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TFEB and TFE3 are novel components of the integrated stress response

https://doi.org/10.15252/embj.201593428

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

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Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

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Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

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Protein kinase RNA-like endoplasmic reticulum kinase (PERK)/calcineurin signaling is a novel pathway regulating intracellular calcium accumulation which might be involved in ventricular arrhythmias in diabetic cardiomyopathy

inferredcites →https://doi.org/10.1016/j.devcel.2011.07.016openalex-snapshot

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

inferredcites →https://doi.org/10.1016/j.prp.2009.01.005openalex-snapshot

Altered expression of key cell cycle regulators in renal cell carcinoma associated with Xp11.2 translocation

inferredcites →https://doi.org/10.1016/j.yexcr.2006.09.015openalex-snapshot

Tfe3 expression is closely associated to macrophage terminal differentiation of human hematopoietic myeloid precursors

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

inferredcites →https://doi.org/10.1038/emboj.2012.32openalex-snapshot

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

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DNA targeting specificity of RNA-guided Cas9 nucleases

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2

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Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

inferredcites →https://doi.org/10.1111/j.1365-2818.2006.01706.xopenalex-snapshot

A guided tour into subcellular colocalization analysis in light microscopy

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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A Gene Network Regulating Lysosomal Biogenesis and Function

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TFEB Links Autophagy to Lysosomal Biogenesis

inferredcites →https://doi.org/10.1126/science.1247005openalex-snapshot

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

inferredcites →https://doi.org/10.1126/scisignal.2002790openalex-snapshot

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

inferredcites →https://doi.org/10.1126/scisignal.2004754openalex-snapshot

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

inferredcites →https://doi.org/10.1128/mcb.18.12.6930openalex-snapshot

Targeting the Microphthalmia Basic Helix-Loop-Helix–Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo

inferredcites →https://doi.org/10.1146/annurev.biochem.73.011303.074134openalex-snapshot

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

inferredcites →https://doi.org/10.1146/annurev.micro.59.031805.133833openalex-snapshot

TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST

inferredcites →https://doi.org/10.1152/ajpcell.00594.2008openalex-snapshot

Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes

inferredcites →https://doi.org/10.1155/2014/925350openalex-snapshot

FOXO Transcription Factors: Their Clinical Significance and Regulation

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NFAT control of innate immunity

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Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs

inferredcites →https://doi.org/10.1523/jneurosci.1598-10.2010openalex-snapshot

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

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Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB‐PGD axis

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Elucidation of brefeldin A-induced ER and Golgi stress responses in Neuro2a cells

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The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing

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NCLs and ER: A stressful relationship

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Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway

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Inhibition of autophagy sensitizes lignan-induced endoplasmic reticulum stress-mediated cell death

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Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells

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High-content screening identifies mTORC1-independent TFEB activators that promote protective autophagy

inferred← citeshttps://doi.org/10.1016/j.bcp.2018.11.016openalex-snapshot

Clomiphene citrate induces nuclear translocation of the TFEB transcription factor and triggers apoptosis by enhancing lysosomal membrane permeabilization

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Risk factors of using late-autophagy inhibitors: Aspects to consider when combined with anticancer therapies

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Emerging role of transcription factor EB in mitochondrial quality control

inferred← citeshttps://doi.org/10.1016/j.brainres.2016.04.042openalex-snapshot

ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway

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Emerging roles of lysosome homeostasis (repair, lysophagy and biogenesis) in cancer progression and therapy

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Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis

inferred← citeshttps://doi.org/10.1016/j.cell.2018.10.044openalex-snapshot

Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis

inferred← citeshttps://doi.org/10.1016/j.cellsig.2021.110134openalex-snapshot

Calcineurin in the heart: New horizons for an old friend

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110796openalex-snapshot

Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114872openalex-snapshot

USP7 protects TFEB from proteasome-mediated degradation

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116499openalex-snapshot

MITF, TFEB, and TFE3 drive distinct adaptive gene expression programs and immune infiltration in melanoma

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Transcriptional regulation of autophagy in aging

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Kidney cancer: from genes to therapy

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Lamprey TFE3 exhibits evolutionarily conserved activation mechanisms and regulates autophagy and immune responses

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A Futile Battle? Protein Quality Control and the Stress of Aging

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The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex

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The Lysosome at the Intersection of Cellular Growth and Destruction

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Sestrin2 drives ER-phagy in response to protein misfolding

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TFE3-mediated impairment of lysosomal biogenesis and defective autophagy contribute to fluoride-induced hepatotoxicity

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TFEB orchestrates ferritinophagy and ferroptosis in ionophore drug-induced hepatotoxicity: unveiling a novel therapeutic avenue

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Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases

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c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder

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Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity

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Inositol triphosphate–triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3

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Activation of ROS-PERK-TFEB by filbertone ameliorates neurodegenerative diseases via enhancing the autophagy-lysosomal pathway

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The role of TFEB in tumor cell autophagy: Diagnostic and therapeutic opportunities

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LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol

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Transcription factor EB: A potential integrated network regulator in metabolic-associated cardiac injury

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eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress

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Epigenetic Control of Autophagy: Nuclear Events Gain More Attention

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Autophagy in cancer cell remodeling and quality control

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Life in lockdown: Orchestrating endoplasmic reticulum and lysosome homeostasis for quiescent cells

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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs

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Lysosomes as hubs of metabolic sensing and cellular homeostasis

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APOE4 confers transcriptomic and functional alterations to primary mouse microglia

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Trigonochinene E promotes lysosomal biogenesis and enhances autophagy via TFEB/TFE3 in human degenerative NP cells against oxidative stress

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Nanoplatform-Guided modulation of organelle dynamics: mechanistic insights and therapeutic strategies

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A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

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Endoplasmic reticulum stress: A key player in immune cell regulation and autoimmune disorders

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How Lysosomes Sense, Integrate, and Cope with Stress

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Ligand-activated progesterone receptor B activates transcription factor EB to promote autophagy in human breast cancer cells

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Failure of lysosomal acidification and endomembrane network in neurodegeneration

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RETRACTED ARTICLE: Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer

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HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin

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TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2

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MCOLN1-mediated PPP3CB activation alleviates neuronal damage by promoting TFEB-dependent autophagic flux in permanent cerebral ischemia

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ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion

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Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease

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Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway

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SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

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Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

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Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis

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Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway

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mTOR pathway occupies a central role in the emergence of latent cancer cells

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SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes

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CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

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TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

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Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

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A TFEB nuclear export signal integrates amino acid supply and glucose availability

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MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

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Golgi organization is regulated by proteasomal degradation

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A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

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Dysregulation of GTPase-activating protein-binding protein1 in the pathogenesis of metabolic dysfunction-associated steatotic liver disease

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TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

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PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson’s disease

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The lysosome as a cellular centre for signalling, metabolism and quality control

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Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis

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Balancing lysosome abundance in health and disease

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Lysosomes as dynamic regulators of cell and organismal homeostasis

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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology

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Selective autophagy in kidney health and disease

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Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

inferred← citeshttps://doi.org/10.1038/s41593-023-01494-2openalex-snapshot

TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy

inferred← citeshttps://doi.org/10.1038/s41598-024-64579-3openalex-snapshot

Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells

inferred← citeshttps://doi.org/10.1038/s42003-021-02278-9openalex-snapshot

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

inferred← citeshttps://doi.org/10.1038/s42003-025-07870-xopenalex-snapshot

Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling

inferred← citeshttps://doi.org/10.1038/s42255-021-00368-wopenalex-snapshot

TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response

inferred← citeshttps://doi.org/10.1038/s43587-023-00524-9openalex-snapshot

A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

inferred← citeshttps://doi.org/10.1038/s44318-024-00233-yopenalex-snapshot

Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction

inferred← citeshttps://doi.org/10.1038/s44318-024-00338-4openalex-snapshot

The integrated stress response drives MET oncogene overexpression in cancers

inferred← citeshttps://doi.org/10.1038/s44319-024-00339-8openalex-snapshot

The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

inferred← citeshttps://doi.org/10.1038/s44319-025-00659-3openalex-snapshot

Differential contribution of TFE3 isoforms to cell motility and invasion

inferred← citeshttps://doi.org/10.1042/bcj20190596openalex-snapshot

A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

inferred← citeshttps://doi.org/10.1073/pnas.2122170119openalex-snapshot

False-positive IRESes from Hoxa9 and other genes resulting from errors in mammalian 5′ UTR annotations

inferred← citeshttps://doi.org/10.1074/jbc.ra118.003471openalex-snapshot

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

inferred← citeshttps://doi.org/10.1074/jbc.ra119.011864openalex-snapshot

The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4

inferred← citeshttps://doi.org/10.1080/10715762.2018.1485075openalex-snapshot

Inhibiting ROS-TFE3-dependent autophagy enhances the therapeutic response to metformin in breast cancer

inferred← citeshttps://doi.org/10.1080/15548627.2018.1463120openalex-snapshot

TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis

inferred← citeshttps://doi.org/10.1080/15548627.2018.1531198openalex-snapshot

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells

inferred← citeshttps://doi.org/10.1080/15548627.2019.1704104openalex-snapshot

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

inferred← citeshttps://doi.org/10.1080/15548627.2020.1788889openalex-snapshot

The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB

inferred← citeshttps://doi.org/10.1080/15548627.2022.2029671openalex-snapshot

The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3

inferred← citeshttps://doi.org/10.1080/15548627.2022.2105561openalex-snapshot

Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity

inferred← citeshttps://doi.org/10.1080/15548627.2023.2173900openalex-snapshot

Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress

inferred← citeshttps://doi.org/10.1080/15548627.2024.2305063openalex-snapshot

ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells

inferred← citeshttps://doi.org/10.1080/15548627.2024.2334111openalex-snapshot

Design and validation of a reporter mouse to study the dynamic regulation of TFEB and TFE3 activity through in vivo imaging techniques

inferred← citeshttps://doi.org/10.1080/15548627.2025.2487036openalex-snapshot

TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling

inferred← citeshttps://doi.org/10.1080/15548627.2026.2629720openalex-snapshot

AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites

inferred← citeshttps://doi.org/10.1080/21505594.2021.2021630openalex-snapshot

The endoplasmic reticulum stress-mediated unfolded protein response protects against infection of goat endometrial epithelial cells by Trueperella pyogenes via autophagy

inferred← citeshttps://doi.org/10.1080/21541248.2016.1218990openalex-snapshot

Rags to riches: Amino acid sensing by the Rag GTPases in health and disease

inferred← citeshttps://doi.org/10.1080/21541264.2016.1264353openalex-snapshot

TFEB and TFE3: The art of multi-tasking under stress conditions

inferred← citeshttps://doi.org/10.1080/27694127.2022.2097822openalex-snapshot

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB

inferred← citeshttps://doi.org/10.1080/27694127.2025.2473765openalex-snapshot

High throughput screening assay for the identification of ATF4 and TFEB activating compounds

inferred← citeshttps://doi.org/10.1083/jcb.201611073openalex-snapshot

PtdIns3P controls mTORC1 signaling through lysosomal positioning

inferred← citeshttps://doi.org/10.1083/jcb.202102001openalex-snapshot

Lysosome biogenesis: Regulation and functions

inferred← citeshttps://doi.org/10.1083/jcb.202307079openalex-snapshot

ATG conjugation–dependent/independent mechanisms underlie lysosomal stress–induced TFEB regulation

inferred← citeshttps://doi.org/10.1083/jcb.202308099openalex-snapshot

Lactylation stabilizes TFEB to elevate autophagy and lysosomal activity

inferred← citeshttps://doi.org/10.1091/mbc.e21-06-0309openalex-snapshot

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

inferred← citeshttps://doi.org/10.1097/pai.0000000000001090openalex-snapshot

Application of TFE3 Immunophenotypic and TFE3 mRNA Expressions in Diagnosis and Prognostication of Adrenal Cortical Neoplasms and Distinction From Kidney Tumors

inferred← citeshttps://doi.org/10.1101/2020.10.27.357897openalex-snapshot

Repression of lysosomal transcription factors Tfeb and Tfe3 is essential for the migration and function of microglia

inferred← citeshttps://doi.org/10.1101/2021.07.26.453823openalex-snapshot

ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling

inferred← citeshttps://doi.org/10.1101/2022.06.23.497394openalex-snapshot

Restoration of β-GC trafficking improves the lysosome function in Gaucher’s disease

inferred← citeshttps://doi.org/10.1101/2022.12.31.522386openalex-snapshot

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

inferred← citeshttps://doi.org/10.1101/2024.01.22.576606openalex-snapshot

Lipid Dysregulation Unveil the Intricate Interplay of Lysosomal and Mitochondrial Changes in Frontotemporal Dementia with GRN Haploinsufficiency

inferred← citeshttps://doi.org/10.1101/2024.01.29.577876openalex-snapshot

Cellular Modeling of CLN6 with IPSC-derived Neurons and Glia

inferred← citeshttps://doi.org/10.1101/2024.06.05.597553openalex-snapshot

HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency

inferred← citeshttps://doi.org/10.1101/2024.09.26.615214openalex-snapshot

Phospholipase D3 regulates lysosomal morphology, biogenesis, and function in neurons

inferred← citeshttps://doi.org/10.1101/2024.10.22.619589openalex-snapshot

AMPK activation promotes transcriptional activation of TFEB through its dephosphorylation

inferred← citeshttps://doi.org/10.1101/2024.11.12.623296openalex-snapshot

Mechanisms driving epigenetic and transcriptional responses of microglia in a neurodegenerative lysosomal storage disorder model

inferred← citeshttps://doi.org/10.1101/2025.01.28.635321openalex-snapshot

Endurance Training Restores Ageing-Impaired Lysosomal Biogenesis Factors in Rest and Response to Acute Exercise in Rat Skeletal Muscle

inferred← citeshttps://doi.org/10.1101/2025.09.05.674552openalex-snapshot

Peripheral inflammation mediates midbrain Lrrk2 kinase activity via Rab32 expression

inferred← citeshttps://doi.org/10.1101/312033openalex-snapshot

A non-canonical lysosome biogenesis pathway generates Golgi-associated lysosomes during epidermal differentiation

inferred← citeshttps://doi.org/10.1101/683359openalex-snapshot

Genome-wide functional genomics screens identify therapeutic vulnerabilities for lymphangioleiomyomatosis

inferred← citeshttps://doi.org/10.1101/gad.287953.116openalex-snapshot

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

inferred← citeshttps://doi.org/10.1101/gad.324657.119openalex-snapshot

MITF—the first 25 years

inferred← citeshttps://doi.org/10.1111/acel.12561openalex-snapshot

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling

inferred← citeshttps://doi.org/10.1111/acel.12689openalex-snapshot

TOR ‐mediated regulation of metabolism in aging

inferred← citeshttps://doi.org/10.1111/acel.70038openalex-snapshot

HLH ‐30/ TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron–Sulfur Cluster Biosynthesis Pathways

inferred← citeshttps://doi.org/10.1111/bph.15702openalex-snapshot

Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels

inferred← citeshttps://doi.org/10.1111/brv.12860openalex-snapshot

The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases

inferred← citeshttps://doi.org/10.1111/fcp.12634openalex-snapshot

Evaluating and modulating TFEB in the control of autophagy: toward new treatments in CNS disorders

inferred← citeshttps://doi.org/10.1111/imcb.70157openalex-snapshot

Lysosomal Rewiring Perpetuates Tumor Immune Evasion in Cancer

inferred← citeshttps://doi.org/10.1111/jcmm.14469openalex-snapshot

EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo

inferred← citeshttps://doi.org/10.1111/jcmm.18257openalex-snapshot

Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1 / TFEB / ABCA1‐SCARB1 signal axis

inferred← citeshttps://doi.org/10.1111/jnc.14564openalex-snapshot

Lysosome biogenesis in health and disease

inferred← citeshttps://doi.org/10.1111/jre.70016openalex-snapshot

The Role of Oxidative Stress in Periodontitis

inferred← citeshttps://doi.org/10.1111/nyas.13131openalex-snapshot

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

inferred← citeshttps://doi.org/10.1111/pcmr.13149openalex-snapshot

TFE3 promotes ferroptosis in melanoma

inferred← citeshttps://doi.org/10.1111/tra.12497openalex-snapshot

The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic

inferred← citeshttps://doi.org/10.1111/tra.12552openalex-snapshot

Phagocytosis of antibody‐opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages

inferred← citeshttps://doi.org/10.1111/tra.12886openalex-snapshot

Pseudophosphatase STYXL1 depletion enhances glucocerebrosidase trafficking to lysosomes via ER stress

inferred← citeshttps://doi.org/10.1111/tra.12911openalex-snapshot

Restoration of β‐GC trafficking improves the lysosome function in Gaucher disease

inferred← citeshttps://doi.org/10.1111/tra.70013openalex-snapshot

FGF Signaling Promotes Lysosome Biogenesis in Chondrocytes via the Mannose Phosphate Receptor Pathway

inferred← citeshttps://doi.org/10.1113/ep093041openalex-snapshot

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

inferred← citeshttps://doi.org/10.1126/sciadv.aaz9805openalex-snapshot

Lysosomal recycling of amino acids affects ER quality control

inferred← citeshttps://doi.org/10.1126/sciadv.abb0205openalex-snapshot

GADD34 is a modulator of autophagy during starvation

inferred← citeshttps://doi.org/10.1126/sciadv.abb9614openalex-snapshot

Beyond the cell factory: Homeostatic regulation of and by the UPR ER

inferred← citeshttps://doi.org/10.1126/sciadv.abp8321openalex-snapshot

A lysosomal regulatory circuit essential for the development and function of microglia

inferred← citeshttps://doi.org/10.1126/scisignal.aau2281openalex-snapshot

TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction

inferred← citeshttps://doi.org/10.1128/mcb.00241-22openalex-snapshot

Invading Bacterial Pathogens Activate Transcription Factor EB in Epithelial Cells through the Amino Acid Starvation Pathway of mTORC1 Inhibition

inferred← citeshttps://doi.org/10.1128/mcb.00489-18openalex-snapshot

Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance

inferred← citeshttps://doi.org/10.1136/jclinpath-2020-206899openalex-snapshot

Gene of the month: TFE 3

inferred← citeshttps://doi.org/10.1146/annurev-cellbio-111315-125407openalex-snapshot

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010716-104936openalex-snapshot

Autophagy: A Druggable Process

inferred← citeshttps://doi.org/10.1152/ajpcell.00080.2023openalex-snapshot

Activating transcription factor 4 regulates mitochondrial content, morphology, and function in differentiating skeletal muscle myotubes

inferred← citeshttps://doi.org/10.1152/ajpendo.00339.2020openalex-snapshot

Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?

inferred← citeshttps://doi.org/10.1152/ajpheart.00145.2017openalex-snapshot

Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy

inferred← citeshttps://doi.org/10.1152/ajprenal.00237.2022openalex-snapshot

Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1

inferred← citeshttps://doi.org/10.1152/physiol.00048.2025openalex-snapshot

Organelle Dysfunction and TNT-Mediated Aggregate Spreading in Neurodegeneration

inferred← citeshttps://doi.org/10.1155/2020/8872639openalex-snapshot

Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells

inferred← citeshttps://doi.org/10.1155/2021/5583215openalex-snapshot

Reactive Oxygen Species as a Link between Antioxidant Pathways and Autophagy

inferred← citeshttps://doi.org/10.1155/2021/8186877openalex-snapshot

GDF‐11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3‐Mediated Autophagy Augmentation

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-18-0269openalex-snapshot

Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma

inferred← citeshttps://doi.org/10.1161/circresaha.121.319377openalex-snapshot

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy

inferred← citeshttps://doi.org/10.1172/jci.insight.132364openalex-snapshot

The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP

inferred← citeshttps://doi.org/10.1172/jci.insight.194102openalex-snapshot

Restoration of impaired lysosomal function mitigates drusen-like deposit formation and cell death in Malattia Leventinese

inferred← citeshttps://doi.org/10.1172/jci176093openalex-snapshot

Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells

inferred← citeshttps://doi.org/10.1177/20503121231157209openalex-snapshot

Transcription factor EB as a key molecular factor in human health and its implication in diseases

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