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Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity

https://doi.org/10.3389/fimmu.2017.00093

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Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms

inferredcites →https://doi.org/10.4049/jimmunol.1403134openalex-snapshot

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

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Temporal expression of different pathways of 1-arginine metabolism in healing wounds.

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Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells

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Hepatitis C Virus–Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1

inferredcites →https://doi.org/10.4049/jimmunol.155.4.2077openalex-snapshot

Transforming growth factor-β stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity

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Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

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Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

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Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

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Th1/Th2-Regulated Expression of Arginase Isoforms in Murine Macrophages and Dendritic Cells

inferredcites →https://doi.org/10.4049/jimmunol.166.4.2173openalex-snapshot

Cutting Edge: Stat6-Dependent Substrate Depletion Regulates Nitric Oxide Production

inferredcites →https://doi.org/10.4049/jimmunol.167.10.5583openalex-snapshot

Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide

inferredcites →https://doi.org/10.4049/jimmunol.167.11.6533openalex-snapshot

Differential Regulation of Nitric Oxide Synthase-2 and Arginase-1 by Type 1/Type 2 Cytokines In Vivo: Granulomatous Pathology Is Shaped by the Pattern of l -Arginine Metabolism

inferredcites →https://doi.org/10.4049/jimmunol.168.2.689openalex-snapshot

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

inferredcites →https://doi.org/10.4049/jimmunol.169.5.2253openalex-snapshot

Shaping Gene Expression in Activated and Resting Primary Macrophages by IL-10

inferredcites →https://doi.org/10.4049/jimmunol.170.1.270openalex-snapshot

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

inferredcites →https://doi.org/10.4049/jimmunol.171.3.1232openalex-snapshot

l -Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes

inferredcites →https://doi.org/10.4049/jimmunol.172.12.7565openalex-snapshot

Enhancer-Mediated Control of Macrophage-Specific Arginase I Expression

inferredcites →https://doi.org/10.4049/jimmunol.174.8.4880openalex-snapshot

STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion

inferredcites →https://doi.org/10.4049/jimmunol.176.1.284openalex-snapshot

Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression

inferredcites →https://doi.org/10.4049/jimmunol.176.10.5918openalex-snapshot

Arginine Transport via Cationic Amino Acid Transporter 2 Plays a Critical Regulatory Role in Classical or Alternative Activation of Macrophages

inferredcites →https://doi.org/10.4049/jimmunol.176.4.2085openalex-snapshot

CD11b+/Gr-1+ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress

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MyD88-Dependent Activation of B220−CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection

inferredcites →https://doi.org/10.4049/jimmunol.179.8.5228openalex-snapshot

CD11b+Ly-6Chi Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis

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Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

inferredcites →https://doi.org/10.4143/crt.2013.45.4.251openalex-snapshot

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

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Neutrophils Suppress Mucosal-Associated Invariant T Cells

inferred← citeshttps://doi.org/10.1111/aji.70196openalex-snapshot

Arginine Metabolism in Decidual Macrophages During Pregnancy

inferred← citeshttps://doi.org/10.1111/exd.14072openalex-snapshot

Melanoma—Time to fast or time to feast? An interplay between PPARs, metabolism and immunity

inferred← citeshttps://doi.org/10.1111/imcb.12728openalex-snapshot

CD14−CD10−CD45+HLA‐DR−SSC+ neutrophils may be granulocytic myeloid‐derived suppressor cell–like cells and relate to disease progression in non‐Hodgkin's lymphoma patients

inferred← citeshttps://doi.org/10.1111/imm.70132openalex-snapshot

Precision Glyco‐Modulated GcMAF2.0 Targets CLEC10A to Bidirectionally Re‐Wire Macrophage States: Cross‐Species Evidence, Mechanistic Omics and Translational Horizons

inferred← citeshttps://doi.org/10.1111/prd.70006openalex-snapshot

Nitrate metabolism and periodontal health: The roles of nitric oxide in microbial killing and immunoregulation

inferred← citeshttps://doi.org/10.1111/sji.12643openalex-snapshot

T‐cell cross‐reactivity may explain the large variation in how cancer patients respond to checkpoint inhibitors

inferred← citeshttps://doi.org/10.1113/jp280090openalex-snapshot

Arginase 1 is involved in lacrimal hyposecretion in male NOD mice, a model of Sjögren's syndrome, regardless of dacryoadenitis status

inferred← citeshttps://doi.org/10.1126/sciadv.abc4275openalex-snapshot

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

inferred← citeshttps://doi.org/10.1126/scitranslmed.aat4162openalex-snapshot

Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome

inferred← citeshttps://doi.org/10.1128/iai.00120-23openalex-snapshot

Arginine Metabolism Powers Salmonella Resistance to Oxidative Stress

inferred← citeshttps://doi.org/10.1128/iai.00791-18openalex-snapshot

Probiotic Exopolysaccharide Protects against SystemicStaphylococcus aureusInfection, Inducing Dual-Functioning Macrophages That Restrict Bacterial Growth and Limit Inflammation

inferred← citeshttps://doi.org/10.1128/iai.00963-19openalex-snapshot

Differential Regulation of l -Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis

inferred← citeshttps://doi.org/10.1128/jb.00362-25openalex-snapshot

ArgT functions as an arginine transporter in Staphylococcus aureus

inferred← citeshttps://doi.org/10.1128/mbio.01076-21openalex-snapshot

CCR2 Signaling Promotes Brain Infiltration of Inflammatory Monocytes and Contributes to Neuropathology during Cryptococcal Meningoencephalitis

inferred← citeshttps://doi.org/10.1136/annrheumdis-2018-214282openalex-snapshot

Critical role for arginase II in osteoarthritis pathogenesis

inferred← citeshttps://doi.org/10.1136/ard-2022-223626openalex-snapshot

L-arginine metabolism inhibits arthritis and inflammatory bone loss

inferred← citeshttps://doi.org/10.1155/2018/1601079openalex-snapshot

Conventional DCs from Male and Female Lupus-Prone B6.NZM Sle1/Sle2/Sle3 Mice Express an IFN Signature and Have a Higher Immunometabolism That Are Enhanced by Estrogen

inferred← citeshttps://doi.org/10.1155/jimr/5568021openalex-snapshot

Neutrophil Plasticity and NETosis in Tumour Microenvironment: Tumour Evolution and Therapy Resistance

inferred← citeshttps://doi.org/10.1161/circulationaha.117.031046openalex-snapshot

Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury

inferred← citeshttps://doi.org/10.1172/jci.insight.126556openalex-snapshot

Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets

inferred← citeshttps://doi.org/10.1172/jci.insight.138581openalex-snapshot

Polymorphonuclear myeloid-derived suppressor cells limit antigen cross-presentation by dendritic cells in cancer

inferred← citeshttps://doi.org/10.1172/jci126923openalex-snapshot

Arginase impedes the resolution of colitis by altering the microbiome and metabolome

inferred← citeshttps://doi.org/10.1172/jci133008openalex-snapshot

Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection

inferred← citeshttps://doi.org/10.1172/jci136288openalex-snapshot

Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus

inferred← citeshttps://doi.org/10.1172/jci145296openalex-snapshot

Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment

inferred← citeshttps://doi.org/10.1177/03009858251352581openalex-snapshot

Immunohistochemical characterization of cells of the mononuclear phagocyte system in the mouse

inferred← citeshttps://doi.org/10.1177/1753425919869436openalex-snapshot

iNOS/Arginase-1 expression in the pulmonary tissue over time during Cryptococcus gattii infection

inferred← citeshttps://doi.org/10.1177/1759091420979567openalex-snapshot

Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder

inferred← citeshttps://doi.org/10.1186/s12882-020-01921-7openalex-snapshot

Macrophage polarization in innate immune responses contributing to pathogenesis of chronic kidney disease

inferred← citeshttps://doi.org/10.1186/s12916-025-03968-5openalex-snapshot

Elevated CD10− neutrophils correlate with non-response and poor prognosis of CD19 CAR T-cell therapy for B-cell acute lymphoblastic leukemia

inferred← citeshttps://doi.org/10.1186/s12917-019-1785-0openalex-snapshot

Stimulation of bovine monocyte-derived macrophages with lipopolysaccharide, interferon-ɣ, Interleukin-4 or Interleukin-13 does not induce detectable changes in nitric oxide or arginase activity

inferred← citeshttps://doi.org/10.1186/s12917-023-03588-2openalex-snapshot

Untargeted metabolomics reveals alternations in metabolism of bovine mammary epithelial cells upon IFN-γ treatment

inferred← citeshttps://doi.org/10.1186/s12964-025-02328-3openalex-snapshot

Urea cycle dysregulation: a new frontier in cancer metabolism and immune evasion

inferred← citeshttps://doi.org/10.1186/s12967-024-05652-3openalex-snapshot

Engineered microparticles modulate arginine metabolism to repolarize tumor-associated macrophages for refractory colorectal cancer treatment

inferred← citeshttps://doi.org/10.1186/s13071-023-06053-zopenalex-snapshot

Transcriptomic profiling of long non-coding RNAs and messenger RNAs in the liver of mice during Toxoplasma gondii infection

inferred← citeshttps://doi.org/10.1186/s13072-025-00575-9openalex-snapshot

Crosstalk between metabolism and epigenetics during macrophage polarization

inferred← citeshttps://doi.org/10.1186/s40425-017-0308-4openalex-snapshot

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

inferred← citeshttps://doi.org/10.1186/s40425-019-0504-5openalex-snapshot

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

inferred← citeshttps://doi.org/10.1189/jlb.1vmr1216-535ropenalex-snapshot

Energy metabolic pathways control the fate and function of myeloid immune cells

inferred← citeshttps://doi.org/10.1245/s10434-022-12202-yopenalex-snapshot

A Translational Randomized Trial of Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer Surgery Patients

inferred← citeshttps://doi.org/10.1371/journal.pntd.0008601openalex-snapshot

Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies

inferred← citeshttps://doi.org/10.1371/journal.pone.0234479openalex-snapshot

STAT3/SOCS3 axis contributes to the outcome of salmonid whirling disease

inferred← citeshttps://doi.org/10.1371/journal.ppat.1007627openalex-snapshot

Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans

inferred← citeshttps://doi.org/10.14739/2310-1237.2022.1.240436openalex-snapshot

Modulating effect of HERV-W ENV on peripheral blood monocytes in patients with different types of multiple sclerosis

inferred← citeshttps://doi.org/10.14814/phy2.15471openalex-snapshot

Ammonium chloride‐induced acidosis exacerbates cystitis and pyelonephritis caused by uropathogenicE. coli

inferred← citeshttps://doi.org/10.15407/biotech13.04.039openalex-snapshot

FATTY ACID COMPOSITION OF PURSLANE SEED WATER EXTRACT AND ITS EFFECT ON METABOLIC PROFILE OF MURINE PERITONEAL MACROPHAGES

inferred← citeshttps://doi.org/10.15421/022075openalex-snapshot

Functional and metabolic characteristics of peripheral blood mononuclear phagocytes in patients with different clinical courses of multiple sclerosis

inferred← citeshttps://doi.org/10.15789/1563-0625-ios-2075openalex-snapshot

Influence of streptococcal arginine deiminase on the leukocyte infiltration in murine air pouch model

inferred← citeshttps://doi.org/10.15789/2220-7619-adf-1363openalex-snapshot

S. pyogenes M49-16 arginine deiminase inhibits proliferative activity of human peripheral blood lymphocytes

inferred← citeshttps://doi.org/10.21203/rs.3.rs-10754442/v1openalex-snapshot

Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomic Study of Peripheral Blood Mononuclear Cells in Patients With Psoriatic Arthritis

inferred← citeshttps://doi.org/10.21203/rs.3.rs-9321051/v1openalex-snapshot

Indirect pharmacology of Amorphophallus rivieri Durieu in pancreatic ductal adenocarcinoma: immune-dependent macrophage remodeling and amino acid-related metabolic alterations

inferred← citeshttps://doi.org/10.2174/0115672050327009240808103542openalex-snapshot

Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.2174/1389557522666211229105703openalex-snapshot

An Update on Arginase Inhibitors and Inhibitory Assays

inferred← citeshttps://doi.org/10.2174/1871530319666190116121451openalex-snapshot

Perspectives on the Therapeutic Benefits of Arginine Supplementation in Cancer Treatment

inferred← citeshttps://doi.org/10.24272/j.issn.2095-8137.2023.007openalex-snapshot

Single-cell profiling of the pig cecum at various developmental stages

inferred← citeshttps://doi.org/10.26508/lsa.202302339openalex-snapshot

Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolism

inferred← citeshttps://doi.org/10.30970/sbi.1102.533openalex-snapshot

Age-related changes of arginase activity and nitric oxide level in phagocytes and their modulation by thymic mesenchymal stromal cells

inferred← citeshttps://doi.org/10.32607/actanaturae.27889openalex-snapshot

A comparative study of genital lichen sclerosus transcriptomes

inferred← citeshttps://doi.org/10.33140/jpr.08.02.07openalex-snapshot

DPP4 valorphin activate NR4As pathway and OPA1 that protect from CoQ10 deficiency from OPA1 dysfunctions and from WMH

inferred← citeshttps://doi.org/10.33425/2690-5191.1100openalex-snapshot

DPP4 Valorphin Activate NR4As Pathway and OPA1 That Protect from CoQ10 Deficiency, OPA1 Dysfunctions and WMH

inferred← citeshttps://doi.org/10.3389/fcell.2018.00168openalex-snapshot

The Sweet Surrender: How Myeloid Cell Metabolic Plasticity Shapes the Tumor Microenvironment

inferred← citeshttps://doi.org/10.3389/fcell.2020.603837openalex-snapshot

Metabolism of Amino Acids in Cancer

inferred← citeshttps://doi.org/10.3389/fcell.2020.613416openalex-snapshot

Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes

inferred← citeshttps://doi.org/10.3389/fcimb.2025.1531084openalex-snapshot

Unveiling the role of the upper respiratory tract microbiome in susceptibility and severity to COVID-19

inferred← citeshttps://doi.org/10.3389/fimmu.2017.00864openalex-snapshot

Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

inferred← citeshttps://doi.org/10.3389/fimmu.2018.00262openalex-snapshot

How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive

inferred← citeshttps://doi.org/10.3389/fimmu.2018.00270openalex-snapshot

Metabolic Modulation in Macrophage Effector Function

inferred← citeshttps://doi.org/10.3389/fimmu.2018.00778openalex-snapshot

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

inferred← citeshttps://doi.org/10.3389/fimmu.2018.01977openalex-snapshot

Turn Back the TIMe: Targeting Tumor Infiltrating Myeloid Cells to Revert Cancer Progression

inferred← citeshttps://doi.org/10.3389/fimmu.2018.02135openalex-snapshot

Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility

inferred← citeshttps://doi.org/10.3389/fimmu.2018.02790openalex-snapshot

Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection

inferred← citeshttps://doi.org/10.3389/fimmu.2019.00771openalex-snapshot

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

inferred← citeshttps://doi.org/10.3389/fimmu.2019.00775openalex-snapshot

Metabolic Control of Dendritic Cell Functions: Digesting Information

inferred← citeshttps://doi.org/10.3389/fimmu.2019.01329openalex-snapshot

The Inhibition of Caspase-1- Does Not Revert Particulate Matter (PM)-Induced Lung Immunesuppression in Mice

inferred← citeshttps://doi.org/10.3389/fimmu.2019.01699openalex-snapshot

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

inferred← citeshttps://doi.org/10.3389/fimmu.2020.00938openalex-snapshot

Myeloid Cell-Derived Arginase in Cancer Immune Response

inferred← citeshttps://doi.org/10.3389/fimmu.2020.617699openalex-snapshot

Inhibition of Arginase 1 Liberates Potent T Cell Immunostimulatory Activity of Human Neutrophil Granulocytes

inferred← citeshttps://doi.org/10.3389/fimmu.2021.614599openalex-snapshot

Reduced Expression of Autophagy Markers and Expansion of Myeloid-Derived Suppressor Cells Correlate With Poor T Cell Response in Severe COVID-19 Patients

inferred← citeshttps://doi.org/10.3389/fimmu.2021.626755openalex-snapshot

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

inferred← citeshttps://doi.org/10.3389/fimmu.2021.633205openalex-snapshot

Natural Killer Cell Interactions With Myeloid Derived Suppressor Cells in the Tumor Microenvironment and Implications for Cancer Immunotherapy

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