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High‐efficient characterization of complex protein drugs by imaged capillary isoelectric focusing with high‐resolution ampholytes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/elps.201800013openalex-snapshot
Coupling imaged capillary isoelectric focusing with mass spectrometry using a nanoliter valve
inferredcites →https://doi.org/10.1002/elps.201900325openalex-snapshot
A novel microchip‐based imaged CIEF‐MS system for comprehensive characterization and identification of biopharmaceutical charge variants
inferredcites →https://doi.org/10.1002/elps.202100295openalex-snapshot
Evaluation of an icIEF‐MS system for comparable charge variant analysis of biotherapeutics with rapid peak identification by mass spectrometry
inferredcites →https://doi.org/10.1002/elps.202200170openalex-snapshot
Characterization of therapeutic mAb charge heterogeneity by iCIEF coupled to mass spectrometry (iCIEF–MS)
inferredcites →https://doi.org/10.1002/jps.20727openalex-snapshot
Antibody Structure, Instability, and Formulation
inferredcites →https://doi.org/10.1016/j.ab.2021.114505openalex-snapshot
A platform method for charge heterogeneity characterization of fusion proteins by icIEF
inferredcites →https://doi.org/10.1016/j.ab.2022.114961openalex-snapshot
Cutting-edge mass spectrometry strategy based on imaged capillary isoelectric focusing (icIEF) technology for characterizing charge heterogeneity of monoclonal antibody
inferredcites →https://doi.org/10.1016/j.aca.2022.339447openalex-snapshot
Applications of capillary electromigration methods for separation and analysis of proteins (2017–mid 2021) – A review
inferredcites →https://doi.org/10.1016/j.bpc.2015.07.004openalex-snapshot
Modeling of protein–anion exchange resin interaction for the human growth hormone charge variants
inferredcites →https://doi.org/10.1016/j.chroma.2011.05.061openalex-snapshot
Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
inferredcites →https://doi.org/10.1016/j.chroma.2021.462274openalex-snapshot
Recent advances in isoelectric focusing of proteins and peptides
inferredcites →https://doi.org/10.1016/j.chroma.2021.462499openalex-snapshot
Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies
inferredcites →https://doi.org/10.1016/j.chroma.2021.462568openalex-snapshot
Ultra-short ion-exchange columns for fast charge variants analysis of therapeutic proteins
inferredcites →https://doi.org/10.1016/j.dib.2020.105435openalex-snapshot
Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry
inferredcites →https://doi.org/10.1016/j.ejpb.2016.01.005openalex-snapshot
N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins
inferredcites →https://doi.org/10.1016/j.ijms.2019.116229openalex-snapshot
Characterization of bispecific and mispaired IgGs by native charge-variant mass spectrometry
inferredcites →https://doi.org/10.1016/j.jpba.2010.08.030openalex-snapshot
Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations
inferredcites →https://doi.org/10.1016/j.jpba.2015.02.037openalex-snapshot
Ion-exchange chromatography for the characterization of biopharmaceuticals
inferredcites →https://doi.org/10.1016/j.trac.2022.116567openalex-snapshot
Imaged capillary isoelectric focusing: Applications in the pharmaceutical industry and recent innovations of the technology
inferredcites →https://doi.org/10.1021/acs.analchem.0c02775openalex-snapshot
New Insights into the Chromatography Mechanisms of Ion-Exchange Charge Variant Analysis: Dispelling Myths and Providing Guidance for Robust Method Optimization
inferredcites →https://doi.org/10.1021/acs.analchem.8b02175openalex-snapshot
High Resolution Capillary Isoelectric Focusing Mass Spectrometry Analysis of Peptides, Proteins, And Monoclonal Antibodies with a Flow-through Microvial Interface
inferredcites →https://doi.org/10.1021/acs.chemrev.1c00212openalex-snapshot
High-Resolution Native Mass Spectrometry
inferredcites →https://doi.org/10.1021/jasms.0c00277openalex-snapshot
Versatile, Sensitive, and Robust Native LC–MS Platform for Intact Mass Analysis of Protein Drugs
inferredcites →https://doi.org/10.1038/s43018-021-00295-5openalex-snapshot
Fusion proteins drive cancer through phase separation
inferredcites →https://doi.org/10.1039/c4ay00447gopenalex-snapshot
Recent advances in the analysis of therapeutic proteins by capillary and microchip electrophoresis
inferredcites →https://doi.org/10.1080/19420862.2018.1525253openalex-snapshot
Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-0789openalex-snapshot
Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate
inferredcites →https://doi.org/10.2174/138920108786786402openalex-snapshot
Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods
inferredcites →https://doi.org/10.3390/ijms22169072openalex-snapshot
Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics
inferredcites →https://doi.org/10.3390/jpm11050355openalex-snapshot
Bispecific Antibodies: A Review of Development, Clinical Efficacy and Toxicity in B-Cell Lymphomas
inferredcites →https://doi.org/10.3390/molecules26102943openalex-snapshot
Antibody–Drug Conjugates—A Tutorial Review
inferredcites →https://doi.org/10.4161/mabs.21328openalex-snapshot
Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies
inferredcites →https://doi.org/10.4161/mabs.23654openalex-snapshot
Therapeutic antibody engineering

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4812100openalex-extracted
An Integrated Protocol Based on Workflows of Imaged Capillary Isoelectric Focusing (Icief) for In-Depth Protein Heterogenous Characterization: High-Efficient Fractionation and Online Mass Spectrometry Detection
inferred← citeshttps://doi.org/10.1002/elps.202300158openalex-snapshot
Strategies for capillary electrophoresis: Method development and validation for pharmaceutical and biological applications—Updated and completely revised edition
inferred← citeshttps://doi.org/10.1002/elps.70024openalex-snapshot
The Hidden Influence: Impacts of Residual Dimethylformamide in NDSB‐211 on icIEF Separation for Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1002/jssc.202300244openalex-snapshot
Capillary electrophoresis‐mass spectrometry for intact protein analysis: Pharmaceutical and biomedical applications (2018–March 2023)
inferred← citeshttps://doi.org/10.1016/j.ab.2023.115312openalex-snapshot
Imaged capillary isoelectric focusing tandem high-resolution mass spectrometry using nano electrospray ionization (ESI) for protein heterogeneity characterization
inferred← citeshttps://doi.org/10.1016/j.ab.2025.115765openalex-snapshot
Imaged capillary isoelectric focusing and online mass spectrometry for milk whey protein characterization in dairy products
inferred← citeshttps://doi.org/10.1016/j.aca.2025.344567openalex-snapshot
Ampholyte-free microfluidic free-flow isoelectric focusing via ion-exchange membranes for particle separation
inferred← citeshttps://doi.org/10.1016/j.greeac.2024.100122openalex-snapshot
Retracted:An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection
inferred← citeshttps://doi.org/10.1016/j.greeac.2025.100204openalex-snapshot
An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection
inferred← citeshttps://doi.org/10.1016/j.jchromb.2024.124238openalex-snapshot
A high stable sample loading for analysis of adult alpha-thalassemia via the improved microarray isoelectric focusing of Hb species
inferred← citeshttps://doi.org/10.1016/j.jchromb.2025.124705openalex-snapshot
Refining proteoform characterization in biopharmaceuticals: A paradigm for the impact of pI markers and carrier ampholytes in imaged capillary isoelectric focusing tandem mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116120openalex-snapshot
Development of a platform method for rapid detection and characterization of domain-specific post-translational modifications in bispecific antibodies
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118212openalex-snapshot
Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization
inferred← citeshttps://doi.org/10.2174/0115665232369708250327081305openalex-snapshot
Imaged Capillary Isoelectric Focusing (icIEF) Platform for Characterization of Charge Variants of Adeno-Associated Virus (AAV) Capsids and Impact on their Transduction Efficiency
inferred← citeshttps://doi.org/10.3389/fchem.2025.1536222openalex-snapshot
Exploring imaged capillary isoelectric focusing parameters for enhanced charge variants quality control
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