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DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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FOXO transcription factors at the interface of metabolism and cancer
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Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases
inferredcites →https://doi.org/10.1007/s11515-014-1338-7openalex-snapshot
Transcriptional regulation of secretory capacity by bZip transcription factors
inferredcites →https://doi.org/10.1007/s12265-016-9683-3openalex-snapshot
Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery
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Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential
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Associated Risk of Malignancy in Patients with Cardiovascular Disease: Evidence and Possible Mechanism
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Caspase-1 recognizes extended cleavage sites in its natural substrates
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Manganese superoxide dismutase and glutathione peroxidase-1 contribute to the rise and fall of mitochondrial reactive oxygen species which drive oncogenesis
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ER stress-induced cell death mechanisms
inferredcites →https://doi.org/10.1016/j.cbpa.2015.10.030openalex-snapshot
Metabolic control of methylation and acetylation
inferredcites →https://doi.org/10.1016/j.cyto.2017.06.003openalex-snapshot
IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases
inferredcites →https://doi.org/10.1016/j.ddstr.2008.11.003openalex-snapshot
Vascular inflammation and atherogenesis are activated via receptors for PAMPs and suppressed by regulatory T cells
inferredcites →https://doi.org/10.1016/j.dnarep.2013.04.015openalex-snapshot
DNA repair mechanisms in dividing and non-dividing cells
inferredcites →https://doi.org/10.1016/j.molcel.2017.05.031openalex-snapshot
The UPR ER : Sensor and Coordinator of Organismal Homeostasis
inferredcites →https://doi.org/10.1016/j.stem.2010.12.012openalex-snapshot
DNA-Damage Response in Tissue-Specific and Cancer Stem Cells
inferredcites →https://doi.org/10.1038/cdd.2014.223openalex-snapshot
Muscle gets stressed? p53 represses and protects
inferredcites →https://doi.org/10.1038/cddis.2015.142openalex-snapshot
Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite
inferredcites →https://doi.org/10.1038/nature02661openalex-snapshot
Gene regulation and DNA damage in the ageing human brain
inferredcites →https://doi.org/10.1038/nrd4023openalex-snapshot
Pharmacological approaches to restore mitochondrial function
inferredcites →https://doi.org/10.1038/nrm.2017.48openalex-snapshot
Non-homologous DNA end joining and alternative pathways to double-strand break repair
inferredcites →https://doi.org/10.1038/nrm3060openalex-snapshot
DNA damage response in adult stem cells: pathways and consequences
inferredcites →https://doi.org/10.1074/jbc.272.14.9496openalex-snapshot
Myeloid-related Protein (MRP) 8 and MRP14, Calcium-binding Proteins of the S100 Family, Are Secreted by Activated Monocytes via a Novel, Tubulin-dependent Pathway
inferredcites →https://doi.org/10.1074/jbc.m115.641191openalex-snapshot
Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis
inferredcites →https://doi.org/10.1074/jbc.m115.663286openalex-snapshot
Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway
inferredcites →https://doi.org/10.1074/jbc.m115.690081openalex-snapshot
Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway
inferredcites →https://doi.org/10.1074/jbc.r117.800169openalex-snapshot
Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress
inferredcites →https://doi.org/10.1083/jcb.201603105openalex-snapshot
Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system
inferredcites →https://doi.org/10.1089/ars.2017.7069openalex-snapshot
Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury
inferredcites →https://doi.org/10.1093/hmg/ddw025openalex-snapshot
Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration
inferredcites →https://doi.org/10.1096/fj.09-143651openalex-snapshot
Regulation of homocysteine metabolism and methylation in human and mouse tissues
inferredcites →https://doi.org/10.1097/bor.0000000000000314openalex-snapshot
Alarming consequences – autoinflammatory disease spectrum due to mutations in proline-serine-threonine phosphatase-interacting protein 1
inferredcites →https://doi.org/10.1097/coc.0000000000000120openalex-snapshot
Cancer Rates in Adults After Cardiac Interventions
inferredcites →https://doi.org/10.1111/febs.13962openalex-snapshot
Mechanistic roles of autophagy in hematopoietic differentiation
inferredcites →https://doi.org/10.1126/science.aaa5612openalex-snapshot
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
inferredcites →https://doi.org/10.1139/cjpp-2016-0515openalex-snapshot
Mitochondrial ROS, uncoupled from ATP synthesis, determine endothelial activation for both physiological recruitment of patrolling cells and pathological recruitment of inflammatory cells
inferredcites →https://doi.org/10.1155/2017/9175806openalex-snapshot
Epigenetics and Oxidative Stress in Aging
inferredcites →https://doi.org/10.1158/1055-9965.epi-13-0090openalex-snapshot
Cancer Risk in Patients with Manifest Vascular Disease: Effects of Smoking, Obesity, and Metabolic Syndrome
inferredcites →https://doi.org/10.1161/atvbaha.111.236927openalex-snapshot
S100A8 and S100A9 in Cardiovascular Biology and Disease
inferredcites →https://doi.org/10.1161/atvbaha.115.305282openalex-snapshot
Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway
inferredcites →https://doi.org/10.1161/atvbaha.115.306964openalex-snapshot
Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation
inferredcites →https://doi.org/10.1161/atvbaha.117.310626openalex-snapshot
IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)
inferredcites →https://doi.org/10.1161/circresaha.116.308501openalex-snapshot
Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells
inferredcites →https://doi.org/10.1177/039463200601900415openalex-snapshot
Processing Sites are Different in the Generation of HLA-A2.1-Restricted, T Cell Reactive Tumor Antigen Epitopes and Viral Epitopes
inferredcites →https://doi.org/10.1177/039463200902200208openalex-snapshot
Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues
inferredcites →https://doi.org/10.1186/1476-4598-3-9openalex-snapshot
Genetic alteration and gene expression modulation during cancer progression.
inferredcites →https://doi.org/10.1186/1479-7364-1-5-355openalex-snapshot
Expression profiling of cardiovascular disease
inferredcites →https://doi.org/10.1186/1756-8722-6-19openalex-snapshot
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers
inferredcites →https://doi.org/10.1186/s13045-016-0351-5openalex-snapshot
Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study
inferredcites →https://doi.org/10.1186/s13045-017-0406-2openalex-snapshot
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
inferredcites →https://doi.org/10.1186/s13045-017-0440-0openalex-snapshot
Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study
inferredcites →https://doi.org/10.1186/s13045-017-0526-8openalex-snapshot
A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
inferredcites →https://doi.org/10.1371/journal.pone.0033628openalex-snapshot
IL-35 Is a Novel Responsive Anti-inflammatory Cytokine — A New System of Categorizing Anti-inflammatory Cytokines
inferredcites →https://doi.org/10.1371/journal.pone.0170358openalex-snapshot
Cellular responses and gene expression profile changes due to bleomycin-induced DNA damage in human fibroblasts in space
inferredcites →https://doi.org/10.14670/hh-25.99openalex-snapshot
The early endosome: a busy sorting station for proteins at the crossroads.
inferredcites →https://doi.org/10.1515/cclm.2007.350openalex-snapshot
Hyperhomocysteinemia, DNA methylation and vascular disease
inferredcites →https://doi.org/10.15252/embj.201694253openalex-snapshot
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels
inferredcites →https://doi.org/10.2741/4127openalex-snapshot
Inflammasomes: sensors of metabolic stresses for vascular inflammation
inferredcites →https://doi.org/10.2741/4383openalex-snapshot
Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair
inferredcites →https://doi.org/10.2741/4595openalex-snapshot
Uremic toxins are conditional danger- or homeostasis-associated molecular patterns
inferredcites →https://doi.org/10.3389/fgene.2017.00065openalex-snapshot
Genetic Variability as a Regulator of TLR4 and NOD Signaling in Response to Bacterial Driven DNA Damage Response (DDR) and Inflammation: Focus on the Gastrointestinal (GI) Tract
inferredcites →https://doi.org/10.3389/fimmu.2018.00045openalex-snapshot
GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg
inferredcites →https://doi.org/10.3390/ijms18081808openalex-snapshot
Crosstalk between DNA Damage and Inflammation in the Multiple Steps of Carcinogenesis
inferredcites →https://doi.org/10.3748/wjg.v9.i1.9openalex-snapshot
Gene expression profiles at different stages of human esophageal squamous cell carcinoma

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
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inferred← citeshttps://doi.org/10.1152/ajplung.00522.2019openalex-snapshot
Noncanonical role for Ku70/80 in the prevention of allergic airway inflammation via maintenance of airway epithelial cell organelle homeostasis
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Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses
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Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways
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Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators
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Diet, Immunity, and Microbiota Interactions: An Integrative Analysis of the Intestine Transcriptional Response and Microbiota Modulation in Gilthead Seabream (Sparus aurata) Fed an Essential Oils-Based Functional Diet
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Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism
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