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Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Hyaluronan-CD44 Promotes Phospholipase C–Mediated Ca2+ Signaling and Cisplatin Resistance in Head and Neck Cancer

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Experimental Evidence That a DNA Polymerase Can Incorporate N7‐Platinated Guanines To Give Platinated DNA

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Retracted: Cisplatin‐induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC‐3 pancreatic tumor xenografts

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Systemic Bcl‐2 antisense oligodeoxynucleotide in combination with cisplatin cures EBV+ nasopharyngeal carcinoma xenografts in SCID mice

inferredcites →https://doi.org/10.1002/ijc.25191openalex-snapshot

Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin

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Targeting of cancer energy metabolism

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Cancer chemoprevention and mitochondria: Targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state

inferredcites →https://doi.org/10.1002/mnfr.200800044openalex-snapshot

Mitochondria as targets for cancer therapy

inferredcites →https://doi.org/10.1007/pl00000762openalex-snapshot

Molecular mechanisms involved in cisplatin cytotoxicity

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Cellular and molecular aspects of drugs of the future: oxaliplatin

inferredcites →https://doi.org/10.1007/s00204-006-0078-0openalex-snapshot

In vitro toxicological evaluation of a dinuclear platinum(II) complex with acetate ligands

inferredcites →https://doi.org/10.1007/s00204-006-0079-zopenalex-snapshot

Down-regulation of hepatic cytochrome P450 enzymes associated with cisplatin-induced acute renal failure in male rats

inferredcites →https://doi.org/10.1007/s10495-009-0323-0openalex-snapshot

Mitochondria as targets for chemotherapy

inferredcites →https://doi.org/10.1007/s10534-005-4451-xopenalex-snapshot

Occurrence, use and potential toxic effects of metals and metal compounds

inferredcites →https://doi.org/10.1007/s11373-005-9025-yopenalex-snapshot

BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53

inferredcites →https://doi.org/10.1016/j.bbamcr.2005.12.007openalex-snapshot

Molecular alterations of cells resistant to platinum drugs: Role of PKCα

inferredcites →https://doi.org/10.1016/j.bbrc.2005.11.038openalex-snapshot

Recognition of cisplatin-damaged DNA by p53 protein: Critical role of the p53 C-terminal domain

inferredcites →https://doi.org/10.1016/j.cbpa.2009.11.015openalex-snapshot

Metal complexes in medicine with a focus on enzyme inhibition

inferredcites →https://doi.org/10.1016/j.cdp.2005.05.004openalex-snapshot

Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells

inferredcites →https://doi.org/10.1016/j.clon.2005.09.001openalex-snapshot

Improved Survival After Concurrent Weekly Cisplatin and Radiotherapy for Cervical Carcinoma with Assessment of Acute and Late Side-effects

inferredcites →https://doi.org/10.1016/j.critrevonc.2004.08.008openalex-snapshot

Recognition and processing of cisplatin- and oxaliplatin-DNA adducts

inferredcites →https://doi.org/10.1016/j.drup.2005.04.006openalex-snapshot

Modifications of DNA by platinum complexes

inferredcites →https://doi.org/10.1016/j.ejphar.2006.01.007openalex-snapshot

Enzymatic studies of cisplatin induced oxidative stress in hepatic tissue of rats

inferredcites →https://doi.org/10.1016/j.neuro.2006.07.005openalex-snapshot

Cisplatin modulates voltage gated channel currents of dorsal root ganglion neurons of rats

inferredcites →https://doi.org/10.1016/j.neuro.2008.12.001openalex-snapshot

Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity

inferredcites →https://doi.org/10.1016/j.neuro.2009.04.014openalex-snapshot

Anti-cancer drugs interfere with intracellular calcium signaling

inferredcites →https://doi.org/10.1016/j.tips.2008.04.001openalex-snapshot

Mitochondrial off targets of drug therapy

inferredcites →https://doi.org/10.1016/j.toxlet.2004.04.015openalex-snapshot

Erythrocyte aminolevulinic acid dehydratase inhibition by cis-platin

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Mechanisms of resistance to cisplatin

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TRAIL and Chemotherapeutic Drugs in Cancer Therapy

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Clinical development of platinum complexes in cancer therapy: an historical perspective and an update

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Particular aspects of platinum compounds used at present in cancer treatment

inferredcites →https://doi.org/10.1016/s1040-8428(02)00017-3openalex-snapshot

Cancer and Metals and Metal Compounds:

inferredcites →https://doi.org/10.1016/s1040-8428(02)00039-2openalex-snapshot

Cancer and Metals and Metal Compounds:

inferredcites →https://doi.org/10.1023/b:glyc.0000043293.46845.07openalex-snapshot

Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis-platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside

inferredcites →https://doi.org/10.1038/ncpuro0068openalex-snapshot

Adjuvant and neoadjuvant chemotherapy for bladder cancer: management and controversies

inferredcites →https://doi.org/10.1038/sj.bjp.0707335openalex-snapshot

IP3 receptor antagonist, 2‐APB, attenuates cisplatin induced Ca2+‐influx in HeLa‐S3 cells and prevents activation of calpain and induction of apoptosis

inferredcites →https://doi.org/10.1038/sj.bjp.0707576openalex-snapshot

[Pt(O,O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway

inferredcites →https://doi.org/10.1038/sj.bjp.0707646openalex-snapshot

[Pt(O,O′‐acac)(γ‐acac)(DMS)], a new Pt compound exerting fast cytotoxicity in MCF‐7 breast cancer cells via the mitochondrial apoptotic pathway

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Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors

inferredcites →https://doi.org/10.1038/sj.cgt.7700798openalex-snapshot

Adenovirus-mediated p53 gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to cisplatin and doxorubicin

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Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin

inferredcites →https://doi.org/10.1038/sj.cgt.7701120openalex-snapshot

Cisplatin enhances the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand gene therapy via recruitment of the mitochondria-dependent death signaling pathway

inferredcites →https://doi.org/10.1038/sj.onc.1209026openalex-snapshot

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

inferredcites →https://doi.org/10.1039/9781847558763openalex-snapshot

Nucleic Acid–Metal Ion Interactions

inferredcites →https://doi.org/10.1074/jbc.m402547200openalex-snapshot

Cisplatin-induced Post-translational Modification of Histones H3 and H4

inferredcites →https://doi.org/10.1080/07357900500449520openalex-snapshot

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inferredcites →https://doi.org/10.1093/nar/gkh716openalex-snapshot

SMC1 coordinates DNA double-strand break repair pathways

inferredcites →https://doi.org/10.1097/01.mlg.0000185596.20207.d2openalex-snapshot

Hearing Genes and Cisplatin Deafness: A Pilot Study

inferredcites →https://doi.org/10.1097/01.mlg.0000197630.85208.36openalex-snapshot

The Histone Deacetylase Inhibitor Sodium Butyrate Protects Against Cisplatin‐Induced Hearing Loss in Guinea Pigs

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The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

inferredcites →https://doi.org/10.1152/ajpcell.00265.2005openalex-snapshot

Mitochondrial density determines the cellular sensitivity to cisplatin-induced cell death

inferredcites →https://doi.org/10.1158/0008-5472.can-05-0121openalex-snapshot

Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway by Inositol Pentakisphosphate Results in Antiangiogenic and Antitumor Effects

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Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells

inferredcites →https://doi.org/10.1159/000084119openalex-snapshot

Overexpression of Protein Kinase Cδ Enhances Cisplatin-Induced Cytotoxicity Correlated with p53 in Gastric Cancer Cell Line

inferredcites →https://doi.org/10.1200/jco.2006.10.077openalex-snapshot

Relationship Between Cisplatin Administration and the Development of Ototoxicity

inferredcites →https://doi.org/10.1210/en.2005-1450openalex-snapshot

Inhibition of Phosphatidylinositol 3-Kinase Increases Efficacy of Cisplatin in in Vivo Ovarian Cancer Models

inferredcites →https://doi.org/10.1681/asn.2005010102openalex-snapshot

A Pathophysiologic Role for T Lymphocytes in Murine Acute Cisplatin Nephrotoxicity

inferredcites →https://doi.org/10.2119/molmed.2010.00002openalex-snapshot

MicroRNA-34a Is Induced via p53 during Cisplatin Nephrotoxicity and Contributes to Cell Survival

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Cisplatin Overdose

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Cisplatin Resistance and Transcription Factors

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Cisplatin Is a DNA-Damaging Antitumour Compound Triggering Multifactorial Biochemical Responses in Cancer Cells: Importance of Apoptotic Pathways

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Other Drugs Acting on Nervous System Associated with QT-Interval Prolongation

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TRAIL Agonists on Clinical Trials for Cancer Therapy: The Promises and the Challenges

inferredcites →https://doi.org/10.2174/187152007779314080openalex-snapshot

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inferredcites →https://doi.org/10.2174/187152010791162270openalex-snapshot

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inferredcites →https://doi.org/10.3390/cancers3011351openalex-snapshot

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inferredcites →https://doi.org/10.3892/ijo.28.1.119openalex-snapshot

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inferredcites →https://doi.org/10.3892/or_00000813openalex-snapshot

miRNA-regulated expression of oncogenes and tumor suppressor genes in the cisplatin-inhibited growth of K562 cells

inferredcites →https://doi.org/10.4161/cbt.5.4.2477openalex-snapshot

Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/ejic.201600325openalex-snapshot

Iridium(III) Complexes of Terpyridine‐ and Terpyridine‐Analogous Ligands Bearing Sugar Residues and Their in vitro Activity

inferred← citeshttps://doi.org/10.1002/ejic.201601078openalex-snapshot

Platinum(II) Complexes of Curcumin Showing Photocytotoxicity in Visible Light

inferred← citeshttps://doi.org/10.1002/ejic.202100120openalex-snapshot

Gold(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity, and Mechanistic Studies

inferred← citeshttps://doi.org/10.1002/ejic.202500349openalex-snapshot

Cu(I) and Cu(II) Complexes with a Piperazine‐Containing N,N,O‐Chelate Ligand: A Combined Theoretical and Experimental Investigation

inferred← citeshttps://doi.org/10.1002/ejoc.201201256openalex-snapshot

Total Syntheses and Biological Evaluation of 3‐O‐Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl‐Mediated Halogenation and Carbonylative Stille Cross‐Coupling

inferred← citeshttps://doi.org/10.1002/ejoc.201500998openalex-snapshot

Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin–Platinum(II) Complex

inferred← citeshttps://doi.org/10.1002/ejoc.201700730openalex-snapshot

Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7‐Deazaadenosine as Scaffold

inferred← citeshttps://doi.org/10.1002/fsn3.2317openalex-snapshot

A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin‐induced nephrotoxicity

inferred← citeshttps://doi.org/10.1002/hed.24664openalex-snapshot

Synthetic β‐nitrostyrene derivative CYT‐Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction

inferred← citeshttps://doi.org/10.1002/hed.24935openalex-snapshot

Cisplatin‐conjugated gold nanoparticles as a theranostic agent for head and neck cancer

inferred← citeshttps://doi.org/10.1002/ijc.32592openalex-snapshot

Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin‐treated rectal cancer: In situ visualization of platinum via synchrotron radiation X‐ray fluorescence spectrometry

inferred← citeshttps://doi.org/10.1002/iub.2446openalex-snapshot

The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies

inferred← citeshttps://doi.org/10.1002/jbt.21730openalex-snapshot

2-Deoxy- d -Glucose Sensitizes Human Ovarian Cancer Cells to Cisplatin by Increasing ER Stress and Decreasing ATP Stores in Acidic Vesicles

inferred← citeshttps://doi.org/10.1002/jccs.202400207openalex-snapshot

BODIPY ‐based iridium and ruthenium complexes: Synthesis, photophysical, and photochemical properties

inferred← citeshttps://doi.org/10.1002/jcp.29040openalex-snapshot

microRNA‐10b confers cisplatin resistance by activating AKT/mTOR/P70S6K signaling via targeting PPARγ in esophageal cancer

inferred← citeshttps://doi.org/10.1002/jcp.31176openalex-snapshot

Epitranscriptomics m 6 A analyses reveal distinct m 6 A marks under tumor necrosis factor α (TNF‐α)‐induced apoptotic conditions in HeLa cells

inferred← citeshttps://doi.org/10.1002/marc.201800171openalex-snapshot

Intramolecular Copper‐Containing Hyperbranched Polytriazole Assemblies for Label‐Free Cellular Bioimaging and Redox‐Triggered Copper Complex Delivery

inferred← citeshttps://doi.org/10.1002/mco2.55openalex-snapshot

Molecular mechanisms of chemo‐ and radiotherapy resistance and the potential implications for cancer treatment

inferred← citeshttps://doi.org/10.1002/med.21734openalex-snapshot

Small molecules regulating reactive oxygen species homeostasis for cancer therapy

inferred← citeshttps://doi.org/10.1002/mnfr.201500955openalex-snapshot

Ginger augmented chemotherapy: A novel multitarget nontoxic approach for cancer management

inferred← citeshttps://doi.org/10.1002/open.202400140openalex-snapshot

Au⋅⋅⋅H−X (X=N or C) Intramolecular Interactions in Gold (I)‐NHC Carbene Complexes with Potential Anticancer Properties: A Quantum Mechanical Study with Two Basis Sets

inferred← citeshttps://doi.org/10.1002/ppsc.202300233openalex-snapshot

NIR Responsive Drug Cocktail Using J‐Aggregates of Indocyanine Green Loaded Polydopamine Nanoparticles for Chemo‐Phototherapy of Cancer

inferred← citeshttps://doi.org/10.1002/prp2.211openalex-snapshot

Role of endoplasmic reticulum stress in drug‐induced toxicity

inferred← citeshttps://doi.org/10.1002/ptr.6180openalex-snapshot

Millepachine showed novel antitumor effects in cisplatin‐resistant human ovarian cancer through inhibiting drug efflux function of ATP ‐binding cassette transporters

inferred← citeshttps://doi.org/10.1002/ptr.7063openalex-snapshot

Phytochemistry, pharmacodynamics, and pharmacokinetics of a classic Chinese herbal formula Danggui Beimu Kushen Wan: A review

inferred← citeshttps://doi.org/10.1002/ptr.7290openalex-snapshot

A mechanistic insight into the biological activities of urolithins as gut microbial metabolites of ellagitannins

inferred← citeshttps://doi.org/10.1002/ptr.7305openalex-snapshot

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

inferred← citeshttps://doi.org/10.1002/ptr.7405openalex-snapshot

Maltol mitigates cisplatin‐evoked cardiotoxicity via inhibiting the PI3K /Akt signaling pathway in rodents in vivo and in vitro

inferred← citeshttps://doi.org/10.1002/slct.201600961openalex-snapshot

Platinated Nucleotides are Substrates for the Human Mitochondrial Deoxynucleotide Carrier (DNC) and DNA Polymerase γ: Relevance for the Development of New Platinum‐Based Drugs.

inferred← citeshttps://doi.org/10.1002/slct.202101459openalex-snapshot

Design, Synthesis and Biological Evaluation of New 5‐(2‐Nitrophenyl)‐1‐aryl‐1 H ‐pyrazoles as Topoisomerase Inhibitors

inferred← citeshttps://doi.org/10.1002/slct.202203615openalex-snapshot

In vitro Analytical Techniques as Screening Tools to investigate the Metal chelate‐DNA interactions

inferred← citeshttps://doi.org/10.1002/slct.202302113openalex-snapshot

Emerging Trends in Metal‐based Anticancer Agents: Drug Design to Clinical Trials and their Mechanism of Action

inferred← citeshttps://doi.org/10.1002/slct.202503997openalex-snapshot

The Role of Milk Thistle ( Silybum marianum ) on Cisplatin‐Induced Genotoxicity in Albino Rats

inferred← citeshttps://doi.org/10.1002/slct.74568openalex-snapshot

Burmannic Acid With Normal Cell Safety Exhibits ROS‐Mediated X‐Ray‐Sensitizing Effects on Oral Cancer Cells

inferred← citeshttps://doi.org/10.1002/smll.202002044openalex-snapshot

Is GSH Chelated Pt Molecule Inactive in Anti‐Cancer Treatment? A Case Study of Pt6GS4

inferred← citeshttps://doi.org/10.1002/smll.202101804openalex-snapshot

Delivery of Cationic Platinum Prodrugs via Reduction Sensitive Polymer for Improved Chemotherapy

inferred← citeshttps://doi.org/10.1002/tox.23896openalex-snapshot

A novel mitochondria‐targeting compound exerts therapeutic effects against melanoma by inducing mitochondria‐mediated apoptosis and autophagy in vitro and in vivo

inferred← citeshttps://doi.org/10.1002/wnan.1347openalex-snapshot

Near‐infrared light‐responsive nanomaterials for cancer theranostics

inferred← citeshttps://doi.org/10.1002/wnan.1884openalex-snapshot

Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects

inferred← citeshttps://doi.org/10.1002/zaac.201300109openalex-snapshot

Derivatisation of an Anti‐Cancer Cationic Antimicrobial Peptide and its Complexation to Platinum(II)

inferred← citeshttps://doi.org/10.1002/zaac.201700022openalex-snapshot

Structure, Physicochemical and Biological Properties of an Aqua (2,2′,2′′‐Nitrilotriacetato)‐oxidovanadium(IV) Salt with 4‐Methylpyridinium Cation

inferred← citeshttps://doi.org/10.1007/978-1-0716-2553-8_16openalex-snapshot

Cancer and Apoptosis

inferred← citeshttps://doi.org/10.1007/978-3-030-76235-3_3openalex-snapshot

A Novel Water-Soluble C60 Fullerene-Based Nano-Platform Enhances Efficiency of Anticancer Chemotherapy

inferred← citeshttps://doi.org/10.1007/978-3-031-10839-6_1openalex-snapshot

Polypharmacy in Cancer Therapy

inferred← citeshttps://doi.org/10.1007/978-3-031-10839-6_5openalex-snapshot

Chemotherapeutic Protocols for the Treatment of Gastrointestinal Tract Cancer

inferred← citeshttps://doi.org/10.1007/978-3-031-15070-8_108openalex-snapshot

Editing the Genome

inferred← citeshttps://doi.org/10.1007/978-3-031-55653-1_1openalex-snapshot

Introduction to Musculoskeletal Tissues and Drug Delivery Systems

inferred← citeshttps://doi.org/10.1007/978-3-031-61877-2_3openalex-snapshot

Eine neuartige wasserlösliche C60-Fulleren-basierte Nano-Plattform erhöht die Effizienz der Krebschemotherapie

inferred← citeshttps://doi.org/10.1007/978-3-032-22043-1_13openalex-snapshot

Organometallic Anticancer Active Compounds: DNA Binding, DNA Cleavage, and Cytotoxicity of Ru(Arene) Complexes

inferred← citeshttps://doi.org/10.1007/978-3-319-19048-8_30openalex-snapshot

The Role of miRNAs in Cisplatin-Resistant HeLa Cells

inferred← citeshttps://doi.org/10.1007/978-3-319-78762-6_7openalex-snapshot

Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC)

inferred← citeshttps://doi.org/10.1007/978-3-662-44559-4_25openalex-snapshot

Mechanisms of Uptake and Interaction of Platinum Based Drugs in Eukaryotic Cells

inferred← citeshttps://doi.org/10.1007/978-981-15-6255-6_17openalex-snapshot

Nanomedicine for Challenging Solid Tumors: Recent Trends and Future Ahead

inferred← citeshttps://doi.org/10.1007/978-981-19-1282-5_47-1openalex-snapshot

Recent Advances of Metal-Based Anticancer Agents and Their In Vivo Potential Against Various Types of Malignancies

inferred← citeshttps://doi.org/10.1007/978-981-19-3824-5_47openalex-snapshot

Recent Advances of Metal-Based Anticancer Agents and Their In Vivo Potential Against Various Types of Malignancies

inferred← citeshttps://doi.org/10.1007/978-981-19-9786-0_23openalex-snapshot

Tool and Techniques on Computer-Aided Drug Design for Targeted Cancer Therapy

inferred← citeshttps://doi.org/10.1007/978-981-97-0146-9_1openalex-snapshot

Introduction

inferred← citeshttps://doi.org/10.1007/978-981-97-1666-1_1openalex-snapshot

Introduction to Drug Resistance in Cancer

inferred← citeshttps://doi.org/10.1007/s00018-024-05187-2openalex-snapshot

USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells

inferred← citeshttps://doi.org/10.1007/s00204-019-02441-6openalex-snapshot

Toxicity of C60 fullerene–cisplatin nanocomplex against Lewis lung carcinoma cells

inferred← citeshttps://doi.org/10.1007/s00210-024-03086-8openalex-snapshot

The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present

inferred← citeshttps://doi.org/10.1007/s00210-025-03899-1openalex-snapshot

3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells

inferred← citeshttps://doi.org/10.1007/s00210-025-04431-1openalex-snapshot

Lipid-based nanocarriers in combination chemotherapy: a promising strategy for advanced skin cancer management

inferred← citeshttps://doi.org/10.1007/s00216-012-6355-2openalex-snapshot

Metallomics in drug development: characterization of a liposomal cisplatin drug formulation in human plasma by CE–ICP–MS

inferred← citeshttps://doi.org/10.1007/s00232-016-9891-4openalex-snapshot

Effects of Cisplatin Electrochemotherapy on Human Neuroblastoma Cells

inferred← citeshttps://doi.org/10.1007/s00232-017-9972-zopenalex-snapshot

Interaction of Newly Platinum(II) with Tris(2-carboxyethyl)phosphine Complex with DNA and Model Lipid Membrane

inferred← citeshttps://doi.org/10.1007/s00280-014-2574-xopenalex-snapshot

Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance

inferred← citeshttps://doi.org/10.1007/s00280-018-3536-5openalex-snapshot

Cisplatin suppresses proliferation, migration and invasion of nasopharyngeal carcinoma cells in vitro by repressing the Wnt/β-catenin/Endothelin-1 axis via activating B cell translocation gene 1

inferred← citeshttps://doi.org/10.1007/s00280-020-04213-xopenalex-snapshot

Enhancing the activity of platinum-based drugs by improved inhibitors of ERCC1–XPF-mediated DNA repair

inferred← citeshttps://doi.org/10.1007/s00405-024-08805-8openalex-snapshot

Efficacy of chemoradiotherapy in elderly patients with stage IV inoperable head and neck cancer

inferred← citeshttps://doi.org/10.1007/s00432-023-04734-xopenalex-snapshot

The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours

inferred← citeshttps://doi.org/10.1007/s00706-018-2316-6openalex-snapshot

Bipyrazole-based palladium(II) complexes as DNA intercalator and artificial metallonuclease

inferred← citeshttps://doi.org/10.1007/s00709-015-0821-6openalex-snapshot

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

inferred← citeshttps://doi.org/10.1007/s00775-014-1133-6openalex-snapshot

Synthesis, characterization, and evaluation of cis-diphenyl pyridineamine platinum(II) complexes as potential anti-breast cancer agents

inferred← citeshttps://doi.org/10.1007/s00775-017-1459-yopenalex-snapshot

In vitro and in vivo anti-tumor effects of selected platinum(IV) and dinuclear platinum(II) complexes against lung cancer cells

inferred← citeshttps://doi.org/10.1007/s00775-018-1560-xopenalex-snapshot

Ruthenium(II)-N-alkyl phenothiazine complexes as potential anticancer agents

inferred← citeshttps://doi.org/10.1007/s00775-018-1596-yopenalex-snapshot

Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging

inferred← citeshttps://doi.org/10.1007/s00775-019-01647-4openalex-snapshot

New organoruthenium compounds with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action

inferred← citeshttps://doi.org/10.1007/s00775-020-01798-9openalex-snapshot

Cytotoxicity, cellular localization and photophysical properties of Re(I) tricarbonyl complexes bound to cysteine and its derivatives

inferred← citeshttps://doi.org/10.1007/s00775-020-01823-xopenalex-snapshot

Experimental and theoretical characterization of the strong effects on DNA stability caused by half-sandwich Ru(II) and Ir(III) bearing thiabendazole complexes

inferred← citeshttps://doi.org/10.1007/s00775-021-01873-9openalex-snapshot

Synthesis, structure and anticancer properties of new biotin- and morpholine-functionalized ruthenium and osmium half-sandwich complexes

inferred← citeshttps://doi.org/10.1007/s00775-021-01892-6openalex-snapshot

Induction of apoptosis on ovarian adenocarcinoma cells, A2780 by tricyclohexylphosphanegold (I) mercaptobenzoate derivatives via intrinsic and extrinsic pathways

inferred← citeshttps://doi.org/10.1007/s00775-021-01895-3openalex-snapshot

Synthesis and evaluation of iridium(III) complexes on antineoplastic activity against human gastric carcinoma SGC-7901 cells

inferred← citeshttps://doi.org/10.1007/s00775-022-01924-9openalex-snapshot

Simultaneous mass spectrometry analysis of cisplatin with oligonucleotide-peptide mixtures: implications for the mechanism of action

inferred← citeshttps://doi.org/10.1007/s00775-023-02030-0openalex-snapshot

Characterization, modes of interactions with DNA/BSA biomolecules and anti-tumor activity of newly synthesized dinuclear platinum(II) complexes with pyridazine bridging ligand

inferred← citeshttps://doi.org/10.1007/s00775-026-02135-2openalex-snapshot

Characterization and biological evaluation of a Rh(III) complex featuring Phosphonate-Modified bipyridine ligands

inferred← citeshttps://doi.org/10.1007/s10072-019-03895-3openalex-snapshot

Propofol alleviates cisplatin-related cognitive impairment

inferred← citeshttps://doi.org/10.1007/s10142-023-01130-zopenalex-snapshot

Regulatory miRNAs, circRNAs and lncRNAs in cell cycle progression of breast cancer

inferred← citeshttps://doi.org/10.1007/s10238-025-01863-0openalex-snapshot

LINC00885 promotes lung squamous cell carcinoma by upregulating SLBP expression to activate PI3K/Akt pathway

inferred← citeshttps://doi.org/10.1007/s10388-021-00865-7openalex-snapshot

Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy

inferred← citeshttps://doi.org/10.1007/s10495-014-1030-zopenalex-snapshot

Inhibition of the JAK/STAT pathway with ruxolitinib overcomes cisplatin resistance in non-small-cell lung cancer NSCLC

inferred← citeshttps://doi.org/10.1007/s10495-019-01515-1openalex-snapshot

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

inferred← citeshttps://doi.org/10.1007/s10495-020-01594-5openalex-snapshot

Exploitation of a novel phenothiazine derivative for its anti-cancer activities in malignant glioblastoma

inferred← citeshttps://doi.org/10.1007/s10534-015-9865-5openalex-snapshot

The effect of 1:2 Ag(I) thiocyanate complexes in MCF-7 breast cancer cells

inferred← citeshttps://doi.org/10.1007/s10534-017-0001-6openalex-snapshot

Characterization and cytotoxic effect of aqua-(2,2′,2′′-nitrilotriacetato)-oxo-vanadium salts on human osteosarcoma cells

inferred← citeshttps://doi.org/10.1007/s10534-020-00235-3openalex-snapshot

New cyclometalated gold (III) complex targeting thioredoxin reductase: exploring as cytotoxic agents and mechanistic insights

inferred← citeshttps://doi.org/10.1007/s10534-021-00302-3openalex-snapshot

Antitumor activity via apoptotic cell death pathway of water soluble copper(II) complexes: effect of the diamino unit on selectivity against lung cancer NCI-H460 cell line

inferred← citeshttps://doi.org/10.1007/s10544-018-0339-8openalex-snapshot

Proliferation arrest, selectivity, and chemosensitivity enhancement of cancer cells treated by a low-intensity alternating electric field

inferred← citeshttps://doi.org/10.1007/s10571-020-00873-8openalex-snapshot

[Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistance in T98G Glioma Cells

inferred← citeshttps://doi.org/10.1007/s10616-019-00333-2openalex-snapshot

Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity

inferred← citeshttps://doi.org/10.1007/s10637-018-0657-yopenalex-snapshot

Hexane partition from Annona crassiflora Mart. promotes cytotoxity and apoptosis on human cervical cancer cell lines

inferred← citeshttps://doi.org/10.1007/s10637-020-01032-yopenalex-snapshot

Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer

inferred← citeshttps://doi.org/10.1007/s10637-021-01158-7openalex-snapshot

Preliminary evaluation of anticancer efficacy of pioglitazone combined with celecoxib for the treatment of non-small cell lung cancer

inferred← citeshttps://doi.org/10.1007/s10735-026-10760-zopenalex-snapshot

Protective role of Actovegin against Cisplatin-evoked testicular damage: evidence from a rat model

inferred← citeshttps://doi.org/10.1007/s10735-026-10828-wopenalex-snapshot

Modified citrus pectin modulates splenic immune responses and galectin expression following cisplatin treatment in Wistar rats

inferred← citeshttps://doi.org/10.1007/s10812-022-01306-8openalex-snapshot

Novel Mononuclear Zinc(II) Complex with Niacin: Crystal Structure, DNA/Protein Interaction, and Cytotoxicity Studies

inferred← citeshttps://doi.org/10.1007/s10856-019-6260-8openalex-snapshot

pH responsible and fluorescent Cy5.5-PEG-g-A-HA/CDDP complex nanoparticles: synthesis, characterization, and application for targeted drug delivery

inferred← citeshttps://doi.org/10.1007/s10876-019-01657-xopenalex-snapshot

RETRACTED ARTICLE: Multifunctional Zinc Metal–Organic Framework for Highly Selective Detection of Picric Acid and Inhibition of Laryngeal Cancer Cell Growth

inferred← citeshttps://doi.org/10.1007/s10895-017-2177-0openalex-snapshot

Anticancer Activity of Copper Complex of (4R)-(-)-2-Thioxo-4-thiazolidinecarboxylic Acid and 3-Rhodaninepropionic Acid on Prostate and Breast Cancer Cells by Fluorescent Microscopic Imaging

inferred← citeshttps://doi.org/10.1007/s10904-020-01815-zopenalex-snapshot

Synthesis and Characterization of Serendipitous Dioxovanadates and Their DNA/BSA Interaction Studies and In Vitro Cytotoxic activity

inferred← citeshttps://doi.org/10.1007/s10904-021-02133-8openalex-snapshot

Systemic Evaluation of Mechanism of Cytotoxicity in Human Colon Cancer HCT-116 Cells of Silver Nanoparticles Synthesized Using Marine Algae Ulva lactuca Extract

inferred← citeshttps://doi.org/10.1007/s10904-025-03723-6openalex-snapshot

Exploring the Biological Efficacy of Zn(II)-Thiosemicarbazone-Ferrocene Complexes: In-Silico and In-Vitro Findings

inferred← citeshttps://doi.org/10.1007/s10973-021-11094-6openalex-snapshot

Thermodynamic behavior of breast cancer cell lines after miltefosine and cisplatin treatment

inferred← citeshttps://doi.org/10.1007/s11010-017-2965-5openalex-snapshot

Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia

inferred← citeshttps://doi.org/10.1007/s11010-018-3472-zopenalex-snapshot

Neuroprotective influence of sitagliptin against cisplatin-induced neurotoxicity, biochemical and behavioral alterations in Wistar rats

inferred← citeshttps://doi.org/10.1007/s11010-026-05675-yopenalex-snapshot

Aurone analog LYK01 exerts oxidative stress-dependent antiproliferation, G2/M arrest, apoptosis, and DNA damage of oral cancer cells involving MAPK modulation

inferred← citeshttps://doi.org/10.1007/s11030-021-10293-5openalex-snapshot

The role of folic acid in inducing of apoptosis by zinc(II) complex in ovary and cervix cancer cells

inferred← citeshttps://doi.org/10.1007/s11033-018-4223-7openalex-snapshot

Effects of electromagnetic field, cisplatin and morphine on cytotoxicity and expression levels of DNA repair genes

inferred← citeshttps://doi.org/10.1007/s11033-019-04954-wopenalex-snapshot

Cytotoxic effects and apoptosis induction of cisplatin-loaded iron oxide nanoparticles modified with chitosan in human breast cancer cells

inferred← citeshttps://doi.org/10.1007/s11033-020-05694-yopenalex-snapshot

Anticancer and cytotoxic effects of troxerutin on HeLa cell line: an in-vitro model of cervical cancer

inferred← citeshttps://doi.org/10.1007/s11033-021-06600-wopenalex-snapshot

A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1

inferred← citeshttps://doi.org/10.1007/s11033-022-08044-2openalex-snapshot

Vitamin D increases the efficacy of cisplatin on bladder cancer cell lines

inferred← citeshttps://doi.org/10.1007/s11033-024-10119-1openalex-snapshot

Anti-cancer effect of sodium pentaborate in combination with cisplatin on lung cancer cell lines

inferred← citeshttps://doi.org/10.1007/s11033-025-10442-1openalex-snapshot

Unraveling the role of withanolides as key modulators in breast cancer mitigation

inferred← citeshttps://doi.org/10.1007/s11051-015-3257-1openalex-snapshot

Comparative effects on rat primary astrocytes and C6 rat glioma cells cultures after 24-h exposure to silver nanoparticles (AgNPs)

inferred← citeshttps://doi.org/10.1007/s11094-025-03299-yopenalex-snapshot

Halopteris scoparia Overcomes Cisplatin Resistance and Their Combination Inhibits Lung Adenocarcinoma Tumor Growth: A Study on Cytotoxicity, Cell Cycle, DNA Fragmentation, Membrane Permeabilization, Oxidative Stress, Apoptosis Regulation and IVIS Imaging

inferred← citeshttps://doi.org/10.1007/s11095-016-2016-zopenalex-snapshot

Enhanced Anti-Tumor Efficacy of Lipid-Modified Platinum Derivatives in Combination with Survivin Silencing siRNA in Resistant Non-Small Cell Lung Cancer

inferred← citeshttps://doi.org/10.1007/s11095-026-04215-zopenalex-snapshot

Platinum(IV) Complexes Suppress Tumor Growth in MDA-MB-231 Cells and a DMBA- Induced Mammary Carcinoma Model

inferred← citeshttps://doi.org/10.1007/s11101-019-09623-1openalex-snapshot

Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential

inferred← citeshttps://doi.org/10.1007/s11144-023-02504-xopenalex-snapshot

The influence of electronic effects on the substitution reactions of N,N′-donor cis-palladium(II) complexes with bidentate (pyridin-2-yl)methyl-aniline ligands

inferred← citeshttps://doi.org/10.1007/s11172-022-3497-zopenalex-snapshot

Hydrolytically stable organometallic ruthenium complexes with glucose-based phosphite ligands

inferred← citeshttps://doi.org/10.1007/s11172-024-4133-xopenalex-snapshot

Physicochemical characteristics and antiproliferative activity of a water-soluble nanoformulation of the PtIV complex with a lonidamine-based ligand

inferred← citeshttps://doi.org/10.1007/s11224-023-02150-yopenalex-snapshot

Exploring the adsorption performance of doped graphene quantum dots as anticancer drug carriers for cisplatin by DFT, PCM, and COSMO approaches

inferred← citeshttps://doi.org/10.1007/s11240-016-1164-5openalex-snapshot

Taxol from Corylus avellana: paving the way for a new source of this anti-cancer drug

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