citeshttps://doi.org/10.1159/000218180openalex-snapshot
Crucial Role of Interleukin-6 in the Development of Norepinephrine-induced Left Ventricular Remodeling in Mice
inferred← citeshttps://doi.org/10.1161/01.cir.0000057545.82749.ffopenalex-snapshot
Alterations in Janus Kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) Signaling in Patients With End-Stage Dilated Cardiomyopathy
inferred← citeshttps://doi.org/10.1161/01.cir.102.2.246openalex-snapshot
Potential Contribution of a Novel Antifibrotic Factor, Hepatocyte Growth Factor, to Prevention of Myocardial Fibrosis by Angiotensin II Blockade in Cardiomyopathic Hamsters
inferred← citeshttps://doi.org/10.1161/01.hyp.0000063884.36641.63openalex-snapshot
Ral GDP Dissociation Stimulator and Ral GTPase Are Involved in Myocardial Hypertrophy
inferred← citeshttps://doi.org/10.1161/01.hyp.35.6.1191openalex-snapshot
Cardiotrophin-1 Increases Angiotensinogen mRNA in Rat Cardiac Myocytes Through STAT3
inferred← citeshttps://doi.org/10.1161/01.res.0000041680.43270.f8openalex-snapshot
Dance Band on the Titanic
inferred← citeshttps://doi.org/10.1161/01.res.0000085562.48906.4aopenalex-snapshot
Activation of gp130 Transduces Hypertrophic Signal Through Interaction of Scaffolding/Docking Protein Gab1 With Tyrosine Phosphatase SHP2 in Cardiomyocytes
inferred← citeshttps://doi.org/10.1161/01.res.84.10.1127openalex-snapshot
Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes
inferred← citeshttps://doi.org/10.1161/01.res.85.10.884openalex-snapshot
Characterization of Insulin-Like Growth Factor-1–Induced Activation of the JAK/STAT Pathway in Rat Cardiomyocytes
inferred← citeshttps://doi.org/10.1161/01.res.86.7.787openalex-snapshot
Leukemia Inhibitory Factor Modulates Cardiogenesis in Embryoid Bodies in Opposite Fashions
inferred← citeshttps://doi.org/10.1161/atvbaha.108.174870openalex-snapshot
Signals Through Glycoprotein 130 Regulate the Endothelial Differentiation of Cardiac Stem Cells
inferred← citeshttps://doi.org/10.1161/circresaha.109.209809openalex-snapshot
Cardiac Fibroblast
inferred← citeshttps://doi.org/10.1161/circresaha.110.226928openalex-snapshot
Multiple Facets of NF-κB in the Heart
inferred← citeshttps://doi.org/10.1161/circresaha.116.308688openalex-snapshot
Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and Dysfunction
inferred← citeshttps://doi.org/10.1161/circresaha.124.323658openalex-snapshot
Repair of the Infarcted Heart: Cellular Effectors, Molecular Mechanisms and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1161/circulationaha.107.755777openalex-snapshot
Severe Heart Failure and Early Mortality in a Double-Mutation Mouse Model of Familial Hypertrophic Cardiomyopathy
inferred← citeshttps://doi.org/10.1161/circulationaha.119.044484openalex-snapshot
gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration
inferred← citeshttps://doi.org/10.1161/hc1002.105225openalex-snapshot
Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Inhibition of Cardiac Hypertrophy In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1161/hc3401.095947openalex-snapshot
Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase
inferred← citeshttps://doi.org/10.1172/jci124778openalex-snapshot
STAT3: a link between CaMKII–βIV-spectrin and maladaptive remodeling?
inferred← citeshttps://doi.org/10.1172/jci89786openalex-snapshot
Redirecting cardiac growth mechanisms for therapeutic regeneration
inferred← citeshttps://doi.org/10.1177/2047487312462827openalex-snapshot
Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 → LIFR/gp 130 → JAK/STAT3 pathway
inferred← citeshttps://doi.org/10.1182/blood-2006-01-010199openalex-snapshot
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration
inferred← citeshttps://doi.org/10.1186/1471-2121-10-55openalex-snapshot
Mechanical strain induces involution-associated events in mammary epithelial cells
inferred← citeshttps://doi.org/10.1186/1471-2407-7-111openalex-snapshot
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
inferred← citeshttps://doi.org/10.1186/1476-4598-7-78openalex-snapshot
Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival
inferred← citeshttps://doi.org/10.1186/s12967-024-05623-8openalex-snapshot
The Abl1 tyrosine kinase is a key player in doxorubicin-induced cardiomyopathy and its p53/p73 cell death mediated signaling differs in atrial and ventricular cardiomyocytes
inferred← citeshttps://doi.org/10.1186/s13020-014-0028-3openalex-snapshot
Protective effects of acacetin isolated from Ziziphora clinopodioides Lam. (Xintahua) on neonatal rat cardiomyocytes
inferred← citeshttps://doi.org/10.1210/en.143.2.492openalex-snapshot
Regulation of IGF-I mRNA and Signal Transducers and Activators of Transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 Myoblasts
inferred← citeshttps://doi.org/10.1371/journal.pone.0053133openalex-snapshot
Long Pentraxin PTX3 Exacerbates Pressure Overload–Induced Left Ventricular Dysfunction
inferred← citeshttps://doi.org/10.1371/journal.pone.0179835openalex-snapshot
STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis
inferred← citeshttps://doi.org/10.1385/ct:3:3:229openalex-snapshot
NF-κB as an Integrator of Diverse Signaling Pathways: The Heart of Myocardial Signaling?
inferred← citeshttps://doi.org/10.1507/endocrj.k10e-150openalex-snapshot
Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones
inferred← citeshttps://doi.org/10.1517/14728222.7.1.49openalex-snapshot
Emerging therapeutic targets in chronic heart failure: Part II
inferred← citeshttps://doi.org/10.1590/s0100-879x2012001000003openalex-snapshot
Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway
inferred← citeshttps://doi.org/10.1634/stemcells.2004-0293openalex-snapshot
JAK2/STAT3 Directs Cardiomyogenesis Within Murine Embryonic Stem Cells In Vitro
inferred← citeshttps://doi.org/10.1681/asn.2005090985openalex-snapshot
Haplotype of Signal Transducer and Activator of Transcription 3 Gene Predicts Cardiovascular Disease in Dialysis Patients
inferred← citeshttps://doi.org/10.1684/ecn.2013.0335openalex-snapshot
LIF and the heart: Just Another Brick in the Wall?
inferred← citeshttps://doi.org/10.21203/rs.3.rs-77650/v1openalex-snapshot
Sorting nexin 3 induces myocardial injury via promoting retromer-dependent nuclear trafficking of STAT3
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