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Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bit.21855openalex-snapshot
C‐terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes
inferredcites →https://doi.org/10.1002/bmc.603openalex-snapshot
Characterization of maleuric acid derivatives on transgenic human monoclonal antibody due to post‐secretional modifications in goat milk
inferredcites →https://doi.org/10.1002/ddr.10344openalex-snapshot
Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies
inferredcites →https://doi.org/10.1002/jps.21014openalex-snapshot
Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity
inferredcites →https://doi.org/10.1002/jps.21180openalex-snapshot
Heterogeneity of Monoclonal Antibodies
inferredcites →https://doi.org/10.1002/jps.21655openalex-snapshot
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain
inferredcites →https://doi.org/10.1002/jps.21749openalex-snapshot
The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies
inferredcites →https://doi.org/10.1002/jps.22504openalex-snapshot
Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody
inferredcites →https://doi.org/10.1002/pro.173openalex-snapshot
Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody
inferredcites →https://doi.org/10.1002/pro.45openalex-snapshot
Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn
inferredcites →https://doi.org/10.1002/rcm.4464openalex-snapshot
Probing deamidation in therapeutic immunoglobulin gamma (IgG1) by ‘bottom‐up’ mass spectrometry with electron transfer dissociation
inferredcites →https://doi.org/10.1006/abio.1999.4275openalex-snapshot
Characterization of Recombinant Human Monoclonal Tissue Necrosis Factor-α Antibody Using Cation-Exchange HPLC and Capillary Isoelectric Focusing
inferredcites →https://doi.org/10.1007/s11095-005-5267-7openalex-snapshot
Structural Characterization of a Recombinant Monoclonal Antibody by Electrospray Time-of-Flight Mass Spectrometry
inferredcites →https://doi.org/10.1007/s11095-007-9241-4openalex-snapshot
Accumulation of Succinimide in a Recombinant Monoclonal Antibody in Mildly Acidic Buffers Under Elevated Temperatures
inferredcites →https://doi.org/10.1007/s11095-011-0534-2openalex-snapshot
Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody
inferredcites →https://doi.org/10.1007/s11095-011-0536-0openalex-snapshot
Elucidation of Degradants in Acidic Peak of Cation Exchange Chromatography in an IgG1 Monoclonal Antibody Formed on Long-Term Storage in a Liquid Formulation
inferredcites →https://doi.org/10.1016/0021-9673(94)01255-dopenalex-snapshot
Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture
inferredcites →https://doi.org/10.1016/0165-2478(94)90085-xopenalex-snapshot
Cationization of a monoclonal antibody to the human immunodeficiency virus REV protein enhances cellular uptake but does not impair antigen binding of the antibody
inferredcites →https://doi.org/10.1016/0969-8051(95)02057-8openalex-snapshot
Modification of antibody isoelectric point affects biodistribution of 111-indium-labeled antibody
inferredcites →https://doi.org/10.1016/j.ab.2005.10.003openalex-snapshot
Analysis of recombinant monoclonal antibody isoforms by electrospray ionization mass spectrometry as a strategy for streamlining characterization of recombinant monoclonal antibody charge heterogeneity
inferredcites →https://doi.org/10.1016/j.ab.2006.10.012openalex-snapshot
Cation exchange–HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain
inferredcites →https://doi.org/10.1016/j.ab.2007.05.012openalex-snapshot
Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H218O
inferredcites →https://doi.org/10.1016/j.ab.2007.09.027openalex-snapshot
A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior
inferredcites →https://doi.org/10.1016/j.ab.2009.05.043openalex-snapshot
Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody
inferredcites →https://doi.org/10.1016/j.ab.2009.09.027openalex-snapshot
Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule
inferredcites →https://doi.org/10.1016/j.ab.2011.07.033openalex-snapshot
On-line characterization of monoclonal antibody variants by liquid chromatography–mass spectrometry operating in a two-dimensional format
inferredcites →https://doi.org/10.1016/j.chroma.2010.10.107openalex-snapshot
Separation of oxidized variants of a monoclonal antibody by anion-exchange
inferredcites →https://doi.org/10.1016/j.chroma.2011.05.061openalex-snapshot
Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography
inferredcites →https://doi.org/10.1016/j.ijpharm.2005.10.024openalex-snapshot
Influence of pH, buffer species, and storage temperature on physicochemical stability of a humanized monoclonal antibody LA298
inferredcites →https://doi.org/10.1016/j.imlet.2006.05.011openalex-snapshot
Effect of posttranslational modifications on the thermal stability of a recombinant monoclonal antibody
inferredcites →https://doi.org/10.1016/j.jchromb.2004.06.052openalex-snapshot
Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells
inferredcites →https://doi.org/10.1016/j.jchromb.2006.11.050openalex-snapshot
Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody
inferredcites →https://doi.org/10.1016/j.jchromb.2007.01.024openalex-snapshot
Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function
inferredcites →https://doi.org/10.1016/j.jchromb.2007.12.001openalex-snapshot
Characterization of the glycosylation state of a recombinant monoclonal antibody using weak cation exchange chromatography and mass spectrometry
inferredcites →https://doi.org/10.1016/j.jchromb.2008.05.045openalex-snapshot
Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G
inferredcites →https://doi.org/10.1016/j.jchromb.2010.02.003openalex-snapshot
Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC
inferredcites →https://doi.org/10.1016/j.jchromb.2010.05.032openalex-snapshot
Characterization of a unique IgG1 mAb CEX profile by limited Lys-C proteolysis/CEX separation coupled with mass spectrometry and structural analysis
inferredcites →https://doi.org/10.1016/j.jchromb.2011.08.015openalex-snapshot
Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody
inferredcites →https://doi.org/10.1016/j.molimm.2009.02.002openalex-snapshot
Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors
inferredcites →https://doi.org/10.1016/j.molimm.2010.12.009openalex-snapshot
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
inferredcites →https://doi.org/10.1016/s0021-9673(98)00521-4openalex-snapshot
Protein variant separations by cation-exchange chromatography on tentacle-type polymeric stationary phases
inferredcites →https://doi.org/10.1016/s0022-3565(25)12257-xopenalex-snapshot
Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.
inferredcites →https://doi.org/10.1016/s0378-4347(00)00548-xopenalex-snapshot
Identification of multiple sources of charge heterogeneity in a recombinant antibody
inferredcites →https://doi.org/10.1016/s0731-7085(02)00479-xopenalex-snapshot
Analysis of isoaspartate in a recombinant monoclonal antibody and its charge isoforms
inferredcites →https://doi.org/10.1016/s0731-7085(97)00178-7openalex-snapshot
Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion
inferredcites →https://doi.org/10.1021/ac0494174openalex-snapshot
In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS
inferredcites →https://doi.org/10.1021/ac050672dopenalex-snapshot
Identification and Characterization of Deamidation Sites in the Conserved Regions of Human Immunoglobulin Gamma Antibodies
inferredcites →https://doi.org/10.1021/ac0617870openalex-snapshot
18O Labeling Method for Identification and Quantification of Succinimide in Proteins
inferredcites →https://doi.org/10.1021/ac801617uopenalex-snapshot
Method to Differentiate Asn Deamidation That Occurred Prior to and during Sample Preparation of a Monoclonal Antibody
inferredcites →https://doi.org/10.1021/ac802708sopenalex-snapshot
Direct Identification and Quantification of Aspartyl Succinimide in an IgG2 mAb by RapiGest Assisted Digestion
inferredcites →https://doi.org/10.1021/ac9006254openalex-snapshot
Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody
inferredcites →https://doi.org/10.1021/bc0256648openalex-snapshot
Monoclonal Antibody Radiopharmaceuticals: Cationization, Pegylation, Radiometal Chelation, Pharmacokinetics, and Tumor Imaging
inferredcites →https://doi.org/10.1021/bi061500topenalex-snapshot
Aspartate Isomerization in the Complementarity-Determining Regions of Two Closely Related Monoclonal Antibodies
inferredcites →https://doi.org/10.1021/bi702238bopenalex-snapshot
Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation
inferredcites →https://doi.org/10.1021/bi800576copenalex-snapshot
Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms
inferredcites →https://doi.org/10.1021/bi951526copenalex-snapshot
Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE: Identification and Effect on Binding Affinity
inferredcites →https://doi.org/10.1021/js970143sopenalex-snapshot
Antioxidants for Prevention of Methionine Oxidation in Recombinant Monoclonal Antibody HER2
inferredcites →https://doi.org/10.1021/js970335nopenalex-snapshot
Pharmacokinetics and Organ Distribution of Cationized Colchicine-Specific IgG and Fab Fragments in Rat
inferredcites →https://doi.org/10.1023/a:1026461830617openalex-snapshot
Determination of the Origin of Charge Heterogeneity in a Murine Monoclonal Antibody
inferredcites →https://doi.org/10.1073/pnas.83.8.2632openalex-snapshot
Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.
inferredcites →https://doi.org/10.1073/pnas.86.12.4761openalex-snapshot
Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein.
inferredcites →https://doi.org/10.1074/jbc.m709987200openalex-snapshot
Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms
inferredcites →https://doi.org/10.1074/jbc.m709988200openalex-snapshot
Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass
inferredcites →https://doi.org/10.1089/108497802760363150openalex-snapshot
Pharmacokinetic Characteristics and Biodistribution of Radioiodinated Chimeric TNT-1, -2, and -3 Monoclonal Antibodies After Chemical Modification with Biotin
inferredcites →https://doi.org/10.1089/cbr.1996.11.203openalex-snapshot
Improved Tumor Localization and Radioimaging with Chemically Modified Monoclonal Antibodies
inferredcites →https://doi.org/10.1593/neo.07721openalex-snapshot
Internalization, Intracellular Trafficking, Biodistribution of Monoclonal Antibody 806: A Novel Anti-Epidermal Growth Factor Receptor Antibody
inferredcites →https://doi.org/10.2174/138920108786786402openalex-snapshot
Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods
inferredcites →https://doi.org/10.4161/mabs.3.6.17959openalex-snapshot
Characterization of the basic charge variants of a human IgG1
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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An Integrated Protocol Based on Workflows of Imaged Capillary Isoelectric Focusing (Icief) for In-Depth Protein Heterogenous Characterization: High-Efficient Fractionation and Online Mass Spectrometry Detection
inferred← citeshttps://doi.org/10.1002/0471266949.bmc160openalex-snapshot
Process Development of Protein Therapeutics
inferred← citeshttps://doi.org/10.1002/0471266949.bmc160.pub2openalex-snapshot
Process Development of Protein Therapeutics
inferred← citeshttps://doi.org/10.1002/9781118703748.ch18openalex-snapshot
Hydrogen Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1002/9781394278572.ch27openalex-snapshot
RELEVANCE AND BIOPHYSICAL ATTRIBUTES OF MONOCLONAL ANTIBODY ISOFORMS
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Mammalian Fed‐batch Cell Culture for Biopharmaceuticals
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Amino Acid‐Based Advanced Liquid Formulation Development for Highly Concentrated Therapeutic Antibodies Balances Physical and Chemical Stability and Low Viscosity
inferred← citeshttps://doi.org/10.1002/biot.202000464openalex-snapshot
Effect of vitamins and metal ions on productivity and charge heterogeneity of IgG1 expressed in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.26259openalex-snapshot
Cell‐controlled hybrid perfusion fed‐batch CHO cell process provides significant productivity improvement over conventional fed‐batch cultures
inferred← citeshttps://doi.org/10.1002/bit.26587openalex-snapshot
Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles
inferred← citeshttps://doi.org/10.1002/bit.27436openalex-snapshot
Impacts on product quality attributes of monoclonal antibodies produced in CHO cell bioreactor cultures during intentional mycoplasma contamination events
inferred← citeshttps://doi.org/10.1002/bit.27628openalex-snapshot
Cysteine in cell culture media induces acidic IgG1 species by disrupting the disulfide bond network
inferred← citeshttps://doi.org/10.1002/bit.27723openalex-snapshot
Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step
inferred← citeshttps://doi.org/10.1002/bit.27776openalex-snapshot
Antibody capture process based on magnetic beads from very high cell density suspension
inferred← citeshttps://doi.org/10.1002/bit.27899openalex-snapshot
Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality
inferred← citeshttps://doi.org/10.1002/bit.27905openalex-snapshot
Assessment of quality attributes for adeno‐associated viral vectors
inferred← citeshttps://doi.org/10.1002/bit.28150openalex-snapshot
Transcriptomic analysis reveals mode of action of butyric acid supplementation in an intensified CHO cell fed‐batch process
inferred← citeshttps://doi.org/10.1002/bit.28605openalex-snapshot
Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity
inferred← citeshttps://doi.org/10.1002/bit.28846openalex-snapshot
Clear insight into complex multimodal resins and impurities to overcome recombinant protein purification challenges: A review
inferred← citeshttps://doi.org/10.1002/btpr.1908openalex-snapshot
Resolution of heterogeneous charged antibody aggregates via multimodal chromatography: A comparison to conventional approaches
inferred← citeshttps://doi.org/10.1002/btpr.1920openalex-snapshot
Effect of ambient light on monoclonal antibody product quality during small‐scale mammalian cell culture process in clear glass bioreactors
inferred← citeshttps://doi.org/10.1002/btpr.1921openalex-snapshot
Modulation of mAb quality attributes using microliter scale fed‐batch cultures
inferred← citeshttps://doi.org/10.1002/btpr.2004openalex-snapshot
Effects of copper on CHO cells: Cellular requirements and product quality considerations
inferred← citeshttps://doi.org/10.1002/btpr.2095openalex-snapshot
Cell culture media supplementation of bioflavonoids for the targeted reduction of acidic species charge variants on recombinant therapeutic proteins
inferred← citeshttps://doi.org/10.1002/btpr.2195openalex-snapshot
Chemically defined media modifications to lower tryptophan oxidation of biopharmaceuticals
inferred← citeshttps://doi.org/10.1002/btpr.2206openalex-snapshot
A high‐throughput capillary isoelectric focusing immunoassay for fingerprinting protein sialylation
inferred← citeshttps://doi.org/10.1002/btpr.2327openalex-snapshot
Impact of cell culture on recombinant monoclonal antibody product heterogeneity
inferred← citeshttps://doi.org/10.1002/btpr.2411openalex-snapshot
Effect of copper variation in yeast hydrolysate on C‐terminal lysine levels of a monoclonal antibody
inferred← citeshttps://doi.org/10.1002/btpr.2498openalex-snapshot
Impact of IgG Fc‐Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy
inferred← citeshttps://doi.org/10.1002/btpr.2548openalex-snapshot
Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic
inferred← citeshttps://doi.org/10.1002/btpr.2730openalex-snapshot
Design of experiments applications in bioprocessing: Chromatography process development using split design of experiments
inferred← citeshttps://doi.org/10.1002/elps.201500219openalex-snapshot
Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non‐denaturing IEF fractionation
inferred← citeshttps://doi.org/10.1002/elps.201800131openalex-snapshot
High‐resolution separation of monoclonal antibodies mixtures and their charge variants by an alternative and generic CZE method
inferred← citeshttps://doi.org/10.1002/elps.202100259openalex-snapshot
Enzymatic removal of sialic acid enables iCIEF stability monitoring of charge variants of a highly sialylated bispecific antibody
inferred← citeshttps://doi.org/10.1002/elps.202100325openalex-snapshot
Sample displacement chromatography of monoclonal antibody charge variants and aggregates
inferred← citeshttps://doi.org/10.1002/elps.202300170openalex-snapshot
CE methods for charge variant analysis of mAbs and complex format biotherapeutics
inferred← citeshttps://doi.org/10.1002/elps.202300221openalex-snapshot
Isolation and characterization of rabies monoclonal antibody charge variants
inferred← citeshttps://doi.org/10.1002/elps.202400084openalex-snapshot
Charge variant analysis of monoclonal antibodies by CZE‐MS using a successive multiple ionic‐polymer layer coating based on diethylaminoethyl‐dextran
inferred← citeshttps://doi.org/10.1002/elps.202400158openalex-snapshot
Offline Coupling of Hydrophobic Interaction Chromatography–Capillary Zone Electrophoresis for Monitoring Charge‐Based Heterogeneity of Recombinant Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1002/elps.70112openalex-snapshot
Optimized iCIEF Fractionation Enables Deep Profiling of Antibody Drug Conjugate Charge Heterogeneity
inferred← citeshttps://doi.org/10.1002/elsc.202000094openalex-snapshot
A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants
inferred← citeshttps://doi.org/10.1002/jctb.4850openalex-snapshot
Protein deamidation in biopharmaceutical manufacture: understanding, control and impact
inferred← citeshttps://doi.org/10.1002/jctb.5636openalex-snapshot
Enhanced product understanding in the QbD paradigm: linkage between charge heterogeneity and stability of monoclonal antibody therapeutic products
inferred← citeshttps://doi.org/10.1002/jps.24224openalex-snapshot
Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1002/jps.24683openalex-snapshot
Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies
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High‐efficient characterization of complex protein drugs by imaged capillary isoelectric focusing with high‐resolution ampholytes
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Imaged capillary isoelectric focusing employing fluorocarbon and methylcellulose coated fused silica capillary for characterization of charge heterogeneity of protein biopharmaceuticals
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Simple Western: Bringing the Western Blot into the Twenty-First Century
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Platform Methods to Characterize the Charge Heterogeneity of Three Common Protein Therapeutics by Imaged Capillary Isoelectric Focusing
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Capillary Isoelectric Focusing: Mass Spectrometry Method for the Separation and Online Characterization of Monoclonal Antibody Charge Variants at Intact and Subunit Levels
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Protein Stability and Characterization
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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
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Understanding the pathway and kinetics of aspartic acid isomerization in peptide mapping methods for monoclonal antibodies
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Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody
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Insights into the generation of monoclonal antibody acidic charge variants during Chinese hamster ovary cell cultures
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Investigation into the impact of tyrosine on the product formation and quality attributes of mAbs in rCHO cell cultures
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Production of an anti-TNFα antibody in murine myeloma cells by perfusion culture
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Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins
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Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development
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Culture temperature modulates monoclonal antibody charge variation distribution in Chinese hamster ovary cell cultures
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Cell culture medium supplemented with taurine decreases basic charge variant levels of a monoclonal antibody
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Reduction of charge variants by CHO cell culture process optimization
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Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7
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Cutting edge approaches for natural product purification
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Liquid chromatography–fluorescence and liquid chromatography–mass spectrometry detection of tryptophan degradation products of a recombinant monoclonal antibody
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Characterization of recombinant monoclonal antibody charge variants using WCX chromatography, icIEF and LC-MS/MS
inferred← citeshttps://doi.org/10.1016/j.ab.2021.114214openalex-snapshot
Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ab.2022.114575openalex-snapshot
A high-resolution multi-attribute method for product characterization, process characterization, and quality control of therapeutic proteins
inferred← citeshttps://doi.org/10.1016/j.ab.2022.114961openalex-snapshot
Cutting-edge mass spectrometry strategy based on imaged capillary isoelectric focusing (icIEF) technology for characterizing charge heterogeneity of monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.ab.2023.115312openalex-snapshot
Imaged capillary isoelectric focusing tandem high-resolution mass spectrometry using nano electrospray ionization (ESI) for protein heterogeneity characterization
inferred← citeshttps://doi.org/10.1016/j.ab.2025.115825openalex-snapshot
Advancing protein heterogeneity analysis: Nano-flow pressure mobilization for precise icIEF fractionation and online MS detection
inferred← citeshttps://doi.org/10.1016/j.aca.2020.12.064openalex-snapshot
Fractionated charge variants of biosimilars: A review of separation methods, structural and functional analysis
inferred← citeshttps://doi.org/10.1016/j.aca.2024.343287openalex-snapshot
Characterization of monoclonal antibody charge variants under near-native separation conditions using nanoflow sheath liquid capillary electrophoresis-mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.addr.2026.115856openalex-snapshot
Emerging techniques for modeling and simulating subcutaneous injection and fate of drugs after injection
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107637openalex-snapshot
Rosmarinic acid, a new raw material, doubled monoclonal antibody titer in cell culture manufacturing
inferred← citeshttps://doi.org/10.1016/j.bej.2022.108438openalex-snapshot
Achieving charge variant profile of innovator molecule during development of monoclonal antibody based biosimilars – Use of media components
inferred← citeshttps://doi.org/10.1016/j.biologicals.2016.12.006openalex-snapshot
Charge variant analysis of proposed biosimilar to Trastuzumab
inferred← citeshttps://doi.org/10.1016/j.biologicals.2019.03.006openalex-snapshot
Modifications of recombinant monoclonal antibodies in vivo
inferred← citeshttps://doi.org/10.1016/j.biologicals.2021.08.002openalex-snapshot
Similarity demonstrated between isolated charge variants of MB02, a biosimilar of bevacizumab, and Avastin® following extended physicochemical and functional characterization
inferred← citeshttps://doi.org/10.1016/j.biologicals.2021.09.001openalex-snapshot
Similarity demonstrated between isolated charge variants of MB02, a biosimilar of bevacizumab, and Avastin® following extended physicochemical and functional characterization
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2020.107577openalex-snapshot
Applications of small molecules in modulating productivity and product quality of recombinant proteins produced using cell cultures
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107831openalex-snapshot
Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture
inferred← citeshttps://doi.org/10.1016/j.bpj.2022.02.002openalex-snapshot
Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody
inferred← citeshttps://doi.org/10.1016/j.ces.2020.116171openalex-snapshot
Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals
inferred← citeshttps://doi.org/10.1016/j.chroma.2014.09.051openalex-snapshot
Use of chelating agents to improve the resolution and consistency of cation-exchange chromatography of monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.chroma.2014.11.021openalex-snapshot
Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range: Validation of the method parameters
inferred← citeshttps://doi.org/10.1016/j.chroma.2020.461786openalex-snapshot
Charge variant analysis of protein-based biopharmaceuticals using two-dimensional liquid chromatography hyphenated to mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462008openalex-snapshot
Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462409openalex-snapshot
Monoclonal antibody charge variant characterization by fully automated four-dimensional liquid chromatography-mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462499openalex-snapshot
Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462506openalex-snapshot
Change of charge variant composition of trastuzumab upon stressing at physiological conditions
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462761openalex-snapshot
Eliminating protein oxidation artifacts during High Performance Liquid Chromatography peak fractionation processes
inferred← citeshttps://doi.org/10.1016/j.chroma.2023.464070openalex-snapshot
Coupling of chromatography and precipitation for adjusting acidic variant content in a monoclonal antibody pool
inferred← citeshttps://doi.org/10.1016/j.chroma.2024.464722openalex-snapshot
In-line buffer exchange in the coupling of Protein A chromatography with weak cation exchange chromatography for the determination of charge variants of immunoglobulin G derived from chinese hamster ovary cell cultures
inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465065openalex-snapshot
Multiple, simultaneous, independent gradients for a versatile multidimensional liquid chromatography. Part II: Application 3 – Scouting optimization strategies for separation of monoclonal antibodies by dual simultaneous independent gradients of pH & salt on a weak cation exchange stationary phase
inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465256openalex-snapshot
Coupling cation and anion exchange chromatography for fast separation of monoclonal antibody charge variants
inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465281openalex-snapshot
In silico mediated workflow for rapid development of downstream processing: Orthogonal product-related impurity removal for a Fc-containing therapeutic
inferred← citeshttps://doi.org/10.1016/j.chroma.2025.465672openalex-snapshot
Ion exchange chromatography of biotherapeutics: Fundamental principles and advanced approaches
inferred← citeshttps://doi.org/10.1016/j.chroma.2026.466761openalex-snapshot
Antigen affinity chromatography for functional separation and efficient characterization of critical monoclonal antibody variants
inferred← citeshttps://doi.org/10.1016/j.clinthera.2024.08.007openalex-snapshot
The Totality of Evidence for SDZ-deno: A Biosimilar to Reference Denosumab
inferred← citeshttps://doi.org/10.1016/j.compchemeng.2019.106532openalex-snapshot
Good modeling practice for industrial chromatography: Mechanistic modeling of ion exchange chromatography of a bispecific antibody
inferred← citeshttps://doi.org/10.1016/j.copbio.2014.06.012openalex-snapshot
Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality
inferred← citeshttps://doi.org/10.1016/j.ejca.2016.01.008openalex-snapshot
Stability of ipilimumab in its original vial after opening allows its use for at least 4 weeks and facilitates pooling of residues
inferred← citeshttps://doi.org/10.1016/j.ejca.2020.04.042openalex-snapshot
Stability of nivolumab in its original vials after opening and handing in normal saline bag for intravenous infusion
inferred← citeshttps://doi.org/10.1016/j.ejpb.2020.10.020openalex-snapshot
Identification of monoclonal antibody variants involved in aggregate formation – Part 1: Charge variants
inferred← citeshttps://doi.org/10.1016/j.ejpb.2020.11.006openalex-snapshot
Optimisation of the use of sliding window deconvolution for comprehensive characterisation of trastuzumab and adalimumab charge variants by native high resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ejpb.2024.114295openalex-snapshot
Assessment of change in the basic variants composition of trastuzumab during dilution in saline for administration
inferred← citeshttps://doi.org/10.1016/j.greeac.2024.100122openalex-snapshot
Retracted:An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection
inferred← citeshttps://doi.org/10.1016/j.greeac.2025.100204openalex-snapshot
An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.147808openalex-snapshot
Multiple analysis based on dual-mode anion-exchange chromatography strategy reveals significant impact of charge heterogeneity on structure and function of dulaglutide
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2021.120723openalex-snapshot
Investigating photodegradation of antibodies governed by the light dosage
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124014openalex-snapshot
How spray drying processing and solution composition can affect the mAbs stability in reconstituted solutions for subcutaneous injections. Part II: Exploring each protein stabilizer effect
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.126907openalex-snapshot
Feasibility and stability evaluation of parabens as an alternative preservative for liquid monoclonal antibody formulations
inferred← citeshttps://doi.org/10.1016/j.ijpx.2022.100155openalex-snapshot
Protein photodegradation in the visible range? Insights into protein photooxidation with respect to protein concentration
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2015.02.026openalex-snapshot
Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2015.10.009openalex-snapshot
Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity
inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.03.031openalex-snapshot
SpeB proteolysis with imaged capillary isoelectric focusing for the characterization of domain-specific charge heterogeneities of reference and biosimilar Rituximab
inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.05.017openalex-snapshot
Development of a rapid RP-UHPLC–MS method for analysis of modifications in therapeutic monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.02.017openalex-snapshot
Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.09.033openalex-snapshot
Determination of isoelectric points and relative charge variants of 23 therapeutic monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.12.003openalex-snapshot
Rapid preparative separation of monoclonal antibody charge variants using laterally-fed membrane chromatography
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.02.042openalex-snapshot
A three-point identity criteria tool for establishing product identity using icIEF method
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.07.037openalex-snapshot
Rapid charge variant analysis of monoclonal antibodies to support lead candidate biopharmaceutical development
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.10.019openalex-snapshot
Identification and quantification of product-related quality attributes in bio-therapeutic monoclonal antibody via a simple, and robust cation-exchange HPLC method compatible with direct online detection of UV and native ESI-QTOF-MS analysis
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.12.021openalex-snapshot
Comparison of imaged capillary isoelectric focusing and cation exchange chromatography for monitoring dextrose-mediated glycation of monoclonal antibodies in infusion solutions
inferred← citeshttps://doi.org/10.1016/j.jchromb.2019.121814openalex-snapshot
A generic method for intact and subunit level characterization of mAb charge variants by native mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jchromb.2020.122485openalex-snapshot
Isolation and characterization of charge variants of infliximab biosimilar HS626
inferred← citeshttps://doi.org/10.1016/j.jchromb.2026.124920openalex-snapshot
Impacts of methionine oxidation on product quality and anti-tumor activity of a therapeutic monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.jchromb.2026.125078openalex-snapshot
In-depth characterization analysis of a bispecific antibody acidic charge variant
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115034openalex-snapshot
From discovery to therapeutic development of monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.03.014openalex-snapshot
Facile preparation of fibrin coated open tubular column for characterization of monoclonal antibody variants by capillary electrochromatography
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.03.029openalex-snapshot
Comparability study of Rituximab originator and follow-on biopharmaceutical
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113107openalex-snapshot
Combination of intact, middle-up and bottom-up levels to characterize 7 therapeutic monoclonal antibodies by capillary electrophoresis – Mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113131openalex-snapshot
Analytical artifacts in characterization of recombinant monoclonal antibody therapeutics
inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113703openalex-snapshot
A hydrophobic interaction chromatography method suitable for quantitating individual monoclonal antibodies contained in co-formulated drug products
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.113963openalex-snapshot
Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114122openalex-snapshot
Freeze thaw and lyophilization induced alteration in mAb therapeutics: Trastuzumab as a case study
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114796openalex-snapshot
Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115147openalex-snapshot
High-sensitivity and high-resolution therapeutic antibody charge variant and impurity characterization by microfluidic native capillary electrophoresis-mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115178openalex-snapshot
Imaged Capillary Isoelectric Focusing (iCIEF) Tandem High Resolution Mass Spectrometry for Charged Heterogeneity of Protein Drugs in Biopharmaceutical Discovery
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116410openalex-snapshot
Assessment of chemical stability of monoclonal antibody and antibody drug conjugate administered by pressurized intraperitoneal aerosol chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.116879openalex-snapshot
Alcohol-based solvents as mobile phases for LC-MS characterization of therapeutic proteins
inferred← citeshttps://doi.org/10.1016/j.jpba.2026.117407openalex-snapshot
Physicochemical and biological characterization of GNR-087, a Tocilizumab biosimilar
inferred← citeshttps://doi.org/10.1016/j.jpha.2020.06.003openalex-snapshot
Use of subcutaneous tocilizumab to prepare intravenous solutions for COVID-19 emergency shortage: Comparative analytical study of physicochemical quality attributes
inferred← citeshttps://doi.org/10.1016/j.jpha.2020.11.006openalex-snapshot
Global characterization of modifications to the charge isomers of IgG antibody
inferred← citeshttps://doi.org/10.1016/j.jpha.2026.101740openalex-snapshot
Charged-tagging ion-exchange chromatography enables rapid, accurate and comprehensive (RAC) profiling of free thiols and charge heterogeneity in mAbs
inferred← citeshttps://doi.org/10.1016/j.molimm.2017.10.020openalex-snapshot
Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants
inferred← citeshttps://doi.org/10.1016/j.omtm.2023.101112openalex-snapshot
Adeno-associated viral capsid stability on anion exchange chromatography column and its impact on empty and full capsid separation
inferred← citeshttps://doi.org/10.1016/j.pep.2026.106958openalex-snapshot
Comparative analysis of charge heterogeneity in anti-sclerostin monoclonal antibodies produced via continuous perfusion and fed-batch processes
inferred← citeshttps://doi.org/10.1016/j.pharma.2023.09.003openalex-snapshot
Charge variants of proposed biosimilar to Omalizumab: Isolation, purification and analysis by HPLC methods
inferred← citeshttps://doi.org/10.1016/j.sampre.2024.100109openalex-snapshot
Effects of thermal treatment on quality of biosimilar and originator monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.seppur.2019.116136openalex-snapshot
Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization
inferred← citeshttps://doi.org/10.1016/j.talanta.2021.122836openalex-snapshot
Bispecific antibody characterization by a combination of intact and site-specific/chain-specific LC/MS techniques
inferred← citeshttps://doi.org/10.1016/j.talanta.2023.125062openalex-snapshot
Characterization of charge variants, including post-translational modifications and proteoforms, of bispecific antigen-binding protein by cation-exchange chromatography coupled to native mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126232openalex-snapshot
Titer and charge-based heterogeneity multiattribute monitoring of mAbs in cell culture harvest using 2D ProA CEX MS
inferred← citeshttps://doi.org/10.1016/j.tibtech.2023.08.008openalex-snapshot
What should next-generation analytical platforms for biopharmaceutical production look like?
inferred← citeshttps://doi.org/10.1016/j.trac.2023.116975openalex-snapshot
Recent capillary electrophoresis applications for upstream and downstream biopharmaceutical process monitoring
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118212openalex-snapshot
Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization
inferred← citeshttps://doi.org/10.1016/j.wpi.2024.102261openalex-snapshot
A comprehensive review and analysis of patents on biological and biosimilar products listed in the purple book
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.08.016openalex-snapshot
Assessing the Impact of Charge Variants on Stability and Viscosity of a High Concentration Antibody Formulation
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.05.023openalex-snapshot
Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.08.009openalex-snapshot
Physicochemical Stability of Monoclonal Antibodies: A Review
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.12.001openalex-snapshot
Physicochemical and Functional Characterization of HS016, a Biosimilar of Adalimumab (Humira)
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.06.014openalex-snapshot
Stability of Opened Durvalumab (IMFINZI) Vials. The Beginning of the End of Costly Product Wastage?
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.05.022openalex-snapshot
Characterization of Therapeutic Antibody Charge Heterogeneity Under Stress Conditions by Microfluidic Capillary Electrophoresis Coupled with Mass Spectrometry
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.08.021openalex-snapshot
Developing analytical ion exchange chromatography methods for antibody drug conjugates containing the hydrolysis-prone succinimide-thioether conjugation chemistry
inferred← citeshttps://doi.org/10.1016/j.xphs.2025.103804openalex-snapshot
Assessing the impact of viscosity lowering excipient on liquid-liquid phase separation for high concentration monoclonal antibody solutions
inferred← citeshttps://doi.org/10.1016/j.xphs.2026.104255openalex-snapshot
Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization
inferred← citeshttps://doi.org/10.1021/ac3032355openalex-snapshot
Characterization of Therapeutic Antibodies and Related Products
inferred← citeshttps://doi.org/10.1021/ac404130aopenalex-snapshot
Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling
inferred← citeshttps://doi.org/10.1021/ac500497nopenalex-snapshot
Microchip Zone Electrophoresis for High-Throughput Analysis of Monoclonal Antibody Charge Variants
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c02775openalex-snapshot
New Insights into the Chromatography Mechanisms of Ion-Exchange Charge Variant Analysis: Dispelling Myths and Providing Guidance for Robust Method Optimization
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c00707openalex-snapshot
Coupling Anion Exchange Chromatography with Native Mass Spectrometry for Charge Heterogeneity Characterization of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02931openalex-snapshot
Multiattribute Monitoring of Charge-Based Heterogeneity of Recombinant Monoclonal Antibodies Using 2D HIC-WCX-MS
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03531openalex-snapshot
A Universal Eluent System for Method Scouting and Separation of Biotherapeutic Proteins by Ion-Exchange, Size-Exclusion, and Hydrophobic Interaction Chromatography
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c05071openalex-snapshot
Mass Spectrometry-Based Charge Heterogeneity Characterization of Therapeutic mAbs with Imaged Capillary Isoelectric Focusing and Ion-Exchange Chromatography as Separation Techniques
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c00791openalex-snapshot
In-Depth Characterization of mAb Charge Variants by On-Line Multidimensional Liquid Chromatography-Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c03648openalex-snapshot
Development of UV–Vis Imaging Compatible Chromatographic Matrix with Application for Injectable Formulation Characterization
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b01452openalex-snapshot
Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b02800openalex-snapshot
Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.6b00822openalex-snapshot
Characterization of Cysteinylation and Trisulfide Bonds in a Recombinant Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b02228openalex-snapshot
On-Line Ion Exchange Liquid Chromatography as a Process Analytical Technology for Monoclonal Antibody Characterization in Continuous Bioprocessing
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b04608openalex-snapshot
Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b05241openalex-snapshot
Charge Variant Analysis of Monoclonal Antibodies Using Direct Coupled pH Gradient Cation Exchange Chromatography to High-Resolution Native Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01322openalex-snapshot
Asparagine Deamidation in a Complementarity Determining Region of a Recombinant Monoclonal Antibody in Complex with Antigen
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