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Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0177(199706)209:2<139::aid-aja1>3.0.co;2-jopenalex-snapshot
Developmental patterning and evolution of the mammalian viscerocranium: Genetic insights into comparative morphology
inferredcites →https://doi.org/10.1002/(sici)1097-0177(199805)212:1<102::aid-aja10>3.0.co;2-9openalex-snapshot
Fate map of the developing chick face: Analysis of expansion of facial primordia and establishment of the primary palate
inferredcites →https://doi.org/10.1002/bies.950190605openalex-snapshot
Genetic analysis of craniofacial development in the vertebrate embryo
inferredcites →https://doi.org/10.1002/jmor.1051130307openalex-snapshot
The embryological development of the effects of Strong's luxoid gene in the mouse
inferredcites →https://doi.org/10.1002/tera.1420010311openalex-snapshot
Responses to selection for plus and minus modifiers of some effects of Strong's luxoid gene on the mouse skeleton
inferredcites →https://doi.org/10.1006/dbio.1993.1219openalex-snapshot
Patterning of Neural Crest Derivatives in the Avian Embryo: in Vivo and in Vitro Studies
inferredcites →https://doi.org/10.1006/dbio.1998.8921openalex-snapshot
MouseAlx3:Anaristaless-like Homeobox Gene Expressed during Embryogenesis in Ectomesenchyme and Lateral Plate Mesoderm
inferredcites →https://doi.org/10.1006/dbio.1998.9116openalex-snapshot
Paired-Related Homeobox Genes Cooperate in Handplate and Hindlimb Zeugopod Morphogenesis
inferredcites →https://doi.org/10.1006/dbio.2001.0330openalex-snapshot
A Population of Caudally Migrating Cranial Neural Crest Cells: Functional and Evolutionary Implications
inferredcites →https://doi.org/10.1016/0012-1606(92)90069-sopenalex-snapshot
Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryos
inferredcites →https://doi.org/10.1016/0092-8674(94)90524-xopenalex-snapshot
Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
inferredcites →https://doi.org/10.1016/0925-4773(94)90063-9openalex-snapshot
The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development
inferredcites →https://doi.org/10.1016/0925-4773(95)00389-iopenalex-snapshot
Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain
inferredcites →https://doi.org/10.1016/s0002-9297(07)62963-2openalex-snapshot
Haploinsufficiency of ALX4 as a Potential Cause of Parietal Foramina in the 11p11.2 Contiguous Gene–Deletion Syndrome
inferredcites →https://doi.org/10.1016/s0166-2236(00)01608-8openalex-snapshot
Emx homeogenes and mouse brain development
inferredcites →https://doi.org/10.1016/s0168-9525(00)89135-0openalex-snapshot
Manipulating the mouse embryo (2nd edn)
inferredcites →https://doi.org/10.1016/s0925-4773(01)00450-6openalex-snapshot
Expression patterns of group-I aristaless-related genes during craniofacial and limb development
inferredcites →https://doi.org/10.1038/83703openalex-snapshot
Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects
inferredcites →https://doi.org/10.1038/ng0796-275openalex-snapshot
Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene
inferredcites →https://doi.org/10.1074/jbc.274.45.32325openalex-snapshot
Site-specific Heterodimerization by Paired Class Homeodomain Proteins Mediates Selective Transcriptional Responses
inferredcites →https://doi.org/10.1136/jmg.37.12.916openalex-snapshot
The ALX4 homeobox gene is mutated in patients with ossification defects of the skull (foramina parietalia permagna, OMIM 168500)
inferredcites →https://doi.org/10.1242/dev.117.2.409openalex-snapshot
The triple origin of skull in higher vertebrates: a study in quail-chick chimeras
inferredcites →https://doi.org/10.1242/dev.121.7.1971openalex-snapshot
Polydactylous limbs in Strong’s Luxoid mice result from ectopic polarizing activity
inferredcites →https://doi.org/10.1242/dev.124.15.2923openalex-snapshot
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
inferredcites →https://doi.org/10.1242/dev.124.20.3999openalex-snapshot
Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
inferredcites →https://doi.org/10.1242/dev.125.14.2711openalex-snapshot
Mutations in mouse Aristaless-like4 cause Strong’s luxoid polydactyly
inferredcites →https://doi.org/10.1242/dev.125.19.3831openalex-snapshot
Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs
inferredcites →https://doi.org/10.1242/dev.125.22.4417openalex-snapshot
The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
inferredcites →https://doi.org/10.1242/dev.126.2.359openalex-snapshot
Physical and genetic interactions between Alx4 and Cart1
inferredcites →https://doi.org/10.1242/dev.126.21.4873openalex-snapshot
The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis
inferredcites →https://doi.org/10.1242/dev.126.3.495openalex-snapshot
prx-1 functions cooperatively with another paired-related homeobox gene,prx-2, to maintain cell fates within the craniofacial mesenchyme
inferredcites →https://doi.org/10.1242/dev.127.2.403openalex-snapshot
Temporospatial cell interactions regulating mandibular and maxillary arch patterning
inferredcites →https://doi.org/10.1242/dev.128.15.2929openalex-snapshot
Prx1andPrx2are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis
inferredcites →https://doi.org/10.1242/dev.99.3.341openalex-snapshot
Epithelial–mesenchymal interactions in the development of chick facial primordia and the target of retinoid action
inferredcites →https://doi.org/10.1387/ijdb.10668975openalex-snapshot
Vertebrate aristaless-related genes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Barramundi (Lates calcarifer) rare coloration patterns: a multiomics approach to understand the “panda” phenotype
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Developmental Disorders of the Craniofacial Complex
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Congenital arhinia with de novo reciprocal translocation, t(3;12)(q13.2;p11.2)
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Craniofacial ciliopathies: A new classification for craniofacial disorders
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A new frontonasal dysplasia syndrome associated with deletion of the SIX2 gene
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Modeling anterior development in mice: Diet as modulator of risk for neural tube defects
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Endochondral ossification of the mouse nasal septum
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Comparison of inherited neural tube defects in companion animals and livestock
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Transforming growth factor‐β3 promotes mesenchymal cell proliferation and angiogenesis mediated by the enhancement of cyclin D1, Flk‐1, and CD31 gene expression during CL/Fr mouse lip fusion
inferred← citeshttps://doi.org/10.1002/bdra.20695openalex-snapshot
Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors
inferred← citeshttps://doi.org/10.1002/bies.10288openalex-snapshot
About face: Signals and genes controlling jaw patterning and identity in vertebrates
inferred← citeshttps://doi.org/10.1002/dvdy.20412openalex-snapshot
Opposing roles of two isoforms of the Prx1 homeobox gene in chondrogenesis
inferred← citeshttps://doi.org/10.1002/dvdy.20646openalex-snapshot
Development of the upper lip: Morphogenetic and molecular mechanisms
inferred← citeshttps://doi.org/10.1002/dvdy.20796openalex-snapshot
21st Century neontology and the comparative development of the vertebrate skull
inferred← citeshttps://doi.org/10.1002/dvdy.24368openalex-snapshot
Molecular mechanisms of midfacial developmental defects
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Ectomesoderm and epithelial–mesenchymal transition‐related genes in spiralian development
inferred← citeshttps://doi.org/10.1002/dvdy.705openalex-snapshot
Lineage‐specific requirements of Alx4 function in craniofacial and hair development
inferred← citeshttps://doi.org/10.1002/dvdy.735openalex-snapshot
Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology
inferred← citeshttps://doi.org/10.1002/dvg.20724openalex-snapshot
Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center
inferred← citeshttps://doi.org/10.1002/gene.10091openalex-snapshot
Isolation of differentially expressed genes from wild‐type and Twist mutant mouse limb buds
inferred← citeshttps://doi.org/10.1002/glia.23870openalex-snapshot
Insights into olfactory ensheathing cell development from a laser‐microdissection and transcriptome‐profiling approach
inferred← citeshttps://doi.org/10.1007/978-1-59259-736-9_22openalex-snapshot
Role of Pax3 and PDGF-α Receptor in Skeletal Morphogenesis and Facial Clefting
inferred← citeshttps://doi.org/10.1007/978-3-031-26098-8_5openalex-snapshot
The Neural Crest and Craniofacial Malformations
inferred← citeshttps://doi.org/10.1007/978-3-319-47507-3_3openalex-snapshot
Embryonic Skeletogenesis and Craniofacial Development
inferred← citeshttps://doi.org/10.1007/978-3-642-54687-7_5openalex-snapshot
The Neural Crest and Craniofacial Malformations
inferred← citeshttps://doi.org/10.1007/s00018-022-04338-7openalex-snapshot
ALX1-transcribed LncRNA AC132217.4 promotes osteogenesis and bone healing via IGF-AKT signaling in mesenchymal stem cells
inferred← citeshttps://doi.org/10.1007/s00018-024-05384-zopenalex-snapshot
Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake
inferred← citeshttps://doi.org/10.1007/s00125-010-1975-6openalex-snapshot
Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets
inferred← citeshttps://doi.org/10.1007/s00125-015-3849-4openalex-snapshot
Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells
inferred← citeshttps://doi.org/10.1007/s00266-013-0096-2openalex-snapshot
Clover-Shaped Advancement Flap for Correction of Short and Broad Columella in a Patient with Frontorhiny
inferred← citeshttps://doi.org/10.1007/s00335-015-9557-zopenalex-snapshot
A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice
inferred← citeshttps://doi.org/10.1007/s00383-010-2658-6openalex-snapshot
HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model
inferred← citeshttps://doi.org/10.1007/s00427-004-0411-7openalex-snapshot
Functional stability of the aristaless gene in appendage tip formation during evolution
inferred← citeshttps://doi.org/10.1007/s00429-002-0292-3openalex-snapshot
Teratogenic effects of suramin on the chick embryo
inferred← citeshttps://doi.org/10.1007/s12033-024-01349-6openalex-snapshot
Genetic Insights into Facial Variation and Craniofacial Development: Unraveling the Interplay of Genes, Expression Patterns, and Evolutionary Significance
inferred← citeshttps://doi.org/10.1016/b978-0-323-05355-6.00001-xopenalex-snapshot
Embryology and Congenital Lesions of the Midface
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2024.09.002openalex-snapshot
Multiple roles for retinoid signaling in craniofacial development
inferred← citeshttps://doi.org/10.1016/j.acthis.2010.05.005openalex-snapshot
Developmental patterns of Ki-67, bcl-2 and caspase-3 proteins expression in the human upper jaw
inferred← citeshttps://doi.org/10.1016/j.ajhg.2009.04.009openalex-snapshot
Frontorhiny, a Distinctive Presentation of Frontonasal Dysplasia Caused by Recessive Mutations in the ALX3 Homeobox Gene
inferred← citeshttps://doi.org/10.1016/j.ajhg.2010.04.002openalex-snapshot
Disruption of ALX1 Causes Extreme Microphthalmia and Severe Facial Clefting: Expanding the Spectrum of Autosomal-Recessive ALX-Related Frontonasal Dysplasia
inferred← citeshttps://doi.org/10.1016/j.cell.2023.12.032openalex-snapshot
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2015.11.004openalex-snapshot
Common mechanisms in development and disease: BMP signaling in craniofacial development
inferred← citeshttps://doi.org/10.1016/j.dib.2018.03.010openalex-snapshot
Gene datasets associated with mouse cleft palate
inferred← citeshttps://doi.org/10.1016/j.gendis.2020.10.003openalex-snapshot
SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100901openalex-snapshot
Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms
inferred← citeshttps://doi.org/10.1016/j.jcms.2026.104645openalex-snapshot
Defining genetic and physiopathological bases of orbital hypertelorism: about a systematic literature review
inferred← citeshttps://doi.org/10.1016/j.job.2019.08.001openalex-snapshot
How the diversity of the faces arises
inferred← citeshttps://doi.org/10.1016/j.job.2024.10.004openalex-snapshot
Conditional heterozygous loss of kit receptor tyrosine kinase in neural crest cell lineage is associated with midline cleft lip and bifid nose deformity
inferred← citeshttps://doi.org/10.1016/j.mod.2008.06.003openalex-snapshot
Signaling through Tgf-β type I receptor Alk5 is required for upper lip fusion
inferred← citeshttps://doi.org/10.1016/j.mod.2011.03.002openalex-snapshot
An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability
inferred← citeshttps://doi.org/10.1016/j.scr.2018.10.015openalex-snapshot
Derivation and characterization of putative craniofacial mesenchymal progenitor cells from human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.semcdb.2016.01.016openalex-snapshot
Using frogs faces to dissect the mechanisms underlying human orofacial defects
inferred← citeshttps://doi.org/10.1016/j.stemcr.2018.06.021openalex-snapshot
Pre-transplantational Control of the Post-transplantational Fate of Human Pluripotent Stem Cell-Derived Cartilage
inferred← citeshttps://doi.org/10.1016/j.tice.2004.06.006openalex-snapshot
Apoptosis distribution in the first molar tooth germ of the field vole (Microtus agrestis)
inferred← citeshttps://doi.org/10.1016/j.ydbio.2005.06.017openalex-snapshot
Function and regulation of Alx4 in limb development: Complex genetic interactions with Gli3 and Shh
inferred← citeshttps://doi.org/10.1016/j.ydbio.2006.05.030openalex-snapshot
Epithelial and ectomesenchymal role of the type I TGF-β receptor ALK5 during facial morphogenesis and palatal fusion
inferred← citeshttps://doi.org/10.1016/j.ydbio.2006.07.047openalex-snapshot
A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus
inferred← citeshttps://doi.org/10.1016/j.ydbio.2007.09.050openalex-snapshot
Smad4 is required to regulate the fate of cranial neural crest cells
inferred← citeshttps://doi.org/10.1016/j.ydbio.2008.03.045openalex-snapshot
TGF-β type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner
inferred← citeshttps://doi.org/10.1016/j.ydbio.2009.04.034openalex-snapshot
Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo
inferred← citeshttps://doi.org/10.1016/j.ydbio.2010.05.496openalex-snapshot
Mesodermal Tbx1 is required for patterning the proximal mandible in mice
inferred← citeshttps://doi.org/10.1016/j.ydbio.2010.06.002openalex-snapshot
Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects
inferred← citeshttps://doi.org/10.1016/j.ydbio.2010.08.015openalex-snapshot
Twist1 activity thresholds define multiple functions in limb development
inferred← citeshttps://doi.org/10.1016/j.ydbio.2012.02.033openalex-snapshot
Median facial clefts in Xenopus laevis: Roles of retinoic acid signaling and homeobox genes
inferred← citeshttps://doi.org/10.1016/j.ydbio.2012.11.014openalex-snapshot
Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules
inferred← citeshttps://doi.org/10.1016/j.ydbio.2013.02.022openalex-snapshot
Pattern and polarity in the development and evolution of the gnathostome jaw: Both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
inferred← citeshttps://doi.org/10.1016/j.ydbio.2014.10.016openalex-snapshot
A gene expression map of the larval Xenopus laevis head reveals developmental changes underlying the evolution of new skeletal elements
inferred← citeshttps://doi.org/10.1016/j.ydbio.2016.11.014openalex-snapshot
The origin and diversification of the developmental mechanisms that pattern the vertebrate head skeleton
inferred← citeshttps://doi.org/10.1016/j.ydbio.2017.03.025openalex-snapshot
Systems biology of facial development: contributions of ectoderm and mesenchyme
inferred← citeshttps://doi.org/10.1016/j.ydbio.2019.11.010openalex-snapshot
Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation
inferred← citeshttps://doi.org/10.1016/j.ydbio.2023.07.005openalex-snapshot
Developmental origin of the mammalian premaxilla
inferred← citeshttps://doi.org/10.1016/j.ydbio.2024.04.004openalex-snapshot
Dyrk1a is required for craniofacial development in Xenopus laevis.
inferred← citeshttps://doi.org/10.1016/j.ydbio.2026.03.008openalex-snapshot
A Twist1-regulated distal enhancer crucial for Alx1 gene expression and function during craniofacial development
inferred← citeshttps://doi.org/10.1016/s0070-2153(08)00602-9openalex-snapshot
Chapter 2 The Etiopathogenesis of Cleft Lip and Cleft Palate
inferred← citeshttps://doi.org/10.1016/s0925-4773(02)00416-1openalex-snapshot
The OAR/aristaless domain of the homeodomain protein Cart1 has an attenuating role in vivo
inferred← citeshttps://doi.org/10.1016/s0960-9822(03)00088-5openalex-snapshot
Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon
inferred← citeshttps://doi.org/10.1016/s1010-5182(06)60003-6openalex-snapshot
Apoptosis as a creative agent of embryonic development of bucca, mentum and nasolacrimal duct. An in vivo study in rats
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Prx, Alx, and Shox genes in craniofacial and appendicular development
inferred← citeshttps://doi.org/10.1038/cdd.2013.97openalex-snapshot
Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development
inferred← citeshttps://doi.org/10.1038/ejhg.2013.160openalex-snapshot
Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation
inferred← citeshttps://doi.org/10.1038/emboj.2010.53openalex-snapshot
Cooperative DNA‐binding and sequence‐recognition mechanism of aristaless and clawless
inferred← citeshttps://doi.org/10.1038/nature20109openalex-snapshot
Developmental mechanisms of stripe patterns in rodents
inferred← citeshttps://doi.org/10.1038/s10038-017-0358-yopenalex-snapshot
Exome sequencing revealed a novel nonsense variant in ALX3 gene underlying frontorhiny
inferred← citeshttps://doi.org/10.1038/s41467-026-74434-wopenalex-snapshot
The alx gene family confers segmental identity to frontonasal cranial neural crest cells
inferred← citeshttps://doi.org/10.1038/s41598-017-00334-1openalex-snapshot
Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy
inferred← citeshttps://doi.org/10.1038/s41598-017-11745-5openalex-snapshot
Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development
inferred← citeshttps://doi.org/10.1038/s41598-018-25998-1openalex-snapshot
FACS-Seq analysis of Pax3-derived cells identifies non-myogenic lineages in the embryonic forelimb
inferred← citeshttps://doi.org/10.1038/s41598-020-71636-0openalex-snapshot
Transcriptional analysis of cleft palate in TGFβ3 mutant mice
inferred← citeshttps://doi.org/10.1038/s41598-024-68016-3openalex-snapshot
Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning
inferred← citeshttps://doi.org/10.1038/s42003-024-05951-xopenalex-snapshot
Unraveling the transcriptomic landscape of eye migration and visual adaptations during flatfish metamorphosis
inferred← citeshttps://doi.org/10.1038/s44161-023-00367-yopenalex-snapshot
Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetes
inferred← citeshttps://doi.org/10.1042/bj20020399openalex-snapshot
OTEX, an androgen-regulated human member of the paired-like class of homeobox genes
inferred← citeshttps://doi.org/10.1042/bj20120962openalex-snapshot
Differential configurations involving binding of USF transcription factors and Twist1 regulateAlx3promoter activity in mesenchymal and pancreatic cells
inferred← citeshttps://doi.org/10.1046/j.1432-0436.2003.7104501.xopenalex-snapshot
Development of calcareous skeletal elements in invertebrates
inferred← citeshttps://doi.org/10.1073/pnas.2304302120openalex-snapshot
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
inferred← citeshttps://doi.org/10.1074/jbc.m400800200openalex-snapshot
The Homeoprotein Alx3 Contains Discrete Functional Domains and Exhibits Cell-specific and Selective Monomeric Binding and Transactivation
inferred← citeshttps://doi.org/10.1086/508214openalex-snapshot
Satb2 Haploinsufficiency Phenocopies 2q32-q33 Deletions, whereas Loss Suggests a Fundamental Role in the Coordination of Jaw Development
inferred← citeshttps://doi.org/10.1093/hmg/ddp391openalex-snapshot
ALX4 dysfunction disrupts craniofacial and epidermal development
inferred← citeshttps://doi.org/10.1093/hmg/ddp543openalex-snapshot
Prdm16 is required for normal palatogenesis in mice
inferred← citeshttps://doi.org/10.1093/hmg/dds423openalex-snapshot
Defective neural crest migration revealed by a Zebrafish model of Alx1-related frontonasal dysplasia
inferred← citeshttps://doi.org/10.1096/fj.202601339ropenalex-snapshot
Retinoic Acid Informs the Positional Identity of Frontonasal Neural Crest Cells Through Alx Family of Transcription Factors
inferred← citeshttps://doi.org/10.1097/00019605-200404000-00002openalex-snapshot
Tibial aplasia, lower extremity mirror image polydactyly, brachyphalangy, craniofacial dysmorphism and genital hypoplasia: further delineation and mutational analysis
inferred← citeshttps://doi.org/10.1111/cge.12822openalex-snapshot
Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia
inferred← citeshttps://doi.org/10.1111/ede.12419openalex-snapshot
Creating morphological diversity in reptilian temporal skull region: A review of potential developmental mechanisms
inferred← citeshttps://doi.org/10.1111/j.1399-0004.2006.00552.xopenalex-snapshot
Adams–Oliver syndrome: clinical description of a four‐generation family and exclusion of five candidate genes
inferred← citeshttps://doi.org/10.1111/j.1442-200x.2004.01927.xopenalex-snapshot
C677T mutation in the MTHFR gene was not found in patients with frontoethmoidal encephalocele in East Java, Indonesia
inferred← citeshttps://doi.org/10.1111/j.1469-7580.2005.00474.xopenalex-snapshot
Regional regulation of palatal growth and patterning along the anterior–posterior axis in mice
inferred← citeshttps://doi.org/10.1111/j.1525-142x.2011.00489.xopenalex-snapshot
Evolution of the Alx homeobox gene family: parallel retention and independent loss of the vertebrate Alx3 gene
inferred← citeshttps://doi.org/10.1111/pcmr.12580openalex-snapshot
Gnawing at striping – how rodents evolve striped patterns
inferred← citeshttps://doi.org/10.1136/jmg.2005.040162openalex-snapshot
High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts
inferred← citeshttps://doi.org/10.1159/000450533openalex-snapshot
Frontonasal Dysplasia: Towards an Understanding of Molecular and Developmental Aetiology
inferred← citeshttps://doi.org/10.11606/d.41.2013.tde-24032014-093037openalex-snapshot
Em busca da etiologia das displasias frontonasais
inferred← citeshttps://doi.org/10.1177/0022034519835204openalex-snapshot
Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development
inferred← citeshttps://doi.org/10.1177/00220345211062049openalex-snapshot
Retinoic Acid Deficiency Underlies the Etiology of Midfacial Defects
inferred← citeshttps://doi.org/10.1177/00220345221074356openalex-snapshot
Transcriptional Regulation of Jaw Osteoblasts: Development to Pathology
inferred← citeshttps://doi.org/10.1177/00220345261471833openalex-snapshot
Molecular Determination of the Frontonasal Identity of Neural Crest Cells
inferred← citeshttps://doi.org/10.1186/s12861-017-0147-zopenalex-snapshot
Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels
inferred← citeshttps://doi.org/10.1186/s12864-018-5186-8openalex-snapshot
Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function
inferred← citeshttps://doi.org/10.1210/me.2005-0472openalex-snapshot
The Homeoprotein Alx3 Expressed in Pancreatic β-Cells Regulates Insulin Gene Transcription by Interacting with the Basic Helix-Loop-Helix Protein E47
inferred← citeshttps://doi.org/10.1242/bio.059189openalex-snapshot
Zebrafish models of alx-linked frontonasal dysplasia reveal a role for Alx1 and Alx3 in the anterior segment and vasculature of the developing eye
inferred← citeshttps://doi.org/10.1242/dev.00511openalex-snapshot
Alx1, a member of the Cart1/Alx3/Alx4 subfamily of Paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
inferred← citeshttps://doi.org/10.1242/dev.01735openalex-snapshot
Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes
inferred← citeshttps://doi.org/10.1242/dev.019778openalex-snapshot
Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs
inferred← citeshttps://doi.org/10.1242/dev.068338openalex-snapshot
Mechanisms of tissue fusion during development
inferred← citeshttps://doi.org/10.1242/dev.129.19.4647openalex-snapshot
Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusion
inferred← citeshttps://doi.org/10.1242/dev.174888openalex-snapshot
The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution
inferred← citeshttps://doi.org/10.1242/dev.197483openalex-snapshot
The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing
inferred← citeshttps://doi.org/10.1242/dev.200533openalex-snapshot
Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts
inferred← citeshttps://doi.org/10.1242/dev.201777openalex-snapshot
aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for planarian head regeneration
inferred← citeshttps://doi.org/10.1242/dev.202095openalex-snapshot
TFAP2 paralogs regulate midfacial development in part through a conserved ALX genetic pathway
inferred← citeshttps://doi.org/10.1242/dmm.009274openalex-snapshot
Facial dysmorphism induced by bone morphogenetic protein receptor type 1A-mediated signaling reduction in neural crest-derived cells
inferred← citeshttps://doi.org/10.1242/dmm.052241openalex-snapshot
The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation
inferred← citeshttps://doi.org/10.1371/journal.pgen.1003851openalex-snapshot
A Critical Role for PDGFRα Signaling in Medial Nasal Process Development
inferred← citeshttps://doi.org/10.1371/journal.pgen.1006149openalex-snapshot
Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007047openalex-snapshot
Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis
inferred← citeshttps://doi.org/10.1371/journal.pgen.1007648openalex-snapshot
Direct-to-consumer DNA testing of 6,000 dogs reveals 98.6-kb duplication associated with blue eyes and heterochromia in Siberian Huskies
inferred← citeshttps://doi.org/10.1371/journal.pone.0000787openalex-snapshot
Insights from Amphioxus into the Evolution of Vertebrate Cartilage
inferred← citeshttps://doi.org/10.1371/journal.pone.0005385openalex-snapshot
Genetic Determinants of Facial Clefting: Analysis of 357 Candidate Genes Using Two National Cleft Studies from Scandinavia
inferred← citeshttps://doi.org/10.1371/journal.pone.0019357openalex-snapshot
An ENU-Mutagenesis Screen in the Mouse: Identification of Novel Developmental Gene Functions
inferred← citeshttps://doi.org/10.1371/journal.pone.0022474openalex-snapshot
A New Mechanistic Scenario for the Origin and Evolution of Vertebrate Cartilage
inferred← citeshttps://doi.org/10.1371/journal.pone.0037685openalex-snapshot
Neural Crest Cell Survival Is Dependent on Rho Kinase and Is Required for Development of the Mid Face in Mouse Embryos
inferred← citeshttps://doi.org/10.1371/journal.pone.0067801openalex-snapshot
Gene Expression Analysis of Zebrafish Melanocytes, Iridophores, and Retinal Pigmented Epithelium Reveals Indicators of Biological Function and Developmental Origin
inferred← citeshttps://doi.org/10.1371/journal.pone.0068774openalex-snapshot
BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation
inferred← citeshttps://doi.org/10.1371/journal.pone.0179078openalex-snapshot
Generation of an immortalized mouse embryonic palatal mesenchyme cell line
inferred← citeshttps://doi.org/10.1387/ijdb.12141426openalex-snapshot
Twist functions in mouse development
inferred← citeshttps://doi.org/10.15252/emmm.202012013openalex-snapshot
ALX1‐related frontonasal dysplasia results from defective neural crest cell development and migration
inferred← citeshttps://doi.org/10.24911/jbcgenetics/183-1530765389openalex-snapshot
Frontonasal dysplasia: a review
inferred← citeshttps://doi.org/10.2517/prpsj.10.311openalex-snapshot
Skeletal matrix proteins of invertebrate animals: Comparative analysis of their amino acid sequences
inferred← citeshttps://doi.org/10.3389/fcell.2022.777887openalex-snapshot
Alx1 Deficient Mice Recapitulate Craniofacial Phenotype and Reveal Developmental Basis of ALX1-Related Frontonasal Dysplasia
inferred← citeshttps://doi.org/10.3389/fcell.2024.1256465openalex-snapshot
Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects
inferred← citeshttps://doi.org/10.3389/fgene.2020.569314openalex-snapshot
Transcription Factors of the Alx Family: Evolutionarily Conserved Regulators of Deuterostome Skeletogenesis
inferred← citeshttps://doi.org/10.3389/fphys.2016.00468openalex-snapshot
Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid2
inferred← citeshttps://doi.org/10.3390/biology12091213openalex-snapshot
Linking Vertebrate Gene Duplications to the New Head Hypothesis
inferred← citeshttps://doi.org/10.3390/cells15171508openalex-snapshot
MAP3K1 Integrates Genetic and Environmental Signals in Eyelid Morphogenesis
inferred← citeshttps://doi.org/10.3390/genes13101808openalex-snapshot
Genome Wide Association Study with Imputed Whole Genome Sequence Data Identifies a 431 kb Risk Haplotype on CFA18 for Congenital Laryngeal Paralysis in Alaskan Sled Dogs
inferred← citeshttps://doi.org/10.3390/ijms21051602openalex-snapshot
Inherited Eye Diseases with Retinal Manifestations through the Eyes of Homeobox Genes
inferred← citeshttps://doi.org/10.3390/jcm13082223openalex-snapshot
Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap
inferred← citeshttps://doi.org/10.4199/c00010ed1v01y201003deb001openalex-snapshot
Transcriptional Control of Neural Crest Development
inferred← citeshttps://doi.org/10.4199/c00127ed1v01y201503deb006openalex-snapshot
Developmental Genetics of the Pharyngeal Arch System
inferred← citeshttps://doi.org/10.4331/wjbc.v6.i3.121openalex-snapshot
Molecular basis of cleft palates in mice
inferred← citeshttps://doi.org/10.53846/goediss-1338openalex-snapshot
Functional characterization of m Satb1 and Satb2 in the developing neocortex
inferred← citeshttps://doi.org/10.70675/6ef5d5a9zc891z42e5zb202z0947a770d42copenalex-snapshot
Caractérisation phénotypique et moléculaire des dysplasies frontonasales
inferred← citeshttps://doi.org/10.7939/r32f7k052openalex-snapshot
Molecular and phenotypic characterization of Cecr2 mouse models: implications for the role of mesenchymal/epithelial regulation in neural tube and renal development
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