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LSD1 Destabilizes FBXW7 Independent of Its Demethylase Activity

https://doi.org/10.2139/ssrn.3281653
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PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
inferredcites →https://doi.org/10.1002/med.21350openalex-extracted
A Systematic Review of Histone Lysine‐Specific Demethylase 1 and Its Inhibitors
inferredcites →https://doi.org/10.1016/j.bbrc.2018.01.192openalex-extracted
FBW7 suppresses cell proliferation and G2/M cell cycle transition via promoting γ-catenin K63-linked ubiquitylation
inferredcites →https://doi.org/10.1016/j.ccell.2014.09.013openalex-extracted
Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities
inferredcites →https://doi.org/10.1016/j.ccell.2015.06.002openalex-extracted
A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
inferredcites →https://doi.org/10.1016/j.ccell.2015.06.011openalex-extracted
Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition
inferredcites →https://doi.org/10.1016/j.ccr.2005.06.005openalex-extracted
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
inferredcites →https://doi.org/10.1016/j.cell.2004.12.012openalex-extracted
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
inferredcites →https://doi.org/10.1016/j.cell.2007.04.042openalex-extracted
Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination
inferredcites →https://doi.org/10.1016/j.cell.2009.05.050openalex-extracted
LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
inferredcites →https://doi.org/10.1016/j.cell.2018.05.052openalex-extracted
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
inferredcites →https://doi.org/10.1016/j.cellsig.2018.02.009openalex-extracted
Physiological functions of FBW7 in cancer and metabolism
inferredcites →https://doi.org/10.1016/j.devcel.2011.09.014openalex-extracted
SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation
inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.073openalex-extracted
Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors
inferredcites →https://doi.org/10.1016/j.molcel.2004.10.014openalex-extracted
Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover
inferredcites →https://doi.org/10.1016/j.molcel.2005.08.027openalex-extracted
Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors
inferredcites →https://doi.org/10.1016/j.molcel.2007.02.022openalex-extracted
Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
inferredcites →https://doi.org/10.1016/j.molcel.2011.04.020openalex-extracted
A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
inferredcites →https://doi.org/10.1016/j.molcel.2011.07.039openalex-extracted
Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
inferredcites →https://doi.org/10.1016/j.molcel.2012.04.012openalex-extracted
Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase
inferredcites →https://doi.org/10.1016/j.molcel.2015.01.010openalex-extracted
A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation
inferredcites →https://doi.org/10.1016/j.molcel.2015.12.010openalex-extracted
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4
inferredcites →https://doi.org/10.1016/j.neo.2016.08.009openalex-extracted
Fbxw7 Deletion Accelerates KrasG12D-Driven Pancreatic Tumorigenesis via Yap Accumulation
inferredcites →https://doi.org/10.1021/acs.jmedchem.5b00037openalex-extracted
Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents
inferredcites →https://doi.org/10.1021/acsmedchemlett.7b00426openalex-extracted
Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Potential Treatment for Different Types of Cancers
inferredcites →https://doi.org/10.1021/tx2003849openalex-extracted
Cyclophosphamide Perturbs Cytosine Methylation in Jurkat-T Cells through LSD1-Mediated Stabilization of DNMT1 Protein
inferredcites →https://doi.org/10.1038/35107009openalex-extracted
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
inferredcites →https://doi.org/10.1038/cr.2015.30openalex-extracted
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer
inferredcites →https://doi.org/10.1038/nature02313openalex-extracted
Inactivation of hCDC4 can cause chromosomal instability
inferredcites →https://doi.org/10.1038/nature04020openalex-extracted
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
inferredcites →https://doi.org/10.1038/nature04021openalex-extracted
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
inferredcites →https://doi.org/10.1038/nature05671openalex-extracted
Opposing LSD1 complexes function in developmental gene activation and repression programmes
inferredcites →https://doi.org/10.1038/nature06092openalex-extracted
p53 is regulated by the lysine demethylase LSD1
inferredcites →https://doi.org/10.1038/nrc1881openalex-extracted
Ubiquitin ligases: cell-cycle control and cancer
inferredcites →https://doi.org/10.1038/nrc2290openalex-extracted
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
inferredcites →https://doi.org/10.1038/nrc3700openalex-extracted
Roles of F-box proteins in cancer
inferredcites →https://doi.org/10.1038/nrm3327openalex-extracted
Molecular mechanisms and potential functions of histone demethylases
inferredcites →https://doi.org/10.1038/onc.2017.158openalex-extracted
LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis
inferredcites →https://doi.org/10.1038/onc.2017.353openalex-extracted
LSD1 promotes S-phase entry and tumorigenesis via chromatin co-occupation with E2F1 and selective H3K9 demethylation
inferredcites →https://doi.org/10.1038/s41580-018-0001-6openalex-extracted
The coming of age of chaperone-mediated autophagy
inferredcites →https://doi.org/10.1038/srep24218openalex-extracted
Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells
inferredcites →https://doi.org/10.1053/j.gastro.2010.05.078openalex-extracted
F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor
inferredcites →https://doi.org/10.1073/pnas.1719168115openalex-extracted
LSD1 activates a lethal prostate cancer gene network independently of its demethylase function
inferredcites →https://doi.org/10.1083/jcb.200709127openalex-extracted
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells
inferredcites →https://doi.org/10.1083/jcb.200711040openalex-extracted
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
inferredcites →https://doi.org/10.1084/jem.20080277openalex-extracted
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7
inferredcites →https://doi.org/10.1093/nar/gkv528openalex-extracted
Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage
inferredcites →https://doi.org/10.1101/gad.229195.113openalex-extracted
Fbw7 dimerization determines the specificity and robustness of substrate degradation
inferredcites →https://doi.org/10.1128/mcb.00305-12openalex-extracted
Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer
inferredcites →https://doi.org/10.1146/annurev.biochem.78.081507.101607openalex-extracted
Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
inferredcites →https://doi.org/10.1158/0008-5472.can-06-4020openalex-extracted
SAG/ROC2/Rbx2 Is a Novel Activator Protein-1 Target that Promotes c-Jun Degradation and Inhibits 12-O-Tetradecanoylphorbol-13-Acetate–Induced Neoplastic Transformation
inferredcites →https://doi.org/10.1186/bcr2788openalex-extracted
Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer
inferredcites →https://doi.org/10.1615/critreveukargeneexpr.v22.i1.40openalex-extracted
Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy
inferredcites →https://doi.org/10.2217/epi-2017-0022openalex-extracted
A Comprehensive Review of Lysine-Specific Demethylase 1 and its Roles in Cancer
inferredcites →https://doi.org/10.4155/fmc-2017-0068openalex-extracted
Advances Toward Lsd1 Inhibitors for Cancer Therapy
inferredcites →https://doi.org/10.7554/elife.00633openalex-extracted
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
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