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Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cam4.1703openalex-snapshot
Randomized, double‐blind, phase two study of ruxolitinib plus regorafenib in patients with relapsed/refractory metastatic colorectal cancer
inferredcites →https://doi.org/10.1002/ijc.22965openalex-snapshot
Hypoxia upregulates carcinoembryonic antigen expression in cancer cells
inferredcites →https://doi.org/10.1002/ijc.28429openalex-snapshot
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo
inferredcites →https://doi.org/10.1002/ijc.29939openalex-snapshot
CD 90+ stromal cells are the major source of IL ‐6, which supports cancer stem‐like cells and inflammation in colorectal cancer
inferredcites →https://doi.org/10.1002/ijc.31978openalex-snapshot
Upregulation of mtSSB by interleukin‐6 promotes cell growth through mitochondrial biogenesis‐mediated telomerase activation in colorectal cancer
inferredcites →https://doi.org/10.1002/jso.10269openalex-snapshot
Serum interleukin‐6 levels reflect the disease status of colorectal cancer
inferredcites →https://doi.org/10.1007/s00384-010-1060-0openalex-snapshot
Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6–STAT3 signaling pathway
inferredcites →https://doi.org/10.1007/s00595-016-1404-7openalex-snapshot
High serum levels of interleukin-6 in patients with advanced or metastatic colorectal cancer: the effect on the outcome and the response to chemotherapy plus bevacizumab
inferredcites →https://doi.org/10.1007/s10456-019-09688-8openalex-snapshot
Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer
inferredcites →https://doi.org/10.1007/s11033-013-2856-0openalex-snapshot
Transcriptional regulation of the survivin gene
inferredcites →https://doi.org/10.1007/s12272-019-01146-9openalex-snapshot
T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer
inferredcites →https://doi.org/10.1016/j.bbamcr.2017.07.001openalex-snapshot
The shedding protease ADAM17: Physiology and pathophysiology
inferredcites →https://doi.org/10.1016/j.bbrc.2017.01.174openalex-snapshot
Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5
inferredcites →https://doi.org/10.1016/j.canlet.2005.12.003openalex-snapshot
Interleukin-6 level in patients with colorectal cancer
inferredcites →https://doi.org/10.1016/j.canlet.2019.05.017openalex-snapshot
Targeting the tumour immune microenvironment for cancer therapy in human gastrointestinal malignancies
inferredcites →https://doi.org/10.1016/j.cellsig.2014.11.013openalex-snapshot
HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells
inferredcites →https://doi.org/10.1016/j.critrevonc.2013.08.004openalex-snapshot
Interleukin-6: An angiogenic target in solid tumours
inferredcites →https://doi.org/10.1016/j.ctrv.2009.05.003openalex-snapshot
Survivin: A new target for anti-cancer therapy
inferredcites →https://doi.org/10.1016/j.cyto.2016.01.001openalex-snapshot
Colorectal cancer cell-derived interleukin-6 enhances the phagocytic capacity and migration of THP-1 cells
inferredcites →https://doi.org/10.1016/j.cyto.2018.11.023openalex-snapshot
Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage
inferredcites →https://doi.org/10.1016/j.ebiom.2019.09.050openalex-snapshot
Intestinal microbiota and colorectal carcinoma: Implications for pathogenesis, diagnosis, and therapy
inferredcites →https://doi.org/10.1016/j.ejphar.2020.173505openalex-snapshot
Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases
inferredcites →https://doi.org/10.1016/j.it.2014.12.008openalex-snapshot
Versatile functions for IL-6 in metabolism and cancer
inferredcites →https://doi.org/10.1016/j.molonc.2015.02.012openalex-snapshot
Hitting the right spot: Mechanism of action of OPB‐31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)
inferredcites →https://doi.org/10.1016/j.smim.2013.12.003openalex-snapshot
Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development
inferredcites →https://doi.org/10.1016/j.ymthe.2019.05.017openalex-snapshot
Hypoxia Induces Drug Resistance in Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop
inferredcites →https://doi.org/10.1016/s0140-6736(12)61900-xopenalex-snapshot
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
inferredcites →https://doi.org/10.1021/acs.jafc.8b00710openalex-snapshot
Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway
inferredcites →https://doi.org/10.1038/nature11252openalex-snapshot
Comprehensive molecular characterization of human colon and rectal cancer
inferredcites →https://doi.org/10.1038/ni.3153openalex-snapshot
IL-6 as a keystone cytokine in health and disease
inferredcites →https://doi.org/10.1038/nrclinonc.2018.8openalex-snapshot
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
inferredcites →https://doi.org/10.1038/s41388-018-0547-yopenalex-snapshot
Targeting colon cancer with the novel STAT3 inhibitor bruceantinol
inferredcites →https://doi.org/10.1038/s41575-019-0189-8openalex-snapshot
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
inferredcites →https://doi.org/10.1038/sj.onc.1205260openalex-snapshot
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
inferredcites →https://doi.org/10.1038/srep44053openalex-snapshot
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
inferredcites →https://doi.org/10.1042/bst20180136openalex-snapshot
The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
inferredcites →https://doi.org/10.1042/cs20110340openalex-snapshot
IL-6/IL-6 receptor system and its role in physiological and pathological conditions
inferredcites →https://doi.org/10.1074/jbc.ra117.001163openalex-snapshot
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling
inferredcites →https://doi.org/10.1084/jem.189.1.63openalex-snapshot
STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene
inferredcites →https://doi.org/10.1084/jem.20100438openalex-snapshot
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer
inferredcites →https://doi.org/10.1089/rej.2018.2089openalex-snapshot
STAT3/c-Myc Axis-Mediated Metabolism Alternations of Inflammation-Related Glycolysis Involve with Colorectal Carcinogenesis
inferredcites →https://doi.org/10.1093/carcin/bgv017openalex-snapshot
Aberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial–mesenchymal transition
inferredcites →https://doi.org/10.1093/intimm/dxq030openalex-snapshot
IL-6: from its discovery to clinical applications
inferredcites →https://doi.org/10.1093/jnci/djr078openalex-snapshot
C-stage in Colon Cancer: Implications of Carcinoembryonic Antigen Biomarker in Staging, Prognosis, and Management
inferredcites →https://doi.org/10.1097/mib.0000000000000236openalex-snapshot
Cytokines, IBD, and Colitis-associated Cancer
inferredcites →https://doi.org/10.1101/cshperspect.a028456openalex-snapshot
Interleukin (IL-6) Immunotherapy
inferredcites →https://doi.org/10.1101/gad.854900openalex-snapshot
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation
inferredcites →https://doi.org/10.1126/science.8511589openalex-snapshot
IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase
inferredcites →https://doi.org/10.1136/gutjnl-2019-319200openalex-snapshot
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis
inferredcites →https://doi.org/10.1155/2020/8032187openalex-snapshot
Interleukin-6 Promotes Epithelial-Mesenchymal Transition and Cell Invasion through Integrin β 6 Upregulation in Colorectal Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0420openalex-snapshot
Inhibition of Adhesion, Invasion, and Metastasis by Antibodies Targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2203openalex-snapshot
Cyclin D1 Is Transcriptionally Regulated by and Required for Transformation by Activated Signal Transducer and Activator of Transcription 3
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-2200openalex-snapshot
A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors
inferredcites →https://doi.org/10.1159/000227619openalex-snapshot
Overexpression and Amplification of c-myc during Progression of Human Colorectal Cancer
inferredcites →https://doi.org/10.1159/000486816openalex-snapshot
The Role of Tumor-Associated Macrophages in Colorectal Carcinoma Progression
inferredcites →https://doi.org/10.1172/jci81340openalex-snapshot
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
inferredcites →https://doi.org/10.1177/0192623309354110openalex-snapshot
Roles for Inflammation and Regulatory T Cells in Colon Cancer
inferredcites →https://doi.org/10.1177/1533034617742312openalex-snapshot
Phosphorylation of STAT3 Promotes Vasculogenic Mimicry by Inducing Epithelial-to-Mesenchymal Transition in Colorectal Cancer
inferredcites →https://doi.org/10.1177/2040620716653745openalex-snapshot
Review of siltuximab in the treatment of multicentric Castleman’s disease
inferredcites →https://doi.org/10.1182/blood-2002-11-3396openalex-snapshot
Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival
inferredcites →https://doi.org/10.1186/1471-2407-12-418openalex-snapshot
The changes of Th17 cells and the related cytokines in the progression of human colorectal cancers
inferredcites →https://doi.org/10.1186/s12885-015-1950-1openalex-snapshot
Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells
inferredcites →https://doi.org/10.1186/s12943-019-0976-4openalex-snapshot
Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
inferredcites →https://doi.org/10.1186/s13046-019-1314-9openalex-snapshot
Exosomal transfer of p-STAT3 promotes acquired 5-FU resistance in colorectal cancer cells
inferredcites →https://doi.org/10.1186/s40880-019-0368-6openalex-snapshot
Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
inferredcites →https://doi.org/10.1210/en.2004-0959openalex-snapshot
Minireview: Cyclin D1: Normal and Abnormal Functions
inferredcites →https://doi.org/10.1371/journal.pone.0065338openalex-snapshot
Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0094508openalex-snapshot
Prognostic Significance of Cyclin D1 Expression in Colorectal Cancer: A Meta-Analysis of Observational Studies
inferredcites →https://doi.org/10.1371/journal.pone.0139727openalex-snapshot
c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer
inferredcites →https://doi.org/10.1593/neo.07971openalex-snapshot
Inhibition of JAK1, 2/STAT3 Signaling Induces Apoptosis, Cell Cycle Arrest, and Reduces Tumor Cell Invasion in Colorectal Cancer Cells
inferredcites →https://doi.org/10.18632/oncotarget.4334openalex-snapshot
SolubleIL6Rrepresents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop
inferredcites →https://doi.org/10.18632/oncotarget.6454openalex-snapshot
Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival
inferredcites →https://doi.org/10.21147/j.issn.1000-9604.2019.03.11openalex-snapshot
Burden of colorectal cancer in China, 1990−2017: Findings from the Global Burden of Disease Study 2017
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3390/cancers11111681openalex-snapshot
Targeting STAT3 in Cancer with Nucleotide Therapeutics
inferredcites →https://doi.org/10.3390/ijms19010003openalex-snapshot
Telomere Biology and Thoracic Aortic Aneurysm
inferredcites →https://doi.org/10.3390/ijms19030730openalex-snapshot
The Balance of Th17 versus Treg Cells in Autoimmunity
inferredcites →https://doi.org/10.3390/ijms19113528openalex-snapshot
The Two-Faced Cytokine IL-6 in Host Defense and Diseases
inferredcites →https://doi.org/10.3748/wjg.v11.i11.1639openalex-snapshot
Serum IL-6, TNFα and CRP levels in Greek colorectal cancer patients: Prognostic implications
inferredcites →https://doi.org/10.3748/wjg.v23.i10.1780openalex-snapshot
Clinicopathological significance of overexpression of interleukin-6 in colorectal cancer
inferredcites →https://doi.org/10.3748/wjg.v26.i16.1912openalex-snapshot
Interleukin-6 compared to the other Th17/Treg related cytokines in inflammatory bowel disease and colorectal cancer
inferredcites →https://doi.org/10.3892/ijo.2014.2259openalex-snapshot
The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer
inferredcites →https://doi.org/10.3892/ijo.2017.3846openalex-snapshot
Regulation of EMT by STAT3 in gastrointestinal cancer (Review)
inferredcites →https://doi.org/10.4103/1319-3767.80378openalex-snapshot
Clinical relevance of serum vascular endothelial growth factor and Interleukin-6 in patients with colorectal cancer
inferredcites →https://doi.org/10.4143/crt.2014.249openalex-snapshot
Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors
inferredcites →https://doi.org/10.4161/cc.4.2.1413openalex-snapshot
IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer
inferredcites →https://doi.org/10.5306/wjco.v2.i6.272openalex-snapshot
Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
inferredcites →https://doi.org/10.7150/ijbs.4614openalex-snapshot
Interleukin-6 - A Key Regulator of Colorectal Cancer Development
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4658837openalex-extracted
High-Iron Diet Accelerates DSS-Induced Colitis and Promotes AOM/DSS-Induced Colon Carcinogenesis in Mice by Activating Ferroptosis-Mediated NF-κB/IL6-STAT3 Signaling Pathway
inferred← citeshttps://doi.org/10.1002/iid3.70283openalex-snapshot
Investigating the Impact of the Secretome From hAMSCs on HT‐29 Colon Cancer Cells via TNF‐α/TGF‐β/c‐MYC Signaling Pathways Using a Three‐Dimensional Cell Culture Model
inferred← citeshttps://doi.org/10.1002/jat.4961openalex-snapshot
Impact of organic pollutants on phenotype and gene expression in human breast cancer cells
inferred← citeshttps://doi.org/10.1002/jcla.24585openalex-snapshot
The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches
inferred← citeshttps://doi.org/10.1002/jsfa.14100openalex-snapshot
Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies
inferred← citeshttps://doi.org/10.1002/path.5987openalex-snapshot
Inhibition of EZH2 suppresses peritoneal angiogenesis by targeting a VEGFR2 / ERK1 /2/ HIF ‐1α‐dependent signaling pathway
inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_25-1openalex-snapshot
Pro-tumorigenic and Anti-tumorigenic Roles of Pro-inflammatory Cytokines in Cancer
inferred← citeshttps://doi.org/10.1007/978-3-032-00749-0_25openalex-snapshot
Pro-tumorigenic and Anti-tumorigenic Roles of Pro-inflammatory Cytokines in Cancer
inferred← citeshttps://doi.org/10.1007/s00384-024-04748-yopenalex-snapshot
Inflammatory bowel disease, colitis, and cancer: unmasking the chronic inflammation link
inferred← citeshttps://doi.org/10.1007/s00423-024-03451-4openalex-snapshot
Peritoneal infection after colorectal cancer surgery induces substantial alterations in postoperative protein levels: an exploratory study
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An integrative analysis of the single-cell transcriptome identifies DUSP4 as an exhaustion-associated gene in tumor-infiltrating CD8+ T cells
inferred← citeshttps://doi.org/10.1007/s10238-026-02066-xopenalex-snapshot
“Cytokine-Mediated tumor sensitization: mechanistic frameworks and therapeutic opportunities in cancer Immunotherapy”
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Impact of IL-6 and IL-1β Gene Variants on Non-small-cell Lung Cancer Risk in Egyptian Patients
inferred← citeshttps://doi.org/10.1007/s10555-023-10126-xopenalex-snapshot
Resveratrol as sensitizer in colorectal cancer plasticity
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PRL-3 as a metastasis-associated phosphatase in colorectal cancer: Mechanisms and therapeutic strategies
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Oral Microbiota Variation: A Risk Factor for Development and Poor Prognosis of Esophageal Cancer
inferred← citeshttps://doi.org/10.1007/s10620-023-07972-8openalex-snapshot
Role of Interleukins in Inflammation-Mediated Tumor Immune Microenvironment Modulation in Colorectal Cancer Pathogenesis
inferred← citeshttps://doi.org/10.1007/s11030-025-11275-7openalex-snapshot
Discovery of FLF-15 as a novel selective inhibitor of ADAM17 to prevent hepatocellular carcinoma metastasis
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Involvement of CXCL12/CXCR4 axis in colorectal cancer: a mini-review
inferred← citeshttps://doi.org/10.1007/s11033-025-10585-1openalex-snapshot
Synergistic effects and mechanism of recombinant viral vector-mediated STAT1 overexpression and STAT3 silencing on glioma U251 apoptosis
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Resolvin D1 Inhibits IL-6-Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Targeting IL-6/STAT3 Signaling
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Pharmacokinetic studies, molecular docking, and molecular dynamics simulations of phytochemicals from Morus alba: a multi receptor approach for potential therapeutic agents in colorectal cancer
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Interleukin-6 serves as a critical factor in various cancer progression and therapy
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Genetic and transcriptomic alterations underlying aggressiveness in 5-fluorouracil-resistant HCT116 cells
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Deciphering the metabolic landscape of colorectal cancer through the lens of AhR-mediated intestinal inflammation
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Crosstalk between visceral adipose tissue secretome and tumoral microenvironment in obesity-induced colorectal cancer
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Semisynthetic and amylase-treated Taraxacum officinale galactans: Combat colorectal cancer with cytokine modifier response
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Deciphering the colorectal tumor microenvironment: Interactions and targets for effective therapy
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In-situ synthesized V2CTx MXene-based immune tag for the electrochemical detection of Interleukin 6 (IL-6) from breast cancer cells
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Bisphenol A interacts with DLGAP5 and regulates IL-6/JAK2/STAT3 signaling pathway to promote tumorigenesis and progression of osteosarcoma
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Curcumin scaffold to dual NF-κB/STAT3 modulators: advancing strategies against chemotherapy-resistant colorectal cancer
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Atrazine-induced carcinogenesis in colorectal cancer: Core gene identification, immune cell infiltration, and cellular validation experiments
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Targeting STAT3 pathway: A promising immunotherapeutic strategy for triple-negative breast cancer – Current status and future outlooks
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Prognostic significance of imaging features of peritumoral adipose tissue in FDG PET/CT of patients with colorectal cancer
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STAT3 as a newly emerging target in colorectal cancer therapy: Tumorigenesis, therapy response, and pharmacological/nanoplatform strategies
inferred← citeshttps://doi.org/10.1016/j.etap.2022.103943openalex-snapshot
Effect of Diacerein on HOTAIR/IL-6/STAT3, Wnt/β-Catenin and TLR-4/NF-κB/TNF-α axes in colon carcinogenesis
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Identification of SRC, AKT1 and MAPK3 as therapeutic targets of apigenin and luteolin in colorectal and colon carcinoma through network pharmacology
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Novel ulvan oligosaccharide derived from the Ulva pertusa alleviates ulcerative colitis by modulating inflammatory responses and tight junction integrity
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Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?
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Gut microbiota regulation of the IL-6/STAT3 pathway: Linking hematopoiesis to colorectal cancer progression
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FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in colorectal cancer
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Synthesis, theoretical investigation, and anti-proliferative assessment of novel fused heterocyclic cellulosic derivatives in colorectal Caco-2 cells via suppressing the IL6/STAT3 pathway
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Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the development of colorectal cancer with an involvement of the STAT3 signaling
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STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response
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STAT3 signaling in pancreatic ductal adenocarcinoma: a candidate therapeutic target
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Exploring the molecular pathways of advanced rectal cancer: A focus on genetic, RNA, and biological technique
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Serum IL-6 level is associated with clinical outcome of intravesical gemcitabine therapy in T1 non-muscle–invasive bladder cancer
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Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme
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Synthesis of Lasalocid-Based Bioconjugates and Evaluation of Their Anticancer Activity
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Exploring Phosphatase and Tensin Homologue Deleted on Chromosome Ten (PTEN) as a Potential Therapeutic Target for Cardiac Hypertrophy
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UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling
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Processed dietary fiber partially hydrolyzed guar gum increases susceptibility to colitis and colon tumorigenesis in mice
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Molecular profiling and bioinformatics validation of CEACAM6, HOXA-AS3 and miR29a in colorectal cancer
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Effects of Exercise-Induced Changes in Myokine Expression on the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1055/s-0042-1749436openalex-snapshot
Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma
inferred← citeshttps://doi.org/10.1080/01635581.2025.2551294openalex-snapshot
Rauvolfia Verticillata Pectic Polysaccharides Alleviate Inflammation-Associated Colorectal Cancer and Correlate with Modulation of Gut Microbiota, Short-Chain Fatty Acid Metabolism, and NF-κB/IL-6/STAT3 Signaling Pathways
inferred← citeshttps://doi.org/10.1080/21655979.2022.2054910openalex-snapshot
Long noncoding RNA regulatory factor X3- antisense RNA 1 promotes non-small cell lung cancer via the microRNA-577/signal transducer and activator of transcription 3 axis
inferred← citeshttps://doi.org/10.1093/carcin/bgaf068openalex-snapshot
Functional significance of the aryl hydrocarbon receptor in oncogenic signaling pathways
inferred← citeshttps://doi.org/10.1097/md.0000000000035452openalex-snapshot
NIFK as a potential prognostic biomarker in colorectal cancer correlating with immune infiltrates
inferred← citeshttps://doi.org/10.1101/2022.01.24.477593openalex-snapshot
Genomic analyses identify significant molecules and biological processes in colorectal cancer cells with DNA damage
inferred← citeshttps://doi.org/10.1101/2024.06.25.600311openalex-snapshot
TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype
inferred← citeshttps://doi.org/10.1111/obr.70070openalex-snapshot
The Role of Chinese Medicine as a Complementary Therapy in the Management of Obesity‐Associated Colorectal Cancer
inferred← citeshttps://doi.org/10.1155/2021/7605057openalex-snapshot
Immunological Differences in Human Peripheral Blood Mononuclear Cells Treated with Traditional Japanese Herbal Medicines Hochuekkito, Juzentaihoto, and Ninjin’yoeito from Different Pharmaceutical Companies
inferred← citeshttps://doi.org/10.1155/2022/7494887openalex-snapshot
Study on the Mechanism of Diosgenin Targeting STAT3 to Inhibit Colon Cancer Proliferation and Migration
inferred← citeshttps://doi.org/10.1155/2022/9311684openalex-snapshot
Clinicopathological Significance of STAT3 and p-STAT3 among 91 Patients with Adenocarcinoma of the Esophagogastric Junction
inferred← citeshttps://doi.org/10.1177/20587384211038345openalex-snapshot
Pro-protein convertase subtilisin/kexin type 9 promotes intestinal tumor development by activating Janus kinase 2/signal transducer and activator of transcription 3/SOCS3 signaling in Apc Min/+ mice
inferred← citeshttps://doi.org/10.1186/s11658-025-00742-6openalex-snapshot
IL-6-induced long noncoding RNA MIR3142HG promotes tumorigenesis by interacting with thioredoxin-1 and STAT3 in human colorectal cancer
inferred← citeshttps://doi.org/10.1186/s12935-021-01982-0openalex-snapshot
Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.1186/s13046-023-02754-6openalex-snapshot
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
inferred← citeshttps://doi.org/10.12677/acm.2023.13122895openalex-snapshot
Research Progress in the Application of Visceral Fat in Gastric Cancer
inferred← citeshttps://doi.org/10.12677/acrem.2026.142033openalex-snapshot
Research Progress on Vaginal Microecology, Inflammatory Factors and Cervical Lesions
inferred← citeshttps://doi.org/10.21037/jgo-22-507openalex-snapshot
Luteolin suppresses the growth of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2473762/v1openalex-snapshot
POLR2J is a potential biomarker for abnormal tumor progression, vorinostat sensitization, immune infiltration, and prognosis of glioblastoma multiform
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3000298/v1openalex-snapshot
Elevated Serum Interleukin-6 Levels Lead to Poorer Treatment Outcomes in Patients with Metastatic Colorectal Cancer, a Pathway That Can Be Interrupted by Bevacizumab
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3374207/v1openalex-snapshot
Transcriptomic analysis of differentially expressed genes in the Winnie mouse model of chronic colitis
inferred← citeshttps://doi.org/10.2174/1386207326666230818092532openalex-snapshot
Overexpression of SOCS2 Inhibits EMT and M2 Macrophage Polarization in Cervical Cancer via IL-6/JAK2/STAT3 Pathway
inferred← citeshttps://doi.org/10.2478/amb-2024-0022openalex-snapshot
New approach in Understanding Colorectal Cancer Immunosuppression and Immunotherapy-Based Strategies in the Treatment of Microsatellite Stable Colorectal Cancer
inferred← citeshttps://doi.org/10.25236/fmsr.2023.051102openalex-snapshot
Serum Interleukin-6 Levels Correlate with the Efficacy of Antiangiogenic Therapy in Metastatic Colorectal Cancer
inferred← citeshttps://doi.org/10.25259/ajc_123_2024openalex-snapshot
La0.6Sr0.4Co0.2Fe0.8O3-∝ (LSCF) biosensor for diagnosing colorectal cancer: A quaternary alloy on an interdigitated electrode
inferred← citeshttps://doi.org/10.30683/1929-2279.2024.13.05openalex-snapshot
Potential of Pre-Operative Serum Interleukin-6 as a Biomarker for Colorectal Cancers
inferred← citeshttps://doi.org/10.32604/biocell.2024.051318openalex-snapshot
Modulatory role of plant-derived metabolites on host-microbiota interactions: personalized therapeutics outlook
inferred← citeshttps://doi.org/10.3389/fendo.2026.1838186openalex-snapshot
Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1057181openalex-snapshot
Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications
inferred← citeshttps://doi.org/10.3389/fimmu.2022.851004openalex-snapshot
The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1497919openalex-snapshot
Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1601423openalex-snapshot
Fusobacterium-associated molecular and immunological alterations in colorectal cancer: Insights from a Norwegian cohort
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1760631openalex-snapshot
P62 in colorectal cancer: from inflammation suppression to cancer promotion
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1775236openalex-snapshot
Occupational silica exposure drives systemic immune dysregulation and tumor microenvironment susceptibility: evidence from a real-world study
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1848654openalex-snapshot
Integrative single-cell analysis reveals TRIM31+ colorectal tumor cells orchestrating macrophage crosstalk within the cancer-immunity regulome
inferred← citeshttps://doi.org/10.3389/fmicb.2022.932047openalex-snapshot
The negative effect of Akkermansia muciniphila-mediated post-antibiotic reconstitution of the gut microbiota on the development of colitis-associated colorectal cancer in mice
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1795882openalex-snapshot
Microbial dysbiosis drives colorectal carcinogenesis via integrated inflammatory, metabolic, and biofilm pathways
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1168298openalex-snapshot
Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
inferred← citeshttps://doi.org/10.3389/fonc.2022.852927openalex-snapshot
Molecular Network of Colorectal Cancer and Current Therapeutic Options
inferred← citeshttps://doi.org/10.3389/fonc.2025.1606286openalex-snapshot
Renal dysfunction as a predictor of recurrence and prognosis in colorectal cancer
inferred← citeshttps://doi.org/10.3389/fonc.2026.1882054openalex-snapshot
Network pharmacology and experimental evidence of the anti-colorectal cancer potential of Xian Lian Jie Du formula: quercetin, kaempferol and luteolin jointly inhibit the HIF1A/IL6/TNF oncogenic pathway
inferred← citeshttps://doi.org/10.3389/fphar.2021.656697openalex-snapshot
Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway
inferred← citeshttps://doi.org/10.3390/antiox13040406openalex-snapshot
Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells
inferred← citeshttps://doi.org/10.3390/antiox13070815openalex-snapshot
Synergistic Mechanisms of Selected Polyphenols in Overcoming Chemoresistance and Enhancing Chemosensitivity in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/app14072930openalex-snapshot
Characteristics of the Colorectal Cancer Microenvironment—Role in Cancer Progression and Therapeutic Possibilities
inferred← citeshttps://doi.org/10.3390/biom12091267openalex-snapshot
Amaryllidaceae Alkaloids Decrease the Proliferation, Invasion, and Secretion of Clinically Relevant Cytokines by Cultured Human Colon Cancer Cells
inferred← citeshttps://doi.org/10.3390/biom12101463openalex-snapshot
Lung Organoids in Smoking Research: Current Advances and Future Promises
inferred← citeshttps://doi.org/10.3390/biomedicines10071670openalex-snapshot
The Role of Inflammatory Cytokines in the Pathogenesis of Colorectal Carcinoma—Recent Findings and Review
inferred← citeshttps://doi.org/10.3390/biomedicines11061773openalex-snapshot
The Effect of Radiotherapy on Cell Survival and Inflammatory Cytokine and Chemokine Secretion in a Co-Culture Model of Head and Neck Squamous Cell Carcinoma and Normal Cells
inferred← citeshttps://doi.org/10.3390/cancers13184720openalex-snapshot
The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis
inferred← citeshttps://doi.org/10.3390/cancers14061393openalex-snapshot
Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells
inferred← citeshttps://doi.org/10.3390/cancers14215350openalex-snapshot
The Role of Fusobacterium nucleatum in Colorectal Cancer Cell Proliferation and Migration
inferred← citeshttps://doi.org/10.3390/cancers15225359openalex-snapshot
Colorectal Liver Metastasis: Can Cytokines Make the Difference?
inferred← citeshttps://doi.org/10.3390/cancers16213588openalex-snapshot
A New IL-6-Inducing Mechanism in Cancer with New Therapeutic Possibilities
inferred← citeshttps://doi.org/10.3390/cancers17020219openalex-snapshot
Alternative Splicing at the Crossroad of Inflammatory Bowel Diseases and Colitis-Associated Colon Cancer
inferred← citeshttps://doi.org/10.3390/cancers18162569openalex-snapshot
Cancer Stem Cells in Colorectal Cancer: From Molecular Mechanisms to Diagnosis, Prognosis and Therapy Implications
inferred← citeshttps://doi.org/10.3390/cells12010138openalex-snapshot
The Cytokine Network in Colorectal Cancer: Implications for New Treatment Strategies
inferred← citeshttps://doi.org/10.3390/cells12060861openalex-snapshot
B7H4 Expression Is More Frequent in MSS Status Colorectal Cancer and Is Negatively Associated with Tumour Infiltrating Lymphocytes
inferred← citeshttps://doi.org/10.3390/cells13201730openalex-snapshot
Molecular Mechanisms of Skatole-Induced Inflammatory Responses in Intestinal Epithelial Caco-2 Cells: Implications for Colorectal Cancer and Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.3390/diseases9040079openalex-snapshot
Exploring the Inflammatory Pathogenesis of Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/gastroent16010006openalex-snapshot
Correlation Between Interleukin IL-6/IL-6 Receptor Polymorphisms (IL6–174C>G and IL6R 1073A>C) and RAS/BRAF Mutations in Patients with Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/ijms232113277openalex-snapshot
PD-L1 Expression in High-Risk Early-Stage Colorectal Cancer—Its Clinical and Biological Significance in Immune Microenvironment
inferred← citeshttps://doi.org/10.3390/ijms24043683openalex-snapshot
The Ketogenic Diet in Colorectal Cancer: A Means to an End
inferred← citeshttps://doi.org/10.3390/ijms24119524openalex-snapshot
Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway
inferred← citeshttps://doi.org/10.3390/ijms241813764openalex-snapshot
Exploring the JAK/STAT Signaling Pathway in Hepatocellular Carcinoma: Unraveling Signaling Complexity and Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/ijms25105166openalex-snapshot
The Role of Wheatgrass in Colorectal Cancer: A Review of the Current Evidence
inferred← citeshttps://doi.org/10.3390/ijms25126777openalex-snapshot
The Development of an Isotope Dilution Mass Spectrometry Method for Interleukin-6 Quantification
inferred← citeshttps://doi.org/10.3390/ijms26157247openalex-snapshot
Immunomodulatory Natural Products in Cancer Organoid-Immune Co-Cultures: Bridging the Research Gap for Precision Immunotherapy
inferred← citeshttps://doi.org/10.3390/ijms27093874openalex-snapshot
Network Pharmacology and Molecular Docking-Based Approach Revealing the Potential Anticancer Compounds and Molecular Mechanisms of Paris polyphylla Against Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/jcm12093127openalex-snapshot
Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring
inferred← citeshttps://doi.org/10.3390/membranes11050312openalex-snapshot
A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer
inferred← citeshttps://doi.org/10.3390/molecules28176354openalex-snapshot
Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production
inferred← citeshttps://doi.org/10.3390/nu16234048openalex-snapshot
Bondarzewia dickinsii Against Colitis-Associated Cancer Through the Suppression of the PI3K/AKT/COX-2 Pathway and Inhibition of PGE2 Production in Mice
inferred← citeshttps://doi.org/10.3390/scipharm90030040openalex-snapshot
Colorectal Cancer Chemoprevention by S-Allyl Cysteine–Caffeic Acid Hybrids: In Vitro Biological Activity and In Silico Studies
inferred← citeshttps://doi.org/10.34172/bi.2022.24209openalex-snapshot
Combination of pioglitazone and dendritic cell to optimize efficacy of immune cell therapy in CT26 tumor models
inferred← citeshttps://doi.org/10.3892/ijo.2024.5673openalex-snapshot
Myeloid‑derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in colorectal cancer (Review)
inferred← citeshttps://doi.org/10.4240/wjgs.v17.i10.111454openalex-snapshot
Reduction in the hepatocellular carcinoma antioncogene SLC39A14 during the malignant progression of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676764openalex-snapshot
Additional file 1 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676767openalex-snapshot
Additional file 2 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676770openalex-snapshot
Additional file 3 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676773openalex-snapshot
Additional file 4 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676776openalex-snapshot
Additional file 5 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676779openalex-snapshot
Additional file 6 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676782openalex-snapshot
Additional file 7 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.14676785openalex-snapshot
Additional file 8 of Identification of collagen genes related to immune infiltration and epithelial-mesenchymal transition in glioma
inferred← citeshttps://doi.org/10.6084/m9.figshare.23700767openalex-snapshot
Additional file 1 of Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
inferred← citeshttps://doi.org/10.6084/m9.figshare.23700779openalex-snapshot
Additional file 2 of Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
inferred← citeshttps://doi.org/10.62347/jewm7691openalex-snapshot
POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway
inferred← citeshttps://doi.org/10.64898/2026.07.01.26357015openalex-snapshot
A Robust Cell-Free RNA Approach for the Early Detection of Colorectal Cancer
inferred← citeshttps://doi.org/10.70675/4c8cef97z8e4fz4245z8588z8d740f2b17feopenalex-snapshot
Rôles du NAD dans la plasticité cellulaire cancéreuse
inferred← citeshttps://doi.org/10.7150/thno.65411openalex-snapshot
HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment
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