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5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes
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2 of the 101 references listed on this page are in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/onc.2011.321 (notice 2024-03-05), 10.1186/s12935-019-0812-3 (notice 2023-04-17).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.11176openalex-snapshot
Role of hMLH1 promoter hypermethylation in drug resistance to 5‐fluorouracil in colorectal cancer cell lines
inferredcites →https://doi.org/10.1002/ijc.24403openalex-snapshot
Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells
inferredcites →https://doi.org/10.1002/iub.1361openalex-snapshot
Micro RNA ‐494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD
inferredcites →https://doi.org/10.1002/jcb.24721openalex-snapshot
MicroRNA-23a Antisense Enhances 5-Fluorouracil Chemosensitivity Through APAF-1/Caspase-9 Apoptotic Pathway in Colorectal Cancer Cells
inferredcites →https://doi.org/10.1002/path.1706openalex-snapshot
Molecular mechanisms of drug resistance
inferredcites →https://doi.org/10.1007/bf03401856openalex-snapshot
MRP8, A New Member of ABC Transporter Superfamily, Identified by EST Database Mining and Gene Prediction Program, Is Highly Expressed in Breast Cancer
inferredcites →https://doi.org/10.1007/s00432-017-2382-xopenalex-snapshot
The extracellular domain of E cadherin linked to invasiveness in colorectal cancer: a new resistance and relapses monitoring serum-bio marker?
inferredcites →https://doi.org/10.1007/s101470300013openalex-snapshot
Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma
inferredcites →https://doi.org/10.1007/s12013-014-0062-xopenalex-snapshot
Overexpression of MicroRNA-122 Re-sensitizes 5-FU-Resistant Colon Cancer Cells to 5-FU Through the Inhibition of PKM2 In Vitro and In Vivo
inferredcites →https://doi.org/10.1007/s12032-015-0703-yopenalex-snapshot
The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116
inferredcites →https://doi.org/10.1007/s13277-015-4755-6openalex-snapshot
Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells
inferredcites →https://doi.org/10.1016/0006-2952(95)00067-aopenalex-snapshot
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil
inferredcites →https://doi.org/10.1016/j.bbaexp.2006.05.001openalex-snapshot
The role of Sp1 and Sp3 in the constitutive DPYD gene expression
inferredcites →https://doi.org/10.1016/j.bbamcr.2012.08.017openalex-snapshot
The emerging multiple roles of nuclear Akt
inferredcites →https://doi.org/10.1016/j.bbrc.2013.11.064openalex-snapshot
Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro
inferredcites →https://doi.org/10.1016/j.biocel.2016.07.024openalex-snapshot
Suppression of TWIST1 enhances the sensitivity of colon cancer cells to 5-fluorouracil
inferredcites →https://doi.org/10.1016/j.canlet.2012.10.004openalex-snapshot
The β6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer
inferredcites →https://doi.org/10.1016/j.canlet.2014.10.029openalex-snapshot
MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells
inferredcites →https://doi.org/10.1016/j.canlet.2016.08.004openalex-snapshot
Macrophages induce resistance to 5-fluorouracil chemotherapy in colorectal cancer through the release of putrescine
inferredcites →https://doi.org/10.1016/j.ccr.2010.10.031openalex-snapshot
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
inferredcites →https://doi.org/10.1016/j.cellimm.2012.06.014openalex-snapshot
Anti-tumor immunity: Myeloid leukocytes control the immune landscape
inferredcites →https://doi.org/10.1016/j.drup.2011.08.001openalex-snapshot
Epigenetics and chemoresistance in colorectal cancer: An opportunity for treatment tailoring and novel therapeutic strategies
inferredcites →https://doi.org/10.1016/j.ejps.2005.10.010openalex-snapshot
The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2016.03.014openalex-snapshot
Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.01.033openalex-snapshot
CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk
inferredcites →https://doi.org/10.1016/j.molcel.2013.04.029openalex-snapshot
Coordinate Transcriptional and Translational Repression of p53 by TGF-β1 Impairs the Stress Response
inferredcites →https://doi.org/10.1016/j.phymed.2015.03.010openalex-snapshot
Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity
inferredcites →https://doi.org/10.1016/j.yexcr.2015.09.011openalex-snapshot
Exploiting a novel miR-519c–HuR–ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer
inferredcites →https://doi.org/10.1016/j.yexcr.2017.09.023openalex-snapshot
miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of rapamycin
inferredcites →https://doi.org/10.1016/s0002-9440(10)62570-9openalex-snapshot
Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease
inferredcites →https://doi.org/10.1038/bjc.2015.101openalex-snapshot
IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer
inferredcites →https://doi.org/10.1038/bjc.2017.38openalex-snapshot
Oncogenic role of PDK4 in human colon cancer cells
inferredcites →https://doi.org/10.1038/cddis.2014.10openalex-snapshot
Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer
inferredcites →https://doi.org/10.1038/cddis.2015.200openalex-snapshot
MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer
inferredcites →https://doi.org/10.1038/nm730openalex-snapshot
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
inferredcites →https://doi.org/10.1038/onc.2011.321openalex-snapshot
RETRACTED ARTICLE: P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance
inferredcites →https://doi.org/10.1038/onc.2012.268openalex-snapshot
Cell fusion promotes chemoresistance in metastatic colon carcinoma
inferredcites →https://doi.org/10.1038/srep27157openalex-snapshot
miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2
inferredcites →https://doi.org/10.1038/srep42226openalex-snapshot
CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer
inferredcites →https://doi.org/10.1038/tpj.2011.65openalex-snapshot
Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer
inferredcites →https://doi.org/10.1038/tpj.2016.91openalex-snapshot
Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells
inferredcites →https://doi.org/10.1055/s-0037-1602238openalex-snapshot
Emerging Systemic Therapies for Colorectal Cancer
inferredcites →https://doi.org/10.1056/nejmoa1500596openalex-snapshot
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
inferredcites →https://doi.org/10.1073/pnas.0308716101openalex-snapshot
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients
inferredcites →https://doi.org/10.1073/pnas.1202989109openalex-snapshot
Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells
inferredcites →https://doi.org/10.1074/jbc.275.10.7087openalex-snapshot
Lack of Oxidative Phosphorylation and Low Mitochondrial Membrane Potential Decrease Susceptibility to Apoptosis and Do Not Modulate the Protective Effect of Bcl-xL in Osteosarcoma Cells
inferredcites →https://doi.org/10.1074/jbc.m412105200openalex-snapshot
DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated Damage
inferredcites →https://doi.org/10.1080/1120009x.1990.11738999openalex-snapshot
Resistance to 5-Fluorouracil and 5-Fluoro;-2’-deoxyuridine Mechanisms and Clinical Implications
inferredcites →https://doi.org/10.1084/jem.20131195openalex-snapshot
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
inferredcites →https://doi.org/10.1093/abbs/gmq125openalex-snapshot
miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines
inferredcites →https://doi.org/10.1093/glycob/11.7.587openalex-snapshot
Cell surface-expressed Thomsen-Friedenreich antigen in colon cancer is predominantly carried on high molecular weight splice variants of CD44
inferredcites →https://doi.org/10.1093/jjco/hyh113openalex-snapshot
Immunohistochemical Evaluation of Thymidylate Synthase (TS) and p16INK4a in Advanced Colorectal Cancer: Implication of TS Expression in 5-FU-based Adjuvant Chemotherapy
inferredcites →https://doi.org/10.1097/md.0000000000002636openalex-snapshot
High Infiltration of Tumor-Associated Macrophages Influences Poor Prognosis in Human Gastric Cancer Patients, Associates With the Phenomenon of EMT
inferredcites →https://doi.org/10.1101/680892openalex-snapshot
Loss of SHMT2 mediates 5-FU chemoresistance by inducing autophagy in colorectal cancer
inferredcites →https://doi.org/10.1101/gad.276568.115openalex-snapshot
Role of TET enzymes in DNA methylation, development, and cancer
inferredcites →https://doi.org/10.1111/cas.14532openalex-snapshot
5‐Fluorouracil resistance mechanisms in colorectal cancer: From classical pathways to promising processes
inferredcites →https://doi.org/10.1111/j.1742-4658.2009.07383.xopenalex-snapshot
MicroRNA‐143 reduces viability and increases sensitivity to 5‐fluorouracil in HCT116 human colorectal cancer cells
inferredcites →https://doi.org/10.1111/jcmm.12742openalex-snapshot
Micro RNA ‐425‐5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10
inferredcites →https://doi.org/10.1139/o07-009openalex-snapshot
Suppression of DPYD expression in RKO Cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression
inferredcites →https://doi.org/10.1155/2016/5874127openalex-snapshot
CCL21 Facilitates Chemoresistance and Cancer Stem Cell‐Like Properties of Colorectal Cancer Cells through AKT/GSK‐3 β /Snail Signals
inferredcites →https://doi.org/10.1158/0008-5472.can-04-3300openalex-snapshot
Down-regulation of Mitochondrial F1F0-ATP Synthase in Human Colon Cancer Cells with Induced 5-Fluorouracil Resistance
inferredcites →https://doi.org/10.1158/0008-5472.can-07-0085openalex-snapshot
SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-08-1569openalex-snapshot
p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
inferredcites →https://doi.org/10.1158/0008-5472.can-12-4718openalex-snapshot
FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0362openalex-snapshot
Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-1854openalex-snapshot
Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis
inferredcites →https://doi.org/10.1158/1535-7163.mct-04-0291openalex-snapshot
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0716openalex-snapshot
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance
inferredcites →https://doi.org/10.1158/1535-7163.mct-10-0061openalex-snapshot
miR-192/miR-215 Influence 5-Fluorouracil Resistance through Cell Cycle-Mediated Mechanisms Complementary to Its Post-transcriptional Thymidilate Synthase Regulation
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0878openalex-snapshot
microRNAs miR-27a and miR-27b Directly Regulate Liver Dihydropyrimidine Dehydrogenase Expression through Two Conserved Binding Sites
inferredcites →https://doi.org/10.1186/s12935-017-0483-xopenalex-snapshot
RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
inferredcites →https://doi.org/10.1186/s12935-019-0812-3openalex-snapshot
RETRACTED ARTICLE: Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway
inferredcites →https://doi.org/10.1186/s13578-017-0145-7openalex-snapshot
The role of GLI1 for 5-Fu resistance in colorectal cancer
inferredcites →https://doi.org/10.1242/bio.015008openalex-snapshot
MicroRNA-204 modulates colorectal cancer cell sensitivity in response to 5-fluorouracil-based treatment by targeting high mobility group protein A2
inferredcites →https://doi.org/10.1245/s10434-012-2246-1openalex-snapshot
MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells
inferredcites →https://doi.org/10.1371/journal.pone.0015366openalex-snapshot
The Inflammatory Microenvironment in Colorectal Neoplasia
inferredcites →https://doi.org/10.15252/emmm.201505492openalex-snapshot
PHD1 regulates p53‐mediated colorectal cancer chemoresistance
inferredcites →https://doi.org/10.1593/neo.04307openalex-snapshot
STRAP Is a Strong Predictive Marker of Adjuvant Chemotherapy Benefit in Colorectal Cancer
inferredcites →https://doi.org/10.18632/oncotarget.11121openalex-snapshot
Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells
inferredcites →https://doi.org/10.18632/oncotarget.14351openalex-snapshot
FOXM1 evokes 5-fluorouracil resistance in colorectal cancer depending on ABCC10
inferredcites →https://doi.org/10.18632/oncotarget.24338openalex-snapshot
5-FU therapeutic drug monitoring as a valuable option to reduce toxicity in patients with gastrointestinal cancer
inferredcites →https://doi.org/10.18632/oncotarget.5541openalex-snapshot
Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages
inferredcites →https://doi.org/10.18632/oncotarget.7895openalex-snapshot
The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells
inferredcites →https://doi.org/10.2174/138920371604150429153309openalex-snapshot
Elevated microRNA-23a Expression Enhances the Chemoresistance of Colorectal Cancer Cells with Microsatellite Instability to 5-Fluorouracil by Directly Targeting ABCF1
inferredcites →https://doi.org/10.2174/157436206777012048openalex-snapshot
Integrin-Mediated Drug Resistance
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3389/fonc.2013.00090openalex-snapshot
The Tumor Microenvironment: A Pitch for Multiple Players
inferredcites →https://doi.org/10.3389/fphar.2017.00047openalex-snapshot
Identification of Predictive DNA Methylation Biomarkers for Chemotherapy Response in Colorectal Cancer
inferredcites →https://doi.org/10.3390/molecules13081551openalex-snapshot
5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies
inferredcites →https://doi.org/10.3892/ijo.19.2.383openalex-snapshot
Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer
inferredcites →https://doi.org/10.3892/ijo.2014.2696openalex-snapshot
Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5-fluorouracil on the HT-29 colon cancer cell line
inferredcites →https://doi.org/10.3892/mmr.2014.2726openalex-snapshot
Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil
inferredcites →https://doi.org/10.3892/mmr.2016.5812openalex-snapshot
Gap junction composed of connexin43 modulates 5-fluorouracil, oxaliplatin and irinotecan resistance on colorectal cancers
inferredcites →https://doi.org/10.3892/ol.2015.3468openalex-snapshot
Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells
inferredcites →https://doi.org/10.3892/ol.2017.5895openalex-snapshot
MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase
inferredcites →https://doi.org/10.3892/or.2015.4479openalex-snapshot
Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade
inferredcites →https://doi.org/10.3892/or_00000613openalex-snapshot
5-Fluorouracil and oxaliplatin modify the expression profiles of microRNAs in human colon cancer cells in vitro
inferredcites →https://doi.org/10.4143/crt.2017.356openalex-snapshot
Participation of CCL1 in Snail-Positive Fibroblasts in Colorectal Cancer Contribute to 5-Fluorouracil/Paclitaxel Chemoresistance
inferredcites →https://doi.org/10.4161/cc.26034openalex-snapshot
TGF-β: An emerging player in drug resistance
inferredcites →https://doi.org/10.6004/jnccn.2018.0061openalex-snapshot
Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology
inferredcites →https://doi.org/10.7150/jca.19142openalex-snapshot
HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Effects of Water Temperature Increase on Transcriptomic, Biochemical, and Histopathological Responses of the Bivalve Species Mytilus Galloprovincialis to the Antineoplastic Drug 5-Fluorouracil
inferred← citeshttps://doi.org/10.1002/2211-5463.13611openalex-snapshot
Relationship between anticancer sensitivities and cellular respiration properties in 5‐fluorouracil‐resistant HCT116 human colorectal cancer cells
inferred← citeshttps://doi.org/10.1002/adfm.202422678openalex-snapshot
Hypoxia Alleviation Enhances the Efficacy of 5‐Fluorouracil in Hypertrophic Scar Therapy via an Oxygen‐Popping Microneedle System
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One‐Pot Synthesis of Luminescent and Photothermal Carbon Boron‐Nitride Quantum Dots Exhibiting Cell Damage Protective Effects
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Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus‐Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion
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Honokiol‐Magnolol‐Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti‐PD‐1 Immunotherapy in Colorectal Cancer by Triggering GSDME‐Dependent Pyroptosis
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DNA‐Damage‐Response‐Targeting Mitochondria‐Activated Multifunctional Prodrug Strategy for Self‐Defensive Tumor Therapy
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DNA‐Damage‐Response‐Targeting Mitochondria‐Activated Multifunctional Prodrug Strategy for Self‐Defensive Tumor Therapy
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Synergistic Anticancer Effects of Akkermansia muciniphila Combined With 5‐Fluorouracil Through BAX/BCL2 Dependent Apoptosis in Colorectal Cancer Cells
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Long noncoding RNA HAGLR sponges miR‐338‐3p to promote 5‐Fu resistance in gastric cancer through targeting the LDHA‐glycolysis pathway
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Delta‐ and Gamma‐Tocotrienols Inhibit the Proliferation of HCC2998 Human Colorectal Carcinoma Cells via Modulation of Histone Modification Pathways Involved in DNA Damage Response
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Total Synthesis and Stereochemical Assignment of Talaroconvolutin A and Talarofuranone: Gram‐scale Synthesis of Ferroptosis Inducer Talaroconvolutin A
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Genomic and biological aspects of resistance to selective poly( ADP ‐ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells
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AZD6738 (Ceralasertib) Enhances Trifluridine's Antitumor Effect in 5‐ FU –Resistant Colorectal Cancer Cells
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Association Between ABCG2 , ABCB1 , ABCC2 Efflux Transporter Single‐Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real‐Life Study
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Circ‐ERBB2 knockdown sensitized colorectal cancer cells to 5‐FU via miR‐181a‐5p/PTEN/Akt pathway
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Evodiamine Enhances Chemosensitivity in Colorectal Cancer by Targeting Ribonucleotide Reductase M2
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EIF3D promotes resistance to 5‐fluorouracil in colorectal cancer through upregulating RUVBL1
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5‐Fluorouracil metabolic pathway genes predict recurrence risk following adjuvant S‐1 therapy: Results of an ancillary analysis from a phase III trial of resected biliary tract cancer (JCOG1202A1)
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Dermatan Sulfate/Chitosan Nanoparticles Loaded with an Anti‐Inflammatory Peptide Increase the Response of Human Colorectal Cancer Cells to 5‐Fluorouracil
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Withaferin A Exerts Cytotoxicity in Single/Multidrug‐Resistant Gastric and Ovarian Cancer Cells and Tumor Xenografts Through the AKT–NF‐κB–STAT3–Survivin Axis
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Multiomics Research Strategies in Cancer: A Growing and Innovative Field
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Novel Perspectives in the Management of Colorectal Cancer: Mechanistic Investigations Into the Reversal of Drug Resistance via Active Constituents Derived From Herbal Medicine
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Nanozymes for Emerging Therapy
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Casein Kinase-1-Alpha Inhibitor (D4476) Sensitizes Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil via Authophagy Flux Inhibition
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Therapeutic efficacy of baicalein and 6-(methylsulfinyl)hexyl isothiocyanate, alone or in combination with 5-fluorouracil, in the treatment of colorectal cancer
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TIMP-2 as a predictive biomarker in 5-Fu-resistant colorectal cancer
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Exploring the potential biological function of GRK2 in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s10142-025-01691-1openalex-snapshot
Multi-omics based consensus subtypes, development of prognostic signature, and identification of INHBB as a potential therapeutic target in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s10495-024-02060-2openalex-snapshot
TRIM23 promotes 5-Fluorouracil resistance in colorectal cancer by upregulating GALNT4 expression
inferred← citeshttps://doi.org/10.1007/s10495-025-02084-2openalex-snapshot
The impact of SEC23A on 5-FU chemotherapy sensitivity and its involvement in endoplasmic reticulum stress-induced apoptosis in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s10495-026-02306-1openalex-snapshot
COL8A1-positive cancer-associated fibroblasts are drivers of 5-fluorouracil resistance in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s10528-025-11041-2openalex-snapshot
Computational Elucidation of Hub Genes and Pathways Correlated with the Development of 5-Fluorouracil Resistance in HCT 116 Colorectal Carcinoma Cell Line
inferred← citeshttps://doi.org/10.1007/s10555-023-10126-xopenalex-snapshot
Resveratrol as sensitizer in colorectal cancer plasticity
inferred← citeshttps://doi.org/10.1007/s10565-026-10147-6openalex-snapshot
Gut microbiota metabolites positively impacts chemotherapy effects in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11033-022-07227-1openalex-snapshot
MicroRNAs and drug resistance in colorectal cancer with special focus on 5-fluorouracil
inferred← citeshttps://doi.org/10.1007/s11033-022-07680-yopenalex-snapshot
Early-stage colon cancer with high MALAT1 expression is associated with the 5-Fluorouracil resistance and future metastasis
inferred← citeshttps://doi.org/10.1007/s11033-024-09431-7openalex-snapshot
Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
inferred← citeshttps://doi.org/10.1007/s11033-024-09562-xopenalex-snapshot
Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
inferred← citeshttps://doi.org/10.1007/s11033-025-11047-4openalex-snapshot
Modulation of NF-κB pathway in cancer therapy by sodium butyrate and Isoproterenol
inferred← citeshttps://doi.org/10.1007/s11033-026-12659-0openalex-snapshot
Protease inhibition: breaking the barriers of chemoresistance in cancer
inferred← citeshttps://doi.org/10.1007/s11094-023-02998-8openalex-snapshot
Mechanism of Antitumor Activity of Gold Glyconanoparticles Against Human Colon Adenocarcinoma Cells
inferred← citeshttps://doi.org/10.1007/s11224-025-02634-zopenalex-snapshot
Comprehensive in silico and experimental study of syringaldehyde-triarylpyridine hybrids as dual-action anticancer and antibiofilm agents
inferred← citeshttps://doi.org/10.1007/s11418-024-01849-4openalex-snapshot
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
inferred← citeshttps://doi.org/10.1007/s11426-023-1920-0openalex-snapshot
Self-assembled amphiphilic NIR-II emissive nano-micelles for imaging-guided photothermal therapy of colorectal cancer
inferred← citeshttps://doi.org/10.1007/s11696-023-02927-9openalex-snapshot
Studying loading of 5-fluorouracil onto the surface of gold–silver nanocomposite utilizing DLS and UV–Vis spectroscopy
inferred← citeshttps://doi.org/10.1007/s12010-024-05072-5openalex-snapshot
Combinatorial Effects of 5-Fluorouracil and Menadione on Wnt/β-Catenin Pathway in Human Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.1007/s12011-023-03803-zopenalex-snapshot
Zinc Oxide Nanoparticles and Cancer Chemotherapy: Helpful Tools for Enhancing Chemo-sensitivity and Reducing Side Effects?
inferred← citeshttps://doi.org/10.1007/s12012-024-09953-3openalex-snapshot
Astemizole Exacerbates 5-Fluorouracil-Triggered Cardiotoxicity by Enhancing Ptgs2
inferred← citeshttps://doi.org/10.1007/s12020-026-04811-4openalex-snapshot
Synergistic antitumor effects of 5-fluorouracil and vorinostat in preclinical models of pheochromocytomas and paragangliomas
inferred← citeshttps://doi.org/10.1007/s12032-023-02105-7openalex-snapshot
Inhibition of IRE1 RNase activity modulates tumor cell progression and enhances the response to chemotherapy in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s12032-023-02201-8openalex-snapshot
Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
inferred← citeshttps://doi.org/10.1007/s12032-023-02204-5openalex-snapshot
TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s12032-025-03078-5openalex-snapshot
Genetic and transcriptomic alterations underlying aggressiveness in 5-fluorouracil-resistant HCT116 cells
inferred← citeshttps://doi.org/10.1007/s12668-025-01857-yopenalex-snapshot
Preparation of Silk Fibroin Nanofibers Containing 5-Fluorouracil for pH-Sensitive Drug Delivery and Synergistic Cancer Therapy
inferred← citeshttps://doi.org/10.1007/s12672-024-01019-8openalex-snapshot
Molecular mechanism of MLCK1 inducing 5-Fu resistance in colorectal cancer cells through activation of TNFR2/NF-κB pathway
inferred← citeshttps://doi.org/10.1007/s12672-024-01036-7openalex-snapshot
Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis
inferred← citeshttps://doi.org/10.1007/s12672-024-01510-2openalex-snapshot
The potential of kaempferol in digestive system tumors: recent advances and mechanistic insights
inferred← citeshttps://doi.org/10.1007/s12672-025-02156-4openalex-snapshot
Blocking lncRNA NOP14-AS1 overcomes 5-Fu resistance of colon cancer cells by modulating miR-30a-5p-LDHA-glucose metabolism pathway
inferred← citeshttps://doi.org/10.1007/s12672-025-02285-wopenalex-snapshot
CSF2 promotes chemoresistance in colorectal cancer by regulating Notch pathway
inferred← citeshttps://doi.org/10.1007/s12672-025-02593-1openalex-snapshot
Dexamethasone, celecoxib, and simvastatin-induced 5-fluorouracil resistance in cancer cells: a possible role of lipid droplet accumulation
inferred← citeshttps://doi.org/10.1007/s13105-022-00894-5openalex-snapshot
Uricase sensitizes hepatocellular carcinoma cells to 5-fluorouracil through uricase-uric acid-UMP synthase axis
inferred← citeshttps://doi.org/10.1007/s13205-026-05028-yopenalex-snapshot
Mechanistic investigation of Juglone (5-hydroxy-1,4-naphthoquinone) as an anti-cancer agent in human colorectal cancer HCT116 and HT-29 cell lines
inferred← citeshttps://doi.org/10.1007/s13577-022-00775-5openalex-snapshot
The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s13577-023-00938-yopenalex-snapshot
Hungatella hathewayi impairs the sensitivity of colorectal cancer cells to 5-FU through decreasing CDX2 expression
inferred← citeshttps://doi.org/10.1007/s13577-026-01435-8openalex-snapshot
Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s40199-024-00545-8openalex-snapshot
Cellular and molecular aspects of drug resistance in cancers
inferred← citeshttps://doi.org/10.1007/s40199-025-00568-9openalex-snapshot
The effect of Fe3O4 biosynthesized through the green synthesis of Silybum marianum and HA in the targeted delivery of 5-Fluorouracil to HCT116 cell line
inferred← citeshttps://doi.org/10.1007/s43188-026-00377-5openalex-snapshot
CALN1 regulates calcium–redox homeostasis and apoptotic responses to 5-fluorouracil in colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/b978-0-443-13870-6.00016-7openalex-snapshot
Decipher the role of cancer stem cells in colorectal cancer based on molecular pathology and its clinical significance
inferred← citeshttps://doi.org/10.1016/b978-0-443-13870-6.00021-0openalex-snapshot
Impact of the microbiome on colorectal cancer development
inferred← citeshttps://doi.org/10.1016/b978-0-443-33475-7.00005-6openalex-snapshot
Artificial intelligence and colorectal cancer drug resistance
inferred← citeshttps://doi.org/10.1016/b978-0-443-33475-7.00009-3openalex-snapshot
Unraveling the mystery of treatment resistance in colorectal cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-33475-7.00014-7openalex-snapshot
Mechanisms of treatment resistance in colorectal cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-43976-6.00018-1openalex-snapshot
Deficient and proficient mismatch repair colon cancers: From mechanism to therapy approaches
inferred← citeshttps://doi.org/10.1016/b978-0-443-44121-9.00007-xopenalex-snapshot
Artificial intelligence in gastrointestinal cancers
inferred← citeshttps://doi.org/10.1016/bs.acr.2023.02.003openalex-snapshot
Interplay between MAP kinases and tumor microenvironment: Opportunity for immunotherapy in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.abb.2024.110176openalex-snapshot
Folic acid-functionalized and acetyl-terminated dendrimers as nanovectors for co-delivery of sorafenib and 5-fluorouracil
inferred← citeshttps://doi.org/10.1016/j.adcanc.2025.100136openalex-snapshot
HDAC3-mediated deacetylation of p21 stabilizes protein levels and promotes 5-FU resistance in colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.ajg.2024.09.003openalex-snapshot
Ginsenoside Rg3 enhances the anticancer effects of 5-fluorouracil in colorectal cancer and reduces drug resistance and the Hedgehog pathway activation
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.07.018openalex-snapshot
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.arcmed.2024.102966openalex-snapshot
Human Intestinal Defensin 5 Ameliorates the Sensitization of Colonic Cancer Cells to 5-Fluorouracil
inferred← citeshttps://doi.org/10.1016/j.bbadis.2023.166922openalex-snapshot
Reactive oxygen species in colorectal cancer adjuvant therapies
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167986openalex-snapshot
Interplay between O-GlcNAcylation and 5-FU response in colorectal cancer: Novel insights from an examination of primary and metastatic cell lines
inferred← citeshttps://doi.org/10.1016/j.bbadis.2026.168287openalex-snapshot
Raman spectroscopic characterization of protein changes induced by 5-fluorouracil in colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188699openalex-snapshot
A synopsis of modern - day colorectal cancer: Where we stand
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189261openalex-snapshot
Combating chemoresistance: Current approaches & nanocarrier mediated targeted delivery
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150262openalex-snapshot
The combination of SHP099 inhibits the malignant biological behavior of L-OHP/5-FU-resistant colorectal cancer cells by regulating energy metabolism reprogramming
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150348openalex-snapshot
Role of Wnt/β-catenin pathway in cancer drug resistance: Insights into molecular aspects of major solid tumors
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150665openalex-snapshot
Calreticulin exposure induced by anticancer drugs is associated with the p53 signaling pathway in colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.151972openalex-snapshot
5-Fluorouracil induces ferroptosis in breast cancer cells via targeting SLC7A11
inferred← citeshttps://doi.org/10.1016/j.bbrep.2025.101957openalex-snapshot
In-silico analysis of nsSNPs in BCL-2 family proteins: Implications for colorectal cancer pathogenesis and therapeutics
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115741openalex-snapshot
Nucleoside-based anticancer drugs: Mechanism of action and drug resistance
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.117400openalex-snapshot
Erbin destabilization by O-GlcNAcylation promotes 5-FU resistance via homologous recombination activation in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117943openalex-snapshot
Identification of hub genes and lncRNAs driving the transition from early response to methotrexate resistance in HT29 colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.biocel.2025.106783openalex-snapshot
Morin inhibits the progression of 5-fluorouracil–resistant colorectal cancer by suppressing autophagy
inferred← citeshttps://doi.org/10.1016/j.bioelechem.2021.107844openalex-snapshot
Nanosecond pulsed electric fields impair viability and mucin expression in mucinous colorectal carcinoma cell
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113237openalex-snapshot
RETRACTED: Interplays between non-coding RNAs and chemokines in digestive system cancers
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113426openalex-snapshot
Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113465openalex-snapshot
Disulfiram increases the efficacy of 5-fluorouracil in organotypic cultures of colorectal carcinoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114373openalex-snapshot
The effects of mesenchymal stem cells on the chemotherapy of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117176openalex-snapshot
SIRT1: a novel regulator in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117576openalex-snapshot
Expediting the development of robust 5-FU-resistant colorectal cancer models using innovative combined in vivo and in vitro strategies
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119273openalex-snapshot
Fatty Acid Synthase (FASN) as a targeted therapeutic in acquired 5-fluorouracil resistance in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.carpta.2025.100775openalex-snapshot
Proteomic analysis reveals a potential anticancer mechanism for a novel effervescent curcumin-ascorbic acid-polysaccharide-β-cyclodextrin inclusion complex towards colorectal cancer cells through modulation of ribosome biogenesis
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112321openalex-snapshot
Circadian rhythm: An emerging force for colorectal cancer treatment
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115061openalex-snapshot
Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases
inferred← citeshttps://doi.org/10.1016/j.chmed.2023.01.004openalex-snapshot
Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
inferred← citeshttps://doi.org/10.1016/j.clinsp.2025.100606openalex-snapshot
Investigating the role of MicroRNA-519d-3p in enhancing chemosensitivity of colorectal cancer cells to 5-Fluorouracil through PFKFB3 targeting
inferred← citeshttps://doi.org/10.1016/j.comptc.2025.115181openalex-snapshot
Calcite nano-structure as a novel drug carrier for 5-Fluorouracil chemotherapy agent: A computational study using DFT and AIMD
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2023.104196openalex-snapshot
Total neoadjuvant therapy in rectal cancer: the evidence and expectations
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2024.104360openalex-snapshot
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2026.105189openalex-snapshot
The critical role of epithelial-mesenchymal transition (EMT) in colorectal cancer progression and therapeutic outcomes
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104335openalex-snapshot
IRE1α-mediated UPR activation in gastrointestinal cancers: Adaptive mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.drup.2024.101193openalex-snapshot
WITHDRAWN: Low miR-224-5p in exosomes confers colorectal cancer 5-FU resistance by upregulating S100A4
inferred← citeshttps://doi.org/10.1016/j.drup.2025.101211openalex-snapshot
Low miR-224–5p in exosomes confers colorectal cancer 5-FU resistance by upregulating S100A4
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175253openalex-snapshot
Long-term resistance to 5-fluorouracil promotes epithelial–mesenchymal transition, apoptosis evasion, autophagy, and reduced proliferation rate in colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176979openalex-snapshot
Resistance to 5-fluorouracil: The molecular mechanisms of development in colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177294openalex-snapshot
Beyond chemotherapy: Exploring 5-FU resistance and stemness in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.ejphar.2025.177964openalex-snapshot
Cuproptosis induced by curcumin interfering with proliferation and energy metabolism in colorectal cancer: 3D tumor model and computational simulations reveal curcumin inhibition of HSPD1 and CALCOCO2
inferred← citeshttps://doi.org/10.1016/j.esmoop.2021.100125openalex-snapshot
Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2021.110646openalex-snapshot
Local co-delivery of 5-fluorouracil and curcumin using Schiff's base cross-linked injectable hydrogels for colorectal cancer combination therapy
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106711openalex-snapshot
Synergistic mechanisms of Banxia Xiexin decoction in overcoming chemoresistance and enhancing chemosensitivity in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.foodchem.2023.136684openalex-snapshot
Can the phenolic compounds of Manuka honey chemosensitize colon cancer stem cells? A deep insight into the effect on chemoresistance and self-renewal
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.138423openalex-snapshot
Isolation, structural characterization and biological activity evaluation of melanoidins from thermally processed cocoa beans, carob kibbles and acorns as potential cytotoxic agents
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.141371openalex-snapshot
Bioavailability and interactions of schisandrin B with 5-fluorouracil in a xenograft mouse model of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102261openalex-snapshot
Iron-driven regulation of nucleotide synthesis reveals metabolic vulnerabilities in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.genrep.2026.102487openalex-snapshot
ATR inhibition by M-4344 reverses 5-fluorouracil resistance in colorectal cancer cells through enhanced DNA damage and suppression of PI3K/AKT signaling
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e16798openalex-snapshot
Sanguisorba officinalis L. enhances the 5-fluorouracil sensitivity and overcomes chemoresistance in 5-fluorouracil-resistant colorectal cancer cells via Ras/MEK/ERK and PI3K/Akt pathways
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27207openalex-snapshot
Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e34362openalex-snapshot
The roles of E2F7 in cancer: Current knowledge and future prospects
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e34535openalex-snapshot
5-Fluorouracil resistance-based immune-related gene signature for COAD prognosis
inferred← citeshttps://doi.org/10.1016/j.humgen.2025.201521openalex-snapshot
Identification of key players in drug resistant colon cancer - An integrative network pharmacology approach
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.125794openalex-snapshot
Engineered multitargeting exosomes carrying miR-323a-3p for CRC therapy
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.140204openalex-snapshot
PepGAT, a chitinase-derived peptide, alters the proteomic profile of colorectal cancer cells and perturbs pathways involved in cancer survival
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124503openalex-snapshot
Magnetic particles with polymeric shells bearing lithocholic and folic acid moieties: Nano-warriors to fight colon cancer
inferred← citeshttps://doi.org/10.1016/j.isci.2025.113801openalex-snapshot
Impact of treatment history on drug resistance of metastatic colorectal cancer organoids
inferred← citeshttps://doi.org/10.1016/j.isci.2026.117129openalex-snapshot
CPS1 promotes colorectal cancer progression by inducing EMT and activating TGF-β/Smad signaling pathway
inferred← citeshttps://doi.org/10.1016/j.isci.2026.117500openalex-snapshot
Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis
inferred← citeshttps://doi.org/10.1016/j.jare.2024.07.022openalex-snapshot
A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.03.036openalex-snapshot
Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.jddst.2022.103663openalex-snapshot
“Response surface methodology and artificial neural network-based modeling and optimization of phosphatidylserine targeted nanocarriers for effective treatment of cancer: In vitro and in silico studies”
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.105730openalex-snapshot
Advancements in 5-fluorouracil-Loaded liposomal nanosystems: A comprehensive review on recent innovations in nanomedicine for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.jddst.2025.107744openalex-snapshot
Biological effects of chlorogenic acid nanoformulations on colorectal cancer cells
inferred← citeshttps://doi.org/10.1016/j.jep.2022.115933openalex-snapshot
A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2024.117988openalex-snapshot
Xianglian Pill combined with 5-fluorouracil enhances antitumor activity and reduces gastrointestinal toxicity in gastric cancer by regulating the p38 MAPK/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120752openalex-snapshot
Jiedu Sangen Decoction inhibits Epithelial-mesenchymal transition of colon adenocarcinoma via POU4F2/Hedgehog pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2026.122154openalex-snapshot
A Pholidota chinensis-derived dihydrophenanthrene acts as a bioactive constituent to trigger GPx4-mediated ferroptosis in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.jpet.2025.103666openalex-snapshot
Network pharmacology and experimental validation reveal that betulin alleviates 5-fluorouracil–induced intestinal injury by inhibiting intestinal senescence and enhances antitumor efficacy
inferred← citeshttps://doi.org/10.1016/j.jsps.2021.12.009openalex-snapshot
Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model
inferred← citeshttps://doi.org/10.1016/j.jsps.2022.09.011openalex-snapshot
Antioxidant and anti-inflammatory activities of lycopene against 5-fluorouracil-induced cytotoxicity in Caco2 cells
inferred← citeshttps://doi.org/10.1016/j.lddd.2026.100375openalex-snapshot
Unveiling biomarkers of chemoresistance: CASP1, ENG, and H6PD in 5-Fu-treated colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.lddd.2026.100570openalex-snapshot
Single-cell transcriptomics identifies a FOXO1/KLF5-associated epithelial program linked to 5-fluorouracil resistance in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122870openalex-snapshot
Research status and potential applications of circRNAs affecting colorectal cancer by regulating ferroptosis
inferred← citeshttps://doi.org/10.1016/j.molliq.2024.125407openalex-snapshot
CMC/Starch/SiO2/ GQDs nanoemulsion for targeted delivery of 5-fluorouracil
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.133942openalex-snapshot
Synthesis of new imidazole-triazole-glycoside hybrids as anti-breast cancer candidates
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2024.111874openalex-snapshot
MicroRNA-532 as a probable diagnostic and therapeutic marker in cancer patients
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201780openalex-snapshot
Antimetabolites synergize with non-genotoxic antibody drug conjugate conditioning in hematopoietic stem cell lentiviral gene therapy
inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106924openalex-snapshot
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156599openalex-snapshot
β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156773openalex-snapshot
Pentagalloyl glucose targets the JAK1/JAK3-STAT3 pathway to inhibit cancer stem cells and epithelial–mesenchymal transition in 5-fluorouracil-resistant colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100868openalex-snapshot
Therapeutic potential of combined treatment with chlorogenic acid and 5-fluorouracil in colorectal cancer through Wnt/β-catenin pathway modulation
inferred← citeshttps://doi.org/10.1016/j.prp.2023.154986openalex-snapshot
Suppression of NSUN2 enhances the sensitivity to chemosensitivity and inhibits proliferation by mediating cell apoptosis in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.prp.2024.155476openalex-snapshot
Circ_0000395 promotes cell growth, metastasis and oxaliplatin resistance by regulating miR-153–5p/MYO6 in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2025.103798openalex-snapshot
Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.10.020openalex-snapshot
Anticancer potential of essential oils from Croton L. species (Euphorbiaceae): A comprehensive review of ethnomedicinal, pharmacological, phytochemical, and toxicological evidence
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.179947openalex-snapshot
Effects of water temperature increase on gene expression, biochemical, and histopathological responses of the bivalve species Mytilus galloprovincialis to the antineoplastic drug 5-fluorouracil
inferred← citeshttps://doi.org/10.1016/j.sjbs.2022.103392openalex-snapshot
Effect of lycopene as an adjuvant therapy with 5-florouracil in human colon cancer
inferred← citeshttps://doi.org/10.1016/j.tice.2025.102771openalex-snapshot
CLMP increases 5-fluorouracil sensitivity in colorectal cancer through the inhibition of autophagy
inferred← citeshttps://doi.org/10.1016/j.xcrp.2026.103508openalex-snapshot
Combining chemotherapy and cold atmospheric plasma treatment: Empirical and theoretical insights
inferred← citeshttps://doi.org/10.1016/j.yexcr.2024.114269openalex-snapshot
PANX2 promotes malignant transformation of colorectal cancer and 5-Fu resistance through PI3K-AKT signaling pathway
inferred← citeshttps://doi.org/10.1016/j.yexcr.2025.114866openalex-snapshot
Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu
inferred← citeshttps://doi.org/10.1016/s1470-2045(21)00343-0openalex-snapshot
Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer
inferred← citeshttps://doi.org/10.1016/s1875-5364(22)60174-2openalex-snapshot
Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c07083openalex-snapshot
Viability-Informed Single-Cell Mass Spectrometry for More Comprehensive Metabolic Analysis
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6c00108openalex-snapshot
Tumor-Responsive Delivery of 5-Fluorouracil from a Redox-Triggered Supramolecular Gelator
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c03761openalex-snapshot
QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c01077openalex-snapshot
Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.2c00876openalex-snapshot
Combining β-Carotene with 5-FU via Polymeric Nanoparticles as a Novel Therapeutic Strategy to Overcome uL3-Mediated Chemoresistance in p53-Deleted Colorectal Cancer Cells
inferred← citeshttps://doi.org/10.1021/acsami.3c02883openalex-snapshot
Mitochondria-Targeted Thymidylate Synthase Inhibitor Based on Fluorescent Molecularly Imprinted Polymers for Tumor Antimetabolic Therapy
inferred← citeshttps://doi.org/10.1021/acsami.5c13893openalex-snapshot
MOF-Based Nanoplatform Enables Synergistic Hypoxia-Activated Chemotherapy and Chemodynamic Therapy for Colon Cancer
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.4c00445openalex-snapshot
Exploiting Matrix Stiffness to Overcome Drug Resistance
inferred← citeshttps://doi.org/10.1021/acsnanomed.6c00199openalex-snapshot
Reprogramming the Tumor Microenvironment and Cancer Therapy via Nanocatalytic Medicine
inferred← citeshttps://doi.org/10.1021/acsomega.1c06394openalex-snapshot
Trapping of 5‑Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5‑Fluorouracil
inferred← citeshttps://doi.org/10.1021/acsomega.2c03635openalex-snapshot
Interaction of 5-Fluorouracil on the Surfaces of Pristine and Functionalized Ca12O12 Nanocages: An Intuition from DFT
inferred← citeshttps://doi.org/10.1021/acsomega.5c06817openalex-snapshot
Radiolabeled 5-Fluorouracil-Loaded Solid Lipid Nanoparticles: A Potential Platform for Colorectal Cancer Imaging
inferred← citeshttps://doi.org/10.1021/acsomega.5c10664openalex-snapshot
TPGS and CS-Surface-Modified DPPC Liposomes Coloaded with Docetaxel and 5‑Fluorouracil: A Potential Avenue for Enhanced Colorectal Cancer Therapy
inferred← citeshttps://doi.org/10.1021/jacsau.5c01249openalex-snapshot
Single-Stranded RNA Origami Remodels Macrophage to Promote the Synergistic Antitumor Effect with 5-Fluorouracil in Pancreatic Cancer
inferred← citeshttps://doi.org/10.1038/s41388-021-02029-4openalex-snapshot
Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway
inferred← citeshttps://doi.org/10.1038/s41388-021-02148-yopenalex-snapshot
The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity
inferred← citeshttps://doi.org/10.1038/s41401-023-01136-0openalex-snapshot
Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells
inferred← citeshttps://doi.org/10.1038/s41418-022-01007-xopenalex-snapshot
Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41419-024-06451-wopenalex-snapshot
c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer
inferred← citeshttps://doi.org/10.1038/s41419-024-06690-xopenalex-snapshot
Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies
inferred← citeshttps://doi.org/10.1038/s41419-024-06848-7openalex-snapshot
Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41420-023-01704-7openalex-snapshot
The RioK1 network determines p53 activity at multiple levels
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