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The Metabolome and Osteoarthritis: Possible Contributions to Symptoms and Pathology

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Identification of phenotypes with different clinical outcomes in knee osteoarthritis: Data from the osteoarthritis initiative

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Risk of Cardiovascular Disease in Patients With Osteoarthritis: A Prospective Longitudinal Study

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Association of Metabolic Risk Factors With Cartilage Degradation Assessed by T2 Relaxation Time at the Knee: Data From the Osteoarthritis Initiative

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Time Trends in the Characteristics of Patients Undergoing Primary Total Knee Arthroplasty

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Knee Extensor Strength and Risk of Structural, Symptomatic, and Functional Decline in Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

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Gene deletion of either interleukin‐1β, interleukin‐1β–converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy

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Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization

inferredcites →https://doi.org/10.1002/art.24550openalex-snapshot

Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint

inferredcites →https://doi.org/10.1002/gps.1690openalex-snapshot

A preliminary metabolomic analysis of older adults with and without depression

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Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis

inferredcites →https://doi.org/10.1002/jor.22949openalex-snapshot

Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis

inferredcites →https://doi.org/10.1002/jor.23482openalex-snapshot

Global and targeted metabolomics of synovial fluid discovers special osteoarthritis metabolites

inferredcites →https://doi.org/10.1002/nbm.3285openalex-snapshot

Correlating high‐resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage

inferredcites →https://doi.org/10.1002/oby.21724openalex-snapshot

Metabolites distinguishing visceral fat obesity and atherogenic traits in individuals with overweight

inferredcites →https://doi.org/10.1002/osp4.63openalex-snapshot

Metabolomics‐identified metabolites associated with body mass index and prospective weight gain among Mexican American women

inferredcites →https://doi.org/10.1007/s00213-018-4992-7openalex-snapshot

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects

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Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy

inferredcites →https://doi.org/10.1007/s11306-013-0574-1openalex-snapshot

Human metabolic correlates of body mass index

inferredcites →https://doi.org/10.1007/s11306-016-0960-6openalex-snapshot

Obesity-related metabolite profiles of black women spanning the epidemiologic transition

inferredcites →https://doi.org/10.1007/s11306-016-1079-5openalex-snapshot

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

inferredcites →https://doi.org/10.1007/s12035-016-0078-xopenalex-snapshot

Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism

inferredcites →https://doi.org/10.1016/0005-2760(86)90007-xopenalex-snapshot

Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma

inferredcites →https://doi.org/10.1016/j.ajpath.2012.06.007openalex-snapshot

Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

inferredcites →https://doi.org/10.1016/j.bbrc.2018.03.117openalex-snapshot

Application of global metabolomic profiling of synovial fluid for osteoarthritis biomarkers

inferredcites →https://doi.org/10.1016/j.cca.2015.01.032openalex-snapshot

Plasma and synovial fluid autotaxin correlate with severity in knee osteoarthritis

inferredcites →https://doi.org/10.1016/j.cca.2016.10.005openalex-snapshot

Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes

inferredcites →https://doi.org/10.1016/j.cca.2016.11.039openalex-snapshot

Predictive diagnosis of major depression using NMR-based metabolomics and least-squares support vector machine

inferredcites →https://doi.org/10.1016/j.cca.2017.12.036openalex-snapshot

Perturbation of muscle metabolism in patients with muscular dystrophy in early or acute phase of disease: In vitro, high resolution NMR spectroscopy based analysis

inferredcites →https://doi.org/10.1016/j.cmet.2018.09.022openalex-snapshot

Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk

inferredcites →https://doi.org/10.1016/j.diabres.2017.07.023openalex-snapshot

Abnormal circulating amino acid profiles in multiple metabolic disorders

inferredcites →https://doi.org/10.1016/j.drudis.2010.03.007openalex-snapshot

Endocannabinoid biosynthesis and inactivation, from simple to complex

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.01.009openalex-snapshot

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation

inferredcites →https://doi.org/10.1016/j.jad.2017.12.030openalex-snapshot

Global arginine bioavailability ratio is decreased in patients with major depressive disorder

inferredcites →https://doi.org/10.1016/j.jbspin.2016.05.018openalex-snapshot

Metabolite profiles of synovial fluid change with the radiographic severity of knee osteoarthritis

inferredcites →https://doi.org/10.1016/j.jdiacomp.2016.02.016openalex-snapshot

Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis

inferredcites →https://doi.org/10.1016/j.joca.2005.04.005openalex-snapshot

Identification of an urinary metabolite profile associated with osteoarthritis

inferredcites →https://doi.org/10.1016/j.joca.2013.04.002openalex-snapshot

An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid

inferredcites →https://doi.org/10.1016/j.joca.2014.10.002openalex-snapshot

Metabolic triggered inflammation in osteoarthritis

inferredcites →https://doi.org/10.1016/j.joca.2014.10.008openalex-snapshot

Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis. A systematic review and meta-analysis

inferredcites →https://doi.org/10.1016/j.joca.2014.11.019openalex-snapshot

Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis

inferredcites →https://doi.org/10.1016/j.joca.2015.01.006openalex-snapshot

Clinical phenotypes in patients with knee osteoarthritis: a study in the Amsterdam osteoarthritis cohort

inferredcites →https://doi.org/10.1016/j.joca.2015.01.013openalex-snapshot

Diabetes is a risk factor for knee osteoarthritis progression

inferredcites →https://doi.org/10.1016/j.joca.2015.12.004openalex-snapshot

Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients

inferredcites →https://doi.org/10.1016/j.joca.2016.03.011openalex-snapshot

Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study

inferredcites →https://doi.org/10.1016/j.joca.2016.08.016openalex-snapshot

Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain

inferredcites →https://doi.org/10.1016/j.joca.2016.09.006openalex-snapshot

Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain

inferredcites →https://doi.org/10.1016/j.joca.2018.03.010openalex-snapshot

Type 2 diabetes patients have accelerated cartilage matrix degeneration compared to diabetes free controls: data from the Osteoarthritis Initiative

inferredcites →https://doi.org/10.1016/j.joca.2018.08.024openalex-snapshot

A systematic review of the small molecule studies of osteoarthritis using nuclear magnetic resonance and mass spectroscopy

inferredcites →https://doi.org/10.1016/j.metabol.2013.01.007openalex-snapshot

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

inferredcites →https://doi.org/10.1016/j.metabol.2015.10.027openalex-snapshot

Abdominal obesity and circulating metabolites: A twin study approach

inferredcites →https://doi.org/10.1016/j.neuroscience.2007.12.041openalex-snapshot

Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid

inferredcites →https://doi.org/10.1016/j.psyneuen.2016.04.017openalex-snapshot

Purine metabolism is dysregulated in patients with major depressive disorder

inferredcites →https://doi.org/10.1016/j.talanta.2017.03.103openalex-snapshot

Capillary electrophoresis tandem mass spectrometry determination of glutamic acid and homocysteine’s metabolites: Potential biomarkers of amyotrophic lateral sclerosis

inferredcites →https://doi.org/10.1016/j.trsl.2015.01.008openalex-snapshot

Lysophosphatidic acid receptor 1 antagonist ki16425 blunts abdominal and systemic inflammation in a mouse model of peritoneal sepsis

inferredcites →https://doi.org/10.1021/ac9000282openalex-snapshot

Pattern Recognition Analysis for the Prediction of Adverse Effects by Nonsteroidal Anti-Inflammatory Drugs Using 1 H NMR-Based Metabolomics in Rats

inferredcites →https://doi.org/10.1021/acs.jproteome.5b00719openalex-snapshot

Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis

inferredcites →https://doi.org/10.1021/acs.jproteome.6b01062openalex-snapshot

Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort

inferredcites →https://doi.org/10.1021/acs.jproteome.8b00190openalex-snapshot

Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies

inferredcites →https://doi.org/10.1021/acs.jproteome.8b00455openalex-snapshot

1H NMR Metabolomics Identifies Underlying Inflammatory Pathology in Osteoarthritis and Rheumatoid Arthritis Synovial Joints

inferredcites →https://doi.org/10.1021/pr2010082openalex-snapshot

Plasma Metabonomics as a Novel Diagnostic Approach for Major Depressive Disorder

inferredcites →https://doi.org/10.1038/ijo.2014.39openalex-snapshot

Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study

inferredcites →https://doi.org/10.1038/ijo.2015.65openalex-snapshot

The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity

inferredcites →https://doi.org/10.1038/nm1060openalex-snapshot

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

inferredcites →https://doi.org/10.1038/nrdp.2016.72openalex-snapshot

Osteoarthritis

inferredcites →https://doi.org/10.1038/nrendo.2014.171openalex-snapshot

Branched-chain amino acids in metabolic signalling and insulin resistance

inferredcites →https://doi.org/10.1038/nrendo.2014.29openalex-snapshot

Insulin resistance and hyperglycaemia in cardiovascular disease development

inferredcites →https://doi.org/10.1038/nrrheum.2010.196openalex-snapshot

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

inferredcites →https://doi.org/10.1038/nrrheum.2011.2openalex-snapshot

Pain, catastrophizing, and depression in the rheumatic diseases

inferredcites →https://doi.org/10.1038/nrrheum.2014.114openalex-snapshot

Is OA a mechanical or systemic disease?

inferredcites →https://doi.org/10.1038/nrrheum.2014.47openalex-snapshot

Osteoarthritis pain: nociceptive or neuropathic?

inferredcites →https://doi.org/10.1038/nrrheum.2016.92openalex-snapshot

Autophagy: controlling cell fate in rheumatic diseases

inferredcites →https://doi.org/10.1038/nrrheum.2017.17openalex-snapshot

Erratum: Autophagy: controlling cell fate in rheumatic diseases

inferredcites →https://doi.org/10.1038/s41366-018-0132-zopenalex-snapshot

Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs

inferredcites →https://doi.org/10.1038/s41598-017-07963-6openalex-snapshot

High-fat diet-induced acceleration of osteoarthritis is associated with a distinct and sustained plasma metabolite signature

inferredcites →https://doi.org/10.1038/srep15925openalex-snapshot

Systemic differences in serum metabolome: a cross sectional comparison of women with localised and widespread pain and controls

inferredcites →https://doi.org/10.1038/srep39672openalex-snapshot

Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies

inferredcites →https://doi.org/10.1038/srep40543openalex-snapshot

Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model

inferredcites →https://doi.org/10.1038/tp.2016.145openalex-snapshot

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

inferredcites →https://doi.org/10.1038/tp.2016.188openalex-snapshot

Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC–MS-based metabonomics

inferredcites →https://doi.org/10.1039/c5mb00711aopenalex-snapshot

Multi-platform mass spectrometry analysis of the CSF and plasma metabolomes of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects

inferredcites →https://doi.org/10.1053/berh.2001.0196openalex-snapshot

The role of nitric oxide in tissue destruction

inferredcites →https://doi.org/10.1053/joca.2001.0509openalex-snapshot

Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis

inferredcites →https://doi.org/10.1074/jbc.270.43.25549openalex-snapshot

Phosphatidic Acid and Lysophosphatidic Acid Induce Haptotactic Migration of Human Monocytes

inferredcites →https://doi.org/10.1074/jbc.m205623200openalex-snapshot

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

inferredcites →https://doi.org/10.1080/03009740701483014openalex-snapshot

The role of nitric oxide in osteoarthritis

inferredcites →https://doi.org/10.1093/gerona/glw046openalex-snapshot

Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging

inferredcites →https://doi.org/10.1093/jnci/djx244openalex-snapshot

A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk

inferredcites →https://doi.org/10.1093/rheumatology/kew207openalex-snapshot

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis

inferredcites →https://doi.org/10.1097/j.pain.0000000000001169openalex-snapshot

Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis

inferredcites →https://doi.org/10.1111/1756-185x.13251openalex-snapshot

Medium‐ and long‐chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end‐stage osteoarthritis patients: a case‐control study

inferredcites →https://doi.org/10.1111/acel.12350openalex-snapshot

Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle‐derived nitric oxide

inferredcites →https://doi.org/10.1111/cns.12372openalex-snapshot

Plasma Amino Acid Profiling in Major Depressive Disorder Treated With Selective Serotonin Reuptake Inhibitors

inferredcites →https://doi.org/10.1111/ejn.12468openalex-snapshot

Involvement of the endocannabinoid system in osteoarthritis pain

inferredcites →https://doi.org/10.1111/ene.12956openalex-snapshot

Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

inferredcites →https://doi.org/10.1111/j.1474-9726.2012.00865.xopenalex-snapshot

Human serum metabolic profiles are age dependent

inferredcites →https://doi.org/10.1111/pcn.12638openalex-snapshot

Plasma metabolome analysis of patients with major depressive disorder

inferredcites →https://doi.org/10.1120/jacmp.v17i2.6144openalex-snapshot

In vivo MR spectroscopy using 3 Tesla to investigate the metabolic profiles of joint fluids in different types of knee diseases

inferredcites →https://doi.org/10.1136/annrheumdis-2011-201242openalex-snapshot

Leptin levels are increased and its negative regulators, SOCS-3 and sOb-R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis

inferredcites →https://doi.org/10.1136/annrheumdis-2013-203308openalex-snapshot

Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

inferredcites →https://doi.org/10.1136/annrheumdis-2013-204599openalex-snapshot

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

inferredcites →https://doi.org/10.1136/ard.16.4.494openalex-snapshot

Radiological Assessment of Osteo-Arthrosis

inferredcites →https://doi.org/10.1136/ard.2009.120857openalex-snapshot

Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis

inferredcites →https://doi.org/10.1136/ard.2010.146399openalex-snapshot

Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

inferredcites →https://doi.org/10.1136/ard.57.9.550openalex-snapshot

Increased expression of human type IIa secretory phospholipase A2 antigen in arthritic synovium

inferredcites →https://doi.org/10.1136/ard.60.6.627openalex-snapshot

Raised levels of F2-isoprostanes and prostaglandin F2α in different rheumatic diseases

inferredcites →https://doi.org/10.1136/bmjopen-2011-000435openalex-snapshot

What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients

inferredcites →https://doi.org/10.1136/bmjopen-2014-006286openalex-snapshot

Classification of osteoarthritis phenotypes by metabolomics analysis

inferredcites →https://doi.org/10.1136/pgmj.2010.146399repopenalex-snapshot

Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype

inferredcites →https://doi.org/10.1142/9789814749411_0012openalex-snapshot

METABOLOMICS DIFFERENTIAL CORRELATION NETWORK ANALYSIS OF OSTEOARTHRITIS

inferredcites →https://doi.org/10.1152/ajpcell.00544.2007openalex-snapshot

LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells

inferredcites →https://doi.org/10.1152/ajpendo.00231.2015openalex-snapshot

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk

inferredcites →https://doi.org/10.1152/ajpendo.1997.272.2.e181openalex-snapshot

Differential regulation of macrophage arginine metabolism: a proposed role in wound healing

inferredcites →https://doi.org/10.1152/ajpheart.00821.2014openalex-snapshot

M2 macrophage accumulation in the aortic wall during angiotensin II infusion in mice is associated with fibrosis, elastin loss, and elevated blood pressure

inferredcites →https://doi.org/10.1155/2013/538765openalex-snapshot

Amyotrophic Lateral Sclerosis and Metabolomics: Clinical Implication and Therapeutic Approach

inferredcites →https://doi.org/10.1155/2014/620920openalex-snapshot

Risk of Type 2 Diabetes among Osteoarthritis Patients in a Prospective Longitudinal Study

inferredcites →https://doi.org/10.1177/1535370217694098openalex-snapshot

Targeted High Performance Liquid Chromatography Tandem Mass Spectrometry-based Metabolomics differentiates metabolic syndrome from obesity

inferredcites →https://doi.org/10.1177/2047487315610663openalex-snapshot

Association between osteoarthritis and cardiovascular disease: Systematic review and meta-analysis

inferredcites →https://doi.org/10.1186/1471-2474-15-217openalex-snapshot

Risk factors for knee replacement due to primary osteoarthritis, a population based, prospective cohort study of 315,495 individuals

inferredcites →https://doi.org/10.1186/1744-8069-10-71openalex-snapshot

Lysophosphatidic Acid and its Receptors LPA1 and LPA3 Mediate Paclitaxel-Induced Neuropathic Pain in Mice

inferredcites →https://doi.org/10.1186/ar2401openalex-snapshot

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

inferredcites →https://doi.org/10.1186/s12864-016-2953-2openalex-snapshot

Metabolomic biosignature differentiates melancholic depressive patients from healthy controls

inferredcites →https://doi.org/10.1186/s12891-016-1286-2openalex-snapshot

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature

inferredcites →https://doi.org/10.1186/s12916-018-1151-2openalex-snapshot

Musculoskeletal conditions may increase the risk of chronic disease: a systematic review and meta-analysis of cohort studies

inferredcites →https://doi.org/10.1186/s12986-016-0095-9openalex-snapshot

Serum metabolic biomarkers distinguish metabolically healthy peripherally obese from unhealthy centrally obese individuals

inferredcites →https://doi.org/10.1186/s13075-014-0482-4openalex-snapshot

Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

inferredcites →https://doi.org/10.1371/annotation/1c88ae20-07d1-4fda-8cd8-058d95af057dopenalex-snapshot

Correction: Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

inferredcites →https://doi.org/10.1371/journal.pone.0010763openalex-snapshot

Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy

inferredcites →https://doi.org/10.1371/journal.pone.0061961openalex-snapshot

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

inferredcites →https://doi.org/10.1371/journal.pone.0073445openalex-snapshot

Topographical Body Fat Distribution Links to Amino Acid and Lipid Metabolism in Healthy Non-Obese Women

inferredcites →https://doi.org/10.1371/journal.pone.0091286openalex-snapshot

All-Cause Mortality and Serious Cardiovascular Events in People with Hip and Knee Osteoarthritis: A Population Based Cohort Study

inferredcites →https://doi.org/10.1371/journal.pone.0091769openalex-snapshot

Sphingolipids in Human Synovial Fluid - A Lipidomic Study

inferredcites →https://doi.org/10.1371/journal.pone.0102635openalex-snapshot

Serum Metabolomic Response of Myasthenia Gravis Patients to Chronic Prednisone Treatment

inferredcites →https://doi.org/10.1371/journal.pone.0123224openalex-snapshot

Significance of Increased Leptin Expression in Osteoarthritis Patients

inferredcites →https://doi.org/10.1371/journal.pone.0148361openalex-snapshot

Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes

inferredcites →https://doi.org/10.1371/journal.pone.0150476openalex-snapshot

Can Urine Metabolomics Be Helpful in Differentiating Neuropathic and Nociceptive Pain? A Proof-of-Concept Study

inferredcites →https://doi.org/10.1371/journal.pone.0165267openalex-snapshot

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis

inferredcites →https://doi.org/10.1371/journal.pone.0165325openalex-snapshot

Association between Knee Osteoarthritis, Cardiovascular Risk Factors, and the Framingham Risk Score in South Koreans: A Cross-Sectional Study

inferredcites →https://doi.org/10.1371/journal.pone.0184388openalex-snapshot

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling

inferredcites →https://doi.org/10.1371/journal.pone.0199618openalex-snapshot

A classification modeling approach for determining metabolite signatures in osteoarthritis

inferredcites →https://doi.org/10.1371/journal.ppat.1000371openalex-snapshot

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

inferredcites →https://doi.org/10.1615/critrevimmunol.v17.i3-4.10openalex-snapshot

Regulatory Functions of Phospholipase A2

inferredcites →https://doi.org/10.1615/critrevimmunol.v37.i2-6.20openalex-snapshot

Regulatory Functions of Phospholipase A2

inferredcites →https://doi.org/10.2106/jbjs.n.01141openalex-snapshot

Prevalence of Total Hip and Knee Replacement in the United States

inferredcites →https://doi.org/10.2337/dc12-0924openalex-snapshot

Diabetes Is an Independent Predictor for Severe Osteoarthritis

inferredcites →https://doi.org/10.3892/etm.2018.5788openalex-snapshot

Gas chromatography‑time of flight/mass spectrometry‑based metabonomics of changes in the urinary metabolic profile in osteoarthritic rats

inferredcites →https://doi.org/10.3899/jrheum.101355openalex-snapshot

Preferential Accumulation of Activated Th1 Cells Not Only in Rheumatoid Arthritis But Also in Osteoarthritis Joints

inferredcites →https://doi.org/10.3899/jrheum.141252openalex-snapshot

Relationship Between Blood Plasma and Synovial Fluid Metabolite Concentrations in Patients with Osteoarthritis

inferredcites →https://doi.org/10.3899/jrheum.141505openalex-snapshot

Downregulation of Tryptophan-related Metabolomic Profile in Rheumatoid Arthritis Synovial Fluid

inferredcites →https://doi.org/10.3945/ajcn.115.110536openalex-snapshot

Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner

inferredcites →https://doi.org/10.7717/peerj.5410openalex-snapshot

Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Correlations between metabolites in the synovial fluid and serum: A mouse injury study

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Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis

inferred← citeshttps://doi.org/10.1007/s10067-020-05106-3openalex-snapshot

Can metabolic profiling provide a new description of osteoarthritis and enable a personalised medicine approach?

inferred← citeshttps://doi.org/10.1007/s10067-020-05511-8openalex-snapshot

A review of applications of metabolomics in osteoarthritis

inferred← citeshttps://doi.org/10.1007/s43465-024-01169-5openalex-snapshot

Metabolomics in Osteoarthritis Knee: A Systematic Review of Literature

inferred← citeshttps://doi.org/10.1007/s43465-024-01305-1openalex-snapshot

Obese Patients Do Not Benefit from Bone Marrow Aspiration Concentrate Injection for Knee Osteoarthritis: A Prospective Cohort Study of 68 Patients

inferred← citeshttps://doi.org/10.1016/j.arr.2020.101249openalex-snapshot

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

inferred← citeshttps://doi.org/10.1016/j.biochi.2026.03.004openalex-snapshot

A single intra-articular injection of IDO-Gal3 shifts synovial fluid metabolic profiles for up to six weeks in male rats with knee instability

inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114046openalex-snapshot

Metabolites as extracellular vesicle cargo in health, cancer, pleural effusion, and cardiovascular diseases: An emerging field of study to diagnostic and therapeutic purposes

inferred← citeshttps://doi.org/10.1016/j.jbspin.2022.105353openalex-snapshot

Microstructural and histomorphological features of osteophytes in late-stage human knee osteoarthritis with varus deformity

inferred← citeshttps://doi.org/10.1016/j.joca.2021.06.013openalex-snapshot

Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA

inferred← citeshttps://doi.org/10.1016/j.joca.2023.09.004openalex-snapshot

Metabolic phenotypes reflect patient sex and injury status: A cross-sectional analysis of human synovial fluid

inferred← citeshttps://doi.org/10.1016/j.joca.2024.06.013openalex-snapshot

Early microRNA and metabolite changes after anterior cruciate ligament reconstruction surgery

inferred← citeshttps://doi.org/10.1016/j.ocarto.2022.100258openalex-snapshot

Identification of a differential metabolite-based signature in patients with late-stage knee osteoarthritis

inferred← citeshttps://doi.org/10.1016/j.phymed.2019.152958openalex-snapshot

Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review

inferred← citeshttps://doi.org/10.1038/s41413-024-00328-6openalex-snapshot

Skeletal interoception in osteoarthritis

inferred← citeshttps://doi.org/10.1038/s41413-024-00370-4openalex-snapshot

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases

inferred← citeshttps://doi.org/10.1038/s41467-024-46663-4openalex-snapshot

Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

inferred← citeshttps://doi.org/10.1039/d2mo00297copenalex-snapshot

The alteration of urinary metabolomics profiles in Kashin–Beck disease in a three consecutive year study

inferred← citeshttps://doi.org/10.1080/14789450.2021.1952868openalex-snapshot

Mass Spectrometry-based Biomarkers for Knee Osteoarthritis: A Systematic Review

inferred← citeshttps://doi.org/10.1097/md.0000000000049805openalex-snapshot

Exploring the cognitive effects of arthritis: A Mendelian randomization study and cross-sectional analysis of NHANES data

inferred← citeshttps://doi.org/10.1101/2023.02.03.527040openalex-snapshot

Metabolomic Phenotypes Reflect Patient Sex and Injury Status: A Cross-Sectional Analysis of Human Synovial Fluid

inferred← citeshttps://doi.org/10.1101/2025.09.26.678886openalex-snapshot

Multi-omics integration at cell type resolution uncovers gene-metabolite mechanisms underlying osteoarthritis heterogeneity

inferred← citeshttps://doi.org/10.1177/15353702231199072openalex-snapshot

Effect of smoking on the redox status of knee osteoarthritis: A preliminary study

inferred← citeshttps://doi.org/10.1177/1759720x231177116openalex-snapshot

Emerging molecular biomarkers in osteoarthritis pathology

inferred← citeshttps://doi.org/10.12677/acm.2025.15123658openalex-snapshot

Research Progress of Osteophytes in Knee Osteoarthritis

inferred← citeshttps://doi.org/10.1371/journal.pone.0305697openalex-snapshot

Effects of a feed supplement, containing undenatured type II collagen (UC II®) and Boswellia Serrata, in the management of mild/moderate mobility disorders in dogs: A randomized, double-blind, placebo controlled, cross-over study

inferred← citeshttps://doi.org/10.14412/1996-7012-2021-1-136-143openalex-snapshot

Standardised Forms of Chondroitin Sulfate as a Pathogenetic Treatment of Osteoarthritis in the Context of Post-Genomic Studies

inferred← citeshttps://doi.org/10.14744/nci.2021.34270openalex-snapshot

Accuracy of Magnetic Resonance Imaging in Assessing Knee Cartilage Changes Over Time in Patients with Osteoarthritis: A Systematic Review

inferred← citeshttps://doi.org/10.1615/critrevimmunol.2024051440openalex-snapshot

Identification of Key Ubiquitination-Related Genes and Their Association with Immune Infiltration in Osteoarthritis Based on the mRNA-miRNA Network

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3488709/v1openalex-snapshot

Metabonomics study on the effects of acupuncture and moxibustion in a rat knee osteoarthritis model

inferred← citeshttps://doi.org/10.22491/2357-9730.131628openalex-snapshot

Update of clinical aspects of knee osteoarthritis: data mining from NMR-based metabolomics of synovial fluid

inferred← citeshttps://doi.org/10.26481/dis.20240220mhopenalex-snapshot

Biomarkers in cartilage repair and osteoarthritis

inferred← citeshttps://doi.org/10.3164/jcbn.24-199openalex-snapshot

Investigation of factors associated with osteoporosis using metabolome analysis

inferred← citeshttps://doi.org/10.33192/smj.2022.94openalex-snapshot

Untargeted Metabolomics Analysis using LC-MSQTOF for Metabolite Profile Comparison between Patients with Myofascial Pain of Upper Trapezius Muscle versus Controls

inferred← citeshttps://doi.org/10.3389/fendo.2024.1488481openalex-snapshot

Novel insights into the role of metabolic disorder in osteoarthritis

inferred← citeshttps://doi.org/10.3389/fgene.2023.1096616openalex-snapshot

Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats

inferred← citeshttps://doi.org/10.3389/fimmu.2024.1335181openalex-snapshot

Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis

inferred← citeshttps://doi.org/10.3389/fmolb.2020.592905openalex-snapshot

Metabolic Signature of Articular Cartilage Following Mechanical Injury: An Integrated Transcriptomics and Metabolomics Analysis

inferred← citeshttps://doi.org/10.3390/biomedicines14020283openalex-snapshot

A Novel Concept of Tissue Micro-Instability as the Underlying Mechanism of Osteophytosis in Human Knee Osteoarthritis

inferred← citeshttps://doi.org/10.3390/ijms20143461openalex-snapshot

Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids

inferred← citeshttps://doi.org/10.3390/ijms23095085openalex-snapshot

Machine Learning and Pathway Analysis-Based Discovery of Metabolomic Markers Relating to Chronic Pain Phenotypes

inferred← citeshttps://doi.org/10.3390/jcm11206013openalex-snapshot

Osteoarthritis: New Insight on Its Pathophysiology

inferred← citeshttps://doi.org/10.3390/life12111799openalex-snapshot

Biomarkers for Osteoarthritis Diseases

inferred← citeshttps://doi.org/10.3390/life13122343openalex-snapshot

Serum Metabolomic Alteration in Rats with Osteoarthritis Treated with Palm Tocotrienol-Rich Fraction Alone or in Combination with Glucosamine Sulphate

inferred← citeshttps://doi.org/10.3390/molecules26237181openalex-snapshot

Analysis of Serum Metabolomics in Rats with Osteoarthritis by Mass Spectrometry

inferred← citeshttps://doi.org/10.5772/intechopen.106308openalex-snapshot

Exosomes - Recent Advances From Bench to Bedside

inferred← citeshttps://doi.org/10.5772/intechopen.110779openalex-snapshot

Perspective Chapter: Exosomes – The Surreptitious Intercellular Messengers in the Body

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