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5-Lipoxygenase inhibitors: a review of recent developments and patents

https://doi.org/10.1517/13543771003602012

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/phrs.2000.0784openalex-snapshot

Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept

inferredcites →https://doi.org/10.1006/pupt.2000.0262openalex-snapshot

Leukotrienes as Mediators of Asthma

inferredcites →https://doi.org/10.1007/pl00000285openalex-snapshot

The mechanism of action of the new antiinflammatory compound ML3000: inhibition of 5-LOX and COX-1/2

inferredcites →https://doi.org/10.1007/s00011-006-6032-zopenalex-snapshot

RBx 7796: A novel inhibitor of 5-lipoxygenase

inferredcites →https://doi.org/10.1007/s00011-007-7149-4openalex-snapshot

Pharmacodynamic and pharmacokinetic characterisation of RBx 7796: a novel 5-lipoxygenase inhibitor

inferredcites →https://doi.org/10.1007/s00011-009-0069-8openalex-snapshot

Cytosolic phospholipase A2 alpha inhibitor, pyrroxyphene, displays anti-arthritic and anti-bone destructive action in a murine arthritis model

inferredcites →https://doi.org/10.1007/s00018-009-0078-3openalex-snapshot

Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo

inferredcites →https://doi.org/10.1007/s00103-005-1024-7openalex-snapshot

Arzneimittelforschung

inferredcites →https://doi.org/10.1007/s00894-002-0076-yopenalex-snapshot

Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme

inferredcites →https://doi.org/10.1007/s11882-008-0057-zopenalex-snapshot

Expanding roles for leukotrienes in airway inflammation

inferredcites →https://doi.org/10.1007/s11926-008-0008-7openalex-snapshot

Licofelone: The answer to unmet needs in osteoarthritis therapy?

inferredcites →https://doi.org/10.1016/0014-5793(86)80831-6openalex-snapshot

The importance of hydroperoxide activation for the detection and assay of mammalian 5‐lipoxygenase

inferredcites →https://doi.org/10.1016/0165-6147(92)90100-kopenalex-snapshot

Designing therapeutically effective 5-lipoxygenase inhibitors

inferredcites →https://doi.org/10.1016/0929-7855(95)00017-kopenalex-snapshot

Arachidonate 5-lipoxygenase

inferredcites →https://doi.org/10.1016/j.bbrc.2009.08.005openalex-snapshot

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E2 synthase-1

inferredcites →https://doi.org/10.1016/j.bcp.2005.04.018openalex-snapshot

Development of 5-lipoxygenase inhibitors—lessons from cellular enzyme regulation

inferredcites →https://doi.org/10.1016/j.bcp.2008.07.009openalex-snapshot

Celecoxib inhibits 5-lipoxygenase

inferredcites →https://doi.org/10.1016/j.bmc.2005.12.062openalex-snapshot

Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues

inferredcites →https://doi.org/10.1016/j.bmc.2006.07.047openalex-snapshot

Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs)

inferredcites →https://doi.org/10.1016/j.bmc.2008.11.074openalex-snapshot

Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, OH scavenging and anti-adhesive activities

inferredcites →https://doi.org/10.1016/j.bmc.2009.10.025openalex-snapshot

Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E2 synthase-1

inferredcites →https://doi.org/10.1016/j.bmcl.2006.01.085openalex-snapshot

Substituted coumarins as potent 5-lipoxygenase inhibitors

inferredcites →https://doi.org/10.1016/j.bmcl.2008.05.071openalex-snapshot

Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A novel class of 5-lipoxygenase inhibitors

inferredcites →https://doi.org/10.1016/j.bmcl.2008.10.009openalex-snapshot

Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

inferredcites →https://doi.org/10.1016/j.bmcl.2008.12.066openalex-snapshot

Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: Evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

inferredcites →https://doi.org/10.1016/j.bmcl.2008.12.108openalex-snapshot

Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoylclusters

inferredcites →https://doi.org/10.1016/j.ejphar.2009.01.044openalex-snapshot

On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance

inferredcites →https://doi.org/10.1016/j.ejphar.2009.02.023openalex-snapshot

MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation

inferredcites →https://doi.org/10.1016/j.ejphar.2009.02.032openalex-snapshot

The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor

inferredcites →https://doi.org/10.1016/j.ejphar.2009.03.062openalex-snapshot

Anti-inflammatory effects and gastrointestinal safety of NNU-hdpa, a novel dual COX/5-LOX inhibitor

inferredcites →https://doi.org/10.1016/j.ejphar.2009.06.058openalex-snapshot

CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

inferredcites →https://doi.org/10.1016/j.lfs.2005.11.017openalex-snapshot

Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase

inferredcites →https://doi.org/10.1016/j.lfs.2007.03.017openalex-snapshot

Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9, a dual cyclooxygenase-2/5-lipoxygenase inhibitor

inferredcites →https://doi.org/10.1016/j.pharmthera.2006.05.009openalex-snapshot

Therapeutic options for 5-lipoxygenase inhibitors

inferredcites →https://doi.org/10.1016/j.plefa.2007.12.006openalex-snapshot

Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors

inferredcites →https://doi.org/10.1016/j.prostaglandins.2007.01.004openalex-snapshot

Additional functions for the cysteinyl leukotrienes recognized through studies of inflammatory processes in null strains

inferredcites →https://doi.org/10.1016/j.prostaglandins.2007.01.008openalex-snapshot

Endothelium-dependent vascular responses induced by leukotriene B4

inferredcites →https://doi.org/10.1016/j.prostaglandins.2009.05.002openalex-snapshot

5-Oxo-ETE and the OXE receptor

inferredcites →https://doi.org/10.1016/j.tibs.2007.06.002openalex-snapshot

5-Lipoxygenase: regulation of expression and enzyme activity

inferredcites →https://doi.org/10.1016/j.tips.2007.11.006openalex-snapshot

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

inferredcites →https://doi.org/10.1016/s0006-2952(02)01387-4openalex-snapshot

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase

inferredcites →https://doi.org/10.1016/s0021-9258(18)53251-8openalex-snapshot

Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone.

inferredcites →https://doi.org/10.1016/s0021-9258(20)81957-7openalex-snapshot

Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate.

inferredcites →https://doi.org/10.1016/s0022-3565(25)11130-0openalex-snapshot

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

inferredcites →https://doi.org/10.1021/jm00024a004openalex-snapshot

Preparation of (R)-(+)-N-[3-[5-[(4-Fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor.

inferredcites →https://doi.org/10.1021/jm050801iopenalex-snapshot

Design and Synthesis of Novel 2-Amino-5-hydroxyindole Derivatives That Inhibit Human 5-Lipoxygenase

inferredcites →https://doi.org/10.1021/jm0510474openalex-snapshot

Synthesis and Structure−Activity Relationship Studies of 1,3-Diarylprop-2-yn-1-ones: Dual Inhibitors of Cyclooxygenases and Lipoxygenases

inferredcites →https://doi.org/10.1021/jm800588xopenalex-snapshot

Novel and Potent Inhibitors of 5-Lipoxygenase Product Synthesis Based on the Structure of Pirinixic Acid

inferredcites →https://doi.org/10.1021/jm801085sopenalex-snapshot

Pirinixic Acid Derivatives as Novel Dual Inhibitors of Microsomal Prostaglandin E2Synthase-1 and 5-Lipoxygenase

inferredcites →https://doi.org/10.1021/jm8015188openalex-snapshot

Synthesis of Celecoxib Analogues Possessing aN-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

inferredcites →https://doi.org/10.1021/jm900212yopenalex-snapshot

Structural Optimization and Biological Evaluation of 2-Substituted 5-Hydroxyindole-3-carboxylates as Potent Inhibitors of Human 5-Lipoxygenase

inferredcites →https://doi.org/10.1021/jm900481copenalex-snapshot

Arylpyrrolizines as Inhibitors of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) or as Dual Inhibitors of mPGES-1 and 5-Lipoxygenase (5-LOX)

inferredcites →https://doi.org/10.1038/372179a0openalex-snapshot

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene

inferredcites →https://doi.org/10.1038/37622openalex-snapshot

Role of cytosolic phospholipase A2 in allergic response and parturition

inferredcites →https://doi.org/10.1038/ng0994-8openalex-snapshot

A mixed message for cystic fibrosis gene therapy

inferredcites →https://doi.org/10.1038/ng1311openalex-snapshot

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

inferredcites →https://doi.org/10.1038/nri2294openalex-snapshot

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

inferredcites →https://doi.org/10.1038/sj.bjp.0705860openalex-snapshot

Molecular pharmacological profile of the nonredox‐type 5‐lipoxygenase inhibitor CJ‐13,610

inferredcites →https://doi.org/10.1038/sj.bjp.0707416openalex-snapshot

The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5‐lipoxygenase products

inferredcites →https://doi.org/10.1042/bj20090856openalex-snapshot

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102

inferredcites →https://doi.org/10.1046/j.1365-2796.1999.00418.xopenalex-snapshot

Asthma and leukotrienes: antileukotrienes as novel anti‐asthmatic drugs

inferredcites →https://doi.org/10.1046/j.1471-4159.1999.0730693.xopenalex-snapshot

Glucocorticoids Stimulate Inflammatory 5‐Lipoxygenase Gene Expression and Protein Translocation in the Brain

inferredcites →https://doi.org/10.1056/nejmra071371openalex-snapshot

Leukotrienes

inferredcites →https://doi.org/10.1073/pnas.0505845102openalex-snapshot

Leukotriene B 4 signaling through NF-κB-dependent BLT 1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia

inferredcites →https://doi.org/10.1073/pnas.050588997openalex-snapshot

5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases

inferredcites →https://doi.org/10.1073/pnas.0505991102openalex-snapshot

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells

inferredcites →https://doi.org/10.1073/pnas.0605150103openalex-snapshot

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A 4 production

inferredcites →https://doi.org/10.1073/pnas.0808993105openalex-snapshot

Functional recognition of a distinct receptor preferential for leukotriene E 4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors

inferredcites →https://doi.org/10.1073/pnas.0809120105openalex-snapshot

ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma

inferredcites →https://doi.org/10.1073/pnas.242716099openalex-snapshot

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

inferredcites →https://doi.org/10.1073/pnas.95.2.663openalex-snapshot

5-Lipoxygenase expression in Langerhans cells of normal human epidermis

inferredcites →https://doi.org/10.1074/jbc.271.11.6179openalex-snapshot

Tyrosine Kinase Activity Modulates Catalysis and Translocation of Cellular 5-Lipoxygenase

inferredcites →https://doi.org/10.1074/jbc.m011205200openalex-snapshot

5-Lipoxygenase Interacts with Coactosin-like Protein

inferredcites →https://doi.org/10.1074/jbc.m109.000901openalex-snapshot

Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice

inferredcites →https://doi.org/10.1074/jbc.m111945200openalex-snapshot

Arachidonic Acid Promotes Phosphorylation of 5-Lipoxygenase at Ser-271 by MAPK-activated Protein Kinase 2 (MK2)

inferredcites →https://doi.org/10.1074/jbc.m312568200openalex-snapshot

Protein Kinase A Inhibits Leukotriene Synthesis by Phosphorylation of 5-Lipoxygenase on Serine 523

inferredcites →https://doi.org/10.1074/jbc.m805593200openalex-snapshot

Phosphorylation of Serine 271 on 5-Lipoxygenase and Its Role in Nuclear Export

inferredcites →https://doi.org/10.1084/jem.192.3.433openalex-snapshot

Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis

inferredcites →https://doi.org/10.1084/jem.20052371openalex-snapshot

Neutrophil-derived leukotriene B4 is required for inflammatory arthritis

inferredcites →https://doi.org/10.1096/fj.01-0909fjeopenalex-snapshot

Extracellular signal‐regulated kinases phosphorylate 5lipoxygenase and stimulate 5‐lipoxygenase product formation in leukocytes

inferredcites →https://doi.org/10.1096/fj.06-7974comopenalex-snapshot

Leukotriene B 4 triggers release of the cathelicidin LL‐37 from human neutrophils: novel lipid‐peptide interactions in innate immune responses

inferredcites →https://doi.org/10.1097/01.tp.0000226065.82066.21openalex-snapshot

Cytosolic Phospholipase A2 Inhibition Attenuates Ischemia-Reperfusion Injury in an Isolated Rat Lung Model

inferredcites →https://doi.org/10.1111/j.1742-7843.2009.00463.xopenalex-snapshot

Biological Evaluation of 2‐(4‐Amino‐Phenyl)‐3‐(3,5‐Dihydroxylphenyl) Propenoic Acid

inferredcites →https://doi.org/10.1124/jpet.108.139444openalex-snapshot

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

inferredcites →https://doi.org/10.1124/jpet.109.158089openalex-snapshot

Pharmacological Characterization of 3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103), a Novel Selective 5-Lipoxygenase-Activating Protein Inhibitor That Reduces Acute and Chronic Inflammation

inferredcites →https://doi.org/10.1124/pr.55.1.8openalex-snapshot

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

inferredcites →https://doi.org/10.1124/pr.58.3.8openalex-snapshot

Eicosanoid Transcellular Biosynthesis: From Cell-Cell Interactions to in Vivo Tissue Responses

inferredcites →https://doi.org/10.1126/science.1144346openalex-snapshot

Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein

inferredcites →https://doi.org/10.1126/science.2820055openalex-snapshot

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

inferredcites →https://doi.org/10.1136/adc.88.7.587openalex-snapshot

Therapeutic implications of sex differences in asthma and atopy

inferredcites →https://doi.org/10.1146/annurev.bi.63.070194.002123openalex-snapshot

5-LIPOXYGENASE

inferredcites →https://doi.org/10.1152/ajplung.00396.2002openalex-snapshot

A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice

inferredcites →https://doi.org/10.1158/1535-7163.mct-09-0290openalex-snapshot

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

inferredcites →https://doi.org/10.1160/th06-02-0069openalex-snapshot

Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase

inferredcites →https://doi.org/10.1161/01.atv.0000082460.58448.01openalex-snapshot

5-Lipoxygenase-Derived Leukotrienes

inferredcites →https://doi.org/10.1161/01.atv.0000172632.96987.2dopenalex-snapshot

Association Between 5-Lipoxygenase Expression and Plaque Instability in Humans

inferredcites →https://doi.org/10.1161/01.res.0000264498.60702.0dopenalex-snapshot

5-Lipoxygenase–Activating Protein

inferredcites →https://doi.org/10.1163/156856001300248380openalex-snapshot

The pharmacological profile of ML3000: A new pyrrolizine derivative inhibiting the enzymes cyclo-oxygenase and 5-lipoxygenase

inferredcites →https://doi.org/10.1182/blood.v97.8.2487openalex-snapshot

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes

inferredcites →https://doi.org/10.1182/blood.v99.3.1044openalex-snapshot

Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes

inferredcites →https://doi.org/10.1183/09031936.98.11030617openalex-snapshot

Effects of a 5-lipoxygenase inhibitor, ABT-761, on exercise-induced bronchoconstriction and urinary LTE4 in asthmatic patients

inferredcites →https://doi.org/10.1186/1471-2172-10-2openalex-snapshot

High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes

inferredcites →https://doi.org/10.1186/ar2461openalex-snapshot

A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin®for treatment of osteoarthritis of the knee

inferredcites →https://doi.org/10.1189/jlb.0808476openalex-snapshot

Leukotriene modifiers in the treatment of cardiovascular diseases

inferredcites →https://doi.org/10.1189/jlb.70.5.830openalex-snapshot

p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line

inferredcites →https://doi.org/10.1248/cpb.53.965openalex-snapshot

Optimization of Imidazole 5-Lipoxygenase Inhibitors and Selection and Synthesis of a Development Candidate

inferredcites →https://doi.org/10.1369/jhc.2008.951855openalex-snapshot

Increased 5-Lipoxygenase Immunoreactivity in the Hippocampus of Patients With Alzheimer's Disease

inferredcites →https://doi.org/10.1517/13543776.15.5.505openalex-snapshot

Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds

inferredcites →https://doi.org/10.2174/092986709789578178openalex-snapshot

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

inferredcites →https://doi.org/10.2174/138161209789058020openalex-snapshot

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis

inferredcites →https://doi.org/10.2174/1568010023344959openalex-snapshot

5-Lipoxygenase: Cellular Biology and Molecular Pharmacology

inferredcites →https://doi.org/10.2500/108854198778557773openalex-snapshot

Effect of Sex Hormones on Eosinophilic Inflammation in Nasal Mucosa

inferredcites →https://doi.org/10.4049/jimmunol.179.11.7883openalex-snapshot

Cysteinyl Leukotrienes Are Autocrine and Paracrine Regulators of Fibrocyte Function

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4111366openalex-extracted

Design and Synthesis of Functionalized4-Aryl-Catechol Derivatives as New Anti-Inflammatory Agents with In Vivo Efficacy PART I

inferred← citeshttps://doi.org/10.1002/9780470015902.a0024630openalex-snapshot

Recent Advances on 5‐Lipoxygenase Biochemistry

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In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors

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Development for a new 5‐lipoxygenase inhibitors of N ‐((6‐(substituted‐amino)‐ 2‐methyl‐2H ‐chromen‐2‐yl)methyl)‐ N ‐methyl benzenesulfonamide derivatives

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Potent Inhibitors of 5‐Lipoxygenase Identified using Pseudoreceptors

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Caulerpenyne and Related Bis‐enol Esters Are Novel‐Type Inhibitors of Human 5‐Lipoxygenase

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Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro

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Guidelines for the in vitro determination of anti‐inflammatory activity

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Detection of mammalian 5‐lipoxygenase activity using the fluorescent probe dihydrorhodamine 123

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From Molecular Docking to 3D‐Quantitative Structure‐Activity Relationships (3D‐QSAR): Insights into the Binding Mode of 5‐Lipoxygenase Inhibitors

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In Silico, In Vitro and In Vivo Anti-inflammatory and Analgesic Activity of Usnic Acid

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Reactive Oxygen Species and Eicosanoid-Mediated Inflammation in Metabolic Disorders

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Hydroxamates as Ribonucleotide Reductase Inhibitors

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Cyclooxygenases and lipoxygenases in cancer

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Citreorosein inhibits degranulation and leukotriene C4 generation through suppression of Syk pathway in mast cells

inferred← citeshttps://doi.org/10.1007/s11696-018-0520-9openalex-snapshot

Synthesis, evaluation and docking studies of some 4-thiazolone derivatives as effective lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1007/s40484-018-0163-4openalex-snapshot

Pharmacodynamics simulation of HOEC by a computational model of arachidonic acid metabolic network

inferred← citeshttps://doi.org/10.1007/s43440-021-00258-8openalex-snapshot

Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury

inferred← citeshttps://doi.org/10.1016/b978-0-12-819218-4.00016-xopenalex-snapshot

Systems pharmacology and molecular docking strategies prioritize natural molecules as antiinflammatory agents

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Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation

inferred← citeshttps://doi.org/10.1016/j.apsb.2021.04.011openalex-snapshot

From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution

inferred← citeshttps://doi.org/10.1016/j.bbamem.2014.04.006openalex-snapshot

Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages

inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.153885openalex-snapshot

Combined computational and experimental studies reveal an altered regiospecific switch in 5-lipoxygenase targeted by AKBA

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Molecular characterization of EP6—A novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor

inferred← citeshttps://doi.org/10.1016/j.bcp.2013.04.015openalex-snapshot

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

inferred← citeshttps://doi.org/10.1016/j.bcp.2013.11.005openalex-snapshot

Novel lipid signaling pathways in Alzheimer's disease pathogenesis

inferred← citeshttps://doi.org/10.1016/j.bcp.2016.04.019openalex-snapshot

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

inferred← citeshttps://doi.org/10.1016/j.bcp.2016.08.023openalex-snapshot

BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

inferred← citeshttps://doi.org/10.1016/j.bcp.2016.11.004openalex-snapshot

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103528openalex-snapshot

4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition

inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.104140openalex-snapshot

Stomopneulactone D from long-spined sea urchin Stomopneustes variolaris: Anti-inflammatory macrocylic lactone attenuates cyclooxygenase-2 expression in lipopolysaccharide-activated macrophages

inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119764openalex-snapshot

Carnosic acid and carnosol promote lipid mediator class-switching toward inflammation resolution in human macrophages

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2018.02.010openalex-snapshot

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis

inferred← citeshttps://doi.org/10.1016/j.bmc.2010.06.047openalex-snapshot

Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists

inferred← citeshttps://doi.org/10.1016/j.bmc.2011.04.034openalex-snapshot

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1

inferred← citeshttps://doi.org/10.1016/j.bmc.2012.06.019openalex-snapshot

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.04.016openalex-snapshot

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases

inferred← citeshttps://doi.org/10.1016/j.bmc.2014.01.027openalex-snapshot

Lead modification: Amino acid appended indoles as highly effective 5-LOX inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2014.03.008openalex-snapshot

Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.09.025openalex-snapshot

5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.12.040openalex-snapshot

Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents

inferred← citeshttps://doi.org/10.1016/j.bmc.2016.01.042openalex-snapshot

A potent and selective inhibitor targeting human and murine 12/15-LOX

inferred← citeshttps://doi.org/10.1016/j.bmc.2018.12.043openalex-snapshot

Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies

inferred← citeshttps://doi.org/10.1016/j.bmc.2019.06.040openalex-snapshot

5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach

inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.10.024openalex-snapshot

Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286

inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.04.006openalex-snapshot

Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1

inferred← citeshttps://doi.org/10.1016/j.bmcl.2023.129464openalex-snapshot

Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells

inferred← citeshttps://doi.org/10.1016/j.brainres.2012.01.031openalex-snapshot

The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway

inferred← citeshttps://doi.org/10.1016/j.chemolab.2020.104188openalex-snapshot

Towards a systematic analysis of structure-activity relationships of 5-LOX inhibitors through activity landscape and chemotype enrichment

inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.03.060openalex-snapshot

Curcumin analogues as possible anti-proliferative & anti-inflammatory agents

inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.05.014openalex-snapshot

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.06.039openalex-snapshot

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.05.033openalex-snapshot

Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.02.042openalex-snapshot

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.10.043openalex-snapshot

Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds

inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.10.020openalex-snapshot

Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.07.026openalex-snapshot

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.08.098openalex-snapshot

Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112518openalex-snapshot

Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112620openalex-snapshot

Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114788openalex-snapshot

Design and synthesis of functionalized 4-aryl-Catechol derivatives as new antiinflammtory agents with in vivo efficacy

inferred← citeshttps://doi.org/10.1016/j.fitote.2020.104712openalex-snapshot

Cannflavins – From plant to patient: A scoping review

inferred← citeshttps://doi.org/10.1016/j.fsi.2024.110095openalex-snapshot

Identification of the arachidonic acid 5-lipoxygenase and its function in the immunity of Apostichopus japonicus

inferred← citeshttps://doi.org/10.1016/j.heliyon.2020.e04304openalex-snapshot

Avenanthramides as lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110419openalex-snapshot

Caffeic acid phenethyl ester analogues as selective inhibitors of 12-lipoxygenase product biosynthesis in human platelets

inferred← citeshttps://doi.org/10.1016/j.jep.2013.11.004openalex-snapshot

Inhibition of 5-lipoxygenase as anti-inflammatory mode of action of Plectranthus zeylanicus Benth and chemical characterization of ingredients by a mass spectrometric approach

inferred← citeshttps://doi.org/10.1016/j.jep.2013.11.052openalex-snapshot

Munronia pinnata (Wall.) Theob.: Unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1

inferred← citeshttps://doi.org/10.1016/j.jep.2016.03.003openalex-snapshot

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action

inferred← citeshttps://doi.org/10.1016/j.jep.2018.04.042openalex-snapshot

Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout

inferred← citeshttps://doi.org/10.1016/j.jmgm.2015.12.001openalex-snapshot

LOX1 inhibition with small molecules

inferred← citeshttps://doi.org/10.1016/j.jmgm.2020.107699openalex-snapshot

A cheminformatic study on chemical space characterization and diversity analysis of 5-LOX inhibitors

inferred← citeshttps://doi.org/10.1016/j.nexres.2025.101061openalex-snapshot

Natural modulators of NF-κB, cytokine, and oxidative stress signaling in coronary artery inflammation

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2015.11.001openalex-snapshot

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108612openalex-snapshot

Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers

inferred← citeshttps://doi.org/10.1016/j.phrs.2015.01.007openalex-snapshot

Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes

inferred← citeshttps://doi.org/10.1016/j.placenta.2014.03.022openalex-snapshot

Human cytomegalovirus infection induces leukotriene B4 and 5-lipoxygenase expression in human placentae and umbilical vein endothelial cells

inferred← citeshttps://doi.org/10.1016/j.prostaglandins.2020.106411openalex-snapshot

An overview of lipoxygenase inhibitors with approach of in vivo studies

inferred← citeshttps://doi.org/10.1016/j.sajb.2020.08.023openalex-snapshot

Pharmacological activities of Hermannol (9-(7-methyloctyl)-9H-xanthene-2,3-diol), a new Xanthene derivative isolated from the roots of Hermannia geniculata Eckl. & Zeyh.

inferred← citeshttps://doi.org/10.1016/j.smim.2017.07.012openalex-snapshot

Biosynthesis of leukotriene B4

inferred← citeshttps://doi.org/10.1016/j.tetlet.2017.05.089openalex-snapshot

Synthesis of heterocycles from arylacetonitriles: Powerful tools for medicinal chemists

inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00930openalex-snapshot

Identification of the Substrate Access Portal of 5-Lipoxygenase

inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00201openalex-snapshot

Targeting Metalloenzymes for Therapeutic Intervention

inferred← citeshttps://doi.org/10.1021/acs.inorgchem.4c05103openalex-snapshot

Development of Ferrocenyl and Ruthenocenyl Zileuton Analogs with Enhanced Bioactivity toward Human 5-Lipoxygenase: Innovation in Drugs for Inflammatory Diseases

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b01008openalex-snapshot

Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones

inferred← citeshttps://doi.org/10.1021/acs.joc.5b02844openalex-snapshot

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B

inferred← citeshttps://doi.org/10.1021/acs.organomet.0c00284openalex-snapshot

Design, Synthesis and Biological Evaluation of Ferrocenyl Thiazole and Thiazolo[5,4-d]thiazole Catechols as Inhibitors of 5-hLOX and as Antibacterials against Staphylococcus aureus. Structural Relationship and Computational Studies

inferred← citeshttps://doi.org/10.1021/acsomega.2c02095openalex-snapshot

Synthesis of a Pyridone-Based Phthalimide Fleximer and Its Characterization and Supramolecular Property Evaluation

inferred← citeshttps://doi.org/10.1021/acsomega.7b01622openalex-snapshot

Computational Analysis of LOX1 Inhibition Identifies Descriptors Responsible for Binding Selectivity

inferred← citeshttps://doi.org/10.1021/acsptsci.6c00163openalex-snapshot

The Substrate-Engine Model of Ferroptosis: Stage-Specific Targeting of Acyl-CoA Synthetase Long-Chain Family Member 4 and 5-Lipoxygenase in Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1021/jm201105aopenalex-snapshot

α-Aryl-N-alkyl Nitrones, as Potential Agents for Stroke Treatment: Synthesis, Theoretical Calculations, Antioxidant, Anti-inflammatory, Neuroprotective, and Brain–Blood Barrier Permeability Properties

inferred← citeshttps://doi.org/10.1021/jm201497kopenalex-snapshot

Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors

inferred← citeshttps://doi.org/10.1021/jm301617jopenalex-snapshot

Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase

inferred← citeshttps://doi.org/10.1021/jm401740wopenalex-snapshot

Indirubin Core Structure of Glycogen Synthase Kinase-3 Inhibitors as Novel Chemotype for Intervention with 5-Lipoxygenase

inferred← citeshttps://doi.org/10.1021/np401010xopenalex-snapshot

One-Step Semisynthesis of Oleacein and the Determination as a 5-Lipoxygenase Inhibitor

inferred← citeshttps://doi.org/10.1038/nrd.2017.194openalex-snapshot

Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications

inferred← citeshttps://doi.org/10.1038/s41593-021-00944-zopenalex-snapshot

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

inferred← citeshttps://doi.org/10.1039/9781849735346-00058openalex-snapshot

Leukotriene A4 Hydrolase: Biology, Inhibitors and Clinical Applications

inferred← citeshttps://doi.org/10.1039/c2cc37905hopenalex-snapshot

Direct access to pyrazolo(benzo)thienoquinolines. Highly effective palladium catalysts for the intramolecular C–H heteroarylation of arenes

inferred← citeshttps://doi.org/10.1039/c5ra28187copenalex-snapshot

2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor

inferred← citeshttps://doi.org/10.1039/c9nj00726aopenalex-snapshot

Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX

inferred← citeshttps://doi.org/10.1070/rcr4791openalex-snapshot

Arbidol: a quarter-century after. Past, present and future of the original Russian antiviral

inferred← citeshttps://doi.org/10.1080/07391102.2020.1855248openalex-snapshot

Predicting multi-enzyme inhibition in the arachidonic acid metabolic network byHeritiera fomesextracts

inferred← citeshttps://doi.org/10.1080/09540105.2016.1272554openalex-snapshot

Myrica rubra leaves as a potential source of a dual 5-LOX/COX inhibitor

inferred← citeshttps://doi.org/10.1080/13543776.2017.1276568openalex-snapshot

Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents

inferred← citeshttps://doi.org/10.1080/13543776.2024.2447067openalex-snapshot

A patent review on arachidonic acid lipoxygenase (LOX) inhibitors for the treatment of neurodegenerative diseases (2018-present)

inferred← citeshttps://doi.org/10.1080/14756366.2016.1220376openalex-snapshot

2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1080/14756366.2017.1423067openalex-snapshot

Insights into biological activity of ureidoamides with primaquine and amino acid moieties

inferred← citeshttps://doi.org/10.1080/14756366.2020.1786082openalex-snapshot

Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1080/14786419.2016.1236098openalex-snapshot

A new glycosidic antioxidant from Ranunculus muricatus L. (Ranunculaceae) exhibited lipoxygenasae and xanthine oxidase inhibition properties

inferred← citeshttps://doi.org/10.1080/14786419.2020.1855169openalex-snapshot

Muricazine, a new hydrazine derivative from Ranunculus muricatus L. with antioxidant, lipoxygenase and urease inhibitory activities

inferred← citeshttps://doi.org/10.1089/ars.2017.7155openalex-snapshot

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy

inferred← citeshttps://doi.org/10.1111/apha.12365openalex-snapshot

Physiological role of taurine – from organism to organelle

inferred← citeshttps://doi.org/10.1111/bcpt.12134openalex-snapshot

Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways

inferred← citeshttps://doi.org/10.1111/bph.12592openalex-snapshot

Elucidation of the molecular mechanism and the efficacyin vivoof a novel 1,4‐benzoquinone that inhibits 5‐lipoxygenase

inferred← citeshttps://doi.org/10.1111/bph.12625openalex-snapshot

The novel benzimidazole derivative BRP ‐7 inhibits leukotriene biosynthesisin vitroandin vivoby targeting 5‐lipoxygenase‐activating protein ( FLAP )

inferred← citeshttps://doi.org/10.1111/cbdd.12874openalex-snapshot

Structure–activity relationship of caffeic acid phenethyl ester analogs as new 5‐lipoxygenase inhibitors

inferred← citeshttps://doi.org/10.1111/cbdd.13360openalex-snapshot

Sinapic acid phenethyl ester as a potent selective 5‐lipoxygenase inhibitor: Synthesis and structure–activity relationship

inferred← citeshttps://doi.org/10.1111/febs.12759openalex-snapshot

Analysis of 5‐lipoxygenase phosphorylation on molecular level by MALDI ‐ MS

inferred← citeshttps://doi.org/10.1111/j.1476-5381.2011.01451.xopenalex-snapshot

2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacyin vivo

inferred← citeshttps://doi.org/10.1111/j.1476-5381.2011.01605.xopenalex-snapshot

On the inhibition of 5‐lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo

inferred← citeshttps://doi.org/10.1124/dmd.118.082073openalex-snapshot

S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy

inferred← citeshttps://doi.org/10.1124/jpet.111.180794openalex-snapshot

Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase

inferred← citeshttps://doi.org/10.1124/mol.118.113480openalex-snapshot

Identification of Peracetylated Quercetin as a Selective 12-Lipoxygenase Pathway Inhibitor in Human Platelets

inferred← citeshttps://doi.org/10.1134/s1068162012030119openalex-snapshot

Synthesis of some quinolinyl chalcone analogues and investigation of their anticancer and synergistic anticancer effect with doxorubicin

inferred← citeshttps://doi.org/10.1142/s2737416523500059openalex-snapshot

Identification of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by an Integrated Method of Pharmacophore Virtual Screening, Docking, QSAR and ADMET Analyses

inferred← citeshttps://doi.org/10.1152/ajpcell.00412.2012openalex-snapshot

Volume-sensitive release of organic osmolytes in the human lung epithelial cell line A549: role of the 5-lipoxygenase

inferred← citeshttps://doi.org/10.1155/2014/931756openalex-snapshot

Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors

inferred← citeshttps://doi.org/10.1155/2015/919616openalex-snapshot

Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine

inferred← citeshttps://doi.org/10.1155/2017/2380531openalex-snapshot

New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition

inferred← citeshttps://doi.org/10.1155/2017/6904634openalex-snapshot

New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis

inferred← citeshttps://doi.org/10.1155/2017/9632018openalex-snapshot

Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs

inferred← citeshttps://doi.org/10.1159/000335846openalex-snapshot

Regulation of Taurine Transport Systems by Protein Kinase CK2 in Mammalian Cells

inferred← citeshttps://doi.org/10.1177/1721727x1201000306openalex-snapshot

Target Identification and Validation of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate, an Anti-Inflammatory Natural Product

inferred← citeshttps://doi.org/10.1186/s40035-022-00322-0openalex-snapshot

Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine

inferred← citeshttps://doi.org/10.1201/b11483-3openalex-snapshot

Lipids

inferred← citeshttps://doi.org/10.1201/b11483-5openalex-snapshot

5-Lipoxygenase Pathway

inferred← citeshttps://doi.org/10.1371/journal.pone.0031833openalex-snapshot

Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

inferred← citeshttps://doi.org/10.1371/journal.pone.0065928openalex-snapshot

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

inferred← citeshttps://doi.org/10.1371/journal.pone.0087708openalex-snapshot

A Fluorescence-Based Assay for Measuring the Redox Potential of 5-Lipoxygenase Inhibitors

inferred← citeshttps://doi.org/10.1517/13543776.2012.694868openalex-snapshot

5-Lipoxygenase inhibitors: a patent evaluation (WO2011161615)

inferred← citeshttps://doi.org/10.1517/13543776.2013.791678openalex-snapshot

5-Lipoxygenase inhibitors: a review of recent patents (2010 – 2012)

inferred← citeshttps://doi.org/10.1517/14728222.2013.843671openalex-snapshot

Targeting leukotriene B4in inflammation

inferred← citeshttps://doi.org/10.1523/jneurosci.2936-14.2015openalex-snapshot

Identification of 12/15-Lipoxygenase as a Regulator of Axon Degeneration through High-Content Screening

inferred← citeshttps://doi.org/10.1556/1326.2026.01403openalex-snapshot

Retention behavior analysis and lipophilicity assessment of COX-2/5-LOX inhibitors using RP-HPLC

inferred← citeshttps://doi.org/10.21248/gups.72230openalex-snapshot

Influence of the CRISPR/Cas mediated knockout of 5-Lipoxygenase on tumour cells

inferred← citeshttps://doi.org/10.2139/ssrn.5708658openalex-snapshot

Synthesis, characterization, and biological evaluation as inhibitors of 5-hLOX / COX-2 of 2-hydroxy-benzylidene-cymanthrenyl-sulfonylhydrazone ligand and its coordination entities

inferred← citeshttps://doi.org/10.2139/ssrn.6512206openalex-snapshot

Synthesis, Crystal Structures and Molecular modeling of 13-Methoxy Derivatives of Sesquiterpene Lactones Ludartin and Arglabin

inferred← citeshttps://doi.org/10.2174/0115743624366056250407071501openalex-snapshot

Advances in Anti-inflammatory Therapies for Cardiovascular Disease and Atherosclerosis

inferred← citeshttps://doi.org/10.2174/0929867326666191210104820openalex-snapshot

Lipoxygenase Inhibitors as Cancer Chemopreventives: Discovery, Recent Developments and Future Perspectives

inferred← citeshttps://doi.org/10.2174/1573394718666220603103458openalex-snapshot

Caffeic Acid Phenethyl Ester: A Potential Anticancer Bioactive Constituent of Propolis

inferred← citeshttps://doi.org/10.2174/1573406417666210604112009openalex-snapshot

Functionalized Homologues and Positional Isomers of Rabbit 15- Lipoxygenase RS75091 Inhibitor

inferred← citeshttps://doi.org/10.2174/1573407219666230321144827openalex-snapshot

An Overview on Sources, Biosynthesis and Bioactivities of Osthole: A Potential Bioactive Compound

inferred← citeshttps://doi.org/10.24018/ejbio.2022.3.2.345openalex-snapshot

Docking and Molecular Dynamics Simulations Reveal A Possible Site of Interaction of Olive Leaf Extract Hydroxytyrosol with Polyunsaturated Fatty Acid 5-Lipoxygenase Human Enzyme

inferred← citeshttps://doi.org/10.31390/gradschool_dissertations.3000openalex-snapshot

Insights into 5-Lipoxygenase Active Site and Catalysis

inferred← citeshttps://doi.org/10.32861/ajls.66openalex-snapshot

inferred← citeshttps://doi.org/10.32861/ajls.66.53.60openalex-snapshot

Protective Effect of Terminalia muelleri Extract on Brain of Streptozotocin-Induced Diabetes in Albino Rats

inferred← citeshttps://doi.org/10.32861/ajls.66.61.66openalex-snapshot

In vitro Anti-Inflammation and Selective Cytotoxicity of Vero and HepG2 Cells by Phenolic Extract From Roots of Hermannia Geniculata Eckl and Zehl

inferred← citeshttps://doi.org/10.3390/antiox14050536openalex-snapshot

Time Course of Plasma Proteomic and Oxylipin Changes Induced by LPS Challenge and Modulated by Antioxidant Supplementation in a Randomized Controlled Trial

inferred← citeshttps://doi.org/10.3390/biom12010099openalex-snapshot

In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

inferred← citeshttps://doi.org/10.3390/biom9110736openalex-snapshot

Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15

inferred← citeshttps://doi.org/10.3390/books978-3-03921-553-9openalex-snapshot

Role of Natural Compounds in Inflammation and Inflammatory-Related Diseases

inferred← citeshttps://doi.org/10.3390/cancers6031500openalex-snapshot

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked

inferred← citeshttps://doi.org/10.3390/ijms19102899openalex-snapshot

Current Disease-Targets for Oleocanthal as Promising Natural Therapeutic Agent

inferred← citeshttps://doi.org/10.3390/ijms20153836openalex-snapshot

A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma

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In Vitro Evaluation and Docking Studies of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer’s Agents

inferred← citeshttps://doi.org/10.3390/molecules190710635openalex-snapshot

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inferred← citeshttps://doi.org/10.3390/molecules22071124openalex-snapshot

Substituted Caffeic and Ferulic Acid Phenethyl Esters: Synthesis, Leukotrienes Biosynthesis Inhibition, and Cytotoxic Activity

inferred← citeshttps://doi.org/10.3390/molecules24132453openalex-snapshot

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

inferred← citeshttps://doi.org/10.3390/nu10050570openalex-snapshot

The Biological Activities of Oleocanthal from a Molecular Perspective

inferred← citeshttps://doi.org/10.3390/ph16040549openalex-snapshot

Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors

inferred← citeshttps://doi.org/10.3390/ph16050666openalex-snapshot

Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen

inferred← citeshttps://doi.org/10.3923/ajb.2017.27.35openalex-snapshot

Cis-parinaric Acid: A Non-redox Inhibitor of Lipoxygenase-1

inferred← citeshttps://doi.org/10.4049/jimmunol.1201920openalex-snapshot

Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator–Activated Receptor α

inferred← citeshttps://doi.org/10.4103/ijpn.ijpn_71_17openalex-snapshot

Aflapin ® : A novel and selective 5-lipoxygenase inhibitor for arthritis management

inferred← citeshttps://doi.org/10.4155/fmc.13.72openalex-snapshot

Structure–Activity Relationship and In Vitro Pharmacological Evaluation of Imidazo[1,2- a ] Pyridine-Based Inhibitors of 5-LO

inferred← citeshttps://doi.org/10.53846/goediss-9086openalex-snapshot

Einfluss der selektiven Inhibition pro inflammatorischer Lipoxygenasen auf die Skelettmuskulatur der ovariektomierten Ratte

inferred← citeshttps://doi.org/10.5530/ijper.57.2s.35openalex-snapshot

Inhalable Solubilized Zileuton for Improved Lung Targeting in vitro and in vivo Analysis

inferred← citeshttps://doi.org/10.5897/ajbr2015.0846openalex-snapshot

Extraction, fractionation and assessment of antioxidant activities of active components of Aframomum sceptrum seeds

inferred← citeshttps://doi.org/10.70675/2e8c4fb3z945fz415bzbeabz2af86e89502dopenalex-snapshot

Métabolites secondaires et analogues hémisynthétiques en série vitaminique E : Obtention et évaluation du potentiel anti-inflammatoire

inferred← citeshttps://doi.org/10.70675/9d9e1f52ze82fz4140zbdefz367ec5062461openalex-snapshot

Design, synthesis and biological evaluation of novel anti-inflammatory agents

inferred← citeshttps://doi.org/10.7939/r3-8b1m-6p97openalex-snapshot

The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy

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