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Phagocytic Glial Cells in Brain Homeostasis

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1 of the 79 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/nn.3560 (notice 2022-01-13).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.22619openalex-snapshot
Apolipoproteins E and J interfere with amyloid‐beta uptake by primary human astrocytes and microglia in vitro
inferredcites →https://doi.org/10.1002/glia.22873openalex-snapshot
Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification
inferredcites →https://doi.org/10.1002/glia.23270openalex-snapshot
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
inferredcites →https://doi.org/10.1002/glia.23664openalex-snapshot
TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment
inferredcites →https://doi.org/10.1002/glia.23943openalex-snapshot
Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
inferredcites →https://doi.org/10.1007/s11481-012-9427-3openalex-snapshot
Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE
inferredcites →https://doi.org/10.1007/s13238-016-0269-2openalex-snapshot
Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia
inferredcites →https://doi.org/10.1016/j.bbi.2010.09.021openalex-snapshot
Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: Implications for its dual function as an apoptotic engulfment receptor
inferredcites →https://doi.org/10.1016/j.bcp.2014.01.008openalex-snapshot
Microglial dysfunction in brain aging and Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.cell.2007.10.036openalex-snapshot
The Classical Complement Cascade Mediates CNS Synapse Elimination
inferredcites →https://doi.org/10.1016/j.celrep.2020.107530openalex-snapshot
IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease
inferredcites →https://doi.org/10.1016/j.immuni.2018.04.016openalex-snapshot
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity
inferredcites →https://doi.org/10.1016/j.isci.2019.05.039openalex-snapshot
CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology
inferredcites →https://doi.org/10.1016/j.jneuroim.2012.06.004openalex-snapshot
Scavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture
inferredcites →https://doi.org/10.1016/j.neulet.2019.134317openalex-snapshot
Microglial clearance of focal apoptotic synapses
inferredcites →https://doi.org/10.1016/j.neuron.2012.03.026openalex-snapshot
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
inferredcites →https://doi.org/10.1016/j.neuron.2017.05.037openalex-snapshot
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
inferredcites →https://doi.org/10.1016/j.neuron.2018.09.017openalex-snapshot
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
inferredcites →https://doi.org/10.1016/j.neuroscience.2013.06.049openalex-snapshot
Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice
inferredcites →https://doi.org/10.1016/j.neuroscience.2020.07.016openalex-snapshot
Engulfment of Toxic Amyloid β-protein in Neurons and Astrocytes Mediated by MEGF10
inferredcites →https://doi.org/10.1016/s0166-2236(98)01349-6openalex-snapshot
Tripartite synapses: glia, the unacknowledged partner
inferredcites →https://doi.org/10.1023/a:1026441907803openalex-snapshot
Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress
inferredcites →https://doi.org/10.1038/labinvest.2016.116openalex-snapshot
CD68/macrosialin: not just a histochemical marker
inferredcites →https://doi.org/10.1038/nature06329openalex-snapshot
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
inferredcites →https://doi.org/10.1038/nature12776openalex-snapshot
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
inferredcites →https://doi.org/10.1038/nature21029openalex-snapshot
Neurotoxic reactive astrocytes are induced by activated microglia
inferredcites →https://doi.org/10.1038/ncomms7176openalex-snapshot
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
inferredcites →https://doi.org/10.1038/nn.3560openalex-snapshot
RETRACTED ARTICLE: TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement
inferredcites →https://doi.org/10.1038/nn.4132openalex-snapshot
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
inferredcites →https://doi.org/10.1038/nrn.2017.36openalex-snapshot
Progranulin, lysosomal regulation and neurodegenerative disease
inferredcites →https://doi.org/10.1038/s41467-017-00037-1openalex-snapshot
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway
inferredcites →https://doi.org/10.1038/s41467-020-19227-5openalex-snapshot
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
inferredcites →https://doi.org/10.1038/s41586-020-03060-3openalex-snapshot
Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
inferredcites →https://doi.org/10.1038/s41593-020-00757-6openalex-snapshot
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
inferredcites →https://doi.org/10.1038/s41593-020-00763-8openalex-snapshot
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice
inferredcites →https://doi.org/10.1038/s41593-020-00780-7openalex-snapshot
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation
inferredcites →https://doi.org/10.1038/s41593-020-0624-8openalex-snapshot
Disease-associated astrocytes in Alzheimer’s disease and aging
inferredcites →https://doi.org/10.1038/s41593-020-0672-0openalex-snapshot
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
inferredcites →https://doi.org/10.1038/s41598-020-66292-3openalex-snapshot
Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3
inferredcites →https://doi.org/10.1039/d1sc03486copenalex-snapshot
Monitoring phagocytic uptake of amyloid β into glial cell lysosomes in real time
inferredcites →https://doi.org/10.1073/pnas.1609896113openalex-snapshot
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes
inferredcites →https://doi.org/10.1073/pnas.1801612115openalex-snapshot
Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH
inferredcites →https://doi.org/10.1083/jcb.201701047openalex-snapshot
The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases
inferredcites →https://doi.org/10.1084/jem.20041611openalex-snapshot
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
inferredcites →https://doi.org/10.1085/jgp.201110596openalex-snapshot
Lysosomal pH and analysis of the counter ion pathways that support acidification
inferredcites →https://doi.org/10.1091/mbc.e06-10-0975openalex-snapshot
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
inferredcites →https://doi.org/10.1093/jnen/61.9.760openalex-snapshot
Astrocytes Are Less Efficient in the Removal of Apoptotic Lymphocytes than Microglia Cells: Implications for the Role of Glial Cells in the Inflamed Central Nervous System
inferredcites →https://doi.org/10.1101/cshperspect.a028761openalex-snapshot
Mechanosensing and Mechanotransduction at Cell–Cell Junctions
inferredcites →https://doi.org/10.1101/gad.229518.113openalex-snapshot
Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons
inferredcites →https://doi.org/10.1126/sciadv.aba3239openalex-snapshot
Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo
inferredcites →https://doi.org/10.1126/science.1202529openalex-snapshot
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
inferredcites →https://doi.org/10.1126/science.aal3589openalex-snapshot
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
inferredcites →https://doi.org/10.1126/science.aaz2288openalex-snapshot
Microglia mediate forgetting via complement-dependent synaptic elimination
inferredcites →https://doi.org/10.1155/2016/4732837openalex-snapshot
Transcription Factor EB Is Selectively Reduced in the Nuclear Fractions of Alzheimer’s and Amyotrophic Lateral Sclerosis Brains
inferredcites →https://doi.org/10.1159/000337115openalex-snapshot
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
inferredcites →https://doi.org/10.1186/s12974-020-01776-7openalex-snapshot
Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain
inferredcites →https://doi.org/10.1186/s13024-016-0098-zopenalex-snapshot
Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons
inferredcites →https://doi.org/10.1186/s13024-018-0281-5openalex-snapshot
Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
inferredcites →https://doi.org/10.1186/s13064-018-0104-yopenalex-snapshot
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
inferredcites →https://doi.org/10.1242/jcs.146365openalex-snapshot
TFEB at a glance
inferredcites →https://doi.org/10.1371/journal.pone.0033090openalex-snapshot
Engulfing Astrocytes Protect Neurons from Contact-Induced Apoptosis following Injury
inferredcites →https://doi.org/10.1371/journal.pone.0094197openalex-snapshot
Activated Scavenger Receptor A Promotes Glial Internalization of Aβ
inferredcites →https://doi.org/10.1371/journal.pone.0155878openalex-snapshot
Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System
inferredcites →https://doi.org/10.1523/jneurosci.0336-15.2015openalex-snapshot
Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus
inferredcites →https://doi.org/10.1523/jneurosci.1419-07.2007openalex-snapshot
Synaptic Islands Defined by the Territory of a Single Astrocyte
inferredcites →https://doi.org/10.1523/jneurosci.3442-16.2017openalex-snapshot
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
inferredcites →https://doi.org/10.1523/jneurosci.3788-13.2014openalex-snapshot
Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis
inferredcites →https://doi.org/10.1523/jneurosci.3850-15.2016openalex-snapshot
Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes
inferredcites →https://doi.org/10.1523/jneurosci.4178-07.2008openalex-snapshot
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function
inferredcites →https://doi.org/10.15252/embj.2020104464openalex-snapshot
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
inferredcites →https://doi.org/10.3389/fbioe.2020.596577openalex-snapshot
Fluid Shear Stress Enhances the Phagocytic Response of Astrocytes
inferredcites →https://doi.org/10.3389/fnagi.2017.00228openalex-snapshot
Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells
inferredcites →https://doi.org/10.3389/fncel.2013.00006openalex-snapshot
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
inferredcites →https://doi.org/10.3389/fneur.2019.00099openalex-snapshot
Astrocyte Mechano-Activation by High-Rate Overpressure Involves Alterations in Structural and Junctional Proteins
inferredcites →https://doi.org/10.4049/jimmunol.162.1.480openalex-snapshot
Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes
inferredcites →https://doi.org/10.4049/jimmunol.167.9.5004openalex-snapshot
Microglial Phagocytosis of Apoptotic Inflammatory T Cells Leads to Down-Regulation of Microglial Immune Activation
inferredcites →https://doi.org/10.4062/biomolther.2012.20.3.245openalex-snapshot
Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease
inferredcites →https://doi.org/10.4103/1673-5374.239449openalex-snapshot
SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes
inferredcites →https://doi.org/10.7554/elife.54083openalex-snapshot
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Pharmacological Toolkit for Human Microglia Identifies Topoisomerase I Inhibitors as Immunomodulators for Alzheimer's Disease
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Impact of sex on neuroimmune contributions to Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.115201openalex-snapshot
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons
inferred← citeshttps://doi.org/10.1016/j.expneurol.2022.114239openalex-snapshot
Implications of microglial heterogeneity in spinal cord injury progression and therapy
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Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system
inferred← citeshttps://doi.org/10.1016/j.mcn.2022.103804openalex-snapshot
Cardiolipin released by microglia can act on neighboring glial cells to facilitate the uptake of amyloid-β (1–42)
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107618openalex-snapshot
MERTK-dependent efferocytosis in Cx3cr1-expressing myeloid cells supports recovery after traumatic brain injury in male mice
inferred← citeshttps://doi.org/10.1016/j.neulet.2022.136852openalex-snapshot
Independent actions by HIV-1 Tat and morphine to increase recruitment of monocyte-derived macrophages into the brain in a region-specific manner
inferred← citeshttps://doi.org/10.1016/j.neulet.2025.138487openalex-snapshot
MEGF10 knockout promotes cortical and hippocampal amyloid deposition in AD mouse model
inferred← citeshttps://doi.org/10.1016/j.tox.2026.154499openalex-snapshot
Time-resolved multi-omics reveals staged mitochondrial dysfunction and neurodegeneration-related changes in a tri-culture BTX neurotoxicity model
inferred← citeshttps://doi.org/10.1038/s41420-023-01382-5openalex-snapshot
Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons
inferred← citeshttps://doi.org/10.1038/s41593-025-02115-wopenalex-snapshot
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
inferred← citeshttps://doi.org/10.1101/2024.02.06.579103openalex-snapshot
A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1111/bph.17343openalex-snapshot
Plumbagin, a novel TRPV2 inhibitor, ameliorates microglia activation and brain injury in a middle cerebral artery occlusion/reperfusion mouse model
inferred← citeshttps://doi.org/10.1111/cns.13942openalex-snapshot
Relationship between chronic hypoxia and seizure susceptibility
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Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms
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Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson’s disease mice brain
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