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Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2021.1335openalex-snapshot
Association of NO 2 and Other Air Pollution Exposures With the Risk of Parkinson Disease
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Transposable elements as new players in neurodegenerative diseases
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The VPS35 gene and Parkinson's disease
inferredcites →https://doi.org/10.1002/mds.26069openalex-snapshot
Gut microbiota are related to Parkinson's disease and clinical phenotype
inferredcites →https://doi.org/10.1002/mds.27019openalex-snapshot
Dysregulation of the causative genes for hereditary parkinsonism in the midbrain in Parkinson's disease
inferredcites →https://doi.org/10.1002/mds.28143openalex-snapshot
MicroRNA Deregulation in Blood Serum Identifies Multiple System Atrophy Altered Pathways
inferredcites →https://doi.org/10.1002/mds.28922openalex-snapshot
Air Pollution and the Risk of Parkinson's Disease: A Review
inferredcites →https://doi.org/10.1002/med.21714openalex-snapshot
Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson's disease
inferredcites →https://doi.org/10.1002/ptr.6663openalex-snapshot
Molecular mechanism of curcumin action in signaling pathways: Review of the latest research
inferredcites →https://doi.org/10.1007/s00018-014-1771-4openalex-snapshot
Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
inferredcites →https://doi.org/10.1007/s00109-021-02071-5openalex-snapshot
Nrf2 as a potential target for Parkinson’s disease therapy
inferredcites →https://doi.org/10.1007/s10571-020-00844-zopenalex-snapshot
Physiological Concentration of H2O2 Supports Dopamine Neuronal Survival via Activation of Nrf2 Signaling in Glial Cells
inferredcites →https://doi.org/10.1007/s11011-021-00879-1openalex-snapshot
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson’s disease
inferredcites →https://doi.org/10.1007/s12035-021-02408-8openalex-snapshot
The Intersection of Parkinson’s Disease, Viral Infections, and COVID-19
inferredcites →https://doi.org/10.1016/0304-3940(94)90684-xopenalex-snapshot
Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
inferredcites →https://doi.org/10.1016/j.arr.2018.06.003openalex-snapshot
Nrf2: Molecular and epigenetic regulation during aging
inferredcites →https://doi.org/10.1016/j.autrev.2016.07.022openalex-snapshot
Parkinson's disease: Autoimmunity and neuroinflammation
inferredcites →https://doi.org/10.1016/j.autrev.2016.09.027openalex-snapshot
Corrigendum to “Parkinson's disease: Autoimmunity and neuroinflammation” [Autoimmun Rev 15 (10) (2016) 1005–1011]
inferredcites →https://doi.org/10.1016/j.autrev.2020.102684openalex-snapshot
Parkinson's disease is an autoimmune disease: A reappraisal
inferredcites →https://doi.org/10.1016/j.bbrc.2011.03.046openalex-snapshot
A novel strategy to activate cytoprotective genes in the injured brain
inferredcites →https://doi.org/10.1016/j.biocel.2013.02.012openalex-snapshot
Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity
inferredcites →https://doi.org/10.1016/j.carbpol.2017.12.022openalex-snapshot
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.ejmech.2017.04.008openalex-snapshot
Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death
inferredcites →https://doi.org/10.1016/j.ejmech.2017.10.052openalex-snapshot
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency
inferredcites →https://doi.org/10.1016/j.ejmech.2019.111862openalex-snapshot
Reasonably activating Nrf2: A long-term, effective and controllable strategy for neurodegenerative diseases
inferredcites →https://doi.org/10.1016/j.expneurol.2020.113247openalex-snapshot
Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic neurodegeneration
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2015.05.034openalex-snapshot
Structural basis of Keap1 interactions with Nrf2
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.02.014openalex-snapshot
The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.06.001openalex-snapshot
Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2020.11.019openalex-snapshot
Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice
inferredcites →https://doi.org/10.1016/j.jns.2017.08.3251openalex-snapshot
Neuroinflammation - A major cause for striatal dopaminergic degeneration in Parkinson's disease
inferredcites →https://doi.org/10.1016/j.jnutbio.2017.09.016openalex-snapshot
Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice
inferredcites →https://doi.org/10.1016/j.jnutbio.2022.108975openalex-snapshot
6-Gingerol exerts a protective effect against hypoxic injury through the p38/Nrf2/HO-1 and p38/NF-κB pathway in H9c2 cells
inferredcites →https://doi.org/10.1016/j.lpm.2017.01.001openalex-snapshot
Epidemiology, environmental risk factors and genetics of Parkinson's disease
inferredcites →https://doi.org/10.1016/j.mito.2019.09.010openalex-snapshot
Emerging concepts of mitochondrial dysfunction in Parkinson’s disease progression: Pathogenic and therapeutic implications
inferredcites →https://doi.org/10.1016/j.nbd.2019.05.012openalex-snapshot
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils
inferredcites →https://doi.org/10.1016/j.nbd.2020.104741openalex-snapshot
Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis
inferredcites →https://doi.org/10.1016/j.neuint.2021.105014openalex-snapshot
Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson's disease: The therapeutic role of Nrf2 activators
inferredcites →https://doi.org/10.1016/j.neuro.2019.07.007openalex-snapshot
The role of zinc, copper, manganese and iron in neurodegenerative diseases
inferredcites →https://doi.org/10.1016/j.pharmthera.2020.107523openalex-snapshot
Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders
inferredcites →https://doi.org/10.1016/j.pharmthera.2021.107989openalex-snapshot
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases
inferredcites →https://doi.org/10.1016/j.vph.2015.03.005openalex-snapshot
The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b01133openalex-snapshot
Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b01527openalex-snapshot
Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson’s Disease Therapy
inferredcites →https://doi.org/10.1021/acschembio.0c00104openalex-snapshot
Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation
inferredcites →https://doi.org/10.1021/acschembio.1c00810openalex-snapshot
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2
inferredcites →https://doi.org/10.1021/acsmedchemlett.9b00163openalex-snapshot
Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator
inferredcites →https://doi.org/10.1038/ncomms14329openalex-snapshot
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome
inferredcites →https://doi.org/10.1038/nrm2256openalex-snapshot
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
inferredcites →https://doi.org/10.1038/s41418-017-0012-4openalex-snapshot
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
inferredcites →https://doi.org/10.1038/s41418-020-0542-zopenalex-snapshot
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
inferredcites →https://doi.org/10.1038/s41556-017-0022-yopenalex-snapshot
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
inferredcites →https://doi.org/10.1038/s41580-020-00324-8openalex-snapshot
Ferroptosis: mechanisms, biology and role in disease
inferredcites →https://doi.org/10.1039/c3md00240copenalex-snapshot
Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening
inferredcites →https://doi.org/10.1073/pnas.1721136115openalex-snapshot
Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models
inferredcites →https://doi.org/10.1074/jbc.x120.015651openalex-snapshot
Findings in redox biology: From H2O2 to oxidative stress
inferredcites →https://doi.org/10.1089/ars.2011.4429openalex-snapshot
Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein
inferredcites →https://doi.org/10.1093/hmg/ddw068openalex-snapshot
Lovastatin protects neurite degeneration inLRRK2-G2019Sparkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity
inferredcites →https://doi.org/10.1093/nar/gks409openalex-snapshot
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
inferredcites →https://doi.org/10.1111/acel.12587openalex-snapshot
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
inferredcites →https://doi.org/10.1146/annurev-neuro-100720-034518openalex-snapshot
Parkinson's Disease Genetics and Pathophysiology
inferredcites →https://doi.org/10.1152/physrev.00044.2005openalex-snapshot
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
inferredcites →https://doi.org/10.1177/1039856216654393openalex-snapshot
Neuropsychiatric manifestations of Parkinson’s disease
inferredcites →https://doi.org/10.1196/annals.1306.017openalex-snapshot
The Relevance of Iron in the Pathogenesis of Parkinson's Disease
inferredcites →https://doi.org/10.1515/bc.2006.164openalex-snapshot
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
inferredcites →https://doi.org/10.2147/jir.s301531openalex-snapshot
LRRK2-NFATc2 Pathway Associated with Neuroinflammation May Be a Potential Therapeutic Target for Parkinson’s Disease
inferredcites →https://doi.org/10.2174/0929867325666181009161048openalex-snapshot
Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease
inferredcites →https://doi.org/10.3233/jpd-140491openalex-snapshot
Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease
inferredcites →https://doi.org/10.3233/jpd-202184openalex-snapshot
Parkinson’s Disease Drug Development Since 1999: A Story of Repurposing and Relative Success
inferredcites →https://doi.org/10.3389/fneur.2020.00395openalex-snapshot
Clinical and Imaging Markers of Prodromal Parkinson's Disease
inferredcites →https://doi.org/10.3389/fnins.2020.00267openalex-snapshot
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/antiox10111649openalex-snapshot
NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
inferredcites →https://doi.org/10.3390/antiox9070597openalex-snapshot
The Role of Oxidative Stress in Parkinson’s Disease
inferredcites →https://doi.org/10.3390/antiox9070630openalex-snapshot
Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/cancers12103023openalex-snapshot
Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer
inferredcites →https://doi.org/10.3390/cells8040364openalex-snapshot
GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches
inferredcites →https://doi.org/10.3390/genes12111840openalex-snapshot
Gene Therapeutic Approaches for the Treatment of Mitochondrial Dysfunction in Parkinson’s Disease
inferredcites →https://doi.org/10.3390/ijms22147630openalex-snapshot
Parkinson’s Disease-Related Genes and Lipid Alteration
inferredcites →https://doi.org/10.3390/ijms22179592openalex-snapshot
An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases
inferredcites →https://doi.org/10.3390/molecules25225474openalex-snapshot
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
inferredcites →https://doi.org/10.4103/1673-5374.300980openalex-snapshot
Oxidative stress factors in Parkinson’s disease
inferredcites →https://doi.org/10.4155/fmc.09.140openalex-snapshot
Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4743925openalex-extracted
Inhibiting Nrf2 Expression Exacerbates Nlrp3 Inflammasome Activation and Dopamine Neuron Degeneration in Parkinson's Disease Models
inferred← citeshttps://doi.org/10.1002/9781394249190.ch16openalex-snapshot
Rational Design of Drugs for Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.1002/ca.70057openalex-snapshot
Programmed Cell Death and Its Therapeutic Implications in Parkinson's Disease: A Review of Apoptosis, Autophagy, Ferroptosis, and Necroptosis
inferred← citeshttps://doi.org/10.1002/jbt.23714openalex-snapshot
Vincamine alleviates brain injury by attenuating neuroinflammation and oxidative damage in a mouse model of Parkinson's disease through the NF‐κB and Nrf2/HO‐1 signaling pathways
inferred← citeshttps://doi.org/10.1007/s00204-023-03660-8openalex-snapshot
Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases
inferred← citeshttps://doi.org/10.1007/s10528-026-11415-0openalex-snapshot
Exercise-Driven NRF2 Activation as a Systemic Neuroprotective Strategy: Integrating Redox Biology, Muscle–Brain Crosstalk, and Therapeutic Targeting in Neurodegeneration
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Co-treatment Strategy Supports Neuroprotection by Intersecting p62-Keap1-NRF2 and Autophagy Signaling Pathways in the Cellular Model of Parkinson's Disease
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inferred← citeshttps://doi.org/10.1007/s11011-023-01214-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11011-024-01452-2openalex-snapshot
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
inferred← citeshttps://doi.org/10.1007/s11064-025-04438-3openalex-snapshot
Possible Mitigating Effect of Nobiletin on Rotenone–Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy
inferred← citeshttps://doi.org/10.1007/s11064-026-04854-zopenalex-snapshot
PARK7/HSPB1-Mediated Neuroprotective Effects of SHED in an In vitro Parkinson’s Disease Model
inferred← citeshttps://doi.org/10.1007/s12035-025-05389-0openalex-snapshot
Nrf2–Keap1 Pathway and NLRP3 Inflammasome in Parkinson’s Disease: Mechanistic Crosstalk and Therapeutic Implications
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The Diet–Multiple Sclerosis Connection: Oxidative Stress and Emerging Mechanisms
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inferred← citeshttps://doi.org/10.1016/j.arr.2023.101915openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.arr.2024.102299openalex-snapshot
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Acupoint stimulation by microneedle alleviates motor dysfunction through modulating striatal dopamine and choline levels and reducing neuroinflammation in the Parkinson's disease mouse model
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inferred← citeshttps://doi.org/10.1016/j.neulet.2022.136997openalex-snapshot
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Lutein inhibits ferroptosis and reduces neuronal cell death induced by Parkinson's disease through the NRF2-HMOX2 signaling axis
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The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease
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Targeting the NRF2 pathway for disease modification in neurodegenerative diseases: mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.3390/antiox11112089openalex-snapshot
Neuroprotective Capability of Narcissoside in 6-OHDA-Exposed Parkinson’s Disease Models through Enhancing the MiR200a/Nrf-2/GSH Axis and Mediating MAPK/Akt Associated Signaling Pathway
inferred← citeshttps://doi.org/10.3390/antiox12030673openalex-snapshot
A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies
inferred← citeshttps://doi.org/10.3390/antiox14050554openalex-snapshot
Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/antiox15020187openalex-snapshot
Sources of Oxidative Stress in Parkinson’s Disease: Pathways and Therapeutic Implications
inferred← citeshttps://doi.org/10.3390/cells12192336openalex-snapshot
Astrocytes in Parkinson’s Disease: From Role to Possible Intervention
inferred← citeshttps://doi.org/10.3390/fermentation12050211openalex-snapshot
Nutraceutical Potential of Fermented Foods: A Perspective on Health and Wellness
inferred← citeshttps://doi.org/10.3390/ijms251910484openalex-snapshot
Hypoxia Pathways in Parkinson’s Disease: From Pathogenesis to Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/ijms262211024openalex-snapshot
Coenzyme Q10 and Intracellular Signalling Pathways: Clinical Relevance
inferred← citeshttps://doi.org/10.3390/ijms262411914openalex-snapshot
Aqueous Extract of Bacopa procumbens and the NAPEL Formulation Mitigate MPTP-Induced Neurotoxicity via Nrf2/HSF1/HIF-1α Signaling in a Parkinson’s Disease Model
inferred← citeshttps://doi.org/10.3390/ph15121554openalex-snapshot
Neuroprotective Effects of Some Nutraceuticals against Manganese-Induced Parkinson’s Disease in Rats: Possible Modulatory Effects on TLR4/NLRP3/NF-κB, GSK-3β, Nrf2/HO-1, and Apoptotic Pathways
inferred← citeshttps://doi.org/10.34172/apb.2024.013openalex-snapshot
AMPK signaling pathway as a potential therapeutic target for Parkinson's disease
inferred← citeshttps://doi.org/10.4103/1673-5374.380878openalex-snapshot
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease
inferred← citeshttps://doi.org/10.4103/cjop.cjop-d-23-00107openalex-snapshot
Icariside II Suppresses Ferroptosis to Protect Against MPP+-Induced Parkinson's Disease through Keap1/Nrf2/GPX4 Signaling
inferred← citeshttps://doi.org/10.51847/bmigiiu1tkopenalex-snapshot
Anti-Neuroinflammatory Effects of 50% Ethanolic Curcuma longa Extract in LPS-Stimulated BV2 Microglia: Involvement of Nrf2/HO-1 Signaling and Inhibition of NF-κB/MAPK
inferred← citeshttps://doi.org/10.6084/m9.figshare.22613510openalex-snapshot
Additional file 1 of The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
inferred← citeshttps://doi.org/10.7717/peerj.19998openalex-snapshot
Functional characteristics, intercellular interactions and pathophysiological associations of astrocytes in Parkinson’s disease
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