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Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice

https://doi.org/10.1084/jem.20121015
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: Effect of viremia levels and antiviral treatment
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Blood coagulation
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Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine
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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
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B7-H1 Determines Accumulation and Deletion of Intrahepatic CD8+ T Lymphocytes
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PD-1: an inhibitory immunoreceptor involved in peripheral tolerance
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Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
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Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
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Restoring function in exhausted CD8 T cells during chronic viral infection
inferredcites →https://doi.org/10.1038/nature05115openalex-snapshot
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
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Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis
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Enhancing SIV-specific immunity in vivo by PD-1 blockade
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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
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The Emerging Toxicity Profiles of Anti–CTLA-4 Antibodies Across Clinical Indications
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Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
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Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
inferredcites →https://doi.org/10.1073/pnas.0307252101openalex-snapshot
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
inferredcites →https://doi.org/10.1073/pnas.0801497105openalex-snapshot
Selective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockade
inferredcites →https://doi.org/10.1073/pnas.0809818106openalex-snapshot
High antigen levels are the cause of T cell exhaustion during chronic viral infection
inferredcites →https://doi.org/10.1073/pnas.1007394107openalex-snapshot
Programmed death-1 (PD-1)–deficient mice are extraordinarily sensitive to tuberculosis
inferredcites →https://doi.org/10.1073/pnas.1015298108openalex-snapshot
Control of Toxoplasma reactivation by rescue of dysfunctional CD8 + T-cell response via PD-1–PDL-1 blockade
inferredcites →https://doi.org/10.1080/713774061openalex-snapshot
Expression and Regulation of the PD-L1 Immunoinhibitory Molecule on Microvascular Endothelial Cells
inferredcites →https://doi.org/10.1083/jcb.200104103openalex-snapshot
Molecular analysis of the interaction of LCMV with its cellular receptor α -dystroglycan
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HLA-A2.1–restricted Education and Cytolytic Activity of CD8+ T Lymphocytes from β2 Microglobulin (β2m) HLA-A2.1 Monochain Transgenic H-2Db β2m Double Knockout Mice
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Nitric Oxide Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice
inferredcites →https://doi.org/10.1084/jem.20022235openalex-snapshot
PD-1 Inhibits Antiviral Immunity at the Effector Phase in the Liver
inferredcites →https://doi.org/10.1084/jem.20071949openalex-snapshot
Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection
inferredcites →https://doi.org/10.1084/jem.20100124openalex-snapshot
Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation
inferredcites →https://doi.org/10.1093/infdis/155.3.465openalex-snapshot
Physiological and Immunologic Disturbances Associated with Shock in a Primate Model of Lassa Fever
inferredcites →https://doi.org/10.1093/infdis/jiq020openalex-snapshot
RSV-Induced Bronchial Epithelial Cell PD-L1 Expression Inhibits CD8+ T Cell Nonspecific Antiviral Activity
inferredcites →https://doi.org/10.1093/intimm/10.10.1563openalex-snapshot
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
inferredcites →https://doi.org/10.1111/j.0105-2896.2005.00242.xopenalex-snapshot
The B7/CD28 costimulatory family in autoimmunity
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00771.xopenalex-snapshot
Costimulatory and coinhibitory receptors in anti‐tumor immunity
inferredcites →https://doi.org/10.1111/j.1600-065x.2010.00923.xopenalex-snapshot
The PD‐1 pathway in tolerance and autoimmunity
inferredcites →https://doi.org/10.1126/science.274.5284.94openalex-snapshot
Phenotypic Analysis of Antigen-Specific T Lymphocytes
inferredcites →https://doi.org/10.1126/science.291.5502.319openalex-snapshot
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
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Broken Barriers: A New Take on Sepsis Pathogenesis
inferredcites →https://doi.org/10.1128/jvi.00062-06openalex-snapshot
Murine Model for Dengue Virus-Induced Lethal Disease with IncreasedVascular Permeability
inferredcites →https://doi.org/10.1128/jvi.01579-09openalex-snapshot
Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion
inferredcites →https://doi.org/10.1128/jvi.79.10.5979-5987.2005openalex-snapshot
Characterization of the Interaction of Lassa Fever Virus with Its Cellular Receptor α-Dystroglycan
inferredcites →https://doi.org/10.1146/annurev-pathol-011110-130158openalex-snapshot
The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment
inferredcites →https://doi.org/10.1152/ajpregu.1998.275.1.r269openalex-snapshot
Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice
inferredcites →https://doi.org/10.1160/th09-03-0208openalex-snapshot
Plasma leakage in dengue haemorrhagic fever
inferredcites →https://doi.org/10.1161/circulationaha.107.709360openalex-snapshot
Endothelial Programmed Death-1 Ligand 1 (PD-L1) Regulates CD8 + T-Cell–Mediated Injury in the Heart
inferredcites →https://doi.org/10.1172/jci40040openalex-snapshot
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
inferredcites →https://doi.org/10.1172/jci44872openalex-snapshot
New therapy to revert dysfunctional antibody responses during HIV-1 infection
inferredcites →https://doi.org/10.1182/blood.v91.10.3527openalex-snapshot
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
inferredcites →https://doi.org/10.1186/1743-422x-8-205openalex-snapshot
Pathogenesis of lassa fever in cynomolgus macaques
inferredcites →https://doi.org/10.1200/jco.2009.26.7609openalex-snapshot
Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
inferredcites →https://doi.org/10.1371/journal.ppat.1000313openalex-snapshot
Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
inferredcites →https://doi.org/10.1371/journal.ppat.1000836openalex-snapshot
T Cell-Dependence of Lassa Fever Pathogenesis
inferredcites →https://doi.org/10.1371/journal.ppat.1001347openalex-snapshot
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) Infection
inferredcites →https://doi.org/10.4049/jimmunol.0800997openalex-snapshot
Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion
inferredcites →https://doi.org/10.4049/jimmunol.1001984openalex-snapshot
Enhanced Antiviral T Cell Function in the Absence of B7-H1 Is Insufficient To Prevent Persistence but Exacerbates Axonal Bystander Damage during Viral Encephalomyelitis
inferredcites →https://doi.org/10.4049/jimmunol.1003304openalex-snapshot
CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition
inferredcites →https://doi.org/10.4049/jimmunol.153.8.3622openalex-snapshot
Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis.
inferredcites →https://doi.org/10.4049/jimmunol.179.3.1979openalex-snapshot
Programmed Death 1 Expression on HIV-Specific CD4+ T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction
inferredcites →https://doi.org/10.4049/jimmunol.180.11.7506openalex-snapshot
Detrimental Contribution of the Immuno-Inhibitor B7-H1 to Rabies Virus Encephalitis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cell Identity and Spatial Distribution of PD‐1/PD‐L1 Blockade Responders
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Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry
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Angiogenesis and Immune Suppression in Cancer
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Blocking of programmed cell death-ligand 1 (PD-L1) expressed on endothelial cells promoted the recruitment of CD8+IFN-γ+ T cells in atherosclerosis
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PD-1⁺ CD8⁺ T cells: roles of PD-1 beyond an exhaustion marker
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Selective expansion of TCF7-expressing tumor-reactive T cell subpopulations during ovarian tumor-infiltrating T cell production ex vivo
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The pleiotropic roles of EZH2 in T-cell immunity and immunotherapy
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Phenotypic, Functional and Transcriptional Heterogeneity in T Cell Exhaustion
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Phenotypic, Functional and Transcriptional Heterogeneity in T Cell Exhaustion
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T cell responses to SARS-COV-2
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The association between the neuroendocrine system and the tumor immune microenvironment: Emerging directions for cancer immunotherapy
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Non-viral siRNA delivery to T cells: Challenges and opportunities in cancer immunotherapy
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Focus on immune checkpoint PD-1/PD-L1 pathway: New advances of polyphenol phytochemicals in tumor immunotherapy
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Astragalus polysaccharide ameliorates CD8+ T cell dysfunction through STAT3/Gal-3/LAG3 pathway in inflammation‐induced colorectal cancer
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Reservoir Host Immune Responses to Emerging Zoonotic Viruses
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
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Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
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Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155
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Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection
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PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage
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Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses
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The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection
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Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection
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IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression
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Cancer Metabolism Drives a Stromal Regenerative Response
inferred← citeshttps://doi.org/10.1016/j.coi.2013.03.003openalex-snapshot
Manipulating the PD-1 pathway to improve immunity
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Heterogeneity and fate choice: T cell exhaustion in cancer and chronic infections
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Checkpoint inhibitors for the treatment of JC virus-related progressive multifocal leukoencephalopathy
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Origin and fine-tuning of effector CD8 T cell subpopulations in chronic infection
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Research progress on immunotherapeutics for triple-negative breast cancer from a single-cell perspective
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Reorienting the immune system in the treatment of cancer by using anti-PD-1 and anti-PD-L1 antibodies
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Previous immune checkpoint inhibitor therapy is associated with decreased COVID-19-related hospitalizations and complications in patients with cancer: Results of a propensity-matched analysis of the OnCovid registry
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Deciphering and Reversing Tumor Immune Suppression
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The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
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The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8+ T Cells in Response to a Lethal Poxvirus Infection
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PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion
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Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
inferred← citeshttps://doi.org/10.1016/j.immuni.2016.07.008openalex-snapshot
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
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The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection
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CD8+ T cells in the cancer-immunity cycle
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The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy
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Immune checkpoint inhibitors and SARS-CoV2 infection
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TLR7-mediated inflammation drives PD-L1 upregulation and T cell exhaustion during influenza A virus infection
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The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses
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Tolerance and exhaustion: defining mechanisms of T cell dysfunction
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T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover
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Immune checkpoint inhibitors-induced systemic capillary leak syndrome: A report of two cases
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Reprogramming away from the exhausted T cell state
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Emerging concepts in PD-1 checkpoint biology
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Self-Delivering RNAi Targeting PD-1 Improves Tumor-Specific T Cell Functionality for Adoptive Cell Therapy of Malignant Melanoma
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Potentiation of immunomodulatory antibody therapy with oncolytic viruses for treatment of cancer
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T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion
inferred← citeshttps://doi.org/10.1038/ni.2619openalex-snapshot
T cell exhaustion: a means or an end?
inferred← citeshttps://doi.org/10.1038/ni.2714openalex-snapshot
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
inferred← citeshttps://doi.org/10.1038/nri.2017.108openalex-snapshot
The diverse functions of the PD1 inhibitory pathway
inferred← citeshttps://doi.org/10.1038/nri3740openalex-snapshot
T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
inferred← citeshttps://doi.org/10.1038/nrm.2017.113openalex-snapshot
Chromatin dependencies in cancer and inflammation
inferred← citeshttps://doi.org/10.1038/s41416-023-02363-2openalex-snapshot
PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade
inferred← citeshttps://doi.org/10.1038/s41467-018-07213-xopenalex-snapshot
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
inferred← citeshttps://doi.org/10.1038/s41467-019-13593-5openalex-snapshot
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome
inferred← citeshttps://doi.org/10.1038/s41467-020-15025-1openalex-snapshot
TIGIT limits immune pathology during viral infections
inferred← citeshttps://doi.org/10.1038/s41467-020-18256-4openalex-snapshot
Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection
inferred← citeshttps://doi.org/10.1038/s41467-021-25057-wopenalex-snapshot
Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment
inferred← citeshttps://doi.org/10.1038/s41577-019-0221-9openalex-snapshot
Defining ‘T cell exhaustion’
inferred← citeshttps://doi.org/10.1038/s41577-019-0223-7openalex-snapshot
Precursor exhausted T cells: key to successful immunotherapy?
inferred← citeshttps://doi.org/10.1038/s41577-020-00454-2openalex-snapshot
Rethinking peripheral T cell tolerance: checkpoints across a T cell’s journey
inferred← citeshttps://doi.org/10.1038/s41577-020-0402-6openalex-snapshot
T cell responses in patients with COVID-19
inferred← citeshttps://doi.org/10.1038/s41577-021-00574-3openalex-snapshot
CD8+ T cell differentiation and dysfunction in cancer
inferred← citeshttps://doi.org/10.1038/s41586-019-1325-xopenalex-snapshot
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
inferred← citeshttps://doi.org/10.1038/s41586-019-1326-9openalex-snapshot
TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
inferred← citeshttps://doi.org/10.1038/s41586-022-05105-1openalex-snapshot
MYB orchestrates T cell exhaustion and response to checkpoint inhibition
inferred← citeshttps://doi.org/10.1038/s41589-018-0155-8openalex-snapshot
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo
inferred← citeshttps://doi.org/10.1038/s41590-018-0185-0openalex-snapshot
Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells
inferred← citeshttps://doi.org/10.1038/s41590-021-00949-7openalex-snapshot
Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity
inferred← citeshttps://doi.org/10.1038/s41590-022-01219-wopenalex-snapshot
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses
inferred← citeshttps://doi.org/10.1038/s41590-024-01961-3openalex-snapshot
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
inferred← citeshttps://doi.org/10.1038/s41590-025-02276-7openalex-snapshot
Lymph nodes fuel KLF2-dependent effector CD8+ T cell differentiation during chronic infection and checkpoint blockade
inferred← citeshttps://doi.org/10.1038/s42255-020-00280-9openalex-snapshot
Metabolic and epigenetic regulation of T-cell exhaustion
inferred← citeshttps://doi.org/10.1073/pnas.1408148111openalex-snapshot
Type I interferon is a therapeutic target for virus-induced lethal vascular damage
inferred← citeshttps://doi.org/10.1073/pnas.1718217115openalex-snapshot
Role of PD-1 during effector CD8 T cell differentiation
inferred← citeshttps://doi.org/10.1080/20013078.2020.1792683openalex-snapshot
In vivo identification of apoptotic and extracellular vesicle‐bound live cells using image‐based deep learning
inferred← citeshttps://doi.org/10.1080/2162402x.2017.1371399openalex-snapshot
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1080/2162402x.2024.2344905openalex-snapshot
The potential role of CMC1 as an immunometabolic checkpoint in T cell immunity
inferred← citeshttps://doi.org/10.1084/jem.20121416openalex-snapshot
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
inferred← citeshttps://doi.org/10.1084/jem.20132577openalex-snapshot
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
inferred← citeshttps://doi.org/10.1084/jem.20142237openalex-snapshot
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
inferred← citeshttps://doi.org/10.1084/jem.20150598openalex-snapshot
High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
inferred← citeshttps://doi.org/10.1084/jem.20180654openalex-snapshot
IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin
inferred← citeshttps://doi.org/10.1084/jem.20241133openalex-snapshot
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells
inferred← citeshttps://doi.org/10.1093/eurheartj/ehaf1080openalex-snapshot
T cells in acute and chronic myocarditis: from diagnosis to treatment
inferred← citeshttps://doi.org/10.1093/infdis/jiab274openalex-snapshot
Anti–PD-L1 Therapy Does Not Improve Survival in a Murine Model of Lethal Staphylococcus aureus Pneumonia
inferred← citeshttps://doi.org/10.1093/infdis/jiu215openalex-snapshot
Postnatal Acquisition of Primary Rhesus Cytomegalovirus Infection is Associated With Prolonged Virus Shedding and Impaired CD4+ T Lymphocyte Function
inferred← citeshttps://doi.org/10.1093/intimm/dxaa039openalex-snapshot
Impact of multiple hits with cognate antigen on memory CD8+ T-cell fate
inferred← citeshttps://doi.org/10.1093/intimm/dxac050openalex-snapshot
Population dynamics and gene regulation of T cells in response to chronic antigen stimulation
inferred← citeshttps://doi.org/10.1093/jimmun/vkaf210openalex-snapshot
Lpar5 regulates the CD8 T-cell response to persistent virus infection by altering exhaustion programming, survival, and NK receptor expression
inferred← citeshttps://doi.org/10.1093/jleuko/qiae256openalex-snapshot
Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression
inferred← citeshttps://doi.org/10.1093/ofid/ofae183openalex-snapshot
Exacerbation of CMV and Nontuberculous Mycobacterial Infections Following PD-1 Blockade for HIV-Associated Kaposi Sarcoma
inferred← citeshttps://doi.org/10.1093/oncolo/oyab083openalex-snapshot
Impact of Immune Checkpoint Inhibitors on COVID-19 Severity in Patients with Cancer
inferred← citeshttps://doi.org/10.1101/2020.02.22.960278openalex-snapshot
Latent Plasticity of Effector-like Exhausted CD8 T cells contributes to memory responses
inferred← citeshttps://doi.org/10.1101/2024.03.16.585350openalex-snapshot
Protective function of ex vivo expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression
inferred← citeshttps://doi.org/10.1101/2025.02.17.634430openalex-snapshot
Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling
inferred← citeshttps://doi.org/10.1101/2025.03.10.642460openalex-snapshot
Humanizing a CD28 signaling domain affects CD8 activation, exhaustion and stem-like precursors
inferred← citeshttps://doi.org/10.1101/2025.08.06.668764openalex-snapshot
Angiogenic CD8 T cells from PWH induce Granzymes-dependent PAR1 activation promoting endothelial inflammation
inferred← citeshttps://doi.org/10.1101/2025.10.19.683142openalex-snapshot
CD8 T cells mediate immunosurveillance for neoantigen+ epithelial stem cells in the colon
inferred← citeshttps://doi.org/10.1111/1759-7714.12494openalex-snapshot
Nivolumab infusion reaction manifesting as plantar erythema and pulmonary infiltrate in a lung cancer patient
inferred← citeshttps://doi.org/10.1111/bjh.18095openalex-snapshot
Resolving sticky relationships between platelets and lymphocytes in COVID‐19 : A role for checkpoint inhibitors?
inferred← citeshttps://doi.org/10.1111/febs.15756openalex-snapshot
Dampening antiviral immunity can protect the host
inferred← citeshttps://doi.org/10.1111/imm.12739openalex-snapshot
CD8 T‐cell regulation by T regulatory cells and the programmed cell death protein 1 pathway
inferred← citeshttps://doi.org/10.1111/imr.13203openalex-snapshot
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections
inferred← citeshttps://doi.org/10.1111/imr.13388openalex-snapshot
Immune checkpoint inhibitors in infectious disease
inferred← citeshttps://doi.org/10.1111/joim.13006openalex-snapshot
Beyond neurotransmission: acetylcholine in immunity and inflammation
inferred← citeshttps://doi.org/10.1111/sji.12036openalex-snapshot
Identification of new internalizing surface receptors on human dendritic cells by phage display antibodies
inferred← citeshttps://doi.org/10.1126/science.aaa7516openalex-snapshot
RETRACTED: The protein LEM promotes CD8 + T cell immunity through effects on mitochondrial respiration
inferred← citeshttps://doi.org/10.1126/science.aac4997openalex-snapshot
Expanding the role of metabolism in T cells
inferred← citeshttps://doi.org/10.1126/sciimmunol.abf3861openalex-snapshot
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
inferred← citeshttps://doi.org/10.1126/sciimmunol.adg3868openalex-snapshot
Cellular and molecular waypoints along the path of T cell exhaustion
inferred← citeshttps://doi.org/10.1126/scitranslmed.aba6006openalex-snapshot
Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice
inferred← citeshttps://doi.org/10.1128/jvi.01263-17openalex-snapshot
Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection
inferred← citeshttps://doi.org/10.1128/jvi.02103-17openalex-snapshot
Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection
inferred← citeshttps://doi.org/10.1128/jvi.03002-13openalex-snapshot
Therapeutic Depletion of Natural Killer Cells Controls Persistent Infection
inferred← citeshttps://doi.org/10.1146/annurev-immunol-041015-055318openalex-snapshot
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
inferred← citeshttps://doi.org/10.1146/annurev-immunol-082223-044122openalex-snapshot
Molecular Mechanisms Governing CD8 T Cell Differentiation and Checkpoint Inhibitor Response in Cancer
inferred← citeshttps://doi.org/10.1146/annurev-immunol-090222-110914openalex-snapshot
T Cell Exhaustion
inferred← citeshttps://doi.org/10.1146/annurev-immunol-101721-064501openalex-snapshot
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging
inferred← citeshttps://doi.org/10.1172/jci.insight.181063openalex-snapshot
Prothrombin prevents fatal T cell–dependent anemia during chronic virus infection of mice
inferred← citeshttps://doi.org/10.1172/jci125297openalex-snapshot
Sphingosine kinase 2 restricts T cell immunopathology but permits viral persistence
inferred← citeshttps://doi.org/10.1186/1742-4690-10-31openalex-snapshot
Molecular signatures of T-cell inhibition in HIV-1 infection
inferred← citeshttps://doi.org/10.1186/s12951-025-03766-4openalex-snapshot
Nanomedicine targeting the PD-1/PD-L1 axis in autoimmune diseases: breaking conventional barriers to restore immune tolerance
inferred← citeshttps://doi.org/10.1186/s12964-016-0160-zopenalex-snapshot
T cell exhaustion: from pathophysiological basics to tumor immunotherapy
inferred← citeshttps://doi.org/10.1186/s40001-025-02694-1openalex-snapshot
The PD-1/PD-L1 pathway and Epstein–Barr virus
inferred← citeshttps://doi.org/10.1189/jlb.4ri0214-126ropenalex-snapshot
Immune control and failure in HCV infection—tipping the balance
inferred← citeshttps://doi.org/10.1200/edbk-25-481556openalex-snapshot
One Step Ahead: Preventing Tumor Adaptation to Immune Therapy
inferred← citeshttps://doi.org/10.12659/msm.910388openalex-snapshot
Correlation of T Cell Immunoglobulin and ITIM Domain (TIGIT) and Programmed Death 1 (PD-1) with Clinicopathological Characteristics of Renal Cell Carcinoma May Indicate Potential Targets for Treatment
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005224openalex-snapshot
PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005656openalex-snapshot
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever
inferred← citeshttps://doi.org/10.1371/journal.ppat.1005667openalex-snapshot
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease
inferred← citeshttps://doi.org/10.1371/journal.ppat.1006498openalex-snapshot
Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection
inferred← citeshttps://doi.org/10.1371/journal.ppat.1008525openalex-snapshot
Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection
inferred← citeshttps://doi.org/10.1371/journal.ppat.1009349openalex-snapshot
PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity
inferred← citeshttps://doi.org/10.1371/journal.ppat.1009892openalex-snapshot
Immunological exhaustion: How to make a disparate concept operational?
inferred← citeshttps://doi.org/10.17537/icmbb24.27openalex-snapshot
Investigation of immune response on LCMV infection using mathematical modelling
inferred← citeshttps://doi.org/10.18632/oncotarget.15489openalex-snapshot
Vitamin D increases programmed death receptor-1 expression in Crohn’s disease
inferred← citeshttps://doi.org/10.20892/j.issn.2095-3941.2020.0338openalex-snapshot
Exhausted T cells and epigenetic status
inferred← citeshttps://doi.org/10.21037/aob-21-2openalex-snapshot
Destiny of CD8+ T cells exhaustion in cancer, and rescue of it: a narrative review
inferred← citeshttps://doi.org/10.2174/1389450116666150825110532openalex-snapshot
Innate and Adaptive Immune Responses in Chronic HCV Infection
inferred← citeshttps://doi.org/10.21873/invivo.13055openalex-snapshot
Age-related Differences in Immune Reactions to SARS-CoV-2 Spike and Nucleocapsid Antigens
inferred← citeshttps://doi.org/10.2310/jim.0000000000000059openalex-snapshot
Ninety-Day Survival Rate of Patients with Sepsis Relates to Programmed Cell Death 1 Genetic Polymorphism rs11568821
inferred← citeshttps://doi.org/10.24884/1682-6655-2025-24-3-13-25openalex-snapshot
Effect of Tumor Necrosis Factor Alpha Inhibitor and Interleukin-6 Inhibitor Therapy on Endothelial Dysfunction in Patients with Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.32469/10355/88918openalex-snapshot
Virus interactions with the sphingolipid network : sphingosine kinase 2 in immunosuppression, immunopathology, and viral propagation
inferred← citeshttps://doi.org/10.33594/000000554openalex-snapshot
Insights into Virus-Induced Immune Mediated Liver Pathology
inferred← citeshttps://doi.org/10.33696/immunology.6.194openalex-snapshot
T cell-Intrinsic Peripheral Tolerance: A Checkpoint Target to Treat Autoimmunity
inferred← citeshttps://doi.org/10.3389/fcimb.2019.00207openalex-snapshot
The PD-1/PD-L1 Axis and Virus Infections: A Delicate Balance
inferred← citeshttps://doi.org/10.3389/fcvm.2025.1646968openalex-snapshot
Myocardial infarction with nonobstructive coronary arteries due to acute coronary vasospasm induced by toripalimab: a case report and review of literature
inferred← citeshttps://doi.org/10.3389/fendo.2026.1861245openalex-snapshot
Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00455openalex-snapshot
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2015.00310openalex-snapshot
Inhibitory Receptors Beyond T Cell Exhaustion
inferred← citeshttps://doi.org/10.3389/fimmu.2015.00603openalex-snapshot
T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity
inferred← citeshttps://doi.org/10.3389/fimmu.2016.00564openalex-snapshot
Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2017.01597openalex-snapshot
PD-1/PD-L1 Blockade: Have We Found the Key to Unleash the Antitumor Immune Response?
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02560openalex-snapshot
Hantavirus-Driven PD-L1/PD-L2 Upregulation: An Imperfect Viral Immune Evasion Mechanism
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02642openalex-snapshot
Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02662openalex-snapshot
Non-hematopoietic Control of Peripheral Tissue T Cell Responses: Implications for Solid Tumors
inferred← citeshttps://doi.org/10.3389/fimmu.2019.00054openalex-snapshot
The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2019.00491openalex-snapshot
A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2019.01181openalex-snapshot
Can Immunogenic Chemotherapies Relieve Cancer Cell Resistance to Immune Checkpoint Inhibitors?
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02298openalex-snapshot
The Diverse Function of PD-1/PD-L Pathway Beyond Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02468openalex-snapshot
SHP-2 in Lymphocytes' Cytokine and Inhibitory Receptor Signaling
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00487openalex-snapshot
The Role of PD-1 in Acute and Chronic Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00986openalex-snapshot
Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection
inferred← citeshttps://doi.org/10.3389/fimmu.2021.765730openalex-snapshot
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1029438openalex-snapshot
Role of regulation of PD-1 and PD-L1 expression in sepsis
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1198551openalex-snapshot
Hierarchical transcriptional network governing heterogeneous T cell exhaustion and its implications for immune checkpoint blockade
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1285554openalex-snapshot
Immune checkpoints in rheumatoid arthritis: progress and promise
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1743170openalex-snapshot
Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion
inferred← citeshttps://doi.org/10.3389/fmicb.2014.00733openalex-snapshot
Endothelial cell dysfunction in viral hemorrhage and edema
inferred← citeshttps://doi.org/10.3390/biomedicines9030260openalex-snapshot
Hypoxia/HIF Modulates Immune Responses
inferred← citeshttps://doi.org/10.3390/cancers11010055openalex-snapshot
Exploiting NK Cell Surveillance Pathways for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/ijms21144918openalex-snapshot
Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders
inferred← citeshttps://doi.org/10.3390/ijms21218159openalex-snapshot
Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance
inferred← citeshttps://doi.org/10.3390/molecules25204831openalex-snapshot
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/nu16234143openalex-snapshot
Polyphenols as Immunomodulators and Epigenetic Modulators: An Analysis of Their Role in the Treatment and Prevention of Breast Cancer
inferred← citeshttps://doi.org/10.3390/v11100885openalex-snapshot
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance
inferred← citeshttps://doi.org/10.3390/v16030390openalex-snapshot
CD8+ T Cells Mediate Lethal Lung Pathology in the Absence of PD-L1 and Type I Interferon Signalling following LCMV Infection
inferred← citeshttps://doi.org/10.3390/vaccines11101563openalex-snapshot
Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8+ T Cells and Causes Immunopathology in Response to Acute LCMV Infection
inferred← citeshttps://doi.org/10.3410/f.726579120.793545055openalex-snapshot
Faculty Opinions recommendation of High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.
inferred← citeshttps://doi.org/10.4049/jimmunol.1402180openalex-snapshot
Programmed Death-1 Controls T Cell Survival by Regulating Oxidative Metabolism
inferred← citeshttps://doi.org/10.4049/jimmunol.1403237openalex-snapshot
CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells
inferred← citeshttps://doi.org/10.4049/jimmunol.1502018openalex-snapshot
Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control
inferred← citeshttps://doi.org/10.4049/jimmunol.1601464openalex-snapshot
Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory
inferred← citeshttps://doi.org/10.4049/jimmunol.2300396openalex-snapshot
Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection
inferred← citeshttps://doi.org/10.4049/jimmunol.2300462openalex-snapshot
SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay
inferred← citeshttps://doi.org/10.4049/jimmunol.2300785openalex-snapshot
Altering β Cell Antigen Exposure to Exhausted CD8+ T Cells Prevents Autoimmune Diabetes in Mice
inferred← citeshttps://doi.org/10.53846/goediss-7670openalex-snapshot
The Role of Glycolysis in shaping the Autoimmune Potential of Myelin-Reactive T Cells in the Course of Experimental Autoimmune Encephalomyelitis
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