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Novel spheroid reservoir bioartificial liver improves survival of nonhuman primates in a toxin-induced model of acute liver failure
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.289.2.217openalex-snapshot
Artificial and Bioartificial Support Systems for Acute and Acute-on-Chronic Liver Failure
inferredcites →https://doi.org/10.1002/bit.21599openalex-snapshot
Cells for bioartificial liver devices: The human hepatoma‐derived cell line C3A produces urea but does not detoxify ammonia
inferredcites →https://doi.org/10.1002/hep.22674openalex-snapshot
Rat hepatocyte spheroids formed by rocked technique maintain differentiated hepatocyte gene expression and function #
inferredcites →https://doi.org/10.1002/hep.23367openalex-snapshot
Ammonia and the Neutrophil in the Pathogenesis of Hepatic Encephalopathy in Cirrhosis
inferredcites →https://doi.org/10.1002/hep.26185openalex-snapshot
Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial
inferredcites →https://doi.org/10.1002/hep.30184openalex-snapshot
Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Posthepatectomy Liver Failure
inferredcites →https://doi.org/10.1002/lt.20446openalex-snapshot
Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver
inferredcites →https://doi.org/10.1016/j.jceh.2014.06.004openalex-snapshot
Pathogenesis of Hepatic Encephalopathy: Role of Ammonia and Systemic Inflammation
inferredcites →https://doi.org/10.1016/j.jcmgh.2015.04.003openalex-snapshot
The Gut Microbiota and Liver Disease
inferredcites →https://doi.org/10.1016/j.jhep.2015.03.021openalex-snapshot
Pivotal preclinical trial of the spheroid reservoir bioartificial liver
inferredcites →https://doi.org/10.1016/j.jhep.2015.05.020openalex-snapshot
A new horizon for liver support in acute liver failure
inferredcites →https://doi.org/10.1016/j.jhep.2016.02.004openalex-snapshot
IL-6 pathway in the liver: From physiopathology to therapy
inferredcites →https://doi.org/10.1016/j.stem.2014.01.003openalex-snapshot
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
inferredcites →https://doi.org/10.1016/s0002-9343(02)01571-1openalex-snapshot
Ammonia levels and the severity of hepatic encephalopathy
inferredcites →https://doi.org/10.1038/cr.2016.6openalex-snapshot
Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes
inferredcites →https://doi.org/10.1038/nm0397-282openalex-snapshot
Infection of human cells by an endogenous retrovirus of pigs
inferredcites →https://doi.org/10.1038/nri1200openalex-snapshot
Macrophage migration inhibitory factor: a regulator of innate immunity
inferredcites →https://doi.org/10.1053/j.gastro.2015.08.053openalex-snapshot
RETRACTED: CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure
inferredcites →https://doi.org/10.1053/jhep.2003.50156openalex-snapshot
Induced Hyperammonemia Alters Neuropsychology, Brain Mr Spectroscopy and Magnetization Transfer in Cirrhosis
inferredcites →https://doi.org/10.1053/jlts.2001.28742openalex-snapshot
S-100b and neuron-specific enolase in patients with fulminant hepatic failure
inferredcites →https://doi.org/10.1053/jlts.2003.50024openalex-snapshot
Membrane barrier of a porcine hepatocyte bioartificial liver
inferredcites →https://doi.org/10.1084/jem.187.9.1463openalex-snapshot
Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion
inferredcites →https://doi.org/10.1097/00007890-199905150-00009openalex-snapshot
TRANSFER OF PORCINE ENDOGENOUS RETROVIRUS ACROSS HOLLOW FIBER MEMBRANES
inferredcites →https://doi.org/10.1097/01.tp.0000080067.79190.3copenalex-snapshot
Membrane pore size impacts performance of a xenogeneic bioartificial liver1
inferredcites →https://doi.org/10.1097/maj.0b013e318232ae0aopenalex-snapshot
Immunosafety Evaluation of a Multilayer Flat-Plate Bioartificial Liver
inferredcites →https://doi.org/10.1099/0022-1317-10-2-195openalex-snapshot
C-type Virus Particles in Pig Kidney Cell Lines
inferredcites →https://doi.org/10.1111/j.1525-1594.2007.00354.xopenalex-snapshot
Extracorporeal Bioartificial Liver Using the Radial‐flow Bioreactor in Treatment of Fatal Experimental Hepatic Encephalopathy
inferredcites →https://doi.org/10.1111/xen.12259openalex-snapshot
Comparison of methods for isolating primary hepatocytes from mini pigs
inferredcites →https://doi.org/10.3727/000000004783983378openalex-snapshot
Cytotoxic Immune Response to a Xenogeneic Bioartificial Liver
inferredcites →https://doi.org/10.3727/096368912x656054openalex-snapshot
Serum-Free Medium and Mesenchymal Stromal Cells Enhance Functionality and Stabilize Integrity of Rat Hepatocyte Spheroids
inferredcites →https://doi.org/10.3748/wjg.v18.i5.435openalex-snapshot
AMacaca mulattamodel of fulminant hepatic failure
inferredcites →https://doi.org/10.3892/etm.2013.1241openalex-snapshot
Artificial and bioartificial liver support systems for acute and acute-on-chronic hepatic failure: A meta-analysis and meta-regression
inferredcites →https://doi.org/10.7326/0003-4819-159-8-201310150-00005openalex-snapshot
Albumin Dialysis With a Noncell Artificial Liver Support Device in Patients With Acute Liver Failure
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4638517openalex-extracted
Activation of APE1 Modulates Nrf2, Inhibits Hepatocyte Ferroptosis and Promotes Hepatocyte Autophagy, Thereby Protecting Against Acute Liver Injury
inferred← citeshttps://doi.org/10.1002/adhm.202101580openalex-snapshot
Bioinspired Artificial Liver System with hiPSC‐Derived Hepatocytes for Acute Liver Failure Treatment
inferred← citeshttps://doi.org/10.1002/biot.202000463openalex-snapshot
Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine
inferred← citeshttps://doi.org/10.1002/btm2.10552openalex-snapshot
A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver
inferred← citeshttps://doi.org/10.1002/btm2.70154openalex-snapshot
The effect of rocking speed and cell inoculation density on hepatic spheroid size: A simple method for size modulation
inferred← citeshttps://doi.org/10.1002/exp.20240469openalex-snapshot
Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications
inferred← citeshttps://doi.org/10.1002/mco2.70795openalex-snapshot
Bioartificial Livers Developed From Gene‐Edited Pig Hepatocyte Organoids Improve Amino Acid and Lipid Profiles in the Plasma of Patients With Liver Failure
inferred← citeshttps://doi.org/10.1007/s10047-019-01133-3openalex-snapshot
End-stage liver failure: filling the treatment gap at the intensive care unit
inferred← citeshttps://doi.org/10.1007/s10753-020-01366-yopenalex-snapshot
Toll-like Receptor 4 Inhibitor TAK-242 Improves Fulminant Hepatitis by Regulating Accumulation of Myeloid-Derived Suppressor Cell
inferred← citeshttps://doi.org/10.1007/s12015-023-10672-5openalex-snapshot
Stem Cell-Based Strategies: The Future Direction of Bioartificial Liver Development
inferred← citeshttps://doi.org/10.1007/s13770-021-00357-wopenalex-snapshot
Liver Organoids: Formation Strategies and Biomedical Applications
inferred← citeshttps://doi.org/10.1007/s44272-024-00012-0openalex-snapshot
Progress, application and challenges of liver organoids
inferred← citeshttps://doi.org/10.1016/b978-0-12-823524-9.00020-4openalex-snapshot
Acute liver failure and bioreactors/liver assist devices
inferred← citeshttps://doi.org/10.1016/b978-0-443-15717-2.00107-4openalex-snapshot
Traditional and 3D Stem Cell Cultures Maintained in Xenobiotic-Free Conditions: Immunological Aspects
inferred← citeshttps://doi.org/10.1016/j.bbe.2021.06.005openalex-snapshot
Cell-based clinical and experimental methods for assisting the function of impaired livers – Present and future of liver support systems
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107565openalex-snapshot
Fabrication and in vitro evaluation of a packed-bed bioreactor based on galactosylated poly(ethylene terephthalate) microfibrous scaffolds
inferred← citeshttps://doi.org/10.1016/j.cobme.2024.100530openalex-snapshot
Cell therapy for liver diseases: From hepatocyte transplantation to bioartificial livers
inferred← citeshttps://doi.org/10.1016/j.cryobiol.2026.105635openalex-snapshot
The interconnection of cryobiology and tissue engineering
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111529openalex-snapshot
Activation of APE1 modulates Nrf2 protected against acute liver injury by inhibit hepatocyte ferroptosis and promote hepatocyte autophagy
inferred← citeshttps://doi.org/10.1016/j.jcyt.2021.04.006openalex-snapshot
Decisional tool for cost of goods analysis of bioartificial liver devices for routine clinical use
inferred← citeshttps://doi.org/10.1016/j.rvsc.2025.105985openalex-snapshot
Organoid-based platforms in livestock: Current advances and future prospects
inferred← citeshttps://doi.org/10.1016/j.stem.2026.04.007openalex-snapshot
Advancing hepatocyte-based therapies: A translational perspective
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c09325openalex-snapshot
Recent Advances in Detection Methods and Toxicological Mechanisms of Amatoxins
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.2c01213openalex-snapshot
Orthotopic Transplantation of Functional Bioengineered Livers in Rats
inferred← citeshttps://doi.org/10.1039/c9bm01879dopenalex-snapshot
A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction
inferred← citeshttps://doi.org/10.1088/1758-5090/ac6e86openalex-snapshot
Bioartificial livers: a review of their design and manufacture
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000788openalex-snapshot
Bioartificial liver: Where lies the path ahead—A review
inferred← citeshttps://doi.org/10.1111/xen.12512openalex-snapshot
Cold storage of porcine hepatocyte spheroids for spheroid bioartificial liver
inferred← citeshttps://doi.org/10.1111/xen.12878openalex-snapshot
Large‐Scale Formation and Long‐Term Culture of Hepatocyte Organoids From Streamlined In Vivo Genome‐Edited GGTA1−/− Pigs for Bioartificial Liver Applications
inferred← citeshttps://doi.org/10.1155/2019/3945672openalex-snapshot
Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials
inferred← citeshttps://doi.org/10.1155/2024/4654912openalex-snapshot
Peripheral Injection of hUC‐MSCs in the Treatment of Acute Liver Failure: A Pre‐Clinical Cohort Study in Rhesus Monkeys
inferred← citeshttps://doi.org/10.1177/03913988221091286openalex-snapshot
In vitro safety and efficacy evaluation of a novel hybrid bioartificial liver system with simulated liver failure serum
inferred← citeshttps://doi.org/10.1177/03913988221145501openalex-snapshot
Establishment of acute liver failure model in Tibetan miniature pig and verified by dual plasma molecular adsorption system
inferred← citeshttps://doi.org/10.1186/s13036-024-00417-4openalex-snapshot
Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
inferred← citeshttps://doi.org/10.1186/s13287-026-04985-8openalex-snapshot
Preclinical efficacy and safety evaluation of human embryonic stem cell-derived functional hepatocytes for a clinical trial in acute liver failure
inferred← citeshttps://doi.org/10.3138/canlivj.2019-0011openalex-snapshot
Proceedings from the 2018 Canadian Association for the Study of the Liver Single Topic Conference—Decompensated cirrhosis: from clinic to transplant
inferred← citeshttps://doi.org/10.3389/fbioe.2020.00895openalex-snapshot
Small-Scale Fluidized Bed Bioreactor for Long-Term Dynamic Culture of 3D Cell Constructs and in vitro Testing
inferred← citeshttps://doi.org/10.3389/fbioe.2025.1572254openalex-snapshot
Evaluation of a single-use bioartificial liver (BAL) biocartridge consisting of cryopreservable alginate encapsulated liver cell spheroids as a component of HepatiCan™, a novel bioartificial liver device
inferred← citeshttps://doi.org/10.3389/fmed.2024.1363979openalex-snapshot
Comprehensive analysis of brain injury parameters in a preclinical porcine model of acute liver failure
inferred← citeshttps://doi.org/10.3390/ijms242015429openalex-snapshot
Adipose Tissue-Derived Mesenchymal Stem Cells Extend the Lifespan and Enhance Liver Function in Hepatocyte Organoids
inferred← citeshttps://doi.org/10.3390/livers2040029openalex-snapshot
Preclinical Experience of the Mayo Spheroid Reservoir Bioartificial Liver (SRBAL) in Management of Acute Liver Failure
inferred← citeshttps://doi.org/10.33978/2307-3586-2020-16-1-46-51openalex-snapshot
Modern Methods of Correction and Prevention of Liver Failure
inferred← citeshttps://doi.org/10.34133/bmr.0043openalex-snapshot
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System
inferred← citeshttps://doi.org/10.3748/wjg.v25.i27.3634openalex-snapshot
Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis of the clinical and preclinical literature
inferred← citeshttps://doi.org/10.3892/etm.2019.7673openalex-snapshot
Human hepatocellular adenoma as a promising cell source for bioartificial liver systems
inferred← citeshttps://doi.org/10.6084/m9.figshare.25414937openalex-snapshot
Additional file 1 of Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
inferred← citeshttps://doi.org/10.7150/thno.40128openalex-snapshot
Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice
inferred← citeshttps://doi.org/10.7150/thno.58515openalex-snapshot
Fiber scaffold bioartificial liver therapy relieves acute liver failure and extrahepatic organ injury in pigs
inferred← citeshttps://doi.org/10.7287/peerj.12579v0.1/reviews/1openalex-snapshot
Peer Review #1 of "Preclinical models of acute liver failure: a comprehensive review (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.12579v0.1/reviews/2openalex-snapshot
Peer Review #2 of "Preclinical models of acute liver failure: a comprehensive review (v0.1)"
inferred← citeshttps://doi.org/10.7287/peerj.12579v0.1/reviews/3openalex-snapshot
Peer Review #3 of "Preclinical models of acute liver failure: a comprehensive review (v0.1)"
inferred← citeshttps://doi.org/10.7717/peerj.12579openalex-snapshot
Preclinical models of acute liver failure: a comprehensive review
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