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Effects of Water Temperature Increase on Transcriptomic, Biochemical, and Histopathological Responses of the Bivalve Species Mytilus Galloprovincialis to the Antineoplastic Drug 5-Fluorouracil

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Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species
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Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and Their Mixture in the Eastern Oyster ( Crassostrea virginica )
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Antineoplastic Agents: Environmental Prevalence and Adverse Outcomes in Aquatic Organisms
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Photocatalytic Degradation of 5‐Fluorouracil by Diatomite‐Supported Titanium Dioxide under UV‐A Irradiation
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p53 Superfamily Proteins in Marine Bivalve Cancer and Stress Biology
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International Agency for Research on Cancer
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Abcb and Abcc transporter homologs are expressed and active in larvae and adults of zebra mussel and induced by chemical stress
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The effects of zinc nanooxide on cellular stress responses of the freshwater mussels Unio tumidus are modulated by elevated temperature and organic pollutants
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Development of histopathological indices in the digestive gland and gonad of mussels: Integration with contamination levels and effects of confounding factors
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Combined effects of seawater acidification and salinity changes in Ruditapes philippinarum
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Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis
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Ecotoxicological effects of lanthanum in Mytilus galloprovincialis: Biochemical and histopathological impacts
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Gene expression and biochemical patterns in the digestive gland of the mussel Mytilus galloprovincialis (Lamarck, 1819) exposed to 17α-ethinylestradiol
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Abnormality of mussel in the early developmental stages induced by graphene and triphenyl phosphate: In silico toxicogenomic data-mining, in vivo, and toxicity pathway-oriented approach
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Drug resistance to 5-FU linked to reactive oxygen species modulator 1
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Increased seawater temperature triggers thermal, oxidative and metabolic response of Ostrea edulis, leading to anaerobiosis
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Effects of Triclosan on Mytilus galloprovincialis hemocyte function and digestive gland enzyme activities: Possible modes of action on non target organisms
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Transcriptomic approach: A promising tool for rapid screening nanomaterial-mediated toxicity in the marine bivalve Mytilus edulis —Application to copper oxide nanoparticles
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Review: Mytilus galloprovincialis: An essential, low-cost model organism for the impact of xenobiotics on oxidative stress and public health
inferredcites →https://doi.org/10.1016/j.chemosphere.2020.127678openalex-extracted
Cytotoxic responses of the anticancer drug cyclophosphamide in the mussel Mytilus galloprovincialis and comparative sensitivity with human cells lines
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Assessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialis
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Bivalve molluscs as bioindicators of multiple stressors in the marine environment: Recent advances
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Acute exposure to sunscreen containing titanium induces an adaptive response and oxidative stress in Mytillus galloprovincialis
inferredcites →https://doi.org/10.1016/j.ecoenv.2019.109899openalex-extracted
The influence of climate change related factors on the response of two clam species to diclofenac
inferredcites →https://doi.org/10.1016/j.ecoenv.2020.111695openalex-extracted
Common and particular biochemical responses of Unio tumidus to herbicide, pharmaceuticals and their combined exposure with heating
inferredcites →https://doi.org/10.1016/j.ecoenv.2022.114365openalex-extracted
Assessment of sulfamethoxazole toxicity to marine mussels (Mytilus galloprovincialis): Combine p38-MAPK signaling pathway modulation with histopathological alterations
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Adverse outcome pathways as a tool for optimization of the biomarker-based assessment of pollutant toxicity: A case study of cadmium in the blue mussels Mytilus edulis
inferredcites →https://doi.org/10.1016/j.ecss.2013.07.008openalex-extracted
Pressures, stresses, shocks and trends in estuarine ecosystems – An introduction and synthesis
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Environmental pharmaceuticals and climate change: The case study of carbamazepine in M. galloprovincialis under ocean acidification scenario
inferredcites →https://doi.org/10.1016/j.envint.2021.106705openalex-extracted
Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its metabolite in aquatic organisms
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Prevalence and sunlight photolysis of controlled and chemotherapeutic drugs in aqueous environments
inferredcites →https://doi.org/10.1016/j.envpol.2023.122490openalex-extracted
Multi-biomarker approach for the (eco)toxicity of UV-filter environmental pollution on the Mediterranean mussel Mytilus galloprovincialis in a multiple stressor context. The case of 4-MBC under salinity shifts.
inferredcites →https://doi.org/10.1016/j.envres.2014.08.014openalex-extracted
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inferredcites →https://doi.org/10.1016/j.envres.2021.111898openalex-extracted
Comparative degradation of 5-fluorouracil in aqueous solution by using H2O2-modified subcritical water, photocatalytic oxidation and electro-Fenton processes
inferredcites →https://doi.org/10.1016/j.envres.2021.112279openalex-extracted
How temperature rise will influence the toxic impacts of 17 α-ethinylestradiol in Mytilus galloprovincialis?
inferredcites →https://doi.org/10.1016/j.etap.2020.103448openalex-extracted
Impacts of salicylic acid in Mytilus galloprovincialis exposed to warming conditions
inferredcites →https://doi.org/10.1016/j.etap.2022.103888openalex-extracted
Comparison of cellular mechanisms induced by pharmaceutical exposure to caffeine and its combination with salicylic acid in mussel Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.etap.2023.104132openalex-extracted
Combined effects of temperature rise and sodium lauryl sulfate in the Mediterranean mussel
inferredcites →https://doi.org/10.1016/j.etap.2023.104314openalex-extracted
Comparative subcellular responses to pharmaceutical exposures in the mussel Mytilus galloprovincialis: An in vitro study
inferredcites →https://doi.org/10.1016/j.fsi.2018.04.058openalex-extracted
A novel toll-like receptor from Mytilus coruscus is induced in response to stress
inferredcites →https://doi.org/10.1016/j.fsi.2018.09.027openalex-extracted
Identification and functional characterization of three myeloid differentiation factor 88 (MyD88) isoforms from thick shell mussel Mytilus coruscus
inferredcites →https://doi.org/10.1016/j.gene.2006.02.015openalex-extracted
Gene transcription profiling in pollutant exposed mussels (Mytilus spp.) using a new low-density oligonucleotide microarray
inferredcites →https://doi.org/10.1016/j.gloplacha.2016.09.011openalex-extracted
The influence of global climate change on the environmental fate of persistent organic pollutants: A review with emphasis on the Northern Hemisphere and the Arctic as a receptor
inferredcites →https://doi.org/10.1016/j.hazadv.2022.100206openalex-extracted
Pharmaceuticals and personal care products as emerging contaminants: Need for combined treatment strategy
inferredcites →https://doi.org/10.1016/j.jece.2017.01.013openalex-extracted
Degradation of cyclophosphamide and 5-fluorouracil in water using UV and UV/H 2 O 2 : Kinetics investigation, pathways and energetic analysis
inferredcites →https://doi.org/10.1016/j.jes.2015.05.002openalex-extracted
Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms
inferredcites →https://doi.org/10.1016/j.jhazmat.2015.04.072openalex-extracted
Titanium dioxide nanoparticles modulate the toxicological response to cadmium in the gills of Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.jhazmat.2021.127264openalex-extracted
Assessment of the impact of aquaculture facilities on transplanted mussels (Mytilus galloprovincialis): Integrating plasticizers and physiological analyses as a biomonitoring strategy
inferredcites →https://doi.org/10.1016/j.jhazmat.2023.130818openalex-extracted
Anticancer drugs in wastewater and natural environments: A review on their occurrence, environmental persistence, treatment, and ecological risks
inferredcites →https://doi.org/10.1016/j.jhazmat.2023.131904openalex-extracted
Combined exposure of the bivalve Mytilus galloprovincialis to polyethylene microplastics and two pharmaceuticals (citalopram and bezafibrate): Bioaccumulation and metabolomic studies
inferredcites →https://doi.org/10.1016/j.jprot.2016.01.010openalex-extracted
Shotgun proteomics to unravel marine mussel (Mytilus edulis) response to long-term exposure to low salinity and propranolol in a Baltic Sea microcosm
inferredcites →https://doi.org/10.1016/j.jtherbio.2021.103154openalex-extracted
Mortality, energy reserves, and oxidative stress responses of three native freshwater mussels to temperature as an indicator of potential impacts of climate change: A laboratory experimental approach
inferredcites →https://doi.org/10.1016/j.jwpe.2023.103490openalex-extracted
Occurrence and spatial distribution of pharmaceuticals and personal care products (PPCPs) in the aquatic environment, their characteristics, and adopted legislations
inferredcites →https://doi.org/10.1016/j.marenvres.2011.11.012openalex-extracted
Two CYP3A-like genes in the marine mussel Mytilus edulis: mRNA expression modulation following short-term exposure to endocrine disruptors
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Energy homeostasis as an integrative tool for assessing limits of environmental stress tolerance in aquatic invertebrates
inferredcites →https://doi.org/10.1016/j.marenvres.2013.06.005openalex-extracted
Differential ABCB and ABCC gene expression and efflux activities in gills and hemocytes of Mytilus galloprovincialis and their involvement in cadmium response
inferredcites →https://doi.org/10.1016/j.marenvres.2013.07.006openalex-extracted
Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms
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Toxic effects of cisplatin cytostatic drug in mussel Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.marenvres.2017.06.009openalex-extracted
Transcriptional and biochemical analysis of antioxidant enzymes in the mussel Mytilus galloprovincialis during experimental exposures to the toxic dinoflagellate Prorocentrum lima
inferredcites →https://doi.org/10.1016/j.marenvres.2022.105839openalex-extracted
Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.marenvres.2024.106418openalex-extracted
Molecular and behavioural responses of the mussel Mytilus edulis exposed to a marine heatwave
inferredcites →https://doi.org/10.1016/j.marpolbul.2005.07.011openalex-extracted
Acetylcholinesterase as a biomarker of exposure to neurotoxic compounds in the clam Tapes philippinarum from the Lagoon of Venice
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Climate change impacts on pollutants mobilization and interactive effects of climate change and pollutants on toxicity and bioaccumulation of pollutants in estuarine and marine biota and linkage to seafood security
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Teaching the fundamentals of electron transfer reactions in mitochondria and the production and detection of reactive oxygen species
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Removal of cytostatic drugs from aquatic environment: A review
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Seasonal variations of gene expression biomarkers in Mytilus galloprovincialis cultured populations: Temperature, oxidative stress and reproductive cycle as major modulators
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Ecotoxicological assessment of the anticancer drug cisplatin in the polychaete Nereis diversicolor
inferredcites →https://doi.org/10.1016/j.scitotenv.2018.04.264openalex-extracted
Mussel digestive gland as a model tissue for assessing xenobiotics: An overview
inferredcites →https://doi.org/10.1016/j.scitotenv.2018.04.318openalex-extracted
Environmental relevant levels of the cytotoxic drug cyclophosphamide produce harmful effects in the polychaete Nereis diversicolor
inferredcites →https://doi.org/10.1016/j.scitotenv.2020.137733openalex-extracted
Evaluating bivalve cytoprotective responses and their regulatory pathways in a climate change scenario
inferredcites →https://doi.org/10.1016/j.scitotenv.2020.138143openalex-extracted
Biochemical and physiological responses of two clam species to Triclosan combined with climate change scenario
inferredcites →https://doi.org/10.1016/j.scitotenv.2020.139797openalex-extracted
Effects of environmentally relevant concentrations of diclofenac in Mytilus trossulus
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(Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future
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Norgestrel causes digestive gland injury in the clam Mactra veneriformis: An integrated histological, transcriptomics, and metabolomics study
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Review of warming and acidification effects to the ecotoxicity of pharmaceuticals on aquatic organisms in the era of climate change
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Ecotoxicity of emerging contaminants in the reproductive organ of marine mussels Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.163766openalex-extracted
Hemocytes in blue mussel Mytilus edulis adopt different energy supply modes to cope with different BDE-47 exposures
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Effects of ifosfamide and cisplatin exposure combined with a climate change scenario on the transcriptome responses of the mussel Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.165786openalex-extracted
The influence of temperature on the effects of lead and lithium in Mytilus galloprovincialis through biochemical, cell and tissue levels: Comparison between mono and multi-element exposures
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.166078openalex-extracted
Antidepressants and their metabolites primarily affect lysosomal functions in the marine mussel, Mytilus galloprovincialis
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.166085openalex-extracted
Can temperature rise change the impacts induced by e-waste on adults and sperm of Mytilus galloprovincialis?
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.168419openalex-extracted
Spawning acts as a metabolic stressor enhanced by hypoxia and independent of sex in a broadcast marine spawner
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.168975openalex-extracted
To what extent is blue mussels caging representative of microplastics in the natural environment?
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Exploring toxicological interactions in a changing sea: The case of the alkaloids caffeine and caulerpin
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From the cellular to tissue alterations induced by two rare earth elements in the mussel species Mytilus galloprovincialis: Comparison between exposure and recovery periods
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Ocean, Cryosphere and Sea Level Change
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Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds
inferredcites →https://doi.org/10.1038/35067589openalex-extracted
Acetylcholinesterase — new roles for an old actor
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5-Fluorouracil: mechanisms of action and clinical strategies
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Mitochondrial Adaptations to Variable Environments and Their Role in Animals’ Stress Tolerance
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The emerging roles of microRNAs in the molecular responses of metabolic rate depression
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Standardized determination of real-time PCR efficiency from a single reaction set-up
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5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes
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Speed it up: How temperature drives toxicokinetics of organic contaminants in freshwater amphipods
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From bivalves to birds: oxidative stress and longevity
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ABCB- and ABCC-type transporters confer multixenobiotic resistance and form an environment-tissue barrier in bivalve gills
inferredcites →https://doi.org/10.1186/s12864-021-07380-0openalex-extracted
Phylogenetic analysis of the caspase family in bivalves: implications for programmed cell death, immune response and development
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Effects of intermittent hypoxia on oxidative stress and protein degradation in molluscan mitochondria
inferredcites →https://doi.org/10.1371/journal.pone.0061502openalex-extracted
Genes of the Mitochondrial Apoptotic Pathway in Mytilus galloprovincialis
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Development and Validation of an Isocratic, Sensitive and Facile RP-HPLC Method for Rapid Analysis of 5-Fluorouracil and Stability Studies Under Various Stress Conditions
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Analysis of Three Anticancer Drugs (5-Fluorouracil, Cyclophosphamide and Hydroxyurea) in Water Samples by HPLC-MS/MS
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Ecotoxicity of Emerging Contaminants in the Reproductive Organ of Marine Mussels Mytilus Galloprovincialis
inferredcites →https://doi.org/10.2983/035.037.0108openalex-extracted
Validation of Reference Genes in MusselMytilus galloprovincialisTissues under the Presence of Okadaic Acid
inferredcites →https://doi.org/10.3389/fonc.2021.658636openalex-extracted
5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent
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Inducing the Alternative Oxidase Forms Part of the Molecular Strategy of Anoxic Survival in Freshwater Bivalves
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Toxicological Evaluation of Acetylsalicylic Acid in Non-Target Organisms: Chronic Exposure on Mytilus galloprovincialis (Lamarck, 1819)
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Neurotoxicity in Marine Invertebrates: An Update
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Respiration and the activity of the respiratory electron transport system in marine zooplankton1
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