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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

https://doi.org/10.1016/j.ejmech.2020.112754
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Quercetin 3‐rhamnoside Exerts Antiinfluenza A Virus Activity in Mice
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A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C
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Nature nominee quercetin's anti‐influenza combat strategy—Demonstrations and remonstrations
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Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression
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The Effects of Flavonoids on Bone
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Quercetin in a lotus leaves extract may be responsible for antibacterial activity
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In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
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Antivirals targeting the polymerase complex of influenza viruses
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Oxidation products of quercetin catalyzed by mushroom tyrosinase
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Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities
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Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities
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Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase
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Hydrolytic cleavage of DNA by quercetin manganese(II) complexes
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Antiviral therapies on the horizon for influenza
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Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy
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Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease
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Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication
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Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections—A review
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Life or death: Neuroprotective and anticancer effects of quercetin
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Antioxidant and anti-inflammatory activities of quercetin and its derivatives
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Flavonoids and age-related disease: Risk, benefits and critical windows
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Efecto de los flavonoides en la prevención del cáncer de pulmón: revisión sistemática
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Copper(II)–Quercetin complexes in aqueous solutions: spectroscopic and kinetic properties
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Probing the impact of quercetin-7-O-glucoside on influenza virus replication influence
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Baloxavir heralds a new era in influenza virus biology
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In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1
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Synthesis, characterization and study of antioxidant activity of quercetin–magnesium complex
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Sa1467 - Anticancer Effects of Quercetin on Cholangiocarcinoma
inferredcites →https://doi.org/10.1016/s0223-5234(99)80087-7openalex-snapshot
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)
inferredcites →https://doi.org/10.1021/acs.jafc.6b00148openalex-snapshot
Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression
inferredcites →https://doi.org/10.1021/acs.jctc.7b00365openalex-snapshot
Accurate DFT-D3 Calculations in a Small Basis Set
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b01227openalex-snapshot
Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives
inferredcites →https://doi.org/10.1021/cb200439zopenalex-snapshot
Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay
inferredcites →https://doi.org/10.1021/ct7001418openalex-snapshot
Self-Consistent Reaction Field Model for Aqueous and Nonaqueous Solutions Based on Accurate Polarized Partial Charges
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A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model
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UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations
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Flavonoid Content of U.S. Fruits, Vegetables, and Nuts
inferredcites →https://doi.org/10.1021/jm049876xopenalex-snapshot
Antimitotic Activity of 5-Hydroxy-7-methoxy-2-phenyl-4-quinolones
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Aqueous Solvation Free Energies of Ions and Ion−Water Clusters Based on an Accurate Value for the Absolute Aqueous Solvation Free Energy of the Proton
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Metal complexes of the flavonoid quercetin: antibacterial properties
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Antioxidative and anti-tumour activities of solid quercetin metal(II) complexes
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The war against influenza: discovery and development of sialidase inhibitors
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Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
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Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine
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N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
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Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase
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Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer
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Evaluation of a quercetin–gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging
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COSMO: a new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient
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DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors
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Mild Selective Hydrolysis of the Methyl Esters of someortho-Substituted Aromatic Carboxylic Acids
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HIV Reverse Transcriptase Inhibitors of Natural Origin
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Anti-Influenza Virus Activities of Flavonoids from the Medicinal PlantElsholtzia rugulosa
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Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents
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Dietary Flavonoids as Cancer Prevention Agents
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DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening
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Influenza virus polymerase inhibitors in clinical development
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MOLREP : an Automated Program for Molecular Replacement
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Coot : model-building tools for molecular graphics
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MolProbity : all-atom structure validation for macromolecular crystallography
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XDS
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Integration, scaling, space-group assignment and post-refinement
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Overview of the CCP 4 suite and current developments
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REFMAC 5 for the refinement of macromolecular crystal structures
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An Integrated Biological Approach to Guide the Development of Metal-Chelating Inhibitors of Influenza Virus PA Endonuclease
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Quercetin reduces susceptibility to influenza infection following stressful exercise
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The Quenching Effect of Flavonoids on 4-Methylumbelliferone, a Potential Pitfall in Fluorimetric Neuraminidase Inhibition Assays
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Novel One-pot Synthesis of Polysubstituted Isocoumarins from Arynes and Trifluoroacetylated β-Diketones
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Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
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Recent progress and challenges in the discovery of new neuraminidase inhibitors
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Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism
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Flavonoids and Cancer Prevention: What Is the Evidence in Humans?
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The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice
inferredcites →https://doi.org/10.3390/molecules16032032openalex-snapshot
Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications
inferredcites →https://doi.org/10.3390/molecules20046978openalex-snapshot
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inferredcites →https://doi.org/10.3390/molecules20058583openalex-snapshot
Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry
inferredcites →https://doi.org/10.3390/nu8030167openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones
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Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites
inferred← citeshttps://doi.org/10.3390/ph18030350openalex-snapshot
Exploiting the Anticancer, Antimicrobial and Antiviral Potential of Naphthoquinone Derivatives: Recent Advances and Future Prospects
inferred← citeshttps://doi.org/10.51248/.v41i1.524openalex-snapshot
Chemical properties of polyphenols: a reviewfocusedonanti-inflammatory and anti-viral medical application
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