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Ophiobolin A, a sesterterpenoid fungal phytotoxin, displays higher in vitro growth-inhibitory effects in mammalian than in plant cells and displays in vivo antitumor activity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<144::aid-cncr24>3.0.co;2-4openalex-snapshot
In vitro characterization of prolactin-induced effects on proliferation in the neoplastic LNCaP, DU145, and PC3 models of the human prostate
inferredcites →https://doi.org/10.1006/abbi.1993.1222openalex-snapshot
Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells
inferredcites →https://doi.org/10.1007/s11418-012-0676-5openalex-snapshot
Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species
inferredcites →https://doi.org/10.1016/0092-8674(94)90544-4openalex-snapshot
H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response
inferredcites →https://doi.org/10.1016/b978-0-444-01082-7.x5001-2openalex-snapshot
Basic Methods in Molecular Biology
inferredcites →https://doi.org/10.1016/j.bcp.2005.06.005openalex-snapshot
Effects of the cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) on the physiology of cultured human keratinocytes
inferredcites →https://doi.org/10.1016/j.bcp.2007.03.002openalex-snapshot
Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24)
inferredcites →https://doi.org/10.1016/j.bmcl.2011.10.079openalex-snapshot
The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways
inferredcites →https://doi.org/10.1016/j.canlet.2010.01.009openalex-snapshot
Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-α priming
inferredcites →https://doi.org/10.1016/j.fct.2006.07.003openalex-snapshot
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products
inferredcites →https://doi.org/10.1016/j.resp.2010.02.007openalex-snapshot
Redox homeostasis in plants. The challenge of living with endogenous oxygen production
inferredcites →https://doi.org/10.1016/j.taap.2011.03.027openalex-snapshot
In vitro anticancer activity, toxicity and structure–activity relationships of phyllostictine A, a natural oxazatricycloalkenone produced by the fungus Phyllosticta cirsii
inferredcites →https://doi.org/10.1016/s0021-9258(17)43208-xopenalex-snapshot
Ophiobolin A. A natural product inhibitor of calmodulin.
inferredcites →https://doi.org/10.1016/s0024-3205(00)00668-8openalex-snapshot
The biology of ophiobolins
inferredcites →https://doi.org/10.1016/s0040-4039(00)72395-1openalex-snapshot
The constitution of cochliobolin
inferredcites →https://doi.org/10.1016/s0074-7696(08)62452-3openalex-snapshot
Tobacco BY-2 Cell Line as the “HeLa” Cell in the Cell Biology of Higher Plants
inferredcites →https://doi.org/10.1021/ja00949a061openalex-snapshot
The Structure of Ophiobolin, a C25 Terpenoid Having a Novel Skeleton
inferredcites →https://doi.org/10.1021/jf052843lopenalex-snapshot
Herbicidal Potential of Ophiobolins Produced by Drechslera gigantea
inferredcites →https://doi.org/10.1021/np980462eopenalex-snapshot
Characterization of 6-epi-3-Anhydroophiobolin B from Cochliobolus heterostrophus
inferredcites →https://doi.org/10.1038/labinvest.3780407openalex-snapshot
Galectin-1 Is Overexpressed in Nasal Polyps under Budesonide and Inhibits Eosinophil Migration
inferredcites →https://doi.org/10.1038/nrg2812openalex-snapshot
Plant immunity: towards an integrated view of plant–pathogen interactions
inferredcites →https://doi.org/10.1038/onc.2011.309openalex-snapshot
Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma
inferredcites →https://doi.org/10.1038/onc.2011.513openalex-snapshot
Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro
inferredcites →https://doi.org/10.1038/sj.jid.5700869openalex-snapshot
Galectin-1 Knockdown Increases Sensitivity to Temozolomide in a B16F10 Mouse Metastatic Melanoma Model
inferredcites →https://doi.org/10.1083/jcb.200409170openalex-snapshot
Hydrogen peroxide as a signal controlling plant programmed cell death
inferredcites →https://doi.org/10.1093/jexbot/52.361.1721openalex-snapshot
Hydrogen peroxide induces programmed cell death features in cultured tobacco BY-2 cells, in a dose-dependent manner
inferredcites →https://doi.org/10.1093/jxb/erj194openalex-snapshot
Reduced expression of top1 gene induces programmed cell death and alters ascorbate metabolism in Daucus carota cultured cells
inferredcites →https://doi.org/10.1093/jxb/erm239openalex-snapshot
The hypersensitive response; the centenary is upon us but how much do we know?
inferredcites →https://doi.org/10.1093/mp/ssp008openalex-snapshot
Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture
inferredcites →https://doi.org/10.1093/mp/ssq077openalex-snapshot
Dihydrosphingosine-Induced Programmed Cell Death in Tobacco BY-2 Cells Is Independent of H2O2 Production
inferredcites →https://doi.org/10.1093/nar/19.6.1349openalex-snapshot
A simple and rapid method for the preparation of plant genomic DNA for PCR analysis
inferredcites →https://doi.org/10.1097/00008390-200504000-00010openalex-snapshot
Epidermal cells: methods and protocols
inferredcites →https://doi.org/10.1097/mjt.0b013e31817c941fopenalex-snapshot
Methods in Molecular Biology
inferredcites →https://doi.org/10.1104/pp.103.035956openalex-snapshot
Production of Reactive Oxygen Species, Alteration of Cytosolic Ascorbate Peroxidase, and Impairment of Mitochondrial Metabolism Are Early Events in Heat Shock-Induced Programmed Cell Death in Tobacco Bright-Yellow 2 Cells
inferredcites →https://doi.org/10.1104/pp.77.2.303openalex-snapshot
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A
inferredcites →https://doi.org/10.1111/j.1365-3040.2008.01867.xopenalex-snapshot
Production of reactive species and modulation of antioxidant network in response to heat shock: a critical balance for cell fate
inferredcites →https://doi.org/10.1111/j.1365-3040.2011.02387.xopenalex-snapshot
Redox regulation in plant programmed cell death
inferredcites →https://doi.org/10.1111/j.1365-313x.2006.02919.xopenalex-snapshot
Hydrogen peroxide, nitric oxide and cytosolic ascorbate peroxidase at the crossroad between defence and cell death
inferredcites →https://doi.org/10.1111/j.1438-8677.2011.00543.xopenalex-snapshot
Galactone‐γ‐lactone‐dependent ascorbate biosynthesis alters wheat kernel maturation
inferredcites →https://doi.org/10.1124/jpet.104.073395openalex-snapshot
Intrinsic and Acquired Forms of Resistance against the Anticancer Ruthenium Compound KP1019 [Indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate (III)] (FFC14A)
inferredcites →https://doi.org/10.1158/0008-5472.can-07-1502openalex-snapshot
Drug Sensitivity Prediction by CpG Island Methylation Profile in the NCI-60 Cancer Cell Line Panel
inferredcites →https://doi.org/10.1210/er.2003-0008openalex-snapshot
Regulation of Cell Cycle Progression by Calcium/Calmodulin-Dependent Pathways
inferredcites →https://doi.org/10.1211/146080800128736312openalex-snapshot
Ophiobolin A, a Novel Apoptosis-inducing Agent from Fungus Strain f-7438
inferredcites →https://doi.org/10.1593/neo.07130openalex-snapshot
4-IBP, a σ1 Receptor Agonist, Decreases the Migration of Human Cancer Cells, Including Glioblastoma Cells, In Vitro and Sensitizes Them In Vitro and In Vivo to Cytotoxic Insults of Proapoptotic and Proautophagic Drugs
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4818930openalex-extracted
Uplc-Q-Tof-Ms/Ms Analysis of Ophiobolins Sesterterpenoids to Mine New and Bioactive Analogues from Bipolaris Eleusines
inferred← citeshttps://doi.org/10.1007/978-1-4939-7668-3_1openalex-snapshot
Programmed Cell Death in Plants: An Overview
inferred← citeshttps://doi.org/10.1007/978-981-16-4935-6_12openalex-snapshot
Green Nanoparticles: A Hope for Targeted Delivery of Natural Therapeuticals for the Management of Glioblastoma Multiforme (GBM)
inferred← citeshttps://doi.org/10.1007/s11095-014-1386-3openalex-snapshot
Incorporation of Ophiobolin A into Novel Chemoembolization Particles for Cancer Cell Treatment
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188338openalex-snapshot
The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.08.066openalex-snapshot
Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure–activity relationship and unique pyrrolylation of primary amines
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.02.007openalex-snapshot
Chemistry and biology of ophiobolin A and its congeners
inferred← citeshttps://doi.org/10.1016/j.jddst.2025.106799openalex-snapshot
Harnessing Nature's nano-architects: Diatom biosilica in biomedical innovations
inferred← citeshttps://doi.org/10.1016/j.phytochem.2024.114267openalex-snapshot
UPLC-Q-TOF-MS/MS analysis of ophiobolins sesterterpenoids and bioactive analogs from Bipolaris eleusines
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00287openalex-snapshot
Structural and Chemical Biology of Terpenoid Cyclases
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00836openalex-snapshot
Drophiobiolins A and B, Bioactive Ophiobolan Sestertepenoids Produced byDreschslera gigantea
inferred← citeshttps://doi.org/10.1039/c6ob01418fopenalex-snapshot
Single dish gradient screening of small molecule localization
inferred← citeshttps://doi.org/10.1039/c8np00050fopenalex-snapshot
Total synthesis of sesterterpenoids
inferred← citeshttps://doi.org/10.1039/d3np00035dopenalex-snapshot
The incredible story of ophiobolin A and sphaeropsidin A: two fungal terpenes from wilt-inducing phytotoxins to promising anticancer compounds
inferred← citeshttps://doi.org/10.1055/s-0033-1360273openalex-snapshot
Methods Applied to the In Vitro Primary Toxicology Testing of Natural Products: State of the Art, Strengths, and Limits
inferred← citeshttps://doi.org/10.1080/14786419.2019.1597352openalex-snapshot
High ophiobolin A production in endophytic fungus Bipolaris sp. associated with Datura metel
inferred← citeshttps://doi.org/10.1080/14786419.2020.1860975openalex-snapshot
Augmented phytotoxic effect of nanoencapsulated ophiobolin A
inferred← citeshttps://doi.org/10.1093/jxb/erv110openalex-snapshot
Low concentrations of the toxin ophiobolin A lead to an arrest of the cell cycle and alter the intracellular partitioning of glutathione between the nuclei and cytoplasm
inferred← citeshttps://doi.org/10.1111/mpp.12162openalex-snapshot
The past, present and future of secondary metabolite research in the D othideomycetes
inferred← citeshttps://doi.org/10.1155/2017/4829180openalex-snapshot
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease
inferred← citeshttps://doi.org/10.1155/2017/9363040openalex-snapshot
Natural Bioactive Compounds: Alternative Approach to the Treatment of Glioblastoma Multiforme
inferred← citeshttps://doi.org/10.1177/0960327116658107openalex-snapshot
The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes
inferred← citeshttps://doi.org/10.1177/1934578x1400900330openalex-snapshot
Phytotoxic Terpenes Produced by Phytopathogenic Fungi and Allelopathic Plants
inferred← citeshttps://doi.org/10.1371/journal.pone.0167672openalex-snapshot
Ophiobolin A Induces Autophagy and Activates the Mitochondrial Pathway of Apoptosis in Human Melanoma Cells
inferred← citeshttps://doi.org/10.1557/adv.2015.22openalex-snapshot
Diatoms Biosilica as Efficient Drug-Delivery System
inferred← citeshttps://doi.org/10.18632/oncotarget.22537openalex-snapshot
Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
inferred← citeshttps://doi.org/10.2174/0929867322666150821101047openalex-snapshot
Sesterterpenoids with Anticancer Activity
inferred← citeshttps://doi.org/10.2174/9789815179699124010006openalex-snapshot
The Role of Terpenoids in Plant Development and Stress Tolerance
inferred← citeshttps://doi.org/10.31296/cmr.8openalex-snapshot
A Brief Review on Structure-Bioactivity Relationship Study of Ophiobolins and Derivatives
inferred← citeshttps://doi.org/10.3390/ijms222011256openalex-snapshot
Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets
inferred← citeshttps://doi.org/10.3390/jof10070445openalex-snapshot
Molecular Characterization and Expression Analysis of a Gene Encoding 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR) from Bipolaris eleusines, an Ophiobolin A-Producing Fungus
inferred← citeshttps://doi.org/10.3390/md15070229openalex-snapshot
The Biological Activities of Sesterterpenoid-Type Ophiobolins
inferred← citeshttps://doi.org/10.3390/micro2020023openalex-snapshot
Diatom Biosilica in Targeted Drug Delivery and Biosensing Applications: Recent Studies
inferred← citeshttps://doi.org/10.3390/molecules181214629openalex-snapshot
Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal Secondary Metabolites Targeting Leukemia Cells
inferred← citeshttps://doi.org/10.3390/molecules31071206openalex-snapshot
From Phytotoxin to Cell-Death Probe: Ophiobolin A and Related Sesterterpenoids in Membrane Stress and Non-Apoptotic Cell Death
inferred← citeshttps://doi.org/10.3390/toxins11120683openalex-snapshot
Screening Mold Colonies by Using Two Toxicity Assays Revealed Indoor Strains of Aspergillus calidoustus Producing Ophiobolins G and K
inferred← citeshttps://doi.org/10.3892/ijo.2017.3858openalex-snapshot
Ophiobolin A, a sesterpenoid fungal phytotoxin, displays different mechanisms of cell death in mammalian cells depending upon the cancer cell origin
inferred← citeshttps://doi.org/10.47371/mycosci.2020.11.002openalex-snapshot
Characterization and phytotoxicity of ophiobolins produced by Bipolaris setariae
inferred← citeshttps://doi.org/10.7554/elife.14601openalex-snapshot
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
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