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Epidermal Growth Factor Rejuvenates Aged Hematopoietic Stem Cells

https://doi.org/10.2139/ssrn.4685388
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Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging
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Hematopoietic stem cell aging: Mechanism and consequence
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DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
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The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells
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Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
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Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation
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Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
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Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
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Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle
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Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
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Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging
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The impact of influenza on the health and health care utilisation of elderly people
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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
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Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
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DNA repair is limiting for haematopoietic stem cells during ageing
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Age-dependent modulation of vascular niches for haematopoietic stem cells
inferredcites →https://doi.org/10.1038/nature21388openalex-extracted
Autophagy maintains the metabolism and function of young and old stem cells
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Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
inferredcites →https://doi.org/10.1038/nm0996-1011openalex-extracted
The aging of hematopoietic stem cells
inferredcites →https://doi.org/10.1038/nrm3420openalex-extracted
DNA damage checkpoints in stem cells, ageing and cancer
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Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
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Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
inferredcites →https://doi.org/10.1038/s41467-023-37783-4openalex-extracted
Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response
inferredcites →https://doi.org/10.1038/s41556-018-0054-yopenalex-extracted
Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage
inferredcites →https://doi.org/10.1038/s41556-022-01053-0openalex-extracted
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing
inferredcites →https://doi.org/10.1038/s41586-021-03795-7openalex-extracted
Aged skeletal stem cells generate an inflammatory degenerative niche
inferredcites →https://doi.org/10.1038/s41591-018-0030-xopenalex-extracted
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche
inferredcites →https://doi.org/10.1073/pnas.022412699openalex-extracted
Multiple hematopoietic defects and delayed globin switching in Ikaros null mice
inferredcites →https://doi.org/10.1073/pnas.0503280102openalex-extracted
Cell intrinsic alterations underlie hematopoietic stem cell aging
inferredcites →https://doi.org/10.1073/pnas.1000834107openalex-extracted
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
inferredcites →https://doi.org/10.1073/pnas.110152897openalex-extracted
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
inferredcites →https://doi.org/10.1073/pnas.1116110108openalex-extracted
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
inferredcites →https://doi.org/10.1074/jbc.m116.752329openalex-extracted
Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency
inferredcites →https://doi.org/10.1084/jem.192.9.1273openalex-extracted
Age-Associated Characteristics of Murine Hematopoietic Stem Cells
inferredcites →https://doi.org/10.1084/jem.20191212openalex-extracted
Endothelial mTOR maintains hematopoiesis during aging
inferredcites →https://doi.org/10.1084/jem.20192283openalex-extracted
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
inferredcites →https://doi.org/10.1084/jem.20210223openalex-extracted
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
inferredcites →https://doi.org/10.1086/590435openalex-extracted
Better Influenza Vaccines for Older People: What Will It Take?
inferredcites →https://doi.org/10.1089/scd.2010.0096openalex-extracted
Platelet Endothelial Cell Adhesion Molecule-1, Stage-Specific Embryonic Antigen-1, and Flk-1 Mark Distinct Populations of Mouse Embryonic Stem Cells During Differentiation Toward Hematopoietic/Endothelial Cells
inferredcites →https://doi.org/10.1093/annonc/mdg169openalex-extracted
Cancer prevalence in the UK: results from the EUROPREVAL study
inferredcites →https://doi.org/10.1126/science.273.5272.242openalex-extracted
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
inferredcites →https://doi.org/10.1126/science.aaa2361openalex-extracted
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
inferredcites →https://doi.org/10.1146/annurev.med.56.082103.104546openalex-extracted
DNA Repair Defects in Stem Cell Function and Aging
inferredcites →https://doi.org/10.1172/jci93940openalex-extracted
Endothelial transplantation rejuvenates aged hematopoietic stem cell function
inferredcites →https://doi.org/10.1182/blood-2003-12-4369openalex-extracted
Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis
inferredcites →https://doi.org/10.1182/blood-2011-01-331041openalex-extracted
An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation
inferredcites →https://doi.org/10.1182/blood-2012-11-469080openalex-extracted
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
inferredcites →https://doi.org/10.1182/blood.2020005895openalex-extracted
Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regeneration
inferredcites →https://doi.org/10.1182/blood.v89.5.1543openalex-extracted
Mouse Strain-Dependent Changes in Frequency and Proliferation of Hematopoietic Stem Cells During Aging: Correlation Between Lifespan and Cycling Activity
inferredcites →https://doi.org/10.1182/bloodadvances.2020003693openalex-extracted
Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation
inferredcites →https://doi.org/10.1210/mend.15.4.0625openalex-extracted
Stage-Sensitive Blockade of Pituitary Somatomammotrope Development by Targeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in Transgenic Mice
inferredcites →https://doi.org/10.1371/journal.pbio.0050201openalex-extracted
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
inferredcites →https://doi.org/10.1371/journal.pbio.1002421openalex-extracted
Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus
inferredcites →https://doi.org/10.15252/embj.201694969openalex-extracted
Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells
inferredcites →https://doi.org/10.15252/embj.201796968openalex-extracted
Erratum To: Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells
inferredcites →https://doi.org/10.1667/rr14444.1openalex-extracted
A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation
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Normalization Methods on Single-Cell RNA-seq Data: An Empirical Survey
inferredcites →https://doi.org/10.3389/fncel.2018.00221openalex-extracted
Revisiting Netrin-1: One Who Guides (Axons)
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External signals regulate continuous transcriptional states in hematopoietic stem cells
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