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Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

https://doi.org/10.1371/journal.pone.0061961

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow‐derived macrophages by TH 1 and TH 2 cytokines

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Alternative Activation of Macrophages: Mechanism and Functions

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Recent advances in arginine metabolism: roles and regulation of the arginases

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Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives

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Immune modulation for treatment of allergic disease

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Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling

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Schistosoma mansoniAntigens Modulate Experimental Allergic Asthma in a Murine Model: a Major Role for CD4+CD25+Foxp3+T Cells Independent of Interleukin-10

inferredcites →https://doi.org/10.1152/ajplung.00025.2009openalex-snapshot

Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma

inferredcites →https://doi.org/10.1152/ajplung.00216.2009openalex-snapshot

Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model

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Arginase Inhibition Protects against Allergen-induced Airway Obstruction, Hyperresponsiveness, and Inflammation

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Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

inferredcites →https://doi.org/10.1182/blood-2004-07-2521openalex-snapshot

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity

inferredcites →https://doi.org/10.1182/blood-2006-06-032599openalex-snapshot

Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils

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Increased arginase activity contributes to airway remodelling in chronic allergic asthma

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Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice

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Obstacles and opportunities for understanding macrophage polarization

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Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity

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Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

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Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis

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Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness

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Additional file 1 of A novel quinoline with airway relaxant effects and anti-inflammatory properties

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Additional file 2 of A novel quinoline with airway relaxant effects and anti-inflammatory properties

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